scholarly journals PENGARUH PEMBERIAN AIR REBUSAN DAUN SALAM (SYZYGIUM POLYANTHUM) TERHADAP PENURUNAN KADAR ASAM URAT

2018 ◽  
Vol 12 (3) ◽  
pp. 222 ◽  
Author(s):  
Aidaa - Andriani
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Uric Acid Level ◽  
Acid Level ◽  
Sampling Method ◽  
The Body ◽  
P Value ◽  
Work Area ◽  
Before And After ◽  
Area Health

<p><em>Gout</em><em> is a disease because of abnormalities purine metabolism (hyperuricemia). </em><em>In gout treatment there are many different ways to lower uric acid levels one by utilizing existing natural vegetation. Plants or plants that can be used is the bay leaf (Syzygium polyanthum)</em><em>. Bay leaf contains flavonoids that can lower uric acid levels. This study intends to find out The Effect Of Water Decoction Bay Leaf </em><em>(Syzygium polyanthum)<strong> </strong></em><em>The Decrease</em><em> Uric Acid Levels In The Work Area Health Center Paninggahan Solok 2013.This research is the method of approach Preeksperimental pretest - posttest, using total sampling method with a sample size of 10 people.</em> <em>The data was collected</em><em> directly to the respondents by interview, observation and measurement sheet uric acid levels and blood sugar.The research found that there are differences in uric acid levels before and after giving the water decoction bay leaf. </em><em>Based on the result test T there are differences in uric acid levels before and after </em><em>giving the water decoction of bay leaf. Where the average uric acid levels before was 7.16 mg / dl, and after the uric acid level was 5.76 mg / dl. Then obtained p value = 0.000. Based on the results of this study concluded that consuming the water decoction of bay leaf can lower uric acid levels, because </em><em>leaves contains flavanoid </em><em>. For that</em><em> gout sufferers is recommended to consume the water decoction of bay leaf  to control uric acid levels in the body.</em> <em>it</em><em> is required to research more about the side effects and benefits of bay leaf.</em></p><p><em>Penyakit asam urat merupakan suatu penyakit karena kelainan metabolisme purin (hiperurisemia). </em><em>U</em><em>ntuk menurunkan kadar asam urat salah satunya dengan memanfaatkan tumbuhan alami yang ada. Tumbuhan atau tanaman yang dapat digunakan adalah daun salam. Daun salam memiliki kandungan flavonoid yang mampu menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui adanya Pengaruh Pemberian Air Rebusan Daun Salam Terhadap Penurunan Kadar Asam Urat .Jenis penelitian ini adalah Pre eksperimental dengan metode pendekatan Pretest – Posttest. dengan menggunakan metode total sampling dengan jumlah sampel sebanyak 10 orang. Pengumpulan data dilakukan secara langsung terhadap responden dengan wawancara, lembar observasi dan pengukuran kadar asam urat dan gula darah. Hasil penelitian ditemukan bahwa terdapat perbedaan kadar asam urat sebelum dan sesudah pemberian air rebusan daun salam. Berdasarkan hasil Uji T terdapat perbedaan kadar asam urat sebelum dan sesudah pemberian air rebusan daun salam. Dimana rata- rata kadar asam urat sebelum adalah 7,16 mg/dl, dan kadar asam urat sesudah adalah 5,76 mg/dl. Maka didapatkan nilai p= 0,000.Berdasarkan hasil penelitian dapat disimpulkan bahwa mengkonsumsi air rebusan daun salam dapat menurunkan kadar asam urat, karena </em><em>flavanoid yang terkandung dalam daun salam</em><em>. Untuk itu dibutuhkan penelitian lebih lanjut tentang efek samping dan manfaat lain dari daun salam. </em></p>

scholarly journals Pengaruh Ramuan Jamu Antihiperkolesterolemia Terhadap Kadar Asam Urat Pasien Dengan Hiperkolesterol Ringan

