Safety profile of Td vaccination in Indonesian pregnant women: a post-marketing surveillance study

BACKGROUND The Indonesian Expanded Program of Immunization has implemented tetanus and diphtheria (Td) vaccination to replace the tetanus toxoid vaccine in pregnant women since the year 2016. Td vaccine is administered to protect against diphtheria and tetanus to the mother and her baby as well. This prospective study was conducted to assess the adverse reactions after Td immunization; besides, a retrospective study was conducted to observe the presence of severe local reaction (Arthus reaction), premature birth, and low birth weight history in the medical records of pregnant women who had received Td immunization in the past year. METHODS A prospective observational study was conducted in 200 pregnant women. Local reactions and systemic events occurring within 28 days after immunization were recorded in the diary card and were confirmed by the health worker in the follow-up visit. A retrospective study was also conducted to evaluate 750 medical records of pregnant women who had received Td immunization. The study was conducted fromSeptember 2017 to January 2018. The study has been registered at ClinicalTrials.gov ID: NCT03383653. RESULTS In 185 pregnant women who completed the study, the most common local reaction was pain, occurring in 33.5% of subjects within 24 hours after vaccination. Fever, other systemic reactions, and serious adverse events were not reported during the observation. In the retrospective study, 647 medical records were validated. No Arthus reaction was observed. The prevalence of premature birth was 1.24%, and that of low birth weight was 2.63%, which were below the normal rates. CONCLUSIONS Td vaccination in pregnant women was safe and well-tolerated.

Download Full-text

Maternal urinary levels of trichloroacetic acid and association with adverse pregnancy outcomes

Journal of Water and Health ◽

10.2166/wh.2019.109 ◽

2019 ◽

Vol 17 (6) ◽

pp. 884-895 ◽

Cited By ~ 1

Author(s):

Funanani Mashau ◽

Esper Jacobeth Ncube ◽

Kuku Voyi

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Pregnancy Outcomes ◽

Premature Birth ◽

Trichloroacetic Acid ◽

Adverse Pregnancy Outcomes ◽

Potential Health ◽

Increased Risk ◽

Adverse Pregnancy

Abstract The current study aimed to determine the association between trichloroacetic acid (TCAA) levels and adverse pregnancy outcomes among third-trimester pregnant women who were exposed to chlorinated drinking water. A total of 205 pregnant women who participated in the disinfection by-products exposure and adverse pregnancy outcome study in South Africa were randomly asked to participate in this study by providing their morning urine sample voids. Samples were analysed for urinary creatinine and TCAA. Furthermore, participants gave individual data using a structured questionnaire. The mean (median) concentration of creatinine-adjusted urinary TCAA was 2.34 (1.95) μg/g creatinine. Elevated levels of creatinine-adjusted TCAA concentrations showed an increased risk of premature birth, small for gestational age (SGA) and low birth weight. There was no significant statistical correlation observed between creatinine-adjusted TCAA concentrations and the total volume of cold water ingested among the study population. No statistically significant association was observed between creatinine-adjusted urinary TCAA and premature birth, SGA and low birth weight newborns among the study subjects. However, the urinary TCAA concentrations identified in this study suggest potential health risks towards women and foetus. Therefore, further studies are warranted to prevent further adverse pregnancy outcomes.

Download Full-text

A retrospective study to assess and correlate maternal periodontal status with term of pregnancy and weight of newborn

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174447 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4589

Author(s):

Mayuri N. Jain ◽

Girish Suragimath ◽

Siddhartha A. Varma ◽

Sameer Anil Zope ◽

Ashwini S. R.

Keyword(s):

Body Mass Index ◽

Retrospective Study ◽

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Body Mass ◽

Periodontal Diseases ◽

Pocket Depth ◽

Clinical Attachment Loss ◽

Periodontal Status

Background: Periodontitis is an inflammatory disease affecting the tooth supporting structures; studies have shown that it also affects the systemic health and conditions like pregnancy. With this background the present retrospective study was conducted to assess and correlate periodontal status of pregnant women with their pregnancy outcome.Methods: A total of 150 pregnant women two days postpartum were examined for periodontal status using following parameters: Oral hygiene index- simplified (OHI-S), modified gingival index (MGI), probing pocket depth (PPD) and clinical attachment loss (CAL). The level of education, body mass index (BMI), gestational age and weight of the baby were recorded and correlated with the periodontal status.Results: Out of 150 women, 83 (55.3%) women suffered from gingivitis and 67 (44.7%) had periodontitis. The incidence of preterm low birth weight babies was seen in 65 (43.33%) women. Body mass index, education level and periodontal disease were significantly associated with preterm low birth weight infants.Conclusions: A significant association was found between periodontitis and preterm low birth infants. The promotion of early detection and treatment of periodontal diseases in women before and during pregnancy will be beneficial. This will minimize the cost of post natal care and morbidity in the new born.

