scholarly journals Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254859
Author(s):  
Elisabeth Buur Stougaard ◽  
Signe Abitz Winther ◽  
Hanan Amadid ◽  
Marie Frimodt-Møller ◽  
Frederik Persson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Risk Stratification ◽  
Boundary Region ◽  
Cross Sectional Study ◽  
Endothelial Glycocalyx ◽  
Capillary Endothelium ◽  
Microvascular Damage ◽  
Cross Sectional

Background Glycocalyx lines the inner surface of the capillary endothelium. Capillaroscopy enables visualization of the sublingual capillaries and measurement of the Perfused Boundary Region (PBR) as an estimate of the glycocalyx. Novel software enables assessment of the PBR estimated at a fixed high flow level (PBR-hf) and an overall microvascular assessment by the MicroVascular Health Score (MVHS). Damaged glycocalyx may represent microvascular damage in diabetes and assessment of its dimension might improve early cardio-renal risk stratification. Aim To assess the associations between PBR, PBR-hf and MVHS and cardio-renal risk factors in persons with type 1 diabetes (T1D); and to compare these dimensions in persons with T1D and controls. Methods Cross-sectional study including 161 persons with T1D stratified according to level of albuminuria and 50 healthy controls. The PBR, PBR-hf and MVHS were assessed by the GlycoCheck device (valid measurements were available in 136 (84.5%) with T1D and in all the controls). Higher PBR and PBR-hf indicate smaller glycocalyx width. Lower MVHS represents a worse microvascular health. Results There were no associations between PBR, PBR-hf or MVHS and the cardio-renal risk factors in persons with T1D, except for higher PBR-hf and lower MVHS in females (p = 0.01 for both). There was no difference in PBR, PBR-hf or MVHS in persons with normo-, micro- or macroalbuminuria. The PBR was higher (2.20±0.30 vs. 2.03±0.18μm; p<0.001) and MVHS lower (3.15±1.25 vs. 3.53±0.86μm; p = 0.02) in persons with T1D compared to controls (p≤0.02). After adjustment for cardio-renal risk factors the difference in PBR remained significant (p = 0.001). Conclusions The endothelial glycocalyx dimension was impaired in persons with T1D compared to controls. We found no association between the endothelial glycocalyx dimension and the level of albuminuria or cardio-renal risk factors among persons with T1D. The use of the GlycoCheck device in T1D may not contribute to cardio-renal risk stratification.

scholarly journals Frequency of Lipohypertrophy and Associated Risk Factors in Young Patients with Type 1 Diabetes: A Cross-Sectional Study

2016 ◽  
Vol 7 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Ayman A. Al Hayek ◽  
Asirvatham A. Robert ◽  
Rim B. Braham ◽  
Mohamed A. Al Dawish
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

Prevalence and risk factors for diabetic retinopathy in a hospital-based population of Australian children and adolescents with type 1 diabetes

2016 ◽  
Vol 29 (10) ◽  
Author(s):  
Stuart Keel ◽  
Catherine Itsiopoulos ◽  
Konstandina Koklanis ◽  
Meri Vukicevic ◽  
Fergus Cameron ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
High Density Lipoproteins ◽  
Cross Sectional ◽  
Emerging Risk

AbstractBackground:The aim of this study was to investigate the prevalence of, and traditional and emerging risk factors associated with, retinopathy in a hospital-based population of Australian children and adolescents with type 1 diabetes.Methods:This was a cross-sectional study of 483 children and adolescents with type 1 diabetes. Medical files were audited to collect all relevant clinical data. Diabetic retinopathy was assessed from colour retinal images by an ophthalmologist.Results:Diabetic retinopathy was observed in 11 (2.3%) participants. Logistic regression revealed that the principal components analysis derived risk profile of: higher serum creatinine, older age, higher systolic blood pressures, higher body mass index, abnormal estimated glomerular filtration rate (eGFR) (<59 mL/min), lower high density lipoproteins (HDL) cholesterol, higher serum sodium, longer duration of diabetes and narrower retinal arteriolar calibre was associated with diabetic retinopathy (ExpB=2.60, 95% CI 1.36/4.96, p=0.004).Conclusions:These results support the concept that the pathogenesis of diabetic retinopathy is likely due to the combined influence of various risk factors, many already identified.