2018 ◽  
Vol 1 (3) ◽  
pp. 172-176
Author(s):  
Zuraida Zulkarnain ◽  
Ulfa Fitriani ◽  
Enggar Wijayanti ◽  
Ulfatun Nisa
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Green Tea ◽  
Uric Acid Level ◽  
Acid Level ◽  
Normal Values ◽  
T Test ◽  
P Value ◽  
Before And After ◽  
Paired T Test

Ramuan jamu antihiperkolesterolemia terdiri dari daun jati cina, daun jati belanda, daun teh hijau, tempuyung, rimpang temulawak, rimpang kunyit dan herba meniran. Daun jati belanda dan daun teh hijau memiliki kandungan purin dalam bentuk kafein dan teobromin yang berpotensi menyebabkan peningkatan asam urat. Penelitian ini bertujuan untuk mengetahui kadar asam urat serum darah pasien yang meminum ramuan jamu antihiperkolesterolemia . Penelitian ini merupakan observasi klinik dengan jumlah subyek 50 orang di Rumah Riset Jamu (RRJ) Hortus Medicus pada tahun 2014. Subjek merupakan pasien dengan diagnosis hiperkolesterolemia ringan (kadar kolesterol serum 200-240 mg/dl) yang diterapi dengan ramuan jamu antihiperkolesterolemia selama 28 hari. Parameter yang dinilai adalah kadar asam urat serum pada awal (H-0) dan akhir obeservasi (H-28). Data diolah dengan uji t berpasangan menggunakan bantuan program SPSS. Hasil terjadi peningkatan rata-rata kadar asam urat dari 5,31+1,17 mg/dl menjadi 5,47+1,29 mg/dl. Peningkatan masih dalam rentang nilai normal. Pada uji t berpasangan diperoleh nilai p=0,384 yang berarti tidak ada perbedaan rerata kadar asam urat sebelum dan sesudah minum jamu. Kesimpulan terdapat peningkatan ringan rerata kadar asam urat serum pasien yang secara statistik tidak bermakna dan masih berada dalam rentang nilai normal setelah pemberian ramuan jamu antihiperkolesterolemia selama 28 hari.   The antihypercholesterolemic jamu formulaconsists of daun jati cina, jati belanda leaf, green tea leaf, tempuyung, curcuma rhizome, turmeric rhizome and meniran. Jati belanda and green tea leaves contain purines in the form of caffeine and theobromine which might increase the uric acid level. This study aimed to determine the uric acid levels in blood serum of patients who consumed antihypercholesterolemic jamu formula. This study was a clinical observation with a total subject of 50 patients at the Hortus Medicinal Jamu  Research Center (RRJ) in 2014. Subjects were patients with a diagnosis of mild hypercholesterolemia (serum cholesterol level of 200-240 mg / dl) treated with antihypercholesterolemicjamu formula for 28 days. The parameters assessed were serum uric acid levels at baseline (D-0) and end of observation (D-28).Data were analysed by paired t-test using SPSS. The results showed an increase in mean uric acid level from 5.31 + 1.17 mg / dl to 5.47 + 1.29 mg / dl. The increase was  still in the range of normal values. Based on paired t test p value = 0.384, there was no difference in mean uric acid levels before and after administration withjamu. It can be concluded that there was a mild increase in the serum uric acid levels of patients which were not statistically significant and were still in the range of normal values ​​after the administration of an antihypercholesterolemic jamu formula for 28 days

scholarly journals Fennel (Foeniculum vulgare) leaf infusion effect on mammary gland activity and kidney function of lactating rats

2019 ◽  
Vol 11 (1) ◽  
pp. 101-105
Author(s):  
NAJDA RIFQIYATI ◽  
ANA WAHYUNI
Keyword(s):  
Uric Acid ◽  
Mammary Gland ◽  
Side Effects ◽  
Kidney Function ◽  
Uric Acid Level ◽  
Acid Level ◽  
Mammary Glands ◽  
Female Rats ◽  
Foeniculum Vulgare ◽  
Treatment Groups

