scholarly journals Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246152
Author(s):  
Seongho Seo ◽  
Ye-Ha Jung ◽  
Dasom Lee ◽  
Won Joon Lee ◽  
Joon Hwan Jang ◽  
...  
Keyword(s):  
Primary Motor Cortex ◽  
Volume Ratio ◽  
Pain Syndrome ◽  
Superior Temporal Gyrus ◽  
Emission Tomography ◽  
Healthy Controls ◽  
Positron Emission ◽  
Postcentral Gyrus ◽  
Distribution Volume Ratio ◽  
Critical Regions

Purpose Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS. The aim of this study was to assess neuroinflammation in FM patients compared with that in patients with CRPS and healthy controls. Methods Neuroinflammation was measured as the distribution volume ratio (DVR) of [11C]-(R)-PK11195 positron emission tomography (PET) in 12 FM patients, 11 patients with CRPS and 15 healthy controls. Results Neuroinflammation in FM patients was significantly higher in the left pre (primary motor cortex) and post (primary somatosensory cortex) central gyri (p < 0.001), right postcentral gyrus (p < 0.005), left superior parietal and superior frontal gyri (p < 0.005), left precuneus (p < 0.01), and left medial frontal gyrus (p = 0.036) compared with healthy controls. Furthermore, the DVR of [11C]-(R)-PK11195 in FM patients demonstrated decreased neuroinflammation in the medulla (p < 0.005), left superior temporal gyrus (p < 0.005), and left amygdala (p = 0.020) compared with healthy controls. Conclusions To the authors’ knowledge, this report is the first to describe abnormal neuroinflammation levels in the brains of FM patients compared with that in patients with CRPS using [11C]-(R)-PK11195 PET. The results suggested that abnormal neuroinflammation can be an important pathological factor in FM. In addition, the identification of common and different critical regions related to abnormal neuroinflammation in FM, compared with patients with CRPS and healthy controls, may contribute to improved diagnosis and the development of effective medical treatment for patients with FM.

scholarly journals Quantification of [18F]florbetapir: A test–retest tracer kinetic modelling study

2018 ◽  
Vol 39 (11) ◽  
pp. 2172-2180 ◽  
Author(s):  
Sandeep SV Golla ◽  
Sander CJ Verfaillie ◽  
Ronald Boellaard ◽  
Sofie M Adriaanse ◽  
Marissa D Zwan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Volume Ratio ◽  
Distribution Volume ◽  
Emission Tomography ◽  
Retest Reliability ◽  
Positron Emission ◽  
Distribution Volume Ratio ◽  
Test Retest Reliability

Accumulation of amyloid beta can be visualized using [18F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [18F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [18F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_VB) was the preferred model for describing [18F]florbetapir kinetics. SRTM-derived non-displaceable binding potential (BPND) correlated well (r2 = 0.83, slope = 0.86) with plasma input-derived distribution volume ratio. Test–retest reliability for plasma input-derived distribution volume ratio, SRTM-derived BPND and SUVr(50–70) were r = 0.88, r = 0.91 and r = 0.86, respectively. In vivo kinetics of [18F]florbetapir could best be described by a reversible two-tissue compartmental model and [18F]florbetapir BPND can be reliably estimated using an SRTM.

scholarly journals Feedback-Controlled Bolus plus Infusion (FC-B/I) Method for Quantitative Drug Assessment in Living Brain with PET

2012 ◽  
Vol 33 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Hiroyuki Ohba ◽  
Norihiro Harada ◽  
Shingo Nishiyama ◽  
Takeharu Kakiuchi ◽  
Yuichi Kimura ◽  
...  
Keyword(s):  
Bolus Injection ◽  
Direct Interaction ◽  
Volume Ratio ◽  
Emission Tomography ◽  
Dependent Manner ◽  
Drug Candidates ◽  
Positron Emission ◽  
Distribution Volume Ratio ◽  
Target Molecules ◽  
Dose Dependent

We have developed a feedback-controlled bolus plus infusion (FC-B/I) method for monitoring the interaction between positron emission tomography (PET) ligands and their specific target molecules with PET. The usefulness of the FC-B/I method was evaluated by the direct interaction between [11C]raclopride, a dopamine D2 receptor (D2R) ligand, and cold raclopride (10 and 100 μg/kg) in the brains of conscious monkeys. The present results demonstrated that the FC-B/I method could achieve the equilibrium state of [11C]raclopride in the striatum of monkey brain, and also that the cold raclopride-induced reduction of [11C]raclopride binding to D2R was observed in a dose-dependent manner. Good correlations of distribution volume ratio of the striatum to cerebellum between the conventional bolus plus infusion (B/I) method and the FC-B/I method as well as between the conventional bolus injection method and the FC-B/I method were observed. These results indicated that the system could be a useful tool for the evaluation of interaction between drug candidates and their target molecules like enzymes, receptors, and transporters by using of their specific PET ligands.

