scholarly journals Salivary proteomics in monitoring the therapeutic response of canine oral melanoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256167
Author(s):  
Sekkarin Ploypetch ◽  
Sittiruk Roytrakul ◽  
Janthima Jaresitthikunchai ◽  
Narumon Phaonakrop ◽  
Patharakrit Teewasutrakul ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Cost Effective ◽  
Term Survival ◽  
Non Invasive ◽  
Oral Melanoma ◽  
Liquid Chromatography Tandem Mass ◽  
Novel Biomarkers ◽  
Saliva Collection ◽  
Short Term Survival

Saliva biomarkers are suitable for monitoring the therapeutic response of canine oral melanoma (COM), because saliva directly contacts the tumor, and saliva collection is non-invasive, convenient and cost effective. The present study aimed to investigate novel biomarkers from the salivary proteome of COM treated with surgery and a chemotherapy drug, carboplatin, 1–6 times, using a liquid chromatography–tandem mass spectrometry approach. The expression of a potential salivary biomarker, ubiquitin D (UBD), was observed and verified by western blot analysis. A significantly increased ratio of free UBD (fUBD) to conjugated UBD (cUBD) was shown in the pre-surgery stage (PreS) in OM dogs with short-term survival (STS) (less than 12 months after surgery) compared with that with long-term survival (more than 12 months after surgery). In dogs with STS, the ratio was also shown to be augmented in PreS compared with that after surgery, followed by treatment with carboplatin twice, 4 and 5 times [After treatment (AT)2, AT4 and AT5]. In addition, the expression of fUBD was enhanced in PreS compared with that of AT2 in the STS group. In conclusion, this study revealed that a ratio of fUBD to cUBD in PreS was plausibly shown to be a potential prognostic biomarker for survival in dogs with OM.

scholarly journals Parenteral Nutrition and Oxidant Load in Neonates

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2631
Author(s):  
Kandeepan Karthigesu ◽  
Robert F. Bertolo ◽  
Robert J. Brown
Keyword(s):  
Parenteral Nutrition ◽  
Storage Temperature ◽  
Oral Feeding ◽  
Published Data ◽  
Short Term ◽  
Antioxidant Defences ◽  
Term Survival ◽  
Nutrient Sources ◽  
Short Term Survival

Neonates with preterm, gastrointestinal dysfunction and very low birth weights are often intolerant to oral feeding. In such infants, the provision of nutrients via parenteral nutrition (PN) becomes necessary for short-term survival, as well as long-term health. However, the elemental nutrients in PN can be a major source of oxidants due to interactions between nutrients, imbalances of anti- and pro-oxidants, and environmental conditions. Moreover, neonates fed PN are at greater risk of oxidative stress, not only from dietary sources, but also because of immature antioxidant defences. Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature. This narrative review of published data provides insight to oxidant molecules generated in PN, nutrient sources of oxidants, and measures to minimize oxidant levels.

scholarly journals Cost-Effectiveness of Pembrolizumab Plus Chemotherapy Versus Pembrolizumab Monotherapy in Metastatic Non-Squamous and Squamous NSCLC Patients With PD-L1 Expression ≥ 50%

2022 ◽  
Vol 12 ◽  
Author(s):  
Qiao Liu ◽  
Zhen Zhou ◽  
Xia Luo ◽  
Lidan Yi ◽  
Liubao Peng ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Life Expectancy ◽  
Cost Effective ◽  
Base Case ◽  
First Line ◽  
Term Survival ◽  
First Line Therapy ◽  
Line Therapy ◽  
Nsclc Patients

Objective To compare the cost-effectiveness of the combination of pembrolizumab and chemotherapy (Pembro+Chemo) versus pembrolizumab monotherapy (Pembro) as the first-line treatment for metastatic non-squamous and squamous non-small-cell lung cancer (NSCLC) with PD-L1expression ≥50%, respectively, from a US health care perspective.Material and Methods A comprehensive Makrov model were designed to compare the health costs and outcomes associated with first-line Pembro+Chemo and first-line Pembro over a 20-years time horizon. Health states consisted of three main states: progression-free survival (PFS), progressive disease (PD) and death, among which the PFS health state was divided into two substates: PFS while receiving first-line therapy and PFS with discontinued first-line therapy. Two scenario analyses were performed to explore satisfactory long-term survival modeling.Results In base case analysis, for non-squamous NSCLC patients, Pembro+Chemo was associated with a significantly longer life expectancy [3.24 vs 2.16 quality-adjusted life-years (QALYs)] and a substantially greater healthcare cost ($341,237 vs $159,055) compared with Pembro, resulting in an ICER of $169,335/QALY; for squamous NSCLC patients, Pembro+Chemo was associated with a slightly extended life expectancy of 0.22 QALYs and a marginal incremental cost of $3,449 compared with Pembro, resulting in an ICER of $15,613/QALY. Our results were particularly sensitive to parameters that determine QALYs. The first scenario analysis yielded lower ICERs than our base case results. The second scenario analysis founded Pembro+Chemo was dominated by Pembro.Conclusion For metastatic non-squamous NSCLC patients with PD-L1 expression ≥50%, first-line Pembro+Chemo was not cost-effective when compared with first-line Pembro. In contrast, for the squamous NSCLC patient population, our results supported the first-line Pembro+Chemo as a cost-effective treatment. Although there are multiple approaches that are used for extrapolating long-term survival, the optimal method has yet to be determined.