Abstract. Rifqiyati N, Wahyuni A. 2019. Fennel (Foeniculum vulgare) leaf  infusion effect on mammary gland activity and kidney function of lactating rats. Nusantara Bioscience 11: 101-105. Fennel (Foeniculum vulgare Mill) leaf, traditionally, is believed to have a potential in increasing and smoothing breast milk production. This study aimed to determine the effect of fennel leaf infusion on milk production and to know the side effects of its use. The material used in the research was infusion of fennel leaves (Foeniculum vulgare Mill) collected from Kopeng, Central Java. The research utilized 12 female rats each with 5 newborns off springs. The experiment was designed in Completed Random Design (CRD) with 4 treatments and 3 replications. Histological preparation of mammary glands was set using paraffin method with HE staining. Kidney function was observed through uric acid level in the blood. The results showed that the diameter of lactiferous ducts and of its lumen diameter were significantly influenced by 15 days fennel leaf infusion treatment. The largest lactiferous duct diameter observed was on P3 treatment group (452.97 ± 75.033 µm) and the smallest was observed in control groups (273.17 ± 38.746 µm). The numbers of active alveoli observed in treatment groups, i.e., in P1 (20 g/300  mL), P2 (40 g/300  mL), and P3 (60 g/300  mL), increased than inactive alveoli. The blood uric acid level observed was 4.0-4.6 mg/dl. The results suggested that the infusion of fennel leaf with a treatment dose of 60 g infusion in 300  mL distilled water administered for 15 days can significantly increase the diameter of lactiferous lumen of female rat mammary glands, and increase the diameter of the alveoli and the number of active alveolar mammary glands. Histological picture of mammary gland also showed that the female rats treated with dose of 60g infusion per 300  mL aquadest increased milk secretion and than the other treatment groups. The treatment also showed no significant side effects.  

scholarly journals A study of angiographic severity in patients with coronary artery disease and hyperuricemia

2015 ◽  
Vol 7 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Shovan Kumar Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
Gensini Score ◽  
Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

scholarly journals Penatalaksanaan Hiperurisemia Pada Penyakit Ginjal Kronik (CKD)

2021 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Haidar Alatas
Keyword(s):  
Weight Loss ◽  
Uric Acid ◽  
Side Effects ◽  
Uric Acid Level ◽  
Alternative Treatment ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Meat Consumption ◽  
Not Given ◽  
High Fructose

Management of hyperuricemia in CKD includes non pharmacology and pharmacology. Non-pharmacological with lifestyle change interventions such as exercise, weight loss, low purine meat consumption, avoid high fructose, reduce alcohol and herbs. The treatment of asymptomatic hyperuricemia in CKD is still controversial. In Japan and Korea given uric acid-lowering drugs when the serum uric acid level (SUA)> 8 mg / dl but in America and Europe are not given drugs for fear of side effects. Soursop fruit consumption can be an alternative treatment for hyperuricemia in CKD both asymptomatic and symptomatic. The recommended drugs for hyperuricemia in CKD are allopurinol and febuxostat. Allopurinol is excreted through the kidneys so it is necessary to adjust the dose in CKD, starting from 50-100 mg / day, increasing it to 200-300 mg / day every 2-5 weeks until SUA <6 mg / dl. The dose may be> 300 mg / day if the patient is notified and the monitor may be toxic. In America, Europe and Japan recommend febuxostat only for the treatment of hyperuricemia.

scholarly journals PENGARUH TERAPI AKUPRESSURE TERHADAP KADAR ASAM URAT DARAH PADA LANSIA

2015 ◽  
Vol 1 (2) ◽  
pp. 62-68
Author(s):  
Arif Rakhman ◽  
Iwan Purnawan ◽  
Arikh Ratna Purwadi
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Nursing Intervention ◽  
T Test ◽  
P Value ◽  
Control Approach ◽  
Blood Uric Acid ◽  
Post Test ◽  
Paired T Test

