scholarly journals Current review of surgical management options for extremity bone sarcomas

2019 ◽  
Vol 4 (5) ◽  
pp. 174-182 ◽  
Author(s):  
Catalin Cirstoiu ◽  
Bogdan Cretu ◽  
Bogdan Serban ◽  
Zsombor Panti ◽  
Mihai Nica
Keyword(s):  
Surgical Management ◽  
Survival Rates ◽  
Bone Sarcoma ◽  
Functional Results ◽  
Bone Transport ◽  
Endoprosthetic Reconstruction ◽  
Management Options ◽  
Surgical Options ◽  
Bone Sarcomas ◽  
Excision Margins

Modern surgical management of extremity bone sarcomas is governed by limb-sparing surgery combined with adjuvant and neoadjuvant chemotherapy. All the resection and reconstruction techniques have to achieve oncologic excision margins, with survival rates and functional results superior to amputation. The main reconstruction techniques of bone defects resulted after resection are: modular endoprosthetic reconstruction; bone graft reconstruction; bone transport; resection arthrodesis; and rotationplasty. Oncologic resection and modular endoprosthetic reconstruction are the generally approved surgical options adopted for the majority of cases in major specialized bone sarcoma centres. Good basic principles, efficient multidisciplinary approach and sustained research in the field can provide a better future for the challenge posed by extremity bone sarcoma treatment. Cite this article: EFORT Open Rev 2019;4:174-182. DOI: 10.1302/2058-5241.4.180048

scholarly journals Tricks and pitfalls in the surgical treatment of malignant bone tumours of the forearm in children and adolescents

2021 ◽  
Vol 15 (4) ◽  
pp. 366-371 ◽  
Author(s):  
Bulent Erol ◽  
Omer Sofulu
Keyword(s):  
Surgical Management ◽  
Multidisciplinary Approach ◽  
Functional Results ◽  
Bone Tumours ◽  
Soft Tissue Reconstruction ◽  
Unique Region ◽  
Reconstruction Methods ◽  
Malignant Bone Tumours ◽  
Tissue Reconstruction ◽  
Bone Sarcomas

Malignant bone tumours around the forearm are rare. Nowadays, oncological and surgical management of bone sarcomas of this region has improved significantly. Although the anatomical features are complex, limb-sparing surgery is possible with wide surgical resection. Biological reconstruction methods are promising in this anatomically unique region. In addition, meticulous soft-tissue reconstruction yields good functional results in the hand and wrist. This study reviews malignant bone tumours of the forearm and their oncological and surgical management. Malignant bone tumours should be treated with a multidisciplinary approach based on chemotherapy, radiotherapy and limb salvage procedures.

scholarly journals Evaluation and management of adolescent idiopathic scoliosis: a review

2017 ◽  
Vol 43 (4) ◽  
pp. E2 ◽  
Author(s):  
Ajit Jada ◽  
Charles E. Mackel ◽  
Steven W. Hwang ◽  
Amer F. Samdani ◽  
James H. Stephen ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Surgical Management ◽  
Spinal Deformity ◽  
Corrective Surgery ◽  
Management Options ◽  
Current Management ◽  
Atypical Features ◽  
Surgical Options

Adolescent idiopathic scoliosis (AIS) is a 3D spinal deformity affecting children between the ages of 11 and 18, without an identifiable etiology. The authors here reviewed the available literature to provide spine surgeons with a summary and update on current management options.Smaller thoracic and thoracolumbar curves can be managed conservatively with observation or bracing, but corrective surgery may be indicated for rapidly growing or larger curves. The authors summarize the atypical features to look for in patients who may warrant further investigation with MRI during diagnosis and review the fundamental principles of the surgical management of AIS.Patients with AIS can be managed very well with a combination of conservative and surgical options. Outcomes for these children are excellent with sustained longer-term results.

scholarly journals Non-invasive treatment in the management of Peyronie’s disease

2019 ◽  
Vol 11 ◽  
pp. 175628721882367 ◽  
Author(s):  
Karen Randhawa ◽  
C. J. Shukla
Keyword(s):  
Sexual Function ◽  
Surgical Management ◽  
Treatment Options ◽  
Invasive Treatment ◽  
Management Options ◽  
Non Invasive ◽  
Nonsurgical Management ◽  
Partner Satisfaction ◽  
Surgical Options