Physicians’ predictions of long-term survival and functional outcomes do not influence the decision to admit patients with advanced disease to intensive care: A prospective study

2020 ◽  
pp. 026921632096393
Author(s):  
Monica Escher ◽  
Mathieu Nendaz ◽  
Fabienne Scherer ◽  
Stéphane Cullati ◽  
Thomas Perneger
Keyword(s):  
Intensive Care ◽  
Functional Outcomes ◽  
Advanced Disease ◽  
Short Term ◽  
Term Survival ◽  
Admission Decisions ◽  
Long Term Prognosis ◽  
A Prospective Study ◽  
Short Term Survival

Background: Long-term survival and functional outcomes should influence admission decisions to intensive care, especially for patients with advanced disease. Aim: To determine whether physicians’ predictions of long-term prognosis influenced admission decisions for patients with and without advanced disease. Design: A prospective study was conducted. Physicians estimated patient survival with intensive care and with care on the ward, and the probability of 4 long-term outcomes: leaving hospital alive, survival at 6 months, recovery of functional status, and recovery of cognitive status. Patient mortality at 28 days was recorded. We built multivariate logistic regression models using admission to the intensive care unit (ICU) as the dependent variable. Setting/participants: ICU consultations for medical inpatients at a Swiss tertiary care hospital were included. Results: Of 201 evaluated patients, 105 (52.2%) had an advanced disease and 140 (69.7%) were admitted to the ICU. The probability of admission was strongly associated with the expected short-term survival benefit for patients with or without advanced disease. In contrast, the predicted likelihood that the patient would leave the hospital alive, would be alive 6 months later, would recover functional status, and would recover initial cognitive capacity was not associated with the decision to admit a patient to the ICU. Even for patients with advanced disease, none of these estimated outcomes influenced the admission decision. Conclusions: ICU admissions of patients with advanced disease were determined by short-term survival benefit, and not by long-term prognosis. Advance care planning and developing decision-aid tools for triage could help limit potentially inappropriate admissions to intensive care.

Minor shifts towards more natural conditions in captivity improve long-term survival among reintroduced Atlantic salmon

2020 ◽  
Vol 77 (5) ◽  
pp. 931-942
Author(s):  
Andrew B. Harbicht ◽  
Dylan J. Fraser ◽  
William R. Ardren
Keyword(s):  
Atlantic Salmon ◽  
Life Histories ◽  
Thermal Conditions ◽  
Cost Effective ◽  
Growth Conditions ◽  
Adult Survival ◽  
Term Survival ◽  
Long Term Survival ◽  
Release Times

Elevating winter water temperatures is a common practice when rearing salmonids for supplementation or reintroduction. Doing so elevates developmental rates, producing larger juveniles with greater smolt-to-adult survival, but does not guarantee improved adult returns to stocked tributaries. To test whether more natural developmental conditions improve adult returns to stocked tributaries, three consecutive cohorts of yearling (age 1+) landlocked Atlantic salmon (Salmo salar) were released into two tributaries of Lake Champlain. Cohorts were reared under two winter thermal conditions (seasonal surface water and above-seasonal groundwater) and (or) two release times (early and normal). Relative to standard hatchery practices, modelled returns to experimental tributaries increased over replicate cohorts by 286% on average following exposure to seasonal rearing temperatures, but decreased by 89% on average when release dates were advanced. By utilizing cost-effective shifts towards hatchery rearing techniques that more closely resemble natural growth conditions, we demonstrate how hatchery programs may improve long-term survival and returns for fish species with complex life histories involved in supplementation and reintroduction programs.

scholarly journals Remote sensing and conservation of isolated indigenous villages in Amazonia

2014 ◽  
Vol 1 (3) ◽  
pp. 140246 ◽  
Author(s):  
Robert S. Walker ◽  
Marcus J. Hamilton ◽  
Aaron A. Groth
Keyword(s):  
Remote Sensing ◽  
Satellite Imagery ◽  
Term Survival ◽  
Surveillance Programme ◽  
Non Invasive ◽  
External Threats ◽  
Indigenous Groups ◽  
Order Of Magnitude ◽  
Population Sizes

The vast forests on the border between Brazil and Peru harbour a number of indigenous groups that have limited contact with the outside world. Accurate estimates of population sizes and village areas are essential to begin assessing the immediate conservation needs of such isolated groups. In contrast to overflights and encounters on the ground, remote sensing with satellite imagery offers a safe, inexpensive, non-invasive and systematic approach to provide demographic and land-use information for isolated peoples. Satellite imagery can also be used to understand the growth of isolated villages over time. There are five isolated villages in the headwaters of the Envira River confirmed by overflights that are visible with recent satellite imagery further confirming their locations and allowing measurement of their cleared gardens, village areas and thatch roofed houses. These isolated villages appear to have population densities that are an order of magnitude higher than averages for other Brazilian indigenous villages. Here, we report on initial results of a remote surveillance programme designed to monitor movements and assess the demographic health of isolated peoples as a means to better mitigate against external threats to their long-term survival.

Abstract 1279: Proteomics signature of long-term versus short-term survival in glioblastoma

2012 ◽  
Author(s):  
Jill Barnholtz-Sloan ◽  
Giridharan Gokulrangan ◽  
Yanwen Chen ◽  
Elizabeth Yohannes ◽  
Jaime Vengoechea ◽  
...  
Keyword(s):  
Short Term ◽  
Term Survival ◽  
Short Term Survival
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