The clinical effectiveness of haemoglobin spray as adjunctive therapy in the treatment of chronic wounds

2017 ◽  
Vol 26 (9) ◽  
pp. 558-568 ◽  
Author(s):  
S. Hunt ◽  
F. Elg
Keyword(s):  
Adjunctive Therapy ◽  
Chronic Wounds ◽  
Clinical Effectiveness

scholarly journals N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Soo Liang Ooi ◽  
Ruth Green ◽  
Sok Cheon Pak
Keyword(s):  
Mood Disorders ◽  
Adjunctive Therapy ◽  
Negative Symptoms ◽  
Clinical Effectiveness ◽  
Good Evidence ◽  
Current Evidence ◽  
Chronic Obstructive ◽  
Obsessive Compulsive ◽  
Brain Functions ◽  
Psychiatric Conditions

N-acetylcysteine, a sulphur-containing amino acid for the treatment of paracetamol overdose and chronic obstructive pulmonary disease, is a widely available off-the-shelf oral antioxidant supplement in many countries. With the potential to modulate several neurological pathways, including glutamate dysregulation, oxidative stress, and inflammation that can be beneficial to the brain functions, N-acetylcysteine is being explored as an adjunctive therapy for many psychiatric conditions. This narrative review synthesises and presents the current evidence from systematic reviews, meta-analyses, and latest clinical trials on N-acetylcysteine for addiction and substance abuse, schizophrenia, obsessive-compulsive and related disorders, and mood disorders. Good evidence exists to support the use of N-acetylcysteine as an adjunct treatment to reduce the total and negative symptoms of schizophrenia. N-acetylcysteine also appears to be effective in reducing craving in substance use disorders, especially for the treatment of cocaine and cannabis use among young people, in addition to preventing relapse in already abstinent individuals. Effects of N-acetylcysteine on obsessive-compulsive and related disorders, as well as on mood disorders, remain unclear with mixed reviews, even though promising evidence does exist. Larger and better-designed studies are required to further investigate the clinical effectiveness of N-acetylcysteine in these areas. Oral N-acetylcysteine is safe and well tolerated without any considerable adverse effects. Current evidence supports its use as an adjunctive therapy clinically for psychiatric conditions, administered concomitantly with existing medications, with a recommended dosage between 2000 and 2400 mg/day.

scholarly journals Hyperbaric Oxygenation as Adjunctive Therapy in the Treatment of Sudden Sensorineural Hearing Loss

2020 ◽  
Vol 21 (22) ◽  
pp. 8588
Author(s):  
Dorota Olex-Zarychta
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Adjunctive Therapy ◽  
Molecular Mechanisms ◽  
Clinical Effectiveness ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
World Health ◽  
Medical Procedure ◽  
Global Burden Of Diseases

Sudden sensorineural hearing loss seems to become a serious social health problem in modern societies. According to the World Health Organization (WHO) reports, adult-onset sensorineural hearing loss is found to be one of the leading diseases at the global level, especially in high-income countries, and is foreseen to move up from the 14th to 7th leading cause of the global burden of diseases by the year 2030. Although the direct mortality rate of this disease is very low, its influence on quality of life is huge; that is the reason why the implementation of the most effective and the safest therapies for the patient is crucial for minimizing the risk of complications and adverse reactions to treatment. The aim of this paper is to present hyperbaric oxygen therapy (HBOT) as a medical procedure useful in the treatment of sudden sensorineural hearing loss as adjunctive therapy of high efficacy. This paper focuses on the molecular mechanisms of action and clinical effectiveness of HBOT in the treatment of idiopathic sudden deafness, taking into consideration both the benefits and potential risks of its implementation.

Evaluation of Clinical Effectiveness of MIST Ultrasound Therapy for the Healing of Chronic Wounds

2006 ◽  
Vol 19 (8) ◽  
pp. 437-446 ◽  
Author(s):  
William J. Ennis ◽  
Wesley Valdes ◽  
Marianne Gainer ◽  
Patricio Meneses
Keyword(s):  
Chronic Wounds ◽  
Clinical Effectiveness ◽  
Ultrasound Therapy ◽  
Mist Ultrasound

scholarly journals Single-Use Negative Pressure Wound Therapy for Chronic Wounds

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Sara D. Khangura ◽  
Carolyn Spry
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wounds ◽  
Length Of Hospital Stay ◽  
Clinical Effectiveness ◽  
Cost Effective ◽  
Wound Therapy ◽  
Single Use ◽  
Evidence Review ◽  
The Impact

