scholarly journals Clinicopathological features of different subtypes in adenomyosis: Focus on early lesions

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254147
Author(s):  
Hiroshi Kobayashi ◽  
Sho Matsubara ◽  
Shogo Imanaka
Keyword(s):  
Early Stage ◽  
Multivariate Logistic Regression Analysis ◽  
Induced Abortion ◽  
Clinicopathological Features ◽  
University Hospital ◽  
Deep Infiltrating Endometriosis ◽  
Early Lesions ◽  
Induced Abortions ◽  
History Of ◽  
Gynecological Disorder

Background The aim of this study is to investigate the clinicopathological features of intrinsic and extrinsic subtypes in adenomyosis. In particular, we focused on the early lesions of adenomyosis. Methods This is a single-center, prospective study of women who elected surgery for adenomyosis at the Department of Gynecology, Nara Medical University Hospital, Kashihara, Japan, from April 2008 to March 2018. Adenomyosis was histologically classified as intrinsic, extrinsic, and others, depending on the type of intramural growth. Adenomyosis that occurs at the inner and outer myometrium was defined as an intrinsic and extrinsic type, respectively. Results One hundred eighty-nine patients with histologically confirmed adenomyosis were classified into three different types, 74 intrinsic type, 78 extrinsic type, and 37 other type. Compared to the intrinsic type, the extrinsic type was more likely to have endometriosis, including ovarian endometrioma (OMA), superficial peritoneal endometriosis (SUP), or deep infiltrating endometriosis (DIE). To further identify the clinicopathological features of early-stage adenomyosis, we focused only on patients with intrinsic and extrinsic types of adenomyosis with less than one-third of muscular layer infiltration. Patients with early-stage intrinsic adenomyosis were more likely to experience induced abortions. Patients with early-stage extrinsic adenomyosis were more likely to have endometriosis. The coexistence of endometriosis and the lack of induced abortion were independent predictors of extrinsic adenomyosis. Multivariate logistic regression analysis identified coexistence of endometriosis as independent predictors of the early stage extrinsic adenomyosis. Conclusion The study suggests that there are at least two types of adenomyosis, where the intrinsic type is closely associated with a history of induced abortion, while the extrinsic type is strongly associated with endometriosis. Adenomyosis might be a gynecological disorder with complex pathogenesis implicating both traumatic and endometriotic factors.

scholarly journals Stillbirth in Canada: anachronistic definition and registration processes impede public health surveillance and clinical care

2021 ◽  
Author(s):  
K.S. Joseph ◽  
Lily Lee ◽  
Laura Arbour ◽  
Nathalie Auger ◽  
Elizabeth K. Darling ◽  
...  
Keyword(s):  
Public Health ◽  
Public Health Surveillance ◽  
Fetal Death ◽  
Clinical Care ◽  
Induced Abortion ◽  
Death Registration ◽  
Starting Point ◽  
Induced Abortions ◽  
History Of ◽  
Definition Of

AbstractThe archaic definition and registration processes for stillbirth currently prevalent in Canada impede both clinical care and public health. The situation is fraught because of definitional problems related to the inclusion of induced abortions at ≥20 weeks’ gestation as stillbirths: widespread uptake of prenatal diagnosis and induced abortion for serious congenital anomalies has resulted in an artefactual temporal increase in stillbirth rates in Canada and placed the country in an unfavourable position in international (stillbirth) rankings. Other problems with the Canadian stillbirth definition and registration processes extend to the inclusion of fetal reductions (for multi-fetal pregnancy) as stillbirths, and the use of inconsistent viability criteria for reporting stillbirth. This paper reviews the history of stillbirth registration in Canada, provides a rationale for updating the definition of fetal death and recommends a new definition and improved processes for fetal death registration. The recommendations proposed are intended to serve as a starting point for reformulating issues related to stillbirth, with the hope that building a consensus regarding a definition and registration procedures will facilitate clinical care and public health.

scholarly journals Induced abortion among married women in China: a study based on the 1997–2017 China Fertility Surveys

