The gut virome of healthy children during the first year of life is diverse and dynamic

In this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant’s immune system or on the health of the infants later in life, remains to be investigated.

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The gut virome of healthy children during the first year of life is diverse and dynamic

10.1101/2020.10.07.329565 ◽

2020 ◽

Author(s):

Blanca Taboada ◽

Patricia Morán ◽

Angélica Serrano-Vázquez ◽

Pavel Iša ◽

Liliana Rojas-Velázquez ◽

...

Keyword(s):

Gastrointestinal Symptoms ◽

First Year ◽

Healthy Children ◽

Virus Species ◽

Human Pathogens ◽

Eukaryotic Virus ◽

One Year ◽

First Year Of Life ◽

Changes Over Time ◽

Composition Changes

AbstractIn this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant’s immune system or on the health of the infants later in life, remains to be investigated.

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The Development of Swallowing Respiratory Coordination

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd18.1.19 ◽

2009 ◽

Vol 18 (1) ◽

pp. 19-24

Author(s):

Maggie-Lee Huckabee

Keyword(s):

Cortical Activation ◽

First Year ◽

Healthy Children ◽

Nasal Airflow ◽

Single Session ◽

Primary Finding ◽

Patterns Of Behavior ◽

Cortical Modulation ◽

First Year Of Life ◽

Swallowing Apnea

Abstract Research exists that evaluates the mechanics of swallowing respiratory coordination in healthy children and adults as well and individuals with swallowing impairment. The research program summarized in this article represents a systematic examination of swallowing respiratory coordination across the lifespan as a means of behaviorally investigating mechanisms of cortical modulation. Using time-locked recordings of submental surface electromyography, nasal airflow, and thyroid acoustics, three conditions of swallowing were evaluated in 20 adults in a single session and 10 infants in 10 sessions across the first year of life. The three swallowing conditions were selected to represent a continuum of volitional through nonvolitional swallowing control on the basis of a decreasing level of cortical activation. Our primary finding is that, across the lifespan, brainstem control strongly dictates the duration of swallowing apnea and is heavily involved in organizing the integration of swallowing and respiration, even in very early infancy. However, there is evidence that cortical modulation increases across the first 12 months of life to approximate more adult-like patterns of behavior. This modulation influences primarily conditions of volitional swallowing; sleep and naïve swallows appear to not be easily adapted by cortical regulation. Thus, it is attention, not arousal that engages cortical mechanisms.

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Teething Symptoms in the First Year of Life and Associated Factors: A Cohort Study

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.34.3.h318882h52616225 ◽

2010 ◽

Vol 34 (3) ◽

pp. 201-206 ◽

Cited By ~ 7

Author(s):

Carlos Alberto Feldens ◽

Italo Medeiros Faraco Junior ◽

Andréia Bertani Ottoni ◽

Eliane Gerson Feldens ◽

Márcia Regina Vítolo

Keyword(s):

Associated Factors ◽

Primary Outcome ◽

First Year ◽

Structured Interviews ◽

Self Medication ◽

Nuclear Families ◽

Dental Examination ◽

Pediatric Dentists ◽

One Year ◽

First Year Of Life

Objective: To investigate the occurrence and management of teething symptoms during the first year of life and associated factors. Study design: 500 children were recruited at birth. Research assessments including structured interviews, anthropometric measurements and dental examination were carried out after birth, at 6 months and at one-year of age. The primary outcome of this study was defined as the occurrence of one or more teething symptoms within the first year of life, as reported by the mother. Results: Teething symptoms were reported in 73% of the children analyzed (273/375). The symptoms most frequently reported were irritability (40.5%), fever (38.9%), diarrhoea (36.0%) and itching (33.6%). Dentists had little influence on the management of symptoms and self-medication to relieve them was a common practice. The risk of reporting teething symptoms was higher for children from nuclear families (p=0.040) and for children from families with higher income (p=0.040). Conclusions: Teething symptoms were highly reported in this population. Pediatric dentists should be accessible and provide adequate orientation when symptoms can be managed at home or immediate referral to health services when more serious diseases are suspected.

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ADENOVIRUS COMPLEMENT-FIXING ANTIBODY TITERS FROM BIRTH THROUGH THE FIRST YEAR OF LIFE

PEDIATRICS ◽

10.1542/peds.32.4.497 ◽

1963 ◽

Vol 32 (4) ◽

pp. 497-500

Author(s):

Rosa Lee Nemir ◽

Donna O'Hare ◽

Stanley Goldstein ◽

Charles B. Hilton

Keyword(s):

Cytopathic Effect ◽

Gradual Increase ◽

Newborn Infants ◽

First Year ◽

Placental Barrier ◽

Culture Studies ◽

Antibody Titers ◽

Level 1 ◽

One Year ◽

First Year Of Life

Complement fixing antibody titers to the adenoviruses were determined in 251 newborn infants, using cord blood. Approximately 95% of these were found to have CF titers of 1:16 or over, the majority (75%) were 1:32 or more. Material from the pharyngeal and rectal swabs of these infants on tissue culture studies (542) on HeLa and amnion cells showed no cytopathic effect in oven 96% of these infants. A longitudinal study of 114 of these infants was made at 3 months intervals; 67 have been observed for one year. At 3 months, only 12% still showed CF antibody titers, and these were chiefly at a low level, 1:16. At the subsequent 3-month interval observations, a gradual rise in CF antibodies were found. At one year of age, approximately 37% had titers of 1:32 on over. The findings of this report support the statement that CF antibodies to adenovirus pass the placental barrier. There is a gradual increase in the percentage of infants with positive CF antibodies after 3 months.