Download Full-text

Age-specific risk factors for adverse maternal and neonatal outcomes in Xiamen, China: A population-based retrospective study

10.21203/rs.2.16200/v1 ◽

2019 ◽

Author(s):

Yin-ling Chen ◽

Li-li Han ◽

Wei-juan Su ◽

Fu-ping Lv ◽

Zheng Chen ◽

...

Keyword(s):

Risk Factors ◽

Retrospective Study ◽

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Pregnant Women ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Population Based ◽

Adverse Pregnancy

Abstract Background: Elderly mothers are increasingly in China. We are aims to explore whether association between pregnancy to delivery interval and adverse pregnancy outcomes is affected by maternal age. Methods: A population-based retrospective study was performed in Xiamen, China. Data were derived from the Medical Birth Registry of Xiamen from 2011 to 2018. Multivariable logistic regression was used to conduct multivariable analyses based on adjusting the factors to evaluate the effect of maternal age on pregnancy outcomes. Results: Among 77,859 pregnant women with specific age, gestational diabetes mellitus (GDM) risk were increased for women aged 40 years or older (42.9%; aRR, 3.84 (3.26-4.51); P < 0.001), but not for pregnant women aged less than 25 years (9.2%; aRR, 0.60 (0.54-0.68)). Increased cesarean, preterm birth, large-for-gestational age (LGA), and low birth weight risks were more pronounced for pregnant women aged 40 years or older (66.5%, 8.4%, 26.5%, and 6.7%, respectively; aRR, 3.77 (3.14-4.52), 1.26 (0.90-1.79), 1.31 (1.08-1.60), and 1.10 (0.74-1.65), respectively; all P < 0.001). Risk of Apgar < 7 at 5 minutes were increased for women < 25 years old compared with women 35 to 39 years old (0.2% vs. 0.1%; aRR, 2.05 (0.85-4.93) vs. 0.63 (0.14-2.86)). Conclusion: Advanced maternal age increased risk of adverse pregnancy outcomes. The risk ratio of GDM, cesarean, preterm birth, LGA, and low birth weight is higher, which suggests pregnant women should guard against related risk factors and choose an appropriate mode of production. Furthermore, pregnant women should choose an ideal age for pregnancy to make themselves and child healthy.

Download Full-text

Advanced Maternal Age and Adverse Maternal and Neonatal Outcomes in Pregnant Women

Current Women s Health Reviews ◽

10.2174/1573404816999201009160848 ◽

2020 ◽

Vol 16 ◽

Author(s):

Reza Omani-Samani ◽

Saman Maroufizadeh ◽

Nafise Saedi ◽

Nasim Shokouhi ◽

Arezoo Esmailzadeh ◽

...

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Cesarean Section ◽

Pregnant Women ◽

Maternal Age ◽

Unwanted Pregnancy ◽

Advanced Maternal Age ◽

Neonatal Outcomes ◽

Maternal And Neonatal Outcomes

Background: Advanced maternal age is an important predictor for maternal and neonatal outcomes such as maternal mortality, low birth weight, stillbirth, preterm birth, cesarean section and preeclampsia. Objective: To determine the association of advanced maternal age and adverse maternal and neonatal outcomes in Iranian pregnant women. Methods: In this hospital-based cross-sectional study, 5117 pregnant women from 103 hospitals in Tehran, Iran, were participated in the study in 2015. The required data were gathered from hospitals which equipped to the department of obstetrics and gynecology. Advanced maternal age was considered as an independent variable and unwanted pregnancy, preeclampsia, preterm birth, cesarean section and low birth weight were considered as interested outcomes. Results: In our study, the prevalence of advanced maternal age was 12.08%. Advanced maternal age was significantly associated with higher risk of unwanted pregnancy (OR: 1.39, 95% CI: 1.12-1.73), preterm birth (OR: 1.75, 95% CI: 1.28- 2.39) and cesarean section (OR: 1.34, 95% CI: 1.03-1.74). In our study, there was no significant relationship between advanced maternal age and preeclampsia but this relationship could be clinically important (OR: 1.48, 95% CI: 0.99-2.20, P=0.052), and there is no significant relationship between advanced maternal age and low birth weight (OR: 1.08, 95% CI: 0.67-1.74, P=0.736). Conclusion: Advanced maternal age is associated with higher risk of unintended pregnancy, preterm birth and cesarean section but our findings did not support advanced maternal age as a risk factor associated with low birth weight.