Limited clinical effectiveness data suggest that single-use negative pressure wound therapy may reduce the frequency of dressing changes when compared with standard wound therapy (evidence from 1 single-arm study). No clinical evidence was identified describing the impact of single-use negative pressure wound therapy on functionality, pain, mortality, length of hospital stay, quality of life, and safety. It is unknown whether single-use or disposable negative pressure wound therapy is cost-effective for the management of chronic wounds (no eligible studies found). One guideline provides recommendations relevant to single-use negative pressure wound therapy with chronic wounds; however, there is no clear link to a robust evidence review reported by the guideline developers.

scholarly journals Assessment of wound area reduction on chronic wounds in dogs with photobiomodulation therapy: A randomized controlled clinical trial

2021 ◽  
pp. 2251-2259
Author(s):  
Somphong Hoisang ◽  
Naruepon Kampa ◽  
Suvaluk Seesupa ◽  
Supranee Jitpean
Keyword(s):  
Wound Healing ◽  
Adjunctive Therapy ◽  
Chronic Wounds ◽  
Photobiomodulation Therapy ◽  
Wound Area ◽  
Area Reduction ◽  
Wound Size ◽  
Significant Difference ◽  
L1 And L2 ◽  
Improve Wound Healing

Background and Aim: Chronic wounds are a clinical problem and require intensive standard wound care. However, this is sometimes insufficient to promote healing. Photobiomodulation therapy (PBMT) can be used as an adjunctive therapy to improve wound healing. Various PBMT devices with different properties and parameter settings as well as different animal species can influence a variety of clinical outcomes. This study aims to assess the use of 830 nm PBMT or simultaneous superpulsed and multiple wavelengths (SPMW; 660, 875, and 905 nm) PBMT on chronic wounds in client-owned dogs. Materials and Methods: This study included 21 client-owned dogs with chronic wounds allocated into three groups: (1) Control group (C) treated with irrigated saline and without PBMT (n=7); (2) L1 group treated with irrigated saline together with the radiation of 830 nm PBMT (n=7); and (3) L2 group treated with irrigated saline together with the radiation of simultaneous SPMW-PBMT (n=7). Wound healing was assessed on the basis of wound size reduction as a percentage of wound area every 2nd day for 15 days using image analysis software (ImageJ software®, National Institutes of Health, Rockville, Maryland, USA). Results: A significant difference in the percentage of wound area reduction was noted between the C and PBMT groups (L1 and L2; p<0.05). The average percentages of wound area reduction at the end of the study (15 days) were 42.39±20.58, 56.98±24.82, and 61.81±27.18 in the C, L1, and L2 groups, respectively. A steady decrease in wound size was noted in both PBMT and non-PBMT groups, and coefficients were 7.77, 8.95, and 10.01 in the C, L1, and L2 groups, respectively. The percentage of wound area reduction was found to be significantly different between the PBMT and non-BPMT groups on day 7 (p<0.05). Conclusion: Based on the results of the current study, using either 830 nm PBMT or simultaneous SPMW-PBMT can accelerate the chronic wound healing process in dogs with a significant reduction in wound area. Therefore, it can be used as an adjunctive therapy to improve wound healing in dogs with reduced treatment duration.

Electron microscopy of keratinocytes cultured on a collagen substrate used as an allograft for the treatment of chronic wounds

1992 ◽  
Vol 50 (2) ◽  
pp. 1104-1105
Author(s):  
Debby A. Jennings ◽  
Michael J. Morykwas ◽  
Louis C. Argenta
Keyword(s):  
Electron Microscopy ◽  
Cell Suspension ◽  
Single Cell ◽  
Chronic Wounds ◽  
Mechanical Stability ◽  
Uv Light ◽  
Type I ◽  
Single Cell Suspension ◽  
Collagen Substrate ◽  
Dermal Collagen

Grafts of cultured allogenic or autogenic keratlnocytes have proven to be an effective treatment of chronic wounds and burns. This study utilized a collagen substrate for keratinocyte and fibroblast attachment. The substrate provided mechanical stability and augmented graft manipulation onto the wound bed. Graft integrity was confirmed by light and transmission electron microscopy.Bovine Type I dermal collagen sheets (100 μm thick) were crosslinked with 254 nm UV light (13.5 Joules/cm2) to improve mechanical properties and reduce degradation. A single cell suspension of third passage neonatal foreskin fibroblasts were plated onto the collagen. Five days later, a single cell suspension of first passage neonatal foreskin keratinocytes were plated on the opposite side of the collagen. The grafts were cultured for one month.The grafts were fixed in phosphate buffered 4% formaldehyde/1% glutaraldehyde for 24 hours. Graft pieces were then washed in 0.13 M phosphate buffer, post-fixed in 1% osmium tetroxide, dehydrated, and embedded in Polybed 812.

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