scholarly journals Intrinsic dimensionality of human behavioral activity data

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218966
Author(s):  
Luana Fragoso ◽  
Tuhin Paul ◽  
Flaviu Vadan ◽  
Kevin G. Stanley ◽  
Scott Bell ◽  
...  
Keyword(s):  
Behavioral Activity ◽  
Activity Data ◽  
Intrinsic Dimensionality

PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE NUMBERED HEADS TOGETHER (NHT) UNTUK MENINGKATKAN HASIL BELAJAR BAHASA INDONESIA SISWA KELAS IVA SD NEGERI 78 PEKANBARU KECAMATAN TENAYAN RAYA

2017 ◽  
Vol 6 (1) ◽  
pp. 32
Author(s):  
Nismarni Nismarni
Keyword(s):  
Cooperative Learning ◽  
Learning Outcomes ◽  
Learning Model ◽  
Instructional Materials ◽  
Test Results ◽  
Activity Data ◽  
Reflection Data ◽  
Teachers And Students ◽  
Bahasa Indonesia ◽  
Daily Test

In the background backs Indonesian learning results obtained by the students is very low because the method of learning that are not relevant. Classroom action research aims to determine the implementation of cooperative learning model Numbered Heads Together (NHT) to improve learning outcomes Indonesian grade IV A SD Negeri 78 Pekanbaru on instructional materials do. The experiment was conducted in two cycles each cycle two meetings and one daily tests. Each cycle stages are: planning, implementation, observation and reflection. Data from the activity of teachers and students in the can from the observation sheet, while, learning outcomes in getting the daily test results. The results showed the activities of teachers and students has increased, in the first cycle of meetings I obtained a score of 33 (68.75%), in the first cycle of meetings II obtained a score of 38 (79.17%), the second cycle of meetings I obtained a score of 40 (83 , 33%), and the second cycle II meeting obtained a score of 44 (91.67%). And in the first cycle of the first meeting of student activity data obtained a score of 27 (56.25%), in the first cycle II meeting increased with the acquisition of a score of 36 (75.00%), and the second cycle first meeting increased to 41 (85.42 %), the second cycle II meeting increased to 45 (93.75%). Learning outcomes of students has increased, this is evidenced by: the preliminary data the number of students who reach KKM amounted to 10 students (28.57%) with an average of learning outcomes at 65.37. Increased in the first cycle by the number of students who completed totaling 26 students (74.28%) with an average of learning outcomes at 76.00. And the second cycle increases with the number of students 32 students (91.42%) with an average of learning outcomes at 86.86. Based on these results it can be concluded that the implementation of cooperative learning model NHT can improve learning outcomes Indonesian grade IV A SD Negeri 78 Pekanbaru. 

Geodesic distances in the intrinsic dimensionality estimation using packing numbers

2014 ◽  
Vol 19 (4) ◽  
pp. 578-591 ◽  
Author(s):  
Rasa Karbauskaitė ◽  
◽  
Gintautas Dzemyda ◽  
Keyword(s):  
Geodesic Distances ◽  
Intrinsic Dimensionality

Neurophysiological and morphological effects in the post-exposure vibration period during experimental modeling

2019 ◽  
pp. 284-290
Author(s):  
Natalya L. Yakimova ◽  
Vladimir A. Pankov ◽  
Aleksandr V. Lizarev ◽  
Viktor S. Rukavishnikov ◽  
Marina V. Kuleshova ◽  
...  
Keyword(s):  
Nervous System ◽  
Evoked Potentials ◽  
Experimental Model ◽  
Visual Evoked Potentials ◽  
The Body ◽  
Behavioral Activity ◽  
Contact Period ◽  
Vibration Exposure ◽  
Visual Evoked

