Obesity, insulin resistance and their interaction on liver enzymes

Introduction To investigate weight status, insulin resistance assessed by HOMA-IR, and their interaction on liver function in non-diabetic Chinese adults. Methods and results A total of 7066 subjects were included, and divided into normal weight (n = 3447), overweight (n = 2801), and obese (n = 818) groups. Data including weight, height, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, y-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were acquired. In multi-linear regression analysis for liver enzymes as dependent variables, insulin resistance emerged as a determinant of ALT (β = 0.165, P<0.001), AST (β = 0.040, P<0.001) and GGT (β = 0.170, P<0.001) after adjusting for age, sex, body mass index, triglyceride, and cholesterol. Interactions between insulin resistance and weight status by body mass index were observed in ALT (P<0.001), AST (P<0.001) and GGT (P = 0.0418). Conclusion Insulin resistance had significant associations with greater risk of elevated ALT, AST and GGT level in non-diabetic Chinese adults, especially among those who were overweight/ obese.

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Body Mass Index, Waist Circumference, Body Fat, Fasting Blood Glucose in a Sample of Moroccan Adolescents Aged 11–17 Years

Journal of Nutrition and Metabolism ◽

10.1155/2012/510458 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

Slimane Mehdad ◽

Abdeslam Hamrani ◽

Khalid El Kari ◽

Asmaa El Hamdouchi ◽

Amina Barakat ◽

...

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Waist Circumference ◽

Body Mass ◽

Body Fat ◽

Significant Relationship ◽

Weight Status ◽

Fasting Blood Glucose ◽

Normal Weight ◽

Screening Tools

Objectives. The study aimed to assess the relationship between body fat and each of body mass index (BMI) and waist circumference (WC), and to test the effectiveness of fat mass (FM), percent of body fat (PBF), BMI, and WC in predicting high levels of fasting blood glucose (FBG).Methods. A total of 167 adolescents aged 11–17 years were recruited from Rabat region. BMI and WC were determined using standard equipments. FM and PBF were derived from isotope dilution technique. FBG was determined by the hexokinase method.Results. Regardless of the weight status, BMI showed a strong positive correlation with FM and PBF in both genders. WC was significantly correlated with FM in boys and girls, and with PBF in different groups of girls and boys of the study sample. However, there was no significant relationship between WC and PBF in normal weight and overweight-obese groups of boys. FBG was highly correlated with FM and PBF in girls of the study sample and in overweight-obese girls. Similar significant relationship between FBG and both BMI and WC was observed in overweight-obese girls, while there was no significant association between FBG and other variables in boys and normal-weight girls.Conclusion. BMI and WC were closely associated with FM and PBF, respectively. However, the degree of these associations depends on gender and weight status. BMI may provide a better proxy estimate of overall adiposity than WC; nevertheless, both of them would appear to be a reasonable surrogate for FM and PBF as screening tools to identify adolescents at risk of developing excess body fat and high level of FBG.

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Body mass index and weight status misperception among a sample of college students in Yogyakarta, Indonesia

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i2.26264 ◽

2017 ◽

Vol 16 (2) ◽

pp. 225-232

Author(s):

Janatin Hastuti ◽

Neni Trilusiana Rahmawati ◽

Rusyad Adi Suriyanto

Keyword(s):

