scholarly journals Early Diagnosis of Neuropathy in Leprosy—Comparing Diagnostic Tests in a Large Prospective Study (the INFIR Cohort Study)

2008 ◽  
Vol 2 (4) ◽  
pp. e212 ◽  
Author(s):  
Wim H. van Brakel ◽  
Peter G. Nicholls ◽  
Einar P. Wilder-Smith ◽  
Loretta Das ◽  
Pramila Barkataki ◽  
...  
Keyword(s):  
Cohort Study ◽  
Early Diagnosis ◽  
Prospective Study ◽  
Diagnostic Tests ◽  
Large Prospective Study

scholarly journals The quest for a headache pattern in giant cell arteritis: A cohort study

2021 ◽  
Vol 4 ◽  
pp. 251581632110241
Author(s):  
Sanne CC Vincenten ◽  
Wim M Mulleners
Keyword(s):  
Cohort Study ◽  
Prospective Study ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Clinical Signs ◽  
Large Prospective Study ◽  
Common Pattern ◽  
Cross Sectional ◽  
Temporal Area ◽  
Pathology Data

Aim: To help clinicians in the diagnostic approach of giant cell arteritis (GCA) by providing a better knowledge on headache patterns in GCA.  Methods: Cross-sectional data of a cohort of 30 known GCA patients regarding symptoms, clinical signs, laboratory and pathology data were collected retrospectively.  Results: Headache was experienced by the majority of our cohort (26/30; 87%) and the most common pattern reported was a continuous, unilateral pain centered in or around the temporal area (13/26; 50% of all headaches). Pain confined to the occiput or frontal areas of the head was rarely reported as well as migrainous or cluster-like headaches.  Conclusion: This data suggests that the headache pattern in GCA is heterogeneous, but that the most common pattern is a continuous, unilateral, temporal headache. Several other patterns were infrequently reported and these should question the clinical diagnosis of GCA. A large prospective study will be necessary to further elaborate these findings.

scholarly journals The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ensieh Memarian ◽  
Peter M. Nilsson ◽  
Isac Zia ◽  
Anders Christensson ◽  
Gunnar Engström
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Waist Circumference ◽  
Kidney Disease ◽  
Prospective Study ◽  
Cox Proportional Hazards ◽  
Large Prospective Study ◽  
Anthropometric Measures ◽  
Increased Risk ◽  
Incidence Of Ckd

Abstract Background It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general population. The aim of this large prospective study was to explore the association between several anthropometric measures of obesity, i. e., body mass index (BMI), waist circumference (WC), waist circumference to height ratio (WHtR), waist-to-hip ratio (WHR), percentage of body fat (BF%), weight, height and incidence of hospitalizations due to CKD, in a population-based cohort study. Methods The ‘Malmö Diet and Cancer Study (MDCS)’ cohort in Sweden was examined during 1991 to 1996. A total of 28,449 subjects underwent measurement of anthropometric measures and blood pressure and filled out a questionnaire. Incidence of in- and outpatient hospital visits for CKD was monitored from the baseline examination over a mean follow-up of 18 years. Cox proportional hazards regression was used to explore the association between anthropometric measures and incidence of CKD, with adjustments for risk factors. Results The final study population included 26,723 subjects, 45-73 years old at baseline. Higher values of BMI, WC, WHR, WHtR and weight were associated with an increased risk of developing CKD in both men and women. Only in women, higher values of BF% was associated with higher risk of CKD. Comparing the 4th vs 1st quartile of the obesity measure, the highest hazard ratio (HR) for CKD in men was observed for BMI, HR 1.51 (95% CI: 1.18-1.94) and weight (HR 1.52 (95% CI: 1.19-1.94). For women the highest HR for CKD was observed for BF%, HR 2.01 (95% CI: 1.45-2.78). Conclusions In this large prospective study, all anthropometric measures of obesity were associated with a substantially increased incidence of CKD, except for BF% in men. Some measures were slightly more predictive for the risk of CKD than others such as BMI and weight in men and BF% in women. In clinical daily practice use of all anthropometric measures of obesity might be equally useful to assess the risk of developing CKD. This study supports the strong evidence for an association between obesity and CKD.