ABSTRAK Pendahuluan: Asam urat adalah produk akhir dari hasil metabolisme purin. Jumlah asam urat dalam darah dipengaruhi oleh makanan tinggi purin dan atau terganggunya pengeluaran asam urat melalui ginjal. Akupresur merupakan salah satu intervensi keperawatan dengan memberikan tekanan pada titik tertentu di permukaan tubuh menggunakan jari. Sudah banyak penelitian mengenai efektivitas terapi akupresur, namun belum ada yang meneliti efek terapi akupresur terhadap asam urat darah. Tujuan: Penelitian ini bertujuan untuk mengetahui efek terapi akupresur terhadap kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Metode: Penelitian ini merupakan penelitian pre experiment dengan pendekatan pre test-post test without control design. Pengambilan sampel menggunakan teknik total sampling. Besarnya sampel adalah 11 responden yang memenuhi kriteria inklusi dan eksklusi. Analisis data menggunakan uji statistik paired t test. Hasil: Rata-rata kadar asam urat darah sebelum dilakukan terapi akupresur adalah 5,99 mg/dl dan rata-rata kadar asam urat setelah dilakukan terapi akupresur adalah 4,04 mg/dl. Hasil uji paired t test didapatkan hasil t hitung = 2,441 (t hitung > dari t tabel) dan nilai p = 0,035 (p value<α = 0,05). Diskusi: Penurunan ini disebabkan adanya perbaikan fungsi ginjal dalam mensekresi asam urat dan penurunan produksi purin dari glikolisis otot yang terjadi akibat stres. Terdapat pengaruh yang signifikan terapi akupresur terhadap kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Terapi akupresur dapat menurunkan kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Kata Kunci: Akupresur, Asam urat, Lansia   ABSTRACT Introduction: Uric acid is the last product of purin metabolism. The amount of uric acid in blood influenced by food high purines and or impairement of uric acid excretion in kidney. Acupressure is one of nursing intervention by giving a pressure on specific point. There was many research about acupressure efectivity, but none did research about the effect of acupressure therapy on blood uric acid level. Objective: This study aimed to find out the effect of acupressure therapy on blood uric acid level towads elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas. Method: This study used pre experiment design with pre test- post test without control approach design and total sampling technique. The amount of sample was 11 respondent which had fulfill the inclution and exclution criteria. Data analysis used by statistical paired t test. Result: The average of uric acid level before accupressure therapy was 5.99 mg/dl and uric acid level after acupressure therapy was 4.04 mg/dl. The result of paired t test was obtained t= 2.441 (obtained t > table t) and value of p=0.035 (p<α=0,05). Discussion: The decrease of average blood uric acid level occured by kidney improvement in uric acid secretion and reduction of purin from muscle glicolisis as a consequence of stress. There was a significant effect of acupressure therapy on blood uric acid level in elderly at Panti Werdha Catur Nugraha Kabupaten Banyumas. Acupressure therapy could decrease blood uric acid level on elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas. Keywords: Acupressure, Elderly, Uric AcidFull printable version: PDF

scholarly journals PERBANDINGAN KADAR ASAM URAT PADA SUBYEK OBES DAN NON-OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Elim Rau ◽  
Jeffrey Ongkowijaya ◽  
Ventje Kawengian
Keyword(s):  
Uric Acid ◽  
Body Fat ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Normal Serum ◽  
The Body ◽  
Obese Group ◽  
Male Students ◽  
Cross Sectional