College Students ◽

Body Mass Index ◽

Regression Analysis ◽

Body Mass ◽

Weight Control ◽

Weight Status ◽

Medical Science ◽

Normal Weight ◽

Ordinal Regression ◽

Ordinal Regression Analysis

Background: Weight status perception associates with objective weight status and is important in the management of weight control. To date, perception of weight status among Indonesian youths has not been reported.Objectives: This study aimed to examine the association between body mass index and weight status perception in a sample of college students in Yogyakarta Province.Materials and Methods: A sample of 209 boys and 269 girls of college students in Yogyakarta Province were measured for their stature and body weight. Body mass index was calculated (BMI). Data of demographic, exercise, and diet were collected. Weight status perception was based on participant responses to a question regarding how they classified their own body size as underweight, normal, overweight, or obese. Ordinal regression analysis was performed to evaluate factors associated with weight status misperception among boys and girls.Results: Overall, 43.5% of boys and 37.5% of girls misclassified their own weight status by actual BMI. Of particular note, 75.9% of obese boys and 78.6% of obese girls underestimated their weight status as overweight or normal weight. Whereas, 9.1% and 23.4% of normal weight boys and girls respectively, overestimated their weight status. Ordinal regression analysis revealed that, weight status misperception from others was significantly contributed (p<0.01) to misperception of weight status among boys and girls with OR of 10.31 and 8.13 respectively. Diet practicing was significantly correlated with weight status misperception in boys (p<0.05) with an OR of 19.57.Conclusions: Weight status misperception was prevalent among normal weight and obese students. Obese students of both gender and normal weight boys tended to underestimate their weight status, whereas normal weight girls were likely to overestimate their weight status.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.225-232

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Retinol-Binding Protein 4 and Its Relation to Insulin Resistance in Obese Children before and after Weight Loss

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-2745 ◽

2008 ◽

Vol 93 (6) ◽

pp. 2287-2293 ◽

Cited By ~ 56

Author(s):

Thomas Reinehr ◽

Birgit Stoffel-Wagner ◽

Christian L. Roth

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Weight Status ◽

Retinol Binding Protein ◽

Homa Index ◽

Obese Children ◽

Retinol Binding Protein 4 ◽

Lean Children

Abstract Context: There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children. Objective: Our objective was to study the longitudinal relationships among RBP4, insulin resistance and weight status in obese children. Design, Setting, and Patients: We conducted a 1-yr longitudinal follow-up study in a primary-care setting with 43 obese children (median age 10.8 yr) and 19 lean children of same the age and gender. Intervention: Our outpatient 1-yr intervention program was based on exercise, behavior, and nutrition therapy. Main Outcomes Measures: Changes of weight status (body mass index sd score), RBP4, molar RBP4/serum retinol (SR) ratio, insulin resistance index homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI). Results: Obese children had significantly (P < 0.01) higher RBP4 concentrations and a higher RBP4/SR ratio compared with lean children. In multiple linear regression analyses adjusted to age, gender, and pubertal stage, RBP4 was significantly correlated to insulin and body mass index. Pubertal children demonstrated significantly decreased QUICKI and significantly increased HOMA index, insulin, and RBP4 concentrations compared with prepubertal children. Changes of RBP4 correlated significantly to changes of insulin (r = 0.29), HOMA index (r = 0.29), QUICKI (r = 0.22), and weight status (r = 0.31). Substantial weight loss in 25 children led to a significant (P < 0.001) decrease of RBP4, RBP4/SR, blood pressure, triglycerides, insulin, and HOMA index and an increase in QUICKI in contrast to the 18 children without substantial weight loss. Conclusion: RBP4 levels were related to weight status and insulin resistance in both cross-sectional and longitudinal analyses, suggesting a relationship between RBP4, obesity, and insulin resistance in children.

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Cross-Sectional and Longitudinal Associations between Body Mass Index and Cardiometabolic Risk Factors in Adolescents in a Country of the African Region

International Journal of Endocrinology ◽

10.1155/2013/801832 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Tanica Lyngdoh ◽