scholarly journals Oral health and risk of upper gastrointestinal cancers in a large prospective study from a high-risk region: Golestan Cohort Study

2021 ◽  
pp. canprevres.0577.2020
Author(s):  
Yukiko Yano ◽  
Christian C. Abnet ◽  
Hossein Poustchi ◽  
Gholamreza Roshandel ◽  
Akram Pourshams ◽  
...  
Keyword(s):  
Cohort Study ◽  
Oral Health ◽  
High Risk ◽  
Prospective Study ◽  
Gastrointestinal Cancers ◽  
Large Prospective Study ◽  
Upper Gastrointestinal

scholarly journals Lifestyle, psychological stress, and incidence of adolescent constipation: results from the Toyama birth cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masaaki Yamada ◽  
Michikazu Sekine ◽  
Takashi Tatsuse ◽  
Yuko Fujimura
Keyword(s):  
Cohort Study ◽  
Prospective Study ◽  
Birth Cohort ◽  
Healthy Lifestyle ◽  
Lifestyle Changes ◽  
Psychological Status ◽  
Birth Cohort Study ◽  
Female Sex ◽  
Bowel Movement Frequency ◽  
Skipping Breakfast

Abstract Background We aimed to clarify the predisposing factors for adolescent constipation in a longitudinal study, because while factors associated with childhood constipation have been reported, prospective studies on the incidence of constipation are lacking. Methods We enrolled 5540 adolescents aged 12 to 13 years from the Toyama Birth Cohort Study—a community-based prospective study examining children’s health. The incidence of constipation, defined as bowel movement frequency of less than once every 2 days, was surveyed during the three-year period from baseline (grade 4) to follow-up (grade 7). Multivariate logistic regression analyses were performed to explore the association between the incidence of adolescent constipation and their lifestyle variables. Results A total of 261 adolescents (4.7%) developed constipation during the three-year period. Female sex (odds ratio [OR] = 2.62,) overweight (OR = 0.60), and infrequent intake of fruits (OR = 1.50) at baseline were associated with the incidence of constipation. Furthermore, factors related to lifestyle changes and psychological status such as skipping breakfast (OR = 1.73), becoming physically inactive (OR = 1.55), and being persistently irritated (OR = 1.80) were significantly associated with the incidence of constipation. Conclusion Our prospective study demonstrated that female sex, insufficient fruit intake, and deteriorating lifestyles such as skipping breakfast and becoming inactive during the 3-year period were associated with the incidence of adolescent constipation. Beyond anecdotal, maintaining a healthy lifestyle is recommended to reduce the incidence of adolescent constipation.

Lifespan of peripheral intravenous short catheters in hospitalized children: A prospective study

2021 ◽  
pp. 112972982110052
Author(s):  
Maria Elizabeth Gómez-Neva ◽  
Martin Alonso Rondon Sepulveda ◽  
Adriana Buitrago-Lopez
Keyword(s):  
Cohort Study ◽  
Prospective Study ◽  
The Other ◽  
Hospitalized Children ◽  
Intravenous Catheter ◽  
Survival Analyses ◽  
Median Lifespan ◽  
Pediatric Services ◽  
A Prospective Study ◽  
Intravenous Catheters