scholarly journals [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome

Medicine ◽  
2017 ◽  
Vol 96 (1) ◽  
pp. e5735 ◽  
Author(s):  
So Yeon Jeon ◽  
Seongho Seo ◽  
Jae Sung Lee ◽  
Soo-Hee Choi ◽  
Do-Hyeong Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Aberrant activation within auditory network is associated with psychiatric comorbidities in interictal migraineurs without aura

2020 ◽  
Author(s):  
Heng-Le Wei ◽  
Yu-Chen Chen ◽  
Yu-Sheng Yu ◽  
Xi Guo ◽  
Gang-Ping Zhou ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Resting State ◽  
Psychiatric Symptoms ◽  
Brain Activation ◽  
Superior Temporal Gyrus ◽  
Anxiety And Depression ◽  
Intracranial Volume ◽  
Healthy Controls ◽  
Postcentral Gyrus ◽  
Underlying Mechanisms

Abstract Background: Resting-state functional magnetic resonance imaging has confirmed auditory network dysfunction in migraine without aura (MwoA). Epidemiological investigations have disclosed that migraine is comorbid with many psychiatric symptoms. However, the underlying mechanisms of auditory cortex dysfunction linked to psychiatric disorders in MwoA remain unclear. The present study aimed to explore associations between brain activation in the auditory cortex and clinical and psychiatric characteristics in patients with MwoA during interictal periods.Methods: Resting-state data were acquired from patients with episodic MwoA (n=34) and healthy controls (n=30). Independent component analysis was used to extract and calculate the resting-state auditory network. Subsequently, we analyzed the correlations between spontaneous activation in the auditory cortex and clinical and psychiatric features in MwoA.Results: Compared with healthy controls, patients with MwoA showed increased activation in the left auditory cortex (i.e., superior temporal gyrus (STG), postcentral gyrus (PoCG) and insula). Brain activation in the left STG was positively correlated with anxiety scores, and activation in the left PoCG was negatively correlated with anxiety and depression scores. No significant differences were found in intracranial volume between the two groups.Conclusions: This study indicated that functional impairment and altered integration within the auditory cortex existed in patients with MwoA in the interictal period, suggesting that auditory cortex disruption as a biomarker may be implemented for the early diagnosis and prediction of neuropsychiatric impairment in MwoA.

No evidence for left superior temporal dysfunction in asymptomatic schizophrenia and bipolar disorder

1999 ◽  
Vol 175 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Stephen Dye ◽  
Sean Spence ◽  
Christopher Bench ◽  
Steven Hirsch ◽  
Martin Stefan ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Regional Cerebral Blood Flow ◽  
Bipolar Affective Disorder ◽  
Superior Temporal Gyrus ◽  
Emission Tomography ◽  
Relative Reduction ◽  
Group Comparison ◽  
Regional Cerebral Blood ◽  
Word Generation ◽  
Positron Emission

BackgroundPositron emission tomography (PET) studies have revealed functional left superior temporal gyrus (STG) abnormalities in symptomatic schizophrenia during word generation.AimsTo discover if this dysfunction is present in asymptomatic schizophrenia. To determine whether, without concurrent symptomatology, schizophrenia and bipolar affective disorder (BPD) are distinguishable by differing regional cerebral blood flow (rCBF) patterns during word generation.MethodA PETverbal fluency protocol was applied to six patients with BPD in remission and six patients with asymptomatic schizophrenia. Analysis included 10 control subjects from a contemporaneous study.ResultsAll groups showed relative reduction of rCBF in both superior temporal cortices. There were no quantitative differences in any group comparison. All groups exhibited negative covariation between rCBF in left prefrontal and right (but not left) temporal regions.ConclusionsAbnormal patterns of left STG function cannot be regarded as a trait marker for schizophrenia. Functional abnormalities may reflect aspects of mental state.

scholarly journals Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 208-209
Author(s):  
Ryan Dougherty ◽  
Amal Wanigatunga ◽  
Murat Bilgel ◽  
Yang An ◽  
Eleanor Simonsick ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Perceived Exertion ◽  
Volume Ratio ◽  
Rating Of Perceived Exertion ◽  
Pittsburgh Compound B ◽  
Brain Volumes ◽  
Positron Emission ◽  
Baltimore Longitudinal Study ◽  
Distribution Volume Ratio ◽  
Cortical Distribution