scholarly journals Association Between Physical Activity Level and Cardiovascular Risk Factors in Adolescents Living with Type 1 Diabetes: A Cross-sectional Study

2020 ◽  
Author(s):  
Nana Wu ◽  
Shannon Bredin ◽  
Veronica Jamnik ◽  
Michael Koehle ◽  
Yanfei Guan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background: Type 1 diabetes (T1D) is associated with a high risk of cardiovascular disease (CVD) and an increased rate of premature mortality from CVD. Regular physical activity can improve overall health and wellbeing and plays an important role in primary and secondary prevention of CVD. Methods: This cross-sectional study assessed cardiovascular risk factors, physical activity, and fitness (and their associations) in young individuals living with T1D and healthy controls. Primary outcomes included blood pressure, lipid profiles, and physical activity (accelerometry). We included a total of 48 individuals living with T1D and 19 healthy controls, aged 12 to 17 years. Statistical differences between groups were determined with chi-square, independent-samples t-tests or analysis of covariance. The associations between aerobic fitness, daily physical activity variables and cardiovascular risk factors were assessed with univariate and multivariate linear regression analysis.Results: In comparison to healthy controls, youth living with T1D showed higher levels of total cholesterol (4.03 ± 0.81 vs. 3.14 ± 0.67 mmol·L-1, p = 0.001), low-density lipoprotein cholesterol (LDL-C) (2.31 ± 0.72 vs. 1.74 ± 0.38 mmol·L-1, p = 0.035), and triglycerides (0.89 ± 0.31 vs. 0.60 ± 0.40 mmol·L-1 p = 0.012), and lower maximal oxygen power (VO2max) (35.48 ± 8.72 vs. 44.43 ± 8.29 mL·kg-1·min-1, p = 0.003), total physical activity counts (346.87 ± 101.97 vs. 451.01 ± 133.52 counts·min-1, p = 0.004), metabolic equivalents (METs) (2.09 ± 0.41 vs. 2.41 ± 0.60 METs, p = 0.033), moderate to vigorous intensity physical activity (MVPA), and the percentage of time spent in MVPA. The level of HDL-C was positively associated with METs (β = 0.29, p = 0.030, model R2 = 0.17), and the level of triglycerides was negatively associated with physical activity counts (β = -0.001, p = 0.018, model R2 = 0.205) and METs (β = -0.359, p = 0.015, model R2 = 0.208) in persons living with T1D. Conclusions:Youth with T1D, despite their young age and short duration of diabetes, present early signs of CVD risk, as well as low physical activity levels and cardiorespiratory fitness compared to healthy controls. Regular physical activity is associated with a beneficial cardiovascular profile in T1D, including improvements in lipid profile. Thus, physical activity participation should be widely promoted in youth living with T1D.

scholarly journals Fear of Self-Injecting and Self-Testing and the Related Risk Factors in Adolescents with Type 1 Diabetes: A Cross-Sectional Study

2016 ◽  
Vol 8 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Ayman A. Al Hayek ◽  
Asirvatham A. Robert ◽  
Saleha Babli ◽  
Khuloud Almonea ◽  
Mohamed A. Al Dawish
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Self Testing ◽  
Related Risk

scholarly journals Female Sex and Obesity Are Risk Factors for Inadequate Calcium Intake in Youth With Type 1 Diabetes

2021 ◽  
Vol 2 ◽  
Author(s):  
Roman Rahmani ◽  
Elizabeth Stevens ◽  
Noya Rackovsky ◽  
Kimberly O. O’Brien ◽  
George J. Schwartz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Bone Health ◽  
Calcium Intake ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Female Sex ◽  
Increased Risk

People with type 1 diabetes (T1D) are at increased risk of developing low bone mineral density and fractures. Optimization of calcium intake is a key component of pediatric bone health care. Despite the known risk factors for impaired bone health in T1D and the known benefits of calcium on bone accrual, there are limited data describing calcium intake in youth with T1D. In this cross-sectional study, calcium intake was assessed in 238 youth with T1D. One third of study participants were found to have inadequate calcium intake. Female sex, especially during adolescence, and obesity were identified as specific risk factors for inadequate calcium intake. Given the known adverse effects of T1D on bone health, efforts to promote calcium intake in youth with T1D should be considered.

