scholarly journals Gambaran Pasien Tuberkulosis Paru Usia Produktif di RSUP Prof. Dr. R. D. Kandou Manado Periode Tahun 2014-2015

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Johanes F. N. Kesek ◽  
Cerelia E. C. Sugeng ◽  
Efata B. I. Polii
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Observational Study ◽  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Acid Fast Bacillus ◽  
Age Group ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Using Data ◽  
Global Health Problem

Abstract: Pulmonary tuberculosis (pulmonary TB) is caused by Mycobacterium tuberculosis, an acid-fast bacillus (AFB). This disease is characterized by pulmonary infiltrates and caseous granuloma formation, fibrosis, as well as cavities. To date, this disease is still a global health problem. The highest incidence of pulmonary TB is usually in productive age between 15 and 44 years. This study was aimed to obtain the profile of pulmonary tuberculosis patients in productive age at RSUP Prof. Dr. R. D. Kandou Manado during years 2014 to 2015. This was a descriptive observational study using data of medical records. The result showed that there were 178 pulmonary TB patients in the age group of 15-44 years. Based on sex, there were 94 males (52.8%) and 84 females (47.2%). TB patients with positive acid-fast bacilli (AFB) in sputum were found in 117 patients (65.7%) and those with negative AFB in 61 patients (34.3%). In conclusion, pulmonary TB patients at productive age (15-44 years) were predominant in males with positive sputum of Mycobacterium tuberculosis.Keyword: pulmonary tuberculosis, productive age Abstrak: Tuberkulosis (TB) paru adalah infeksi paru yang disebabkan oleh Mycobacterium tuberculosis, yaitu sejenis basil tahan asam (BTA). Penyakit ini ditandai oleh adanya infiltrat paru dan pembentukan granuloma kaseosa, fibrosis, dan kavitas. Penyakit TB paru masih merupakan masalah global dengan insidensi tertinggi biasanya mengenai usia produktif, antara 15–44 tahun. Penelitian ini bertujuan untuk mengetahui gambaran pasien tuberkulosis paru usia produktif di RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2014-2015. Jenis penelitian ialah deskriptif observasional menggunakan data rekam medis. Hasil penelitian mendapatkan 178 pasien TB paru pada golongan usia 15-44 tahun. Berdasarkan jenis kelamin didapatkan 94 orang laki-laki (52,8%) dan 84 orang perempuan (47,2%). Pasien TB dengan hasil pemeriksaan sputum BTA (+) sebanyak 117 orang (65,7%) dan pasien dengan hasil pemeriksaan sputum BTA (-) sebanyak 61 orang (34,3%). Simpulan penelitian ini ialah penderita TB paru pada usia produktif (15-44 tahun) lebih sering didapatkan pada jenis kelamin laki-laki dan dengan hasil pemeriksaan sputum BTA (+).Kata kunci: tuberkulosis paru, usia produktif

scholarly journals Diagnostic challenges and Gene-Xpert utility in detecting Mycobacterium tuberculosis among suspected cases of Pulmonary tuberculosis

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251858
Author(s):  
Shaila Kabir ◽  
M. Tanveer Hossain Parash ◽  
Nor Amalina Emran ◽  
A. B. M. Tofazzal Hossain ◽  
Sadia Choudhury Shimmi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Predictive Value ◽  
Demographic Data ◽  
Nucleic Acid Amplification ◽  
Age Group ◽  
Cross Sectional ◽  
Care Clinic ◽  
Pulmonary Tb ◽  
Smear Negative