2021 ◽  
Vol 5 (1) ◽  
pp. 83-99
Author(s):  
Zhixin Wei ◽  
Dian Yu ◽  
Hongyan Liu
Keyword(s):  
Contraceptive Use ◽  
Unmet Need ◽  
Induced Abortion ◽  
Married Women ◽  
First Century ◽  
Reproductive Age ◽  
Induced Abortions ◽  
Sex Selective Abortion ◽  
History Of ◽  
And Gender

AbstractThis study uses four sets of data from China Fertility Surveys completed during the years 1997–2017 to analyze the trend of induced abortion, with a focus on the twenty-first century. Married women of reproductive age who had a history of pregnancy during the 5 years prior to participating in a survey were the research object. The study also examines the variation of abortion proportions among different subgroups during different time periods, including an examination of the number and gender of children, place of residence, and contraceptive use of women who had induced abortions. The results show that the occurrence of induced abortion has decreased gradually, and that the risk of induced abortion was higher for those who had given birth to fewer children. However, induced abortion among women with two children has increased in recent years. It is noteworthy that induced abortions among childless premarital women have continued to increase in recent years, and that the sexual and reproductive health problems of adolescents remain of great concern. The occurrence of induced abortions after childbirth increased for those with one or two children, showing that the unmet need for contraception after childbirth should receive more attention. In addition, sex-selective abortion has been decreasing gradually, but still exists today.

The “Abortion Pill” Misoprostol in Brazil: Women’s Empowerment in a Conservative and Repressive Political Environment

2020 ◽  
Vol 110 (5) ◽  
pp. 677-684
Author(s):  
Ilana Löwy ◽  
Marilena Cordeiro Dias Villela Corrêa
Keyword(s):  
Reproductive Rights ◽  
Unwanted Pregnancy ◽  
Induced Abortion ◽  
Political Environment ◽  
Satisfactory Solution ◽  
Us States ◽  
Dense Networks ◽  
Induced Abortions ◽  
History Of ◽  
Widespread Access

In the aftermath of the introduction of severe restrictions on abortion in several US states, some activists have argued that providing widespread access to an abortive drug, misoprostol, will transform an induced abortion into a fully private act and therefore will empower women. In Brazil, where abortion is criminalized, the majority of women who wish to terminate an unwanted pregnancy already use the illegal, but easily accessible, misoprostol. We examine the history of misoprostol as an abortifacient in Brazil from the late 1980s until today and the professional debates on the teratogenicity of this drug. The effects of a given pharmaceutical compound, we argue, are always articulated, elicited, and informed within dense networks of sociocultural, economic, legal, and political settings. In a conservative and repressive environment, the use of misoprostol for self-induced abortions, even when supported by formal or informal solidarity networks, is far from being a satisfactory solution to the curbing of women’s reproductive rights.

scholarly journals INDUCED ABORTION;

2014 ◽  
Vol 21 (06) ◽  
pp. 1098-1102
Author(s):  
Uzma Asif ◽  
Asma Mudassir ◽  
Salma Zaman
Keyword(s):  
Rural Areas ◽  
Descriptive Study ◽  
Induced Abortion ◽  
Easy Access ◽  
Categorical Variables ◽  
Abdominal Ultrasonography ◽  
Mortality And Morbidity ◽  
Induced Abortions ◽  
Unwanted Pregnancies ◽  
History Of