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Epidemiology of Physician-Diagnosed Allergic Rhinitis in Childhood

PEDIATRICS ◽

10.1542/peds.94.6.895 ◽

1994 ◽

Vol 94 (6) ◽

pp. 895-901

Author(s):

Anne L. Wright ◽

Catharine J. Holberg ◽

Marilyn Halonen ◽

Fernando D. Martinez ◽

Wayne Morgan ◽

...

Keyword(s):

Risk Factors ◽

Allergic Rhinitis ◽

Immunoglobulin E ◽

Age At Onset ◽

First Year ◽

Healthy Children ◽

Early Introduction ◽

Maternal Cigarette Smoking ◽

History Of ◽

First Year Of Life

Objective. To investigate the natural history of and risk factors for allergic rhinitis in the first 6 years of life. Methods. Parents of 747 healthy children followed from birth completed a questionnaire when the child was 6 years old. Data were obtained regarding physician-diagnosed allergic rhinitis (PDAR), associated symptoms, and age at onset. Risk-factor data were taken from earlier questionnaires, and data regarding immunoglobulin E (IgE) and skin-test reactivity were obtained at age 6. Results. By the age of 6, 42% of children had PDAR. Children whose rhinitis began in the first year of life had more respiratory symptoms at age 6 and were more likely to have a diagnosis of asthma. Early introduction of foods or formula, heavy maternal cigarette smoking in the first year of life, and higher IgE, as well as parental allergic disorders, were associated with early development of rhinitis. Risk factors for PDAR that remained significant in a multivanate model included maternal history of physician-diagnosed allergy (odds ratio: 2.2, 95% confidence interval: 1.35-3.54), asthma in the child (4.06, 2.06-7.99), and IgE greater than 100 IU/mL at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were significantly higher only among those with high IgE and those who had dogs. Conclusion. Allergic rhinitis developing in the first years of life is an early manifestation of an atopic predisposition, which may be triggered by early environmental exposures.

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Immunity to Diphtheria, Pertussis, Tetanus, and Poliomyelitis in Children with Acute Lymphocytic Leukemia After Cessation of Chemotherapy

PEDIATRICS ◽

10.1542/peds.67.2.222 ◽

1981 ◽

Vol 67 (2) ◽

pp. 222-229 ◽

Cited By ~ 1

Author(s):

A. van der Does-van den Berg ◽

J. Hermans ◽

J. Nagel ◽

G. van Steenis

Keyword(s):

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

First Year ◽

Healthy Children ◽

Healthy Control ◽

Antibody Titers ◽

Group A ◽

One Year ◽

Group B ◽

Antibody Levels

Antibody titers to diphtheria, pertussis, tetanus, and poliomyelitis (types I to III) were measured in previously vaccinated children with acute lymphocytic leukemia in remission after cessation of therapy. The response to revaccination one year after therapy was stopped was also studied. The patients' antibody titers were compared with those of healthy children, matched for age and sex. Two groups of patients were studied: one group (group A, N = 30) was given two drugs (6-mercaptopurine, methotrexate); the other group (group B, N= 19) was given three drugs (6-mercaptopurine, methotrexate, and cyclophosphamide) for maintenance treatment. In general, the patients' antibody titers were lower than those of healthy children, but in most patients they were still at levels considered to be protective. No significant differences in antibody levels between the two patient groups were found. A spontaneous rise in antibody titers in the first year after termination of therapy was not observed. After revaccination the rise in antibody titers was correlated with preexisting antibody titers in the same way in patients as in healthy children, and the antibody titers in patients and in healthy control subjects were on roughly the same level.

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In congenital hypothyroidism bone maturation at birth may be a predictive factor of psychomotor development during the first Year of life irrespective of other variables related to treatment

Acta Endocrinologica ◽

10.1530/eje.0.1490001 ◽

2003 ◽

pp. 1-6 ◽

Cited By ~ 42

Author(s):

M Wasniewska ◽

F De Luca ◽

A Cassio ◽

N Oggiaro ◽

P Gianino ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Psychomotor Development ◽