Abstract: Uric acid is the end product of purine metabolism. Circulating uric acid in the human body is produced by the body (endogenous uric acid) as well as derived from food (exogenous uric acid). Normal serum uric acid level is <7.0 mg / dL in men and <6.0 in women. Obesity can be defined as excess body fat. One of the markers used for body fat content is body mass index (BMI). This study aimed to compare the levels of uric acid in obese and non-obese subjects. This was an analytical study with a cross sectional design. The population is students of Faculty of Medicine University of Sam Ratulangi Manado. Samples were male students of batch 2013. There were 42 male students, consisted of 21 obese and 21 non-obese students. The results showed that the average of uric acid levels in obese group was 8.05 mg/dL and in non-obese group 6.63 mg/dL. In the obese group, 67% had an increase in uric acid level meanwhile in the non-obese group only 38%. The statistical test showed a sig 0,009. Conclusion: In this study, the average of uric acid level in obese group was significantly higher than in the non-obese group. However, there were students with either normal or high uric acid levels in both groups.Keywords: uric acid, obeseAbstrak: Asam urat merupakan produk akhir metabolisme purin. Asam urat yang beredar di dalam tubuh manusia di produksi sendiri oleh tubuh (asam urat endogen) dan berasal dari makanan (asam urat eksogen). Normalnya kadar asam urat serum <7,0 mg/dL pada pria dan <6,0 mg/dL pada wanita. Obesitas dapat di definisikan sebagai kelebihan lemak tubuh. Penanda kandungan lemak tubuh yang digunakan ialah indeks masa tubuh (IMT). Penelitian ini bertujuan untuk mengetahui perbandingan kadar asam urat pada subyek obes dan non obes. Penelitian ini bersifat analitik dengan pendekatan potong lintang. Populasi penelitian ialah mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Manado. Sampel idalah mahasiswa pria angkatan 2013 dan didapatkan 42 orang yang terbagi atas 21 obes dan 21 non obes. Hasil penelitian memperlihatkan rerata kadar asam urat pada obes 8,05 mg/dL dan pada non-obes 6,63 mg/dL. Peningkatan kadar asam urat ditemukan 67% pada kelompok obes dan 38% pada kelompok non-obes. Uji statistik menunjukkan nilai sig 0,009. Simpulan: Pada penelitian ini rerata kadar asam urat pada kelompok obes lebih tinggi secara bermakna daripada kelompok non-obes. Walaupun demikian, pada kedua kelompok ditemukan mahasiswa dengan kadar asam urat normal maupun meningkat.Kata kunci: asam urat, obesitas

scholarly journals Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

2020 ◽  
Vol 4 (1) ◽  
pp. 20-22
Author(s):  
Hudda Abbas ◽  
Samina Badar ◽  
Zunera Javed ◽  
Mohammad Ahmed Abdelmoneam Ramdan
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Outpatient Department ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Third Trimester

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.

scholarly journals Pengaruh Pemberian Sari Buah Kersen terhadap Kadar Asam Urat pada Penderita Hiperurisemia

Jurnal Gizi ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Himeldah Isa Mahendra ◽  
Puspito Arum
Keyword(s):  
Uric Acid ◽  
Treatment Group ◽  
Vitamin C ◽  
Uric Acid Level ◽  
Acid Level ◽  
The Body ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Muntingia Calabura

Hyperuricemia is a health condition characterized by increasing uric acid levels in the body. Jamaican cherry (Muntingia calabura) is vitamin C containing fruit that have lowering-purine effect.The aim of this study was to determine the effect of Kersen (Muntingia calabura) extract on uric acidlevels. This was experimental study with pretest-posttest control group design. Male and female aged above 50 years and not taking vitamins were reqruites as subjects . In this study, the subjects were divided into control and treatment group with the total of 17 subjects for each group. The subjects consume 40.5 grams Kersen. The uric acid level was measured by helath professionals using Easy Touch. The diference of uric acid level were analized using Wilcoxon test  and Man-Whitney test, and the correlation and effect of Kersen were analyzed using Partial Correlation test and LinearRegression Test. The results show that uric acid levels in the treatment group were above normal as well as the control group because at the beginning of the study there were differences in the subject selection of each group. The results show that there is an effect of granting cherry juice to uric acid level ( p 0.004).Keywords: Gout, Hyperuricemia, Cherry Fruit, Vitamin C.