Bharathi Viswanathan ◽

Edwin van Wijngaarden ◽

Gary J. Myers ◽

Pascal Bovet

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Young Adults ◽

Body Mass ◽

Weight Status ◽

Cardiometabolic Risk ◽

Linear Regression Analysis ◽

Cardiometabolic Risk Factors ◽

Cross Sectional

We assessed the association between several cardiometabolic risk factors (CRFs) (blood pressure, LDL-cholesterol, HDL-cholesterol, triglycerides, uric acid, and glucose) in 390 young adults aged 19-20 years in Seychelles (Indian Ocean, Africa) and body mass index (BMI) measured either at the same time (cross-sectional analysis) or at the age of 12–15 years (longitudinal analysis). BMI tracked markedly between age of 12–15 and age of 19-20. BMI was strongly associated with all considered CRFs in both cross-sectional and longitudinal analyses, with some exceptions. Comparing overweight participants with those having a BMI below the age-specific median, the odds ratios for high blood pressure were 5.4/4.7 (male/female) cross-sectionally and 2.5/3.9 longitudinally (P<0.05). Significant associations were also found for most other CRFs, with some exceptions. In linear regression analysis including both BMI at age of 12–15 and BMI at age of 19-20, only BMI at age of 19-20 remained significantly associated with most CRFs. We conclude that CRFs are predicted strongly by either current or past BMI levels in adolescents and young adults in this population. The observation that only current BMI remained associated with CRFs when including past and current levels together suggests that weight control at a later age may be effective in reducing CRFs in overweight children irrespective of past weight status.

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Positive Association Between Body Mass Index and Hematologic Parameters, Including RBC, WBC and Platelet Count, in Korean Children and Adolescent

10.21203/rs.3.rs-576071/v1 ◽

2021 ◽

Author(s):

Hwal Rim Jeong ◽

Young Seok Shim

Keyword(s):

Body Mass Index ◽

Children And Adolescents ◽

Body Mass ◽

Linear Regression Analysis ◽

Positive Association ◽

Multiple Linear Regression Analysis ◽

Normal Weight ◽

Overweight And Obesity ◽

Korean Children ◽

Children And Adolescent

Abstract Objective: To investigate the associations between hematologic parameters and obesity in children and adolescents.Methods: A total of 7,997 subjects (4,259 boys, 3,738 girls) aged 10–18 years was enrolled and hematologic parameters, including WBC, RBC, Hb, Hct, and platelet levels, were recorded and compared against body mass index (BMI) classified into normal-weight, overweight, and obesity groups.Results : The obesity group had significantly higher mean levels of WBC (7.16 vs. 6.16 (x103/mm3), p<0.001), RBC (4.90 vs. 4.82 (x106/mm3), p<0.001), Hb (14.07 vs. 13.99 (g/dL), p<0.05), Hct (42.31 vs. 41.91 (%), p<0.001) and platelets (311.87 vs. 282.66 (x103/mm3), p<0.001) than the normal-weight group after adjusting for obesity and sex. BMI SDS was significantly positively associated with WBC (β=0.275, p<0.001), RBC (β=0.028, p<0.001), Hb (β=0.034, p<0.001), Hct (β=0.152, p<0.001), and platelets (β=8.372, p<0.001) after adjusting for age, sex, and possible socioeconomic confounders in a multiple linear regression analysis.Conclusion: Higher BMI is associated with elevated WBC, RBC, Hb, Hct and platelet counts in children and adolescents. Because higher hematologic parameters are potential risk factors for obesity-related morbidity, more attention should be paid to evaluating and interpreting hematologic parameters in children and adolescents with obesity

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The Federated Practice of Soccer Influences Hamstring Flexibility in Healthy Adolescents: Role of Age and Weight Status

Sports ◽

10.3390/sports8040049 ◽

2020 ◽

Vol 8 (4) ◽

pp. 49

Author(s):

Jesús Gustavo Ponce-González ◽

José V. Gutiérrez-Manzanedo ◽

Guillermo De Castro-Maqueda ◽

Victor Jose Fernández-Torres ◽

Jorge R. Fernández-Santos

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Weight Status ◽

Normal Weight ◽

Deep Flexion ◽

Hamstring Flexibility ◽

Weight Groups ◽

Effect Of Age

The aim of this study was to compare the hamstring flexibility between federated soccer and non-federated adolescents, and also to evaluate the effect of age and weight status on hamstring flexibility. The participants were 234 students (11–18 years old) divided into: (i) G1: non-federated (n = 127), and (ii) G2: federated in soccer (n = 107). The deep flexion of the trunk (DF) test and the sit and reach test (SRT) were performed. G2 showed higher values for the DF and SRT compared to G1 (p < 0.05). Both flexibility tests correlated positively (r = 0.4, p < 0.001). Body mass index (BMI) was negatively correlated with the DF test (r = −0.3, p < 0.001), but not with the SRT. Divided by BMI, the underweight and normal weight groups had higher scores in the DF test compared with the overweight and obese groups (p < 0.001). BMI was negatively correlated with hamstring flexibility. Federated soccer students present higher scores of hamstring flexibility.