First Year ◽

X Rays ◽

Bone Maturation ◽

Gestation Age ◽

Group A ◽

One Year ◽

First Year Of Life ◽

Tsh Levels

OBJECTIVE: To evaluate in a cohort of infants with congenital hypothyroidism (CH): (a) the frequency of bone maturation (BM) retardation at birth and (b) whether BM delay at birth may be considered as a tool to make a prognosis of psychomotor status at the age of 1 Year, irrespective of other variables related to treatment. DESIGN: BM at birth, CH severity and developmental quotient (DQ) at the age of 1 Year were retrospectively evaluated in 192 CH infants selected by the following inclusion criteria: (a) gestation age ranging between 38 and 42 weeks; (b) onset of therapy within the first Month of life; (c) initial thyroxine (l-T(4)) dosage ranging from 10 to 12 microg/kg/day; (d) normalization of serum thyrotropin (TSH) levels before the age of 3 Months; (e) Monthly adjustments of l-T(4) dose during the first Year of life with serum TSH levels ranging from 0.5 to 4 mIU/l; (f) no major diseases and/or physical handicaps associated with CH; (g) availability of both thyroid scanning and knee X-rays at the time of treatment initiation; (h) availability of DQ assessment at an average age of 12 Months. METHODS: BM was considered normal if the distal femur bony nucleus diameter exceeded 3 mm (group A) or retarded if either this nucleus was absent (subgroup B1) or its diameter was <3 mm (subgroup B2). DQ was evaluated with the Brunet-Lezine test. RESULTS: In 44.3% of cases BM was either delayed (23.5%) or severely delayed (20.8%). The risk of BM retardation was higher in the patients with athyreosis than in the remaining patients (41/57 vs 44/135, chi(2)=25.13, P<0.005). BM-retarded infants showed a more severe biochemical picture of CH at birth and a lower DQ at the age of one Year compared with the group A patients. If compared with infants of subgroup B2 those of subgroup B1 exhibited significantly lower T(4) levels at birth and a more frequent association with athyreosis (70.0 vs 30.0%; chi(2)=7.49, P<0.01), whereas DQ was superimposable in both subgroups. CONCLUSIONS: (a) BM at birth is delayed in almost half of CH patients and (b) CH severity per se can affect DQ at the age of 1 Year irrespective of other variables related to therapy.

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HEMATOPOIESIS IN PREMATURE INFANTS WITH SPECIAL CONSIDERATION OF THE EFFECT OF IRON AND OF ANIMAL-PROTEIN FACTOR

PEDIATRICS ◽

10.1542/peds.16.6.753 ◽

1955 ◽

Vol 16 (6) ◽

pp. 753-762

Author(s):

James A. Wolff ◽

Alice M. Goodfellow

Keyword(s):

Premature Infants ◽

Animal Protein ◽

Iron Therapy ◽

First Year ◽

Protein Factor ◽

Anemia Of Prematurity ◽

Significant Difference ◽

One Year ◽

First Year Of Life ◽

Weight Groups

Normal values in the first 3 months of life have been determined for hemoglobin, erythrocytes, reticulocytes, platelets, leukocytes and differential counts for premature infants with birth weights less than 1200 gm., and for those between 1200 and 1500 gm. at birth. No significant difference was found in the degree of depression of levels of hemoglobin and erythrocytes when values in the 2 weight groups were compared. Two reticulocyte peaks occur during the first 3 months of life. The first peak is present immediately after birth. The second peak, at about the eighth week, coincides with the occurrence of the greatest degree of anemia. Neither iron therapy nor treatment with animal-protein factor containing vitamin B12 and Aureomycin®, started before the end of the third week of life, had a statistically significant effect on the early phase of the anemia of prematurity. Untreated premature infants and those given animal-protein factor were anemic at the end of the first year of life. Subjects given iron therapy had normal hemoglobin values at one year of age. Blood transfusion is rarely necessary in the treatment of the anemia of prematurity.

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Being born to a single mother in France: trajectories of father’s involvement over the first year of life

Longitudinal and Life Course Studies ◽

10.1332/175795919x15720984151059 ◽

2020 ◽

Vol 11 (1) ◽

pp. 123-149

Author(s):

Ariane Pailhé ◽

Lidia Panico ◽

Marieke Heers

Keyword(s):

Father Involvement ◽

Single Mother ◽

First Year ◽

Parental Relationships ◽

Father Engagement ◽

Child Involvement ◽

Nationally Representative ◽

One Year ◽

First Year Of Life ◽

Representative Cohort

This paper characterises families where the father is not living (or not living permanently) with the child from around birth, and identifies the drivers of the evolution of father contact over the first year of life across different types of household. We use a recent, nationally representative cohort of children born in France in 2011, Elfe (the Etude longitudinale française depuis l’enfance), and latent clustering techniques to identify different groups of households characterised by non-residential fatherhood. We show that non-residential fatherhood from around birth is not a marginal phenomenon in France, and it corresponds to a heterogeneity of situations, describing both advantaged and low involvement fathers, as well less disadvantaged but involved groups. Over the first year of life, most non-resident fathers managed to keep in contact with their child, including relatively disadvantaged groups such as migrant and young parents, although groups characterised by low father involvement shortly after birth lost contact. On the other hand, among a group of very involved non-resident fathers who were in a relationship with the mother, we observed high levels of contact and indeed co-residence when the child was one year of age. A number of channels emerged to explain the correlations between our latent groups and father contact at one year: notably, father engagement around birth, especially whether the father formally recognised the child. Trajectories of father–child involvement and of parental relationships are therefore at least as important as socio-economic conditions to understand future father contact.

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