The incidence of pulmonary tuberculosis (PTB) can be reduced by preventing transmission with rapid and precise case detection and early treatment. The Gene-Xpert MTB/RIF assay is a useful tool for detecting Mycobacterium tuberculosis (MTB) with rifampicin resistance within approximately two hours by using a nucleic acid amplification technique. This study was designed to reduce the underdiagnosis of smear-negative pulmonary TB and to assess the clinical and radiological characteristics of PTB patients. This cross-sectional study included 235 participants who went to the Luyang primary health care clinic from September 2016 to June 2017. The demographic data were analyzed to investigate the association of patient gender, age group, and ethnicity by chi-square test. To assess the efficacy of the diagnostic test, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. The area under the curve for sputum for both AFB and gene-Xpert was analyzed to compare their accuracy in diagnosing TB. In this study, TB was more common in males than in females. The majority (50.71%) of the cases belonged to the 25–44-year-old age group and the Bajau ethnicity (57.74%). Out of 50 pulmonary TB cases (smear-positive with AFB staining), 49 samples were positive according to the Gene-Xpert MTB/RIF assay and was confirmed by MTB culture. However, out of 185 smear-negative presumptive cases, 21 cases were positive by Gene-Xpert MTB/RIF assay in that a sample showed drug resistance, and these results were confirmed by MTB culture, showing resistance to isoniazid. In comparison to sputum for AFB, Gene-Xpert showed more sensitivity and specificity with almost complete accuracy. The additional 21 PTB cases detection from the presumptive cases by GeneXpert had significant impact compared to initial observation by the routine tests which overcame the diagnostic challenges and ambiguities.

scholarly journals Profil Penderita Penyakit Tuberkulosis Paru BTA Positif yang Ditemukan di BP4 Lubuk Alung periode Januari 2012 – Desember 2012

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Eni Yulvia Susilayanti ◽  
Irvan Medison ◽  
Erkadius Erkadius
Keyword(s):  
Health Care ◽  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Medical Center ◽  
Pulmonary Diseases ◽  
Sputum Smear ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Suspected Tuberculosis ◽  
History Of

AbstrakTuberkulosis masih merupakan masalah kesehatan di Indonesia karena prevalensi yang masih tinggi,i terutama di negara berkembang. Karena penyebarannya yang tinggi, maka perlu diketahui bagaimana profil penderita penyakit ini agar penularannya bisa diminimalkan. Tujuan dari penelitian ini adalah untuk mengetahui profil penderita tuberculosis paru BTA positif yang berobat di Balai Pengobatan Penyakit Paru (BP4) Lubuk Alung periode 1 Januari 2012 – 31 Desember 2012. Penelitian ini bersifat deskriptif retrospektif. Instrumen yang digunakan adalah data dari rekam medik di Balai Pengobatan Penyakit Paru (BP4) Lubuk Alung sejak 1 Januari 2012 – 31 Desember 2012. Populasi yang ada seluruhnya dijadikan subjek penelitian. Kemudian dilakukan pencatatan dari beberapa variabel yang diteliti. Hasil penelitian ini menunjukkan bahwa dalam periode tersebut jumlah penderita yang berobat ke BP4 Lubuk Alung adalah 19.440 orang, sebanyak 3.224 orang diantaranya suspek. Penderita BTA (+) 1.109 orang. Jenis kelamin laki-laki (70,8%) lebih banyak dari perempuan. Usia terbanyak adalah 21-30 tahun (23,2%). Daerah asal terbanyak adalah Kab. Padang Pariaman (29,4%). Derajat kepositifan BTA sputum terbanyak berupa positif tiga (+3) adalah (44,2%). Tipe penderita terbanyak merupakan penderita kasus baru sebanyak (91,7%). Keluhan terbanyak yang dirasakan ketika berobat adalah batuk (99%). Sebanyak (13,4%) memiliki penyakit penyerta selain tuberkulosis. Riwayat penggunaan obat sebelumnya sebanyak (11,3%). Sebanyak (99%) dirujuk ke puskesmas dan unit pelayanan kesehatan terdekat. Berdasarkan pendataan profil penderita TB Paru BTA Positif bisa dilihat paling banyak adalah derajat (+3) dan dirujuk ke unit pelayanan terdekat.Kata kunci: profil, tuberkulosis paruAbstractTuberculosis is still a health problem in Indonesia because the prevalence is still high, especially in developing countries. Due to the speed of spread, it is necessary to know the profile of people who suffer from this disease, so the transmission can be minimized. The purpose of this study was to determine the profile of positive acid-fast-bacilli (BTA) in pulmonary tuberculosis patients who seek treatment at Medical Center for Pulmonary Diseases (BP4) Lubuk Alung during the period 1 January 2012-31 December 2012.This is a descriptive retrospective study by taking the data from medical records in BP4 Lubuk Alung. Using the enterety of the population. The results of this study indicate that in this period the number of people who went to BP4 Lubuk Alung were 19.440 people, 3.224 of them suspected tuberculosis. Patients with BTA (+) was 1.109 people. We found male 70.78%. Most are 21-30 years of age 23.2%. The area of origin mostly from Kab. Padang Pariaman 29.4%. The degree of sputum smear positivity mostly positive three (+3) was 44.2%. Type of most patients are people with new cases 91.7%. Most complaints was cough 99%. A total of 13.44% had concomitant diseases other than tuberculosis. History of previous anti tuberculosis drugs (OAT) we found in 11.3%. And 99% are referred to hospitals and health care units nearby. Based on the data collection, profile of positif pulmonary TB patients is (+3) and mostly referred to the nearest health center and service unit.Keywords:profile, pulmonary tuberculosis

