scholarly journals Potential biomarkers of major depression diagnosis and chronicity

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257251
Author(s):  
Ana Cecília de Menezes Galvão ◽  
Raíssa Nobrega Almeida ◽  
Geovan Menezes de Sousa Júnior ◽  
Mário André Leocadio-Miguel ◽  
Fernanda Palhano-Fontes ◽  
...  
Keyword(s):  
Major Depression ◽  
Rating Scale ◽  
Serum Cortisol ◽  
First Episode ◽  
Major Depression Disorder ◽  
Reactive Protein ◽  
Mature Brain ◽  
Healthy Control ◽  
Depression Disorder ◽  
Potential Use

Background Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. Results For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity. Conclusion These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice.

scholarly journals Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

2019 ◽  
Vol 70 (9) ◽  
pp. 3383-3386 ◽  
Author(s):  
Luminita Diana Hritcu ◽  
Manuela Padurariu ◽  
Alin Ciobica ◽  
Cristina Horhogea ◽  
Mihaela Claudia Spataru ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Major Depression ◽  
Present Report ◽  
Serum Cortisol ◽  
Control Group ◽  
Major Depression Disorder ◽  
Related Factors ◽  
Cortisol Levels ◽  
Irritable Bowel ◽  
Depression Disorder

The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.

Sub-regional hippocampal volumes in first-episode drug-naïve major depression disorder

2021 ◽  
pp. 136178
Author(s):  
Mu-N Liu ◽  
Jakobus Gerick Pantouw ◽  
Kai-Chun Yang ◽  
Li-Yu Hu ◽  
Ying-Jay Liou ◽  
...  
Keyword(s):  
Major Depression ◽  
First Episode ◽  
Major Depression Disorder ◽  
Drug Naïve ◽  
Depression Disorder

scholarly journals Depressive symptoms and neurotrophin levels in ostomy patients

2018 ◽  
Vol 67 (3) ◽  
pp. 166-173
Author(s):  
Daniela Vicente Bavaresco ◽  
Mágada Tessmann Schwalm ◽  
Luciano Kurtz Jornada ◽  
Luiz Felipe Andrade Quadros ◽  
Bruna Simon ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Major Depression ◽  
Peripheral Blood ◽  
Healthy Controls ◽  
Major Depression Disorder ◽  
Significant Difference ◽  
Healthy Control ◽  
Axis I ◽  
Cortisol Levels ◽  
Depression Disorder

ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.

scholarly journals Pathophysiology of Major Depression by Clinical Stages

2021 ◽  
Vol 12 ◽  
Author(s):  
Ana Cecília de Menezes Galvão ◽  
Raíssa Nobrega Almeida ◽  
Geovan Menezes de Sousa ◽  
Mario André Leocadio-Miguel ◽  
Fernanda Palhano-Fontes ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sleep Quality ◽  
Strong Relationship ◽  
Serum Cortisol ◽  
First Episode ◽  
Future Research ◽  
Control Group ◽  
Reactive Protein ◽  
Mature Brain ◽  
Biological Tests

The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression.

Belastungen in der Kindheit und dissoziative Symptomatik bei Patienten mit psychischen Störungen

2013 ◽  
Vol 42 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Johanna Fiess ◽  
Astrid Steffen ◽  
Christian Pietrek ◽  
Brigitte Rockstroh
Keyword(s):  
Major Depression ◽  
Major Depression Disorder ◽  
Dissoziative Symptome ◽  
Kindheit Und Jugend ◽  
Depression Disorder

Theoretischer Hintergrund: Dissoziative Symptome treten bei verschiedenen psychischen Störungen auf und werden bei einigen Störungen mit traumatischen Erfahrungen assoziiert. Fragestellung: Wird der Zusammenhang zwischen dissoziativer Symptomatik und belastenden Erfahrungen moduliert durch die Art der Erfahrung und das Alter zum Zeitpunkt der Belastung? Methode: Bei 82 Patienten (Borderline-Persönlichkeitsstörung, BPS; Major Depression Disorder, MDD) und 54 gesunden Kontrollpersonen wurden per Interview belastende Erfahrungen während Kindheit und Jugend (3 – 16 Jahre) ermittelt. Zusammenhänge zwischen Belastung und dissoziativer Symptomatik wurden regressionsanalytisch unter Berücksichtigung von Diagnose und komorbider Posttraumatischer Belastungsstörung (PTBS) untersucht. Ergebnisse: Dissoziative Symptomatik korreliert bei BPD und MDD (mit komorbider PTBS) positiv mit emotionalem (neben sexuellem) Missbrauch und mit Belastungen in der Pubertät. Schlussfolgerung: Therapeutische Berücksichtigung emotionaler und pubertärer Belastung könnte die (Behandlung erschwerende) dissoziative Symptomatik reduzieren.

Sign in / Sign up

Export Citation Format

Share Document