Abstract Higher level of and greater longitudinal increase in perceived fatigability are linked to cognitive decline and lower brain volumes in older adults. However, it remains unclear whether perceived fatigability is associated with Alzheimer’s disease-related brain pathology. In the BLSA, 163 participants without neurological disease or cognitive impairment (aged 74.7+/-8.4 years, 45% men) were assessed for perceived fatigability using rating of perceived exertion after a 5-minute (0.67 m/s) treadmill walk and Aß burden using 11C-Pittsburgh compound B (PiB) positron emission tomography. Forty-four participants were PiB+ based on a mean cortical distribution volume ratio (DVR) cut point of 1.066. After adjusting for demographics, body composition, comorbidities and ApoE-e4, higher perceived fatigability was not associated with PiB+ status (OR=0.84; 95% CI: 0.69, 1.05). Results suggest perceived fatigability may contribute to cognitive decline through pathways other than Aß pathology. Future studies should target other mechanisms linking perceived fatigability and cognitive decline.

scholarly journals Intravoxel incoherent motion perfusion in patients with Moyamoya disease: comparison with 15O-gas positron emission tomography

2019 ◽  
Vol 8 (5) ◽  
pp. 205846011984658
Author(s):  
Shoko Hara ◽  
Masaaki Hori ◽  
Ryo Ueda ◽  
Akifumi Hagiwara ◽  
Shihori Hayashi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
White Matter ◽  
Moyamoya Disease ◽  
Cerebral Blood Volume ◽  
Mean Transit Time ◽  
Emission Tomography ◽  
Intravoxel Incoherent Motion ◽  
Healthy Controls ◽  
Diffusion Weighted Images ◽  
Positron Emission

Background Intravoxel incoherent motion magnetic resonance imaging (IVIM) enables non-invasive measurement of brain perfusion. Purpose To investigate whether IVIM could be used to evaluate the hemodynamic disturbance of Moyamoya disease (MMD) by comparison with the gold-standard 15O-gas positron emission tomography (PET) method. Material and Methods Ten consecutive patients with MMD (six women; mean age = 42.8 years) and 10 age-matched healthy controls were evaluated by diffusion-weighted images with 12 different b values in the range of 0–900 s/mm2 and 15O-gas PET. Tomographic maps of IVIM parameters, perfusion fraction ( f ), pseudo-diffusion coefficient ( D*), and f・D*, as well as cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) maps obtained with PET, were normalized and hemispheric gray and white matter values were calculated. IVIM parametric values were compared with PET parameters and with clinically assessed disease severity. Results There was significant correlation between D* and MTT ( r = –0.74, P < 0.001) and between f・D* and CBF ( r = 0.52, P = 0.02) in the cortical areas. The f values in the white matter were significantly higher in symptomatic MMD patients than in healthy controls ( P = 0.01). Conclusion IVIM may be used to non-invasively investigate cerebral hemodynamic impairment in patients with MMD. Further evaluation is needed to establish IVIM usage in clinical settings.

scholarly journals Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET

2019 ◽  
Vol 26 (6) ◽  
pp. 668-678 ◽  
Author(s):  
Valeria T Barletta ◽  
Elena Herranz ◽  
Costantina A Treaba ◽  
Russell Ouellette ◽  
Ambica Mehndiratta ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Tracer Uptake ◽  
Emission Tomography ◽  
7 Tesla ◽  
Healthy Controls ◽  
Multilinear Regression ◽  
Neurological Disability ◽  
Standardized Uptake Values ◽  
Positron Emission ◽  
The Brain

Background: Activated microglia, which can be detected in vivo by 11C-PBR28 positron emission tomography (PET), represent a main component of MS pathology in the brain. Their role in the cerebellum is still unexplored, although cerebellar involvement in MS is frequent and accounts for disability progression. Objectives: We aimed at characterizing cerebellar neuroinflammation in MS patients compared to healthy subjects by combining 11C-PBR28 MRI-Positron Emission Tomography (MR-PET) with 7 Tesla (T) MRI and assessing its relationship with brain neuroinflammation and clinical outcome measures. Methods: Twenty-eight MS patients and 16 healthy controls underwent 11C-PBR28 MR-PET to measure microglia activation in normal appearing cerebellum and lesions segmented from 7 T scans. Patients were evaluated using the Expanded Disability Status Scale and Symbol Digit Modalities Test. 11C-PBR28 binding was assessed in regions of interest using 60–90 minutes standardized uptake values normalized by a pseudo-reference region in the brain normal appearing white matter. Multilinear regression was used to compare tracer uptake in MS and healthy controls and assess correlations with clinical scores. Results: In all cerebellar regions examined, MS patients showed abnormally increased tracer uptake, which correlated with cognitive and neurological disability. Conclusion: Neuroinflammation is widespread in the cerebellum of patients with MS and related to neurological disability and cognitive impairment.

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