scholarly journals Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

2020 ◽  
Vol 9 (11) ◽  
pp. e2559119873
Author(s):  
Ana Paula Biadola ◽  
André Aparecido dos Santos Correa ◽  
Amanda Aparecida Silva de Aguiar ◽  
Ualter Guilherme Cipriano Rosa ◽  
Paulo José Mascarenhas Mazaro ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Clinical Prognosis ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Single Center Study ◽  
Using Data

Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

scholarly journals GAMBARAN KADAR HEMOGLOBIN DAN INDEKS ERITROSIT PADA PASIEN TUBERKULOSIS PARU DI RSUD DR. M. HAULUSSY AMBON PERIODE JANUARI 2017 – APRIL 2018

2021 ◽  
Vol 2 (2) ◽  
pp. 82-89
Author(s):  
Reinhard Wilson Talakua ◽  
Vina Z. Latuconsina ◽  
Siti Hadjar Malawat
Keyword(s):  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Descriptive Study ◽  
Age Group ◽  
Common Complication ◽  
Major Health Problem ◽  
Major Health ◽  
Pulmonary Tb ◽  
Number Of Patients ◽  
Infection Disease

Pulmonary tuberculosis (TB) is an infection disease caused by Mycobacterium tuberculosis. Pulmonary TB remain a major health problem and the most common cause of death in the world especially in developing countries. Pulmonary TB infection could cause clinical manifestation, which is haematology disorders like anemia. Many studies has reported anemia as a common complication in patients with pulmonary TB. This research aims to determine haemoglobin levels and erythrocytes index of patients with pulmonary TB at RSUD Dr. M. Haulussy Ambon in the periods from January 2017 - April 2018. This research uses a descriptive study by using medical records of patients with pulmonary TB. Among 65 patients with pulmonary TB, number of patients with anemia are 44 cases (67,7%) and 21 cases (32,3%) are not anemia. Pulmonary TB with anemia most suffered by male as much 24 cases (72,7%). The age group suffered most is 18-30 years old as much 23 cases (69,7%), but the age group suffered most according to percentage is 51-60 years old as much 80%. The most common types of anemia is hipocromic micrositer as much 23 cases (52,3%). Haemoglobin levels in patients with pulmonary TB are found most below the normal value or anemia and the most common types of anemia is hipocromic micrositer. Needs to be done more research on the analysis of the relation between anemia with pulmonary TB. Keywords: pulmonary tuberculosis, haemoglobin, erythrocytes index

scholarly journals Hasil diagnostik Mycobacterium tuberculosis pada penderita batuk ≥2 minggu dengan pewarnaan Ziehl-Neelsen di Puskesmas Bailang dan Puskesmas Bengkol Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Stephanie O. Wilar ◽  
John Porotu'o ◽  
Olivia Waworuntu
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Positive Result ◽  
Descriptive Study ◽  
Acid Fast Bacillus ◽  
Tuberculosis Patients ◽  
Tuberculosis Transmission ◽  
Source Of Infection ◽  
Keywords Tuberculosis ◽  
Infection Source ◽  
Global Health Problem

Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Transmission occurs by air droplet infection. Source of infection is sputum of pulmonary tuberculosis patients. To date, tuberculosis is still a global health problem. In Indonesia the number of tuberculosis cases increases annualy. Most tuberculosis patients complain of cough ≥2 weeks. This study was aimed to determine the diagnostic results of M. tuberculosis in the sputum of patients cough ≥2 weeks with Ziehl-Neelsen staining at Puskesmas Bailang and Bengkol. This was a descriptive study. Subjects were patients with complaints of cough ≥2 weeks at Puskesmas Bailang and Bengkol. The results showed that there were 25 patients with cough ≥2 weeks that came for treatment consisted of 12 patients at Puskesmas Bailang and 13 patients at Puskesmas Bengkol. Most of them were males and aged 36-55 years. There was 1 patient (8.33%) that had positive result of acid-fast bacillus at Puskesmas Bailang however, at Puskesmas Bengkol none had positive result. Keywords: tuberculosis, cough more than two weeks, BTA examination. Abstrak: Tuberkulosis (TB) adalah penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis. Penularan terjadi melalui udara dari droplet infeksi. Sumber infeksi ialah penderita tuberkulosis paru yang membatukkan dahaknya. Hingga saat ini tuberkulosis masih merupakan masalah kesehatan dunia. Di Indonesia kasus tuberkulosis menunjukkan peningkatan dari tahun ke tahun. Diantara sekian banyak kasus tuberkulosis, pasien datang berobat dengan keluhan batuk ≥2 minggu. Penelitian ini bertujuan untuk mengetahui hasil diagnostik M. tuberculosis dari sputum penderita batuk ≥2 minggu dengan pewarnaan Ziehl- Neelsen di Puskesmas Bailang dan Bengkol. Jenis penelitian ialah deskriptif. Subjek penelitian ialah pasien dengan keluhan batuk ≥2 minggu di Puskesmas Bailang dan Bengkol. Hasil penelitian mendapatkan sebanyak 25 pasien dengan batuk ≥2 minggu yang datang berobat di Puskesmas Bailang dan Bengkol, terdiri dari 12 pasien dari Bailang dan 13 pasien dari Bengkol. Keluhan batuk ≥2 minggu lebih banyak ditemukan pada laki-laki, dan usia 36-55 tahun. Hasil pemeriksaan BTA di Puskesmas Bailang ditemukan 1 pasien (8,33%) positif sedangkan di Puskesmas Bengkol tidak ditemukan BTA positif.Kata kunci: tuberkulosis, batuk lebih dari dua minggu, pemeriksaan BTA.

scholarly journals Hubungan Efektivitas Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Penderita TB Paru di Puskesmas Padasuka Bandung Tahun 2014

2017 ◽  
Vol 3 (1) ◽  
pp. 22
Author(s):  
Upik Rahmi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Successful Treatment ◽  
Sampling Technique ◽  
Economic Life ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
The Social ◽  
Relationship Of

AbstrakLatar belakang : Penyakit Tuberkulosis Paru (TB Paru) adalah suatu penyakit infeksi kronik yang mengenai jaringan paru yang disebabkan oleh kuman Mycobacterium tuberculosis dan penyakit ini dapat menyebabkan kecacatan fisik dan sosial serta dapat mempengaruhi kehidupan sosial ekonomi penderita. Penelitian ini bertujuan untuk mengetahui hubungan efektifitas Pengawas Menelan Obat (PMO) dengan keberhasilan pengobatan penderita TB Paru di wilayah kerja Puskemas Padasuka Bandung.Metode : Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah penderita TB Paru BTA (+) yang memiliki PMO dan telah menjalani pengobatan 6 bulan dengan jumlah 40 responden menggunakan Teknik Total Sampling. Penelitian ini dilakukan di wilayah kerja Puskemas Padasuka Bandung Tahun 2014.Hasil : Dari 40 responden sebagian besar yaitu 31 (77.5%) efektif dalam pengawasan menelan obat dan 26 responden (65%) berhasil (sembuh). Hasil analisa menunjukkan ada hubungan yang signifikan antara efektifitas pengawas menelan obat (PMO) dengan kesembuhan penderita TB paru ( Pvalue = 0,002, nilai POR = 9,341).Kesimpulan : Ada hubungan yang signifikan antara efektifitas kegiatan PMO dengan keberhasilan pengobatan penderita TB paru Abstract Background: Pulmonary TB is a chronic infectious disease affecting the lung tissue caused by Mycobacterium tuberculosis, and the disease can lead to physical disability and social development and can affect the social and economic life of the patient. This study aims to determine the relationship of the effectiveness of the Supervisory Swallowing Drugs to the successful treatment of pulmonary TB patients in the region of Puskemas Padasuka Bandung. Methods: The study was a descriptive analytic research with cross-sectional approach. The population in this study are patients with TB BTA (+) which has been undergoing treatment PMO and 6 months with the number of 40 respondents using total sampling technique. This research was conducted in the working area Puskemas Padasuka Bandung 2014. Results: Of the 40 respondents most of which 31 (77.5%) effective in monitoring dope and 26 respondents (65%) managed (cured). The analysis shows no significant correlation between the effectiveness of a treatment supporter (PMO) to cure pulmonary tuberculosis patients (pvalue = 0.002, the value of POR = 9.341).Conclusion: there is a significant correlation between the effectiveness of the PMO with the successful treatment of pulmonary tuberculosis patients.