Peyronies disease (PD) is estimated to affect approximately 3–9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. Several non-surgical options are currently being employed in the treatment of PD that may reduce or stabilize both objective measures (e.g. penile length and deformity) and subjective measures (including sexual function, pain and partner satisfaction). Nonsurgical management can allow patients to avoid the morbidities associated with surgery and still achieve improved functional and aesthetic outcomes. In this article we explore the current non-surgical management options for PD including oral, mechanical therapies, intralesional and topical treatments. We also briefly discuss future treatment options in the form of stem cell therapy.

scholarly journals Cardiac Magnetic Resonance in Endomyocardial Fibrosis

2021 ◽  
pp. 263246362098563
Author(s):  
Shruthi Kalyan Athni ◽  
Johann Christopher
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Left Ventricle ◽  
Surgical Management ◽  
Symptomatic Relief ◽  
Endomyocardial Fibrosis ◽  
Management Options ◽  
High Level

Endomyocardial fibrosis is a rare cardiomyopathy. There has to be a high level of suspicion to make the diagnosis. The treatment is based on symptomatic relief and surgical management is based on the exact pathology found in the left ventricle apex. MRI is a robust investigation which can confirm diagnosis and provide management options and prognosis.

scholarly journals The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2478
Author(s):  
George N. Tzanakakis ◽  
Eirini-Maria Giatagana ◽  
Aikaterini Berdiaki ◽  
Ioanna Spyridaki ◽  
Kyoko Hida ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Bone Sarcoma ◽  
Response To Therapy ◽  
Targeted Therapeutics ◽  
Attractive Therapeutic Target ◽  
Bone Sarcomas ◽  
Agent Development ◽  
Insulin Like Growth Factors ◽  
Igf Signaling

Bone sarcomas, mesenchymal origin tumors, represent a substantial group of varying neoplasms of a distinct entity. Bone sarcoma patients show a limited response or do not respond to chemotherapy. Notably, developing efficient chemotherapy approaches, dealing with chemoresistance, and preventing metastasis pose unmet challenges in sarcoma therapy. Insulin-like growth factors 1 and 2 (IGF-1 and -2) and their respective receptors are a multifactorial system that significantly contributes to bone sarcoma pathogenesis. Whereas failures have been registered in creating novel targeted therapeutics aiming at the IGF pathway, new agent development should continue, evaluating combinatorial strategies for enhancing antitumor responses and better classifying the patients that could best benefit from these therapies. A plausible approach for developing a combinatorial strategy is to focus on the tumor microenvironment (TME) and processes executed therein. Herewith, we will discuss how the interplay between IGF-signaling and the TME constituents affects sarcomas’ basal functions and their response to therapy. This review highlights key studies focusing on IGF signaling in bone sarcomas, specifically studies underscoring novel properties that make this system an attractive therapeutic target and identifies new relationships that may be exploited. Potential direct and adjunct therapeutical implications of the extracellular matrix (ECM) effectors will also be summarized.

scholarly journals Imaging of Bone Sarcomas and Soft-Tissue Sarcomas

2021 ◽  
Author(s):  
Jasminka Igrec ◽  
Michael H. Fuchsjäger
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Bone Cancer ◽  
Bone Sarcoma ◽  
Daily Practice ◽  
Imaging Evaluation ◽  
Key Points ◽  
Bone Sarcomas ◽  
Publication Period ◽  
Ct And Mri

Background In the diagnosis of bone and soft-tissue sarcomas, the continuous advancement of various imaging modalities has improved the detection of small lesions, surgical planning, assessment of chemotherapeutic effects, and, importantly, guidance for surgery or biopsy. Method This review was composed based on a PubMed literature search for the terms “bone sarcoma,” “bone cancer” and “soft tissue sarcoma,” “imaging,” “magnetic resonance imaging”, “computed tomography”, “ultrasound”, “radiography”, and “radiomics” covering the publication period 2005–2020. Results and Conclusion As discussed in this review, radiography, ultrasound, CT, and MRI all play key roles in the imaging evaluation of bone and soft-tissue sarcomas. In daily practice, advanced MRI techniques complement standard MRI but remain underused, as they are considered time-consuming, technically challenging, and not reliable enough to replace biopsy and histology. PET/MRI and radiomics have shown promise regarding the imaging of sarcomas in the future. Key Points:  Citation Format

scholarly journals Isolated Duodenal Crohn's Disease: A Case Report and a Review of the Surgical Management