Objective: To estimate the recommended lifespan of 223 peripheral intravenous accesses in pediatric services. Method: In this cohort study, we monitored the time of intravenous catheter between insertion and removal in children aged up to 15 years old in a Hospital from Bogotá-Colombia. The routine catheter observations was registered in questionnaires during nursing shifts. Survival analyses were performed to analyze the lifespan of the catheter free of complications. Results: The median lifespan of peripheral intravenous catheters without complications was 129 h (IQR 73.6–393.4 h). This median time free from complications was much lower for children ⩽1 year 98.3 h (IQR 63–141 h), than for participants aged >1 year 207.4 h (IQR 100–393 h). Catheters of 24 G (gauge) caliber had a median complication free time of 128 h (IQR 69–207 h) and 22 G calibers 144 h (IQR 103–393 h). Conclusions: In this study, 75% of peripheral indwell catheters remained free from complications for 74 h, the other extreme 25% of these patients could remain up to 393 h.

scholarly journals Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Fulvia Pimpinelli ◽  
Francesco Marchesi ◽  
Giulia Piaggio ◽  
Diana Giannarelli ◽  
Elena Papa ◽  
...  
Keyword(s):  
Prospective Study ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Active Treatment ◽  
Myeloproliferative Neoplasm ◽  
Large Prospective Study ◽  
Lower Response ◽  
Ongoing Treatment ◽  
Vaccine Immunogenicity

AbstractIn a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2 weeks after the second dose was significantly lower in the ten patients with myelofibrosis compared to the 32 with essential thrombocythemia (n = 17) and polycythemia vera (n = 15) grouped together, both in terms of neutralizing anti-SARS-CoV-2 IgG titers and seroprotection rates (32.47 AU/mL vs 217.97 AU/mL, p = 0.003 and 60% vs 93.8%, p = 0.021, respectively). Ruxolitinib, which was the ongoing treatment in five patients with myelofibrosis and three with polycythemia vera, may be implicated in reducing vaccine immunogenicity (p = 0.076), though large prospective study is needed to address this issue.

scholarly journals Early diagnosis of mortality using admission CT perfusion in severe traumatic brain injury patients (ACT-TBI): protocol for a prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e047305
Author(s):  
Susan Alcock ◽  
Divjeet Batoo ◽  
Sudharsana Rao Ande ◽  
Rob Grierson ◽  
Marco Essig ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cohort Study ◽  
Brain Injury ◽  
Early Diagnosis ◽  
Hospital Mortality ◽  
Brain Death ◽  
Severe Traumatic Brain Injury ◽  
Health Research ◽  
Ct Perfusion ◽  
Severe Tbi

IntroductionSevere traumatic brain injury (TBI) is a catastrophic neurological condition with significant economic burden. Early in-hospital mortality (<48 hours) with severe TBI is estimated at 50%. Several clinical examinations exist to determine brain death; however, most are difficult to elicit in the acute setting in patients with severe TBI. Having a definitive assessment tool would help predict early in-hospital mortality in this population. CT perfusion (CTP) has shown promise diagnosing early in-hospital mortality in patients with severe TBI and other populations. The purpose of this study is to validate admission CTP features of brain death relative to the clinical examination outcome for characterizing early in-hospital mortality in patients with severe TBI.Methods and analysisThe Early Diagnosis of Mortality using Admission CT Perfusion in Severe Traumatic Brain Injury Patients study, is a prospective cohort study in patients with severe TBI funded by a grant from the Canadian Institute of Health Research. Adults aged 18 or older, with evidence of a severe TBI (Glasgow Coma Scale score ≤8 before initial resuscitation) and, on mechanical ventilation at the time of imaging are eligible. Patients will undergo CTP at the time of first imaging on their hospital admission. Admission CTP compares with the reference standard of an accepted bedside clinical assessment for brainstem function. Deferred consent will be used. The primary outcome is a binary outcome of mortality (dead) or survival (not dead) in the first 48 hours of admission. The planned sample size for achieving a sensitivity of 75% and a specificity of 95% with a CI of ±5% is 200 patients.Ethics and disseminationThis study has been approved by the University of Manitoba Health Research Ethics Board. The findings from our study will be disseminated through peer-reviewed journals and presentations at local rounds, national and international conferences. The public will be informed through forums at the end of the study.Trial registration numberNCT04318665

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