scholarly journals INSIDENSI TB PARU KASUS BARU PADA PASIEN DENGAN DM TIPE 2 DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Himyatul Hidayah ◽  
Surya Amal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Private Hospital ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Hiv Aids

Penyakit tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, menjadi penyakit infeksi penyebab kematian kedua di dunia setelah HIV-AIDS. Prevalensi kejadian TB di Indonesia menempati urutan ketiga setelah India dan China. Diabetes mellitus diperkirakan penyebab 15% kasus tuberkulosis saat ini, karena penyakit diabetes mellitus dapat merusak pertahanan host. Tujuan penelitian ini untuk mengetahui insidensi TB paru kasus baru dengan DM tipe 2 di salah satu rumah sakit swasta Cikampek. Instrumen penelitian yang digunakan adalah data sekunder rekam medik pasien TB paru kasus baru yang menjalani rawat jalan selama bulan April – September 2017 di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek. Hasil penelitian ini menunjukkan bahwa dari 83 pasien TB paru kasus baru terdapat 26 pasien TB paru kasus baru dengan DM Tipe 2.  Frekuensi TB paru kasus baru dengan DM tipe 2 lebih banyak pada kelompok jenis kelamin perempuan (53,85%), usia >54 tahun (65,39%), hasil pemeriksaan BTA sputum negatif (61,50%), lamanya pengobatan yang dianjurkan >8 bulan (53,85%).  Disimpulkan bahwa insidensi tuberkulosis paru kasus baru dengan DM tipe 2 rawat jalan di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek selama bulan April – September 2017 adalah sebesar 31,33%. Kata Kunci: Insidensi, Tuberkulosis paru, Diabetes mellitus tipe 2 Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis, it became the second leading cause of death in the world after HIV-AIDS. The prevalence of incidence of TB in Indonesia ranked third after India and China. Diabetes mellitus thought to be the cause 15 % the case of tuberculosis at the present time, due to disease of diabetes mellitus can be damaging to defense host. The purpose of this study was to know the incidence of new cases of pulmonary TB with type 2 diabetes mellitus in one of the private hospital Cikampek. The research instrument used was secondary data from the medical records of new TB pulmonary outpatients during April - September 2017 in the polyclinic internal medicine in one of the private hospital Cikampek. The result of study indicate that of the 83 new cases of pulmonary tuberculosis patients there were 26 new cases of pulmonary tuberculosis patients with type 2 diabetes mellitus. The frequency of pulmonary tuberculosis a new case with type 2 DM be greater among a group of the female sex (53,85 %), the age of >54 years (65,39%), results smear sputum negative (61,50%), length of treatment recommended >8 months (53,85%). It was concluded that the incidence of new cases of pulmonary TB with type 2 diabetes mellitus outpatients care in one of the private hospital Cikampek during the month of April – September2017 was recorded at 31,33 %. Keywords: Incidence, Pulmonary tuberculosis, Type 2 diabetes mellitus

scholarly journals Gambaran eritrosit urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Gracia S. Sinaga ◽  
Glady I. Rambert ◽  
Mayer F. Wowor
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Observational Research ◽  
Inclusion Criteria ◽  
High Power Field ◽  
Tuberculosis Patients ◽  
Duration Of Therapy ◽  
Normal Urine ◽  
Global Health Problem

Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis remains a major global health problem and ranks as the second leading cause of death from an infectious disease worldwide. Anti-tuberculosis drugs, such as streptomycin and rifampicin are nephrotoxic. If the kidney function decreased, especially the glomerulus there can be found blood cells in the urine. A small number of erythrocytes may be found in normal urine, about 0-2 cells per HPF (High Power Field). But more than three erythrocytes per HPF is generally considered hematuria. This study aims to describe about how the urine erythrocytes in adult pulmonary tuberculosis patients at RSUP Prof. Dr. R. D. Kandou Manado. Research design used is descriptive observational research. Samples were urine samples of all pulmonary tuberculosis patients that suit to inclusion criteria. This study was conducted from October to November 2016. The results of chemical urinalysis of urine erythrocytes are negative in 20 patients and positive in 10 patients, while the results of microscopic urinalysis of urine erythrocytes are normal in 26 patients and hematuria in 4 patients. Conclusion: Hematuria mostly found in males, age 56-65 years old, default tuberculosis type, the first category of anti-tuberculosis drugs, the duration of therapy about 3-4 months, and in patients with comorbid disease.Keywords: pulmonary tuberculosis, urinalysis, hematuria Abstrak: Tuberkulosis merupakan penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis. Tuberkulosis masih merupakan salah satu masalah kesehatan masyarakat di dunia dan menduduki peringkat kedua penyebab kematian oleh penyakit infeksi di dunia. Obat anti-tuberkulosis seperti streptomisin dan rifampisin memiliki efek nefrotoksik. Apabila fungsi ginjal terutama glomerulus telah rusak maka dapat ditemukan adanya eritrosit dalam urin. Pada urin normal terdapat eritrosit sekitar 0-2 sel/LPB. Jika ditemukan 3 sel/LPB atau lebih, maka disebut hematuria. Penelitian ini bertujuan untuk mengetahui gambaran eritrosit urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R.D. Kandou Manado. Desain penelitian yang digunakan adalah deskriptif observasional. Sampel penelitian adalah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria inklusi. Penelitian dilakukan sejak Oktober-November 2016. Dari hasil pemeriksaan eritrosit urin secara kimia didapatkan hasil negatif pada 20 pasien dan hasil positif pada 10 pasien, sedangkan pemeriksaan mikroskopis eritrosit urin ditemukan hasil normal pada 26 pasien dan hasil hematuria pada 4 pasien. Simpulan: Hematuria didapatkan lebih banyak pada pasien laki-laki, pada kelompok usia 56-65 tahun, pada jenis kasus putus obat, pada jenis pengobatan kategori 1, pada lama pengobatan 3-4 bulan, dan pada pasien dengan penyakit penyerta. Kata kunci: tuberkulosis paru, urinalisis, hematuria

scholarly journals Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Dewi Kartika Turbawaty ◽  
Adhi Kristianto Sugianli ◽  
Arto Yuwono Soeroto ◽  
Budi Setiabudiawan ◽  
Ida Parwati
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Screening Test ◽  
Causes Of Death ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Sensitivity Specificity ◽  
Global Health Problem

Pulmonary tuberculosis (TB) is a major global health problem and is one of the top 10 causes of death worldwide. Our study aimed to evaluate the performance of urinary Mycobacterium tuberculosis (Mtb) antigens cocktail (ESAT6, CFP10, and MPT64) compared with culture and microscopy. This descriptive cross-sectional study was conducted in Dr. Hasan Sadikin General Hospital, Bandung, from January 2014 to October 2016. A total of 141 pulmonary tuberculosis patients were included. Sputum samples were examined for acid-fast bacilli (ZN stain) and mycobacterial culture (LJ); the Mtb antigens cocktail was examined in the urine sample. The positivity rate of TB detection from the three methods was as follows: AFB 52/141 (36.9%), culture 50/141 (35.5%), and urinary Mtb antigens cocktail 95/141 (67.4%). Sensitivity, specificity, PPV, and NPV of urinary Mtb antigens cocktail were 68.2%, 33%, 31.6%, and 69.6%, respectively. Validity of combination of both methods with culture as a gold standard yielded sensitivity, specificity, PPV, and NPV of 90%, 28.6%, 40.9%, and 83.8%, respectively. Combination of urinary Mtb antigens cocktail with AFB as a screening test gives a good sensitivity, although the specificity is reduced. Urinary Mtb antigens cocktail can be used as screening test for pulmonary tuberculosis.