Rational use of rasburicase for the treatment and management of tumor lysis syndrome

2017 ◽  
Vol 24 (3) ◽  
pp. 176-184 ◽  
Author(s):  
Suhail A Shaikh ◽  
Bernard L Marini ◽  
Shannon M Hough ◽  
Anthony J Perissinotti
Keyword(s):  
Acute Kidney Injury ◽  
Uric Acid ◽  
High Risk ◽  
Uric Acid Level ◽  
Acid Level ◽  
Tumor Lysis Syndrome ◽  
Kidney Injury ◽  
P Value ◽  
Tumor Lysis ◽  
Conservative Group

Purpose There is a lack of high-level evidence identifying meaningful outcomes and the optimal place in therapy of rasburicase in patients with, or at high risk for tumor lysis syndrome. The primary objective of this study was to evaluate and characterize outcomes resulting from an institution-specific guideline emphasizing supportive care, xanthine oxidase inhibitors, and lower doses of rasburicase. Methods In this retrospective chart review, we compared conservative rasburicase dosing, in accordance with newly developed UMHS tumor lysis syndrome guidelines, with aggressive rasburicase in adult patients (≥ 18 years of age) with hematological or solid tumor malignancies, and a uric acid level between 8 and 15 mg/dL. The primary efficacy outcome assessed the difference in the proportion of patients achieving a uric acid level <8 mg/dL within 48 h using a one-sided noninferiority test. The principle safety outcomes analyzed included incidence of acute kidney injury and hemodialysis requirement. Results One hundred sixty-one patients met inclusion criteria and were included in the study. Within 48 h of an elevated uric acid level, treatment was successful in 97.03% of patients in the conservative group, as compared with 98.33% in the aggressive group (difference, 1.3 percentage points; 95% confidence interval [CI], −3.33 to 5.93). Furthermore, there was no difference in the proportion of patients requiring hemodialysis (2.97% vs. 10.0%, p-value 0.079), or incidence of acute kidney injury (4.0% vs. 12.5%, p-value 1.00) between the treatment group and control group, respectively. Conclusions Conservative rasburicase use was noninferior to aggressive rasburicase use in patients with or at high risk for tumor lysis syndrome.

scholarly journals A STUDY OF SERUM URIC ACID IN DIABETES MELLITUS AND PREDIABETES IN A SOUTH INDIAN TERTIARY CARE HOSPITAL

2012 ◽  
Vol 02 (02) ◽  
pp. 18-23
Author(s):  
Sudhindra Rao M. ◽  
Bino John Sahayo
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
South Indian Population ◽  
Care Hospital ◽  
South Indian

Abstract Background: Several epidemiologic studies have reported that high serum levels of uric acid are strongly associated with prevalent health conditions such as obesity, insulin resistance, metabolic syndrome, essential hypertension and renal disease. This study aimed to investigate the level of serum uric acid in Type 2 diabetes mellitus, pre-diabetics and non diabetics (controls) in south Indian population. Methods: Uric acid level was measured by Uricase-PAP methodology in patients with Diabetes (n=71)/Pre diabetes (n=12)/ Control groups (n=34). Using ANOVA test, uric acid levels in the above three groups were compared based on age, sex and other factors which can affect uric acid level. Results: The mean serum uric acid level was lower in control group (3.84mg/dl), rose in pre-diabetics (4.88mg/dl) and again decreased in diabetics (3.78mg/dl). P value comparing control and pre-diabetes was 0.009, p-value comparing pre-diabetes and diabetes was 0.003 and p-value comparing control and diabetes was 0.982 (p value <0.05 being significant). Conclusion: The serum uric acid level being higher in pre-diabetes than controls and lower in diabetes mellitus than pre-diabetes may serve as a potential inexpensive biomarker of deterioration of glucose metabolism.

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