Objective: To determine the frequency and types of various complications and in-- hospital maternal outcome in induced abortion. Study design: An observational descriptive study. Place and Duration: Islam Medical College Sialkot, from January 2011 to January 2013. Methods and Materials: A descriptive study, 130 patients of induced abortion were selected by purposive convenient method. All patients with history of induced abortion were included. All patients with history of spontaneous or medically induced abortions were excluded. Patients were asked who performed the abortion, reason for seeking abortion, techniques and material used. Patients underwent a thorough clinical examination. Routine investigations, abdominal ultrasonography were performed. Evacuation of retained products of conception and Laparotomy was done if required. Pre--designed research proforma was used. SPSS--17 was used to analyze data. Frequency and percentages were calculated for categorical variables. Means and standard deviations were calculated for quantitative data like age, blood pressures, gestational age, and lab parameters. Results: Majority of the patients 63/130 were in the age group 31years and above,123 patients were married while 07 patients were unmarried., 76.92% (100/130) patients were illiterate, , 52.30% (68/130)of patients were from the urban and 47.69% (62/130)were from the rural areas. In 126 (96.92%) cases, abortion was done to get unwanted pregnancies terminated. Majority of cases were induced by unskilled persons. Majority, 51.53%(67/130) were para 5 and above. Commonest method employed was instrumentation which was used in 93.07% cases. Hemorrhage was seen in 69.23%, fever in 50% abdominal pain in 16.19%. Evacuation and curettage was done in 91 (70%) cases, laparotomy in 25 (19.23%) and only 14 (10.76%) were managed conservatively. Twenty five patients who underwent laparotomy had gut and uterine injuries. Seven women (5.38%) died during the study due to septicaemia and DIC. Postoperative complications occurred in 8 (6.15%) patients. Conclusions: Maternal mortality and morbidity due to induced abortion is still very high. Being a preventable cause of death, it can be controlled by proper implementations of family planning programs, training of midwives and easy access to contraceptive methods.

scholarly journals Pregnancy after the diagnosis of lymphangioleiomyomatosis (LAM)

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Lisha Shen ◽  
Whenshuai Xu ◽  
Jinsong Gao ◽  
Jun Wang ◽  
Jiannan Huang ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Induced Abortion ◽  
Reproductive Age ◽  
Renal Angiomyolipoma ◽  
College Hospital ◽  
Spontaneous Bleeding ◽  
Abortion Complications ◽  
Induced Abortions ◽  
Baseline Information ◽  
History Of

Abstract Background Lymphangioleiomyomatosis (LAM) is a rare disease that almost exclusively affects women of reproductive age. Patients are warned of the increased risks if they become pregnant. However, information on pregnancy in patients after the diagnosis of LAM is limited. Methods Patients were collected from the LAM registry study at Peking Union Medical College Hospital, Beijing, China. Patients with a history of pregnancy after the diagnosis of LAM were included. Medical records were reviewed, and baseline information and data during and after pregnancy were collected in May 2018. Results Thirty patients with a total of 34 pregnancies after the diagnosis of LAM were included. Livebirth, spontaneous abortion and induced abortion occurred in 10, 6 and 18 pregnancies, respectively. Sirolimus treatment was common (17/34). A total of 6/10, 5/6, and 6/18 patients with livebirths, spontaneous abortions, and induced abortions respectively, had a history of sirolimus treatment. Ten pregnancies (29.4%) had LAM-associated complications during pregnancy, including the exacerbation of dyspnea in 7 patients, pneumothorax in 3 patients (2 resulting in induced abortion and 1 successful parturition), and spontaneous bleeding of renal angiomyolipomas in 2 patients (both having successful parturition). No chylothorax was found during pregnancy. There were six pregnancies in six patients (17.6%) who had a history of livebirth after sirolimus treatment for LAM (all having successful parturition and healthy infants); two of these patients reported exacerbated dyspnea after parturition compared with before pregnancy. Conclusions Patients with LAM, especially those taking sirolimus before pregnancy, were at a higher risk of spontaneous abortion. Complications such as pneumothorax, bleeding of renal angiomyolipoma, and exacerbated dyspnea during pregnancy were common. In patients without spontaneous abortion, sirolimus discontinuation before or during pregnancy did not lead to increased adverse neonatal outcomes.