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METS-IR, a Novel Score to Evaluate Insulin Sensitivity, is Associated with the Urinary Albumin–Creatinine Ratio in Chinese Adults: A Cross-sectional REACTION Study

10.21203/rs.3.rs-154508/v1 ◽

2021 ◽

Author(s):

Wanlu Su ◽

Jie Wang ◽

Songyan Yu ◽

Kang Chen ◽

Wenhua Yan ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Body Mass Index ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Urinary Albumin ◽

Creatinine Ratio ◽

Chinese Adults ◽

Albumin Creatinine Ratio

Abstract Background: The metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based metabolic index used as a substitution marker of insulin resistance and for cardiovascular disease evaluation. However, whether METS-IR is associated with the urinary albumin–creatinine ratio (UACR) is not well known. Therefore, we explored the age- and sex-related associations between METS-IR and UACR and compared the discriminative ability of the METS-IR index and its components for elevated UACR. Methods: This study included 37,290 subjects from the REACTION study (Risk Evaluation of cAncers in Chinese diabeTic Individuals: a IONgitudinal study). METS-IR was calculated as follows:(Ln[2×fasting blood glucose{mg/dL}+fasting triglyceride level{mg/dL}]×body mass index)/(Ln [high-density lipoprotein cholesterol{mg/dL}]). Participants were divided into four groups on the basis of METS-IR: <25%, 25%–49%, 50%–74%, and ≥75%. Logistic regression analyses were conducted to determine the associations between METS-IR vs. its components{(fasting blood glucose(FBG), fasting triglyceride level, body mass index, and high-density lipoprotein cholesterol} with UACR. Results: Participants with the highest quartile METS-IR, particularly men,presented a more significant trend towards elevated UACR than towards its components (odds ratio [OR]: 1.260, 95% confidence interval [CI]:1.152–1.378, P<0.001 in all subjects; OR: 1.321, 95% CI: 1.104–1.579, P=0.002 in men; OR: 1.201, 95% CI: 1.083–1.330, P < 0.001 in women). There were significant associations between METS-IR and UACR in younger participants (<65 years for women and 55–64 years for men) and those with an estimated glomerular filtration rate ≥ 90 mL/min/1.73 m2. Increased METS-IR was significantly associated with UACR in men with FBG ≥ 5.6 mmol/L or postprandial blood glucose ≥ 7.8 mmol/L and systolic blood pressure ≥ 120mmHg or diastolic blood pressure ≥ 80 mmHg. The relationships were significant in women with diabetes and hypertension. Conclusions: Increased METS-IR was significantly associated with elevated UACR, and its discriminative power for elevated UACR was superior to that of its components. The findings support the clinical significance of METS-IR for evaluating the cardiometabolic risk and renal function damage among Chinese adults.

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INTERRELATIONS BETWEEN LEPTIN & OBESITY

Journal of Saidu Medical College, Swat ◽

10.52206/jsmc.2013.3.1.252-257 ◽

1969 ◽

Vol 3 (1) ◽

pp. 252-257

Author(s):