Introduction. Vibration disease continues to occupy one of the leading places in the structure of professional pathology. In workers after the termination of contact with vibration generalization and progression of violations in an organism is noted. The pathogenetic mechanisms of the progredient course of disturbances in the nervous system in the post-contact period of vibration exposure remain insufficiently studied.The aim of the study was to test an experimental model of vibration exposure to assess the neurophysiological and morphological effects of vibration in rats in the dynamics of the post-contact period.Materials and methods. The work was performed on 168 white male outbred rats aged 3 months weighing 180–260 g. The vibration effect was carried out on a 40 Hz vibrating table for 60 days 5 times a week for 4 hours a day. Examination of animals was performed after the end of the physical factor, on the 30th, 60th and 120th day of the post-contact period. To assess the long-term neurophysiological and morphofunctional effects of vibration in rats, we used indicators of behavioral reactions, bioelectric activity of the somatosensory zone of the cerebral cortex, somatosensory and visual evoked potentials, parameters of muscle response, morphological parameters of nervous tissue.Results. In the dynamics of the post-contact period observed the preservation of violations of tentatively research, motor and emotional components of behavior. In the Central nervous system instability of activity of rhythms of an electroencephalogram, decrease in amplitude of visual evoked potentials, lengthening of latency of somatosensory evoked potentials, decrease in total number of normal neurons and astroglia is established. In the peripheral nervous system remained changes in indicators: increasing duration and latency, reducing the amplitude of the neuromuscular response.Conclusions: The experimental model allows us to study the long-term neurophysiological and morphological effects of vibration on the body. The formation and preservation of changes in behavioral activity, neurophysiological and morphological effects of vibration from the 30th to the 120th day of the post-contact period were confirmed.

Truck Weight Enforcement Measures of Effectiveness: Development and Software Application

1998 ◽  
Vol 1643 (1) ◽  
pp. 152-160 ◽  
Author(s):  
F. R. Hanscom ◽  
M. W. Goelzer
Keyword(s):  
Software Tool ◽  
Field Evaluation ◽  
Seasonal Effects ◽  
Data Sets ◽  
Activity Data ◽  
Software Application ◽  
Enforcement Effort ◽  
Measures Of Effectiveness ◽  
Truck Weight ◽  
Enforcement Activity

A software tool was developed to determine what is accomplished as the result of truck weight enforcement efforts. Traditionally applied measures (e.g., numbers of trucks weighed and citations issued) have simply provided indications of enforcement effort. These previously applied measures failed to provide results in terms of real enforcement objectives, such as deterring overweight trucks and minimizing pavement wear and tear. Consequently the need exists to develop and validate truck weight enforcement measures of effectiveness (MOE). MOEs were developed via a series of analytical procedures. They were subsequently validated in a comprehensive four-state field evaluation. Matched (weigh-in-motion) (WIM) data sets, collected under controlled baseline and enforcement conditions, were analyzed to determine the sensitivity of candidate MOEs to actual enforcement activity. Data collection conditions were controlled in order to avoid contamination from hour-of-day, day-of-week, and seasonal effects. The following MOEs, were validated on the basis of their demonstrated sensitivity to truck weight enforcement objectives and the presence of enforcement activity: (1) severity of overweight violations, (2) proportion of overweight trucks, (3) average equivalent single-axle load (ESAL), (4) excess ESALs, and (5) bridge formula violations. These measures are sensitive to legal load-limit compliance objectives of truck weight enforcement procedures as well as the potential for overweight trucks to produce pavement deterioration. The software User Guide that statistically compares calculated MOEs between observed enforcement conditions is described in this paper. The User Guide also allows users to conduct an automated pavement design life analysis estimating, the theoretical pavement-life effect resulting from the observed enforcement activity.

QSAR Analysis of Selected Antimicrobial Structures Belonging to Nitro-derivatives of Heterocyclic Compounds

2020 ◽  
Vol 17 (2) ◽  
pp. 214-225 ◽  
Author(s):  
Piotr Kawczak ◽  
Leszek Bober ◽  
Tomasz Bączek
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Molecular Descriptors ◽  
Microbiological Activity ◽  
Activity Data ◽  
Qsar Analysis ◽  
Qsar Models ◽  
Nitro Derivatives ◽  
Semi Empirical ◽  
Derivatives Of

Background: Nitro-derivatives of heterocyclic compounds were used as active agents against pathogenic microorganisms. A set of 4- and 5-nitroimidazole derivatives exhibiting antimicrobial activity was analyzed with the use of Quantitative Structure-Activity Relationships (QSAR) method. The study included compounds used both in documented treatment and those described as experimental. Objective: The purpose of this study was to demonstrate the common and differentiating characteristics of the above-mentioned chemical compounds alike physicochemically as well as pharmacologically based on the quantum chemical calculations and microbiological activity data. Methods: During the study PCA and MLR analysis were performed, as the types of proposed chemometric approach. The semi-empirical and ab initio level of in silico molecular modeling was performed for calculations of molecular descriptors. Results: QSAR models were proposed based on chosen descriptors. The relationship between the nitro-derivatives structure and microbiological activity data was able to class and describe the antimicrobial activity with the use of statistically significant molecular descriptors. Conclusion: The applied chemometric approaches revealed the influential features of the tested structures responsible for the antimicrobial activity of studied nitro-derivatives.