Download Full-text

HPV Prevalence and its Association with Perinatal Outcomes among Singleton Mothers: Analysis of Pregnancy Risk Assessment and Monitoring System (PRAMS) Data, 2004-2011

Current Women s Health Reviews ◽

10.2174/1573404814666180517085022 ◽

2019 ◽

Vol 15 (2) ◽

pp. 143-149 ◽

Cited By ~ 1

Author(s):

Harpriya Kaur ◽

Delf Schmidt-Grimminger ◽

Baojiang Chen ◽

K.M. Monirul Islam ◽

Steven W. Remmenga ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Monitoring System ◽

Large Population ◽

Perinatal Outcomes ◽

Hpv Infection ◽

Adverse Outcomes ◽

P Value ◽

Pregnancy Risk

Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women. Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes. Results: Approximately 1.4% of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia (7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs. 10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95% CI: 1.14-3.30). Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.

Download Full-text

High Prevalence of Low Birth Weight Babies Born to Pregnant Women Referred to a District Hospital in Rural Zambia

Maternal and Child Health Journal ◽

10.1007/s10995-021-03190-8 ◽

2021 ◽

Author(s):

Julie M. Buser ◽

Carol J. Boyd ◽

Cheryl A. Moyer ◽

Davy Zulu ◽

Alice Ngoma-Hazemba ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

District Hospital ◽

High Prevalence ◽

Low Birth Weight Babies ◽

Rural Zambia

Download Full-text

Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study

Chemosphere ◽

10.1016/j.chemosphere.2019.05.103 ◽

2019 ◽

Vol 231 ◽

pp. 225-232 ◽

Cited By ~ 10

Author(s):

Qingzhi Hou ◽

Lulu Huang ◽

Xiaoting Ge ◽

Aimin Yang ◽

Xiaoyu Luo ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Case Control Study ◽

Case Control ◽

Low Birth Weight Infants ◽

Nested Case Control ◽

Control Study

Download Full-text

Inadequate Gestational Weight Gain and Exposure to Second-Hand Smoke during Pregnancy Increase the Risk of Low Birth Weight: A Cross-Sectional Study among Full-Term Infants

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18031068 ◽

2021 ◽

Vol 18 (3) ◽

pp. 1068

Author(s):

Muliana Edi ◽

Yit Chin ◽

Fui Woon ◽

Geeta Appannah ◽

Poh Lim ◽

...

Keyword(s):

Weight Gain ◽

Birth Weight ◽

Pregnant Women ◽

Medical Records ◽

Cross Sectional Study ◽

Second Hand Smoke ◽

Sectional Study ◽

Cross Sectional ◽

Shs Exposure ◽

At Home

Despite the advancement of the healthcare system, low birth weight (LBW) remains as one of the leading causes of under-five mortality. This cross-sectional study aimed to determine the prevalence of LBW and its associated factors among 483 third trimester pregnant women recruited from six selected public health clinics in the Federal Territory of Kuala Lumpur and the state of Selangor, Malaysia. Pregnant women were interviewed for information on socio-demographic characteristics, smoking behaviour, and second-hand smoke (SHS) exposure at home and in the workplace. Information on the obstetrical history and prenatal care visits history were retrieved from the maternal medical records, while infant’s birth outcomes were retrieved from infant medical records. The prevalence of LBW (<2.5 kg) in infants was 10.4%, with a mean birth weight of 3.0 [standard deviation (SD) 0.4] kg. Results from the multivariable logistic regression model showed that inadequate weight gained during pregnancy [odds ratio (OR) = 2.41, 95% confidence interval (CI) = 1.18–4.90] and exposure to SHS at home (OR = 1.92, 95% CI = 1.03–3.55) were significantly associated with LBW. In conclusion, pregnant women should monitor their rate of weight gain throughout pregnancy and avoid SHS exposure at home to reduce the risk of delivering LBW infants.

Download Full-text