ABOUT THE PERIODIZATION AND CHRONOLOGY OF THE HISTORY OF TAURIC CHERSONESUS IN THE PRE-ROMAN AND THE LATE ANTIQUE PERIODS

2020 ◽  
Vol 6 (72) (3) ◽  
pp. 127-148
Author(s):  
S. V. Ushakov
Keyword(s):  
Scientific Literature ◽  
Early Stage ◽  
Late Antique ◽  
Ancient History ◽  
History Of ◽  
Transitional Time ◽  
Early Byzantine

Hundreds of scientific works are devoted to the study of the Tauric Chersonesus, but the problem of chronology and periodization of its ancient history is not sufficiently developed in historiography. Analysis of scientific literature and a number of sources concerning this subject allows to define the chronological framework and to reveal 10 stages of the history of ancient Chersonesos (as a preliminary definition). The early stage, the Foundation and formation of the Polis, is defined from the middle/last third of the VI century (or the first half of the V century BC) to the end of the V century BC. The end of the late-Antique − early-Byzantine (transitional) time in Chersonesos can be attributed to the second half of the VI – first third of the VII centuries ad).

High Risk of One-year Stroke Recurrence in Patients with Younger Age and Prior History of Ischemic Stroke

2019 ◽  
Vol 16 (3) ◽  
pp. 250-257 ◽  
Author(s):  
Jiann-Der Lee ◽  
Ya-Han Hu ◽  
Meng Lee ◽  
Yen-Chu Huang ◽  
Ya-Wen Kuo ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Ischemic Stroke ◽  
Multivariate Logistic Regression Analysis ◽  
Stroke Recurrence ◽  
Prior History ◽  
Multivariate Logistic Regression ◽  
Cart Analysis ◽  
Younger Age ◽  
History Of ◽  
One Year

Background and Purpose: Recurrent ischemic strokes increase the risk of disability and mortality. The role of conventional risk factors in recurrent strokes may change due to increased awareness of prevention strategies. The aim of this study was to explore the potential risk factors besides conventional ones which may help to affect the advances in future preventive concepts associated with one-year stroke recurrence (OSR). Methods: We analyzed 6,632 adult patients with ischemic stroke. Differences in clinical characteristics between patients with and without OSR were analyzed using multivariate logistic regression and classification and regression tree (CART) analyses. Results: Among the study population, 525 patients (7.9%) had OSR. Multivariate logistic regression analysis revealed that male sex (OR 1.243, 95% CI 1.025 – 1.506), age (OR 1.015, 95% CI 1.007 - 1.023), and a prior history of ischemic stroke (OR 1.331, 95% CI 1.096 – 1.615) were major factors associated with OSR. CART analysis further identified age and a prior history of ischemic stroke were important factors for OSR when classified the patients into three subgroups (with risks of OSR of 8.8%, 3.8%, and 12.5% for patients aged > 57.5 years, ≤ 57.5 years/with no prior history of ischemic stroke, and ≤ 57.5 years/with a prior history of ischemic stroke, respectively). Conclusions: Male sex, age, and a prior history of ischemic stroke could increase the risk of OSR by multivariate logistic regression analysis, and CART analysis further demonstrated that patients with a younger age (≤ 57.5 years) and a prior history of ischemic stroke had the highest risk of OSR.

HIGHER EDUCATION IN ANCIENT INDIA

2018 ◽  
Vol 6 (26) ◽  
Author(s):  
Satyendra Singh Chahar ◽  
Nirmal Singh
Keyword(s):  
Cultural History ◽  
Early Stage ◽  
University Education ◽  
Educational Institutions ◽  
Educational Method ◽  
Men And Women ◽  
Ancient India ◽  
Herbert Spencer ◽  
History Of ◽  
The Ideal

University education -on almost modern lines existed in India as early as 800 B.C. or even earlier. The learning or culture of ancient India was chiefly the product of her hermitages in the solitude of the forests. It was not of the cities. The learning of the forests was embodied in the books specially designated as Aranyakas "belonging to the forests." The ideal of education has been very grand, noble and high in ancient India. Its aimaccording to Herbert Spencer is the 'training for completeness of life' and ‘the molding o character of men and women for the battle of life’. The history of the educational institutions in ancient India shows a glorious dateline of her cultural history. It points to a long history altogether. In the early stage it was rural, not urban. British Sanskrit scholar Arthur Anthony Macdonell says "Some hundreds of years must have been needed for all that is found" in her culture. The aim of education was at the manifestation of the divinity in men, it touches the highest point of knowledge. In order to attain the goal the whole educational method is based on plain living and high thinking pursued through eternity.

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