MOHAMMAD SHAFIQUE ◽

HABIBULLAH QURESHI ◽

FAIZA SAJID

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Blood Glucose ◽

Waist Circumference ◽

Body Mass ◽

Fasting Blood Glucose ◽

Hip Circumference ◽

Serum Leptin ◽

Waist To Hip Ratio ◽

Obese Subjects

Objective: Excess body weight is the sixth most important risk factor contributing to the overall burden ofdisease worldwide. The circulating leptins have been found to play a vital role in the regulation of appetite,glucose homeostasis and body fat. Therefore, this study was designed to measure serum leptin and insulinresistance in non obese and obese young adults and to correlate them with obesity parameters: body massindex, waist circumference, waist-to-hip ratio and metabolic indices.Methods: A total of 43 non- obese subjects, 20 male and 23 female aged 20- 25 years and 46 obese subjects,25 male and 21 female with age 28- 37 years were studied. All subjects selected for study were normotensiveand non-diabetic. Variables measured were Body Mass Index (BMI), waist to hip ratio(WHR), bloodpressure, serum leptin, insulin, fasting blood glucose, oral glucose tolerance test (OGTT), and lipid profile.Results: Serum leptin was significantly higher in females than males 8.8 ± 2.10 SEM and 2.2 ± 0.26 ng/mlSEM respectively in non-obese.As well, Serum leptin was significantly higher in females than males 23.0 ±3.98 SEM and 12.5 ± 2.24 ng/ml SEM respectively in obese group. Serum leptin was significantly higher inobese males, and obese females compared to non- obese subjects. Serum leptin significantly, and positivelycorrelated with BMI (r = 0.440), hip circumference (r =0.425), insulin (r = 0.334), and homeostasis Model ofAssessment - Insulin Resistance (HOMA-IR)r= 0.334 whereas HOMA-IR positively correlated with BMI,waist Circumference, fasting insulin, fasting blood glucose, triglycerides (TG), TG/HDL-Cholesterol ratioand negatively correlated with HDL-Cholesterol.Conclusions: Serum leptin levels increase with obesity, and are higher in females in both non-obese andobese individuals. Serum leptin significantly correlated with hip circumference. Increased serum leptin,especially in obese subjects, should be taken as a warning sign of energy imbalance, poor diet,hyperinsulinemia, insulin resistance, or changes in other metabolic risk factors that are stronglyassociated with cardiovascular diseases and type 2 diabetes. Key words: Anthropometry, body mass index, insulin resistance, leptin, obesity,

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The effect of body mass index on blood pressure in adults with hypertension

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20205542 ◽

2020 ◽

Vol 10 (1) ◽

pp. 77

Author(s):

Tushar Balchand Chudiwal ◽

Anil Gulingayya Nanjannavar

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Weight Status ◽

Randomized Study ◽

Normal Weight ◽

Overweight And Obesity ◽

Obese Patients ◽

Hypertensive Patients

Background: We investigated the association of body mass index (BMI) measurements in adult hypertensive patients with normal weight and overweight including obesity.Methods: This was a randomized study performed in Udaipur, India, on 200 hypertensive patients aged (32-90) years. Patients were divided according to their body weight (normal weight vs overweight and obesity) into two groups. Weight, height and BMI were measured to estimate the various categories of bodyweight.Results: We found significant relations between body weight and blood pressure. Patients with normal weight had a normal blood pressure. However, a significant increase in blood pressure was observed in patients with overweight and obesity.Conclusions: BMI is related with weight status in hypertensive overweight / obese patients.

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Psychosocial factors, eating behaviour and Body Mass Index

10.31234/osf.io/r6av9 ◽

2021 ◽

Author(s):

Marine MAS ◽

Stephanie Chambaron ◽

Emilienne Quiot ◽

Claire Chabanet ◽

Marie-Claude Brindisi

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Sensation Seeking ◽

Weight Status ◽

Eating Behaviour ◽

Hierarchical Cluster ◽

Normal Weight ◽

Overweight And Obesity ◽

Negative Consequences ◽

Adequate Treatment

Objective: Obesity is a multifactorial condition that is associated with high levels of morbidity and mortality, but the negative consequences of obesity vary between individuals. Considerable evidence suggests that Body Mass Index (BMI) needs to be completed with an assessment of psychological and behavioural factors related to obesity in order to provide adequate treatment for patients with obesity. However, there is a lack of understanding concerning psychological factors and behavioural patterns related to weight status. The present study aimed to identify different profiles of individuals with normal-weight, overweight and obesity Methods: Seventy-six healthy individuals were weighed and measured, then characterized according to their responses to several questionnaires assessing sociodemographic variables, food-related variables, quality of life variables, body image, and psychological aspects.Results: Our results show that health and body dissatisfaction, sensation seeking, and frequent consumption of fatty-savoury foods were higher in individuals with higher BMI. Moreover, a hierarchical cluster analysis permitted to identify 3 profiles of individuals with various weight statuses: satisfied, protected and vulnerable. Conclusions: The implication of these findings in caring patients is crucial and more research on the various phenotypes that can be found within overweight and obesity groups must be encouraged.

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