scholarly journals Initial Presentations Predict Mortality in Pulmonary Tuberculosis Patients - A Prospective Observational Study

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e23715 ◽  
Author(s):  
Jia-Yih Feng ◽  
Wei-Juin Su ◽  
Yu-Chi Chiu ◽  
Shiang-Fen Huang ◽  
Yung-Yang Lin ◽  
...  
Keyword(s):  
Observational Study ◽  
Pulmonary Tuberculosis ◽  
Prospective Observational Study ◽  
Tuberculosis Patients

scholarly journals The burden and treatment of HIV in tuberculosis patients in Papua Province, Indonesia: a prospective observational study

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Gysje J Pontororing ◽  
Enny Kenangalem ◽  
Dina B Lolong ◽  
Govert Waramori ◽  
Sandjaja ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Tuberculosis Patients

scholarly journals Serum Procalcitonin Levels Predict Mortality Risk in Patients With Pulmonary Tuberculosis: A Single-Center Prospective Observational Study

2020 ◽  
Vol 222 (10) ◽  
pp. 1651-1654
Author(s):  
Takeshi Osawa ◽  
Masato Watanabe ◽  
Kozo Morimoto ◽  
Masao Okumura ◽  
Takashi Yoshiyama ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Mortality Risk ◽  
Prospective Observational Study ◽  
Bacterial Load ◽  
Serum Levels ◽  
Risk Indicator ◽  
Radiographic Findings ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Immunodeficiency Virus

Abstract Globally, tuberculosis is the leading infectious cause of death; discovering biomarkers that predict a high mortality risk may improve treatment outcomes. We prospectively enrolled 252 pulmonary tuberculosis patients who were not coinfected with human immunodeficiency virus and initiated antituberculosis treatment, measured serum procalcitonin levels (PCT), and assessed mortality risk. PCT serum levels higher than 0.13 (day 0), 0.05 (day 7), 0.12 (day 14), or 0.06 (day 28) ng/mL predicted nonsurvivors with odds ratios of 7.9, 14.3, 20.0, and 7.3, respectively (P ≤ .005 for all), respectively. Therefore, serum PCT levels are a promising mortality risk indicator for patients with pulmonary tuberculosis. Main Point. For patients with pulmonary tuberculosis, a promising mortality risk indicator is the level of serum procalcitonin, which is weakly associated with sputum bacterial load and independent of radiographic findings.

scholarly journals Gambaran Pasien Tuberkulosis Paru Usia Produktif di RSUP Prof. Dr. R. D. Kandou Manado Periode Tahun 2014-2015

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Johanes F. N. Kesek ◽  
Cerelia E. C. Sugeng ◽  
Efata B. I. Polii
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Observational Study ◽  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Acid Fast Bacillus ◽  
Age Group ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Using Data ◽  
Global Health Problem

Abstract: Pulmonary tuberculosis (pulmonary TB) is caused by Mycobacterium tuberculosis, an acid-fast bacillus (AFB). This disease is characterized by pulmonary infiltrates and caseous granuloma formation, fibrosis, as well as cavities. To date, this disease is still a global health problem. The highest incidence of pulmonary TB is usually in productive age between 15 and 44 years. This study was aimed to obtain the profile of pulmonary tuberculosis patients in productive age at RSUP Prof. Dr. R. D. Kandou Manado during years 2014 to 2015. This was a descriptive observational study using data of medical records. The result showed that there were 178 pulmonary TB patients in the age group of 15-44 years. Based on sex, there were 94 males (52.8%) and 84 females (47.2%). TB patients with positive acid-fast bacilli (AFB) in sputum were found in 117 patients (65.7%) and those with negative AFB in 61 patients (34.3%). In conclusion, pulmonary TB patients at productive age (15-44 years) were predominant in males with positive sputum of Mycobacterium tuberculosis.Keyword: pulmonary tuberculosis, productive age Abstrak: Tuberkulosis (TB) paru adalah infeksi paru yang disebabkan oleh Mycobacterium tuberculosis, yaitu sejenis basil tahan asam (BTA). Penyakit ini ditandai oleh adanya infiltrat paru dan pembentukan granuloma kaseosa, fibrosis, dan kavitas. Penyakit TB paru masih merupakan masalah global dengan insidensi tertinggi biasanya mengenai usia produktif, antara 15–44 tahun. Penelitian ini bertujuan untuk mengetahui gambaran pasien tuberkulosis paru usia produktif di RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2014-2015. Jenis penelitian ialah deskriptif observasional menggunakan data rekam medis. Hasil penelitian mendapatkan 178 pasien TB paru pada golongan usia 15-44 tahun. Berdasarkan jenis kelamin didapatkan 94 orang laki-laki (52,8%) dan 84 orang perempuan (47,2%). Pasien TB dengan hasil pemeriksaan sputum BTA (+) sebanyak 117 orang (65,7%) dan pasien dengan hasil pemeriksaan sputum BTA (-) sebanyak 61 orang (34,3%). Simpulan penelitian ini ialah penderita TB paru pada usia produktif (15-44 tahun) lebih sering didapatkan pada jenis kelamin laki-laki dan dengan hasil pemeriksaan sputum BTA (+).Kata kunci: tuberkulosis paru, usia produktif

scholarly journals Study of rifampicin resistance among newly diagnosed pulmonary tuberculosis patients with type 2 diabetes mellitus: a prospective observational study

2021 ◽  
Vol 9 (7) ◽  
pp. 2035
Author(s):  
Vipul Kumar ◽  
Jyoti Yadav ◽  
Aparna Parmar ◽  
Ritu Aggarwal ◽  
K. B. Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Prospective Observational Study ◽  
Rifampicin Resistance ◽  
Age Group ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Mdr Tb ◽  
A Prospective Study

Background: Rifampicin (RIF) resistance in new cases of pulmonary tuberculosis is a matter of concern. Diabetes Mellitus triples the risk of developing tuberculosis. Early detection of TB and its resistance status in diabetics can help in improving the care and treatment outcomes of both diseases.Methods: It was a prospective study conducted from February 2019 to March 2020 in PGIMS, Rohtak on 50 patients of DM with newly diagnosed Pulmonary TB. Rifampicin resistance was detected by CBNAAT on sputum, induced sputum and BAL samples. Results: Mean age of study subjects was 51.24±10.421 (in years) with M: F ratio of 3:1 and maximum patients in 50-59 age group. The average BMI in patients was 22.49±2.42 kg/m2. The most common presenting complaint was cough (92%) followed by fever (68%). Mean serum HBA1c was 9.66±2.24 and mean FBS and PPBS was 195.81±59.08 and 302.02±99.01 mg/dl respectively. Out of 36 cases who gave sputum, 29 (80.55%) were detected rifampicin sensitive and 7 (19.44%) were rifampicin resistant whereas out of 11 who were induced, 9 (81.8%) were rifampicin sensitive and 2(18.18%) were rifampicin resistant. Out of 3 cases detected by BAL CBNAAT, 2 (66.6%) were rifampicin sensitive and 1 (33.33%) was rifampicin resistant. Overall, 10(20%) patients were detected Rifampicin resistant by CBNAAT.Conclusions: We found that TB-DM patients had a higher proportion of drug resistance (20%), so DM should be considered as an independent risk factor for MDR-TB and effective measures are required for early diagnosis of MDR-TB.

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