scholarly journals GAMBARAN KADAR ASAM URAT PADA PENDERITA TUBERKULOSIS PARU YANG MENERIMA TERAPI OBAT ANTI TUBERKULOSIS DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2014 – JUNI 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Irwanto Kondo ◽  
M. C. P. Wongkar ◽  
Jeffrey Ongkowijaya
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Uric Acid ◽  
Pulmonary Tuberculosis ◽  
Female Ratio ◽  
Intensive Phase ◽  
Antituberculosis Drugs ◽  
Tuberculosis Patients ◽  
Male Female Ratio ◽  
Amino Salicylic Acid ◽  
Using Data

Abstract: Pulmonary tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. There are 6 kinds of essential drugs which have been used: isoniazid, amino salicylic acid, streptomycin, ethambutol, rifampicin, and pyrazinamide. As reported, pyrazinamide and ethambutol can cause increased levels of uric acid. This study aimed to obtain the uric acid profile in tuberculosis patients treated with antituberculosis drugs in Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study using data of the Medical Record Department of Prof. Dr. R. D. Kandou Hospital Manado. Of 25 tuberculosis patients treated with antituberculosis drugs, the uric acid levels were as follows: high in 15 patients (60%), normal in 9 patients (36%), and low in 1 patient (4%). The highest proportion of tuberculosis patients who had hyperuricemia after treated with antituberculosis drugs were male (73.33%) and age 46-65 years (46.67%). The increased uric acid level mainly occurred in the intensive phase of treatment (0-2 months), and in patients taking the combination of pyrazinamide and ethambutol. The most common comorbid disease was anemia (53.33%). Conclusion: Hyperuricemia was found in 60% of TB patients receiving antituberculosis drugs with a male : female ratio 2.75:1, mainly occurred in the intensive phase of treatment (0-2 months) and in patients who used a combination of pyrazinamide and ethambutol.Keywords: pulmonary tuberculosis, anti-tuberculosis drugs, uric acid Abstrak: Tuberkulosis (TB) paru adalah suatu penyakit infeksi kronik yang disebabkan Mycobacterium tuberculosis. Terdapat 6 macam obat esensial yang telah dipakai, yaitu: isoniazid (H), para amino salisilik asid, streptomisin, etambutol, rifampisin, dan pirazinamid. Pirazinamid dan etambutol dilaporkan dapat menyebabkan peningkatan kadar asam urat. Penelitian ini bertujuan untuk mendapatkan gambaran kadar asam urat pada pasien TB paru yang menerima obat antituberkulosis (OAT) di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif retrospektif dengan mengambil data sekunder di Instalasi Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil pemeriksaan laboratorium dari 25 pasien TB yang menjalani terapi OAT memperlihatkan 15 pasien (60%) dengan kadar asam urat tinggi, 9 pasien (36%) normal, dan 1 pasien (4%) kadar asam urat rendah. Proporsi tertinggi pasien TB yang mengalami hiperurisemia setelah menerima OAT ialah laki-laki (73,33%), rentang umur 46-65 tahun (46,67%). Peningkatan terutama terjadi pada fase intensif pengobatan (0-2 bulan), dan pada pasien yang mengonsumsi kombinasi pirazinamid dan etambutol. Penyakit komorbid terbanyak ialah anemia (53,33%). Simpulan: Hiperurisemia ditemukan pada 60% pasien TB yang menjalani terapi OAT, jenis kelamin laki-laki lebih banyak dari perempuan (2,75:1), peningkatan terutama terjadi pada pengobatan fase intensif (0-2 bulan), dan pada pasien yang menggunakan kombinasi pirazinamid dan etambutol. Kata kunci: tuberkulosis paru, obat anti tuberkulosis, asam urat

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