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Faruk Karateke ◽  
Ebru Menekşe ◽  
Koray Das ◽  
Sefa Ozyazici ◽  
Pelin Demirtürk
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Medical Treatment ◽  
Immunosuppressive Therapy ◽  
Surgical Management ◽  
Surgical Intervention ◽  
Surgical Options ◽  
Crohn’S Diseases

Crohn's disease may affect any segment of the gastrointestinal tract; however, isolated duodenal involvement is rather rare. It still remains a complex clinical entity with a controversial management of the disease. Initially, patients with duodenal Crohn' s disease (DCD) are managed with a combination of antiacid and immunosuppressive therapy. However, medical treatment fails in the majority of DCD patients, and surgical intervention is required in case of complicated disease. Options for surgical management of complicated DCD include bypass, resection, or stricturoplasty procedures. In this paper, we reported a 33-year-old male patient, who was diagnosed with isolated duodenal Crohn’s diseases, and reviewed the surgical options in the literature.

Surgical management options and postoperative functional outcomes of petrous apex cholesteatoma

2011 ◽  
Vol 131 (11) ◽  
pp. 1142-1149 ◽  
Author(s):  
Jae-Jin Song ◽  
Yong-Hwi An ◽  
Soon-Hyun Ahn ◽  
Jae Chul Yoo ◽  
Jun Ho Lee ◽  
...  
Keyword(s):  
Surgical Management ◽  
Functional Outcomes ◽  
Petrous Apex ◽  
Management Options

scholarly journals The basic characteristics of extracellular vesicles and their potential application in bone sarcomas

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shenglong Li
Keyword(s):  
Extracellular Vesicles ◽  
Membrane Vesicles ◽  
Bone Sarcoma ◽  
Biologically Active ◽  
Signal Molecules ◽  
Diagnosis And Prognosis ◽  
Bone Sarcomas ◽  
Basic Characteristics ◽  
Almost All ◽  
Sarcoma Cells

AbstractBone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis.

scholarly journals Advantages of CO2 laser use in surgical management of otosclerosis

2003 ◽  
Vol 60 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Svjetlana Matkovic ◽  
Boris Kitanoski ◽  
Zivorad Malicevic
Keyword(s):  
Hearing Loss ◽  
Surgical Management ◽  
Co2 Laser ◽  
Functional Results ◽  
Bony Labyrinth ◽  
Study Results ◽  
Classical Technique ◽  
Prospective Comparative Study ◽  
The Difference ◽  
Determination Of Parameters

Background. Otosclerosis is a progressive osteo-destructive disorder of the bony labyrinth in which the fixation of the stapes causes the hearing loss. The aim of this study was the postoperative determination of parameters of the effect of surgical intervention on hearing and the incidence of complications and, on the basis of the differences in the examined parameters of the study, the estimation of the eficacy of the two mentioned surgical thechniques in the treatment of otosclerosis. Methods. In our research 40 patients with conductive hearing loss caused by otosclerosis underwent surgery with CO2 laser. Functional results were compared postoperatively with the results of 40 patients operated by the classical technique without the use of CO2 laser. The research was accomplished as a prospective comparative study. Results. The air-bone interval (gap) as the difference between the rim of air and bone conductivity for separate frequencies did not significantly differ between the control and the experimental group. Both methods were effective in closing the air-bone gap with the rates of closure to within 10 dB in 82.6% and 75.3% for the laser and drill, respectively. The incidence of tinnitus was significantly lower in patients who underwent surgery with CO2 laser. The frequency of intraoperative and postoperative complications was significantly lower in the laser group. Differences were statistically significant for all parameters (p<0.05). Conclusion. On the basis of the degree of postoperative hearing improvement, tinnitus and the incidence of complications it can be concluded that the use of CO2 laser during inverse stapedoplasty represents an effective and safe method, justifying the promotion of its use in the surgical management of otosclerosis.

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