scholarly journals Glycemic control associated factors in type 1 diabetes mellitus patients: a cross sectional study

2015 ◽  
Vol 7 (S1) ◽  
Author(s):  
Patrícia Ramos Guzatti ◽  
Amely PS Balthazar ◽  
Maria Heloisa Busi da Silva Canalli ◽  
Thais Fagnani Machado
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association between central non-dipping pattern and platelet morphology in adults with type 1 diabetes without cardiovascular disease: a cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Kulecki ◽  
Dariusz Naskret ◽  
Mikolaj Kaminski ◽  
Dominika Kasprzak ◽  
Pawel Lachowski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Distribution Width ◽  
Non Invasive ◽  
Platelet Morphology ◽  
Oscillometric Device

AbstractThe non-dipping pattern is nighttime systolic blood pressure (SBP) fall of less than 10%. Several studies showed that the non-dipping pattern, increased mean platelet volume (MPV), and platelet distribution width (PDW) are associated with elevated cardiovascular risk. Hypertensives with the non-dipping pattern have higher MPV than the dippers but this relationship was never investigated among people with type 1 diabetes mellitus (T1DM). This study aimed to investigate the association between the central dipping pattern and platelet morphology in T1DM subjects. We measured the central and brachial blood pressure with a validated non-invasive brachial oscillometric device—Arteriograph 24—during twenty-four-hour analysis in T1DM subjects without diagnosed hypertension. The group was divided based on the central dipping pattern for the dippers and the non-dippers. From a total of 62 subjects (32 males) aged 30.1 (25.7–37) years with T1DM duration 15.0 (9.0–20) years, 36 were non-dippers. The non-dipper group had significantly higher MPV (MPV (10.8 [10.3–11.5] vs 10.4 [10.0–10.7] fl; p = 0.041) and PDW (13.2 [11.7–14.9] vs 12.3 [11.7–12.8] fl; p = 0.029) than dipper group. Multivariable logistic regression revealed that MPV (OR 3.74; 95% CI 1.48–9.45; p = 0.005) and PDW (OR 1.91; 95% CI 1.22–3.00; p = 0.005) were positively associated with central non-dipping pattern adjusting for age, sex, smoking status, daily insulin intake, and height. MPV and PDW are positively associated with the central non-dipping pattern among people with T1DM.

scholarly journals Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. e002099
Author(s):  
Yuji Komorita ◽  
Masae Minami ◽  
Yasutaka Maeda ◽  
Rie Yoshioka ◽  
Toshiaki Ohkuma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Fracture Risk ◽  
Bone Fracture ◽  
Severe Hypoglycemia ◽  
Japanese Patients ◽  
Anatomic Site ◽  
Cross Sectional ◽  
History Of

IntroductionType 1 diabetes (T1D) is associated with higher fracture risk. However, few studies have investigated the relationship between severe hypoglycemia and fracture risk in patients with T1D, and the results are controversial. Besides, none has investigated the risk factors for fracture in Asian patients with T1D. The aim of the present study was to investigate the prevalence of bone fracture and its relationship between severe hypoglycemia and other risk factors in Japanese patients with T1D.Research design and methodsThe single-center cross-sectional study enrolled 388 Japanese patients with T1D (mean age, 45.2 years; women, 60.4%; mean duration of diabetes, 16.6 years) between October 2019 and April 2020. The occurrence and circumstances of any fracture after the diagnosis of T1D were identified using a self-administered questionnaire. The main outcomes were any anatomic site of fracture and fall-related fracture. Severe hypoglycemia was defined as an episode of hypoglycemia that required the assistance of others to achieve recovery.ResultsA total of 92 fractures occurred in 64 patients, and 59 fractures (64%) were fall-related. Only one participant experienced fracture within the 10 years following their diagnosis of diabetes. In logistic regression analysis, the multivariate-adjusted ORs (95% CIs) of a history of severe hypoglycemia were 2.11 (1.11 to 4.09) for any fracture and 1.91 (0.93 to 4.02) for fall-related fracture. Fourteen of 18 participants with multiple episodes of any type of fracture had a history of severe hypoglycemia (p<0.001 vs no fracture).ConclusionsWe have shown that a history of severe hypoglycemia is significantly associated with a higher risk of bone fracture in Japanese patients with T1D.

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