Evaluation of Chemotherapeutic Activity of the Selected Bases’ Analogues of Nucleic Acids Supported by ab initio Various Quantum Chemical Calculations

2020 ◽  
Vol 16 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Piotr Kawczak ◽  
Leszek Bober ◽  
Tomasz Bączek
Keyword(s):  
Biological Activity ◽  
Nucleic Acids ◽  
Ab Initio ◽  
Quantum Chemical Calculations ◽  
Quantum Chemical ◽  
Structural Parameters ◽  
Principal Component ◽  
Polarizable Continuum Model ◽  
Activity Data ◽  
Qsar Models

Background: Pharmacological and physicochemical classification of bases’ selected analogues of nucleic acids is proposed in the study. Objective: Structural parameters received by the PCM (Polarizable Continuum Model) with several types of calculation methods for the structures in vacuo and in the aquatic environment together with the huge set of extra molecular descriptors obtained by the professional software and literature values of biological activity were used to search the relationships. Methods: Principal Component Analysis (PCA) together with Factor Analysis (FA) and Multiple Linear Regressions (MLR) as the types of the chemometric approach based on semi-empirical ab initio molecular modeling studies were performed. Results: The equations with statistically significant descriptors were proposed to demonstrate both the common and differentiating characteristics of the bases' analogues of nucleic acids based on the quantum chemical calculations and biological activity data. Conclusion: The obtained QSAR models can be used for predicting and explaining the activity of studied molecules.

Kinetic Behaviour of Amylase According to pH: A New Perspective for Starch Hydrolysis Process

2020 ◽  
Vol 16 (2) ◽  
pp. 135-144
Author(s):  
Ravneet K. Grewal ◽  
Baldeep Kaur ◽  
Gagandeep Kaur
Keyword(s):  
Metal Ions ◽  
Competitive Inhibition ◽  
Deae Cellulose ◽  
Kinetic Studies ◽  
Cost Effective ◽  
Starch Hydrolysis ◽  
Divalent Metal Ions ◽  
Activity Data ◽  
Time Saving ◽  
Alkaline Conditions

Background: Amylases are the most widely used biocatalysts in starch saccharification and detergent industries. However, commercially available amylases have few limitations viz. limited activity at low or high pH and Ca2+ dependency. Objective: The quest for exploiting amylase for diverse applications to improve the industrial processes in terms of efficiency and feasibility led us to investigate the kinetics of amylase in the presence of metal ions as a function of pH. Methods: The crude extract from soil fungal isolate cultures is subjected to salt precipitation, dialysis and DEAE cellulose chromatography followed by amylase extraction and is incubated with divalent metal ions (i.e., Ca2+, Fe2+, Cu2+, and Hg2+); Michaelis-Menton constant (Km), and maximum reaction velocity (Vmax) are calculated by plotting the activity data obtained in the absence and presence of ions, as a function of substrate concentration in Lineweaver-Burk Plot. Results: Kinetic studies reveal that amylase is inhibited un-competitively at 5mM Cu2+ at pH 4.5 and 7.5, but non-competitively at pH 9.5. Non-competitive inhibition of amylase catalyzed starch hydrolysis is observed with 5mM Hg2+ at pH 9.5, which changes to mixed inhibition at pH 4.5 and 7.5. At pH 4.5, Ca2+ induces K- and V-type activation of amylase catalyzed starch hydrolysis; however, the enzyme has V-type activation at 7mM Ca2+ under alkaline conditions. Also, K- and V-type of activation of amylase is observed in the presence of 7mM Fe2+ at pH 4.5 and 9.5. Conclusion: These findings suggest that divalent ions modulation of amylase is pH dependent. Furthermore, a time-saving and cost-effective solution is proposed to overcome the challenges of the existing methodology of starch hydrolysis in starch and detergent industries.

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