scholarly journals Recent Advances in Metal Nanoparticles for the Synthesis of N-Containing Heterocyclic Compounds

2021 ◽  
Vol 33 (5) ◽  
pp. 949-955
Author(s):  
Aayushi Chanderiya ◽  
Gowhar A. Naikoo ◽  
Ratnesh Das ◽  
Israr U. Hassan ◽  
Sushil K. Kashaw ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Heterocyclic Compounds ◽  
Organic Reactions ◽  
The Past ◽  
Recent Advances ◽  
Potential Applications ◽  
Green Conditions

Heterocyclic compounds are indispensable organic structures because of their promising potential applications in medicinal, pharmaceutical and other related fields of chemistry. Exploring these heterocyclic compounds by evaluating metal nanoparticles as efficient nanocatalysts have attracted the researchers over the past decades, due to their stability, recyclability, reusability rather than conventional catalysts. Most of the nano-catalyzed organic reactions are taking place in benign and under green conditions. In this mini-review, we have documented synthesis of some of the recent N-containing heterocyclic compounds by utilizing advanced nanoparticles as effective catalysts. It has been concluded that exercising these nanocatalysts for the synthesis of N-containing heterocyclic compounds not only enhanced the yield of the product but has extensively increased the selectivity of the desired products via greener approach.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Recent advances of 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) in photocatalytic transformations

2019 ◽  
Vol 55 (38) ◽  
pp. 5408-5419 ◽  
Author(s):  
Tian-Yi Shang ◽  
Ling-Hui Lu ◽  
Zhong Cao ◽  
Yan Liu ◽  
Wei-Min He ◽  
...  
Keyword(s):  
Organic Reactions ◽  
The Past ◽  
Recent Advances

In this review, the recent advances of the application of 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) as a photoredox catalyst in the past three years (2016–2018) for various organic reactions are summarized.

Formic Acid as an Inexpensive and Convenient Reagent

2020 ◽  
Vol 24 ◽  
Author(s):  
Xiao-hua CAI ◽  
Su-qian CAI ◽  
Bing XIE
Keyword(s):  
Formic Acid ◽  
Green Synthesis ◽  
Chemical Industry ◽  
Hydrogen Donor ◽  
Organic Reactions ◽  
The Past ◽  
Recent Advances ◽  
Versatile Reagent

Abstract:: Formic acid (HCOOH) as an inexpensive and versatile reagent has attracted broad attention in the field of green synthesis and chemical industry. Formic acid acts not only as a convenient and less toxic CO surrogate, but also as an excel-lent formylative reagent, C1 source and hydrogen donor in organic reactions. Over the past decades, many exciting contribu-tions have been made which have helped chemists to understand the mechanisms of these reactions. The review will exam-ine recent advances in the utilization of formic acid as economical, practical and multipurpose reactant in synthetic trans-formations.

scholarly journals Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7523
Author(s):  
Helen A. Goulart ◽  
Daniela R. Araujo ◽  
Filipe Penteado ◽  
Raquel G. Jacob ◽  
Gelson Perin ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Environmentally Friendly ◽  
The Past ◽  
Recent Advances ◽  
Inorganic Species ◽  
Species Being ◽  
Potassium Peroxymonosulfate

Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become becoming a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations.

Recent Advances in Denitrogenative Reactions of Pyridotriazoles

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3564-3576 ◽  
Author(s):  
Ilya P. Filippov ◽  
Gleb D. Titov ◽  
Nikolai V. Rostovskii
Keyword(s):  
Lewis Acids ◽  
Heterocyclic Compounds ◽  
Short Review ◽  
Diazo Compounds ◽  
Metal Compounds ◽  
The Past ◽  
Recent Advances ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Chain Isomerization

AbstractDiazo compounds display versatile reactivity and therefore are widely used in organic synthesis. Diazo compounds bearing a 2-pyridyl or a related azine moiety on the diazo carbon exist in the form of fused 1,2,3-triazoles. In this short review, we summarize the recent advances in denitrogenative reactions of [1,2,3]triazolo[1,5-a]pyridines (‘pyridotriazoles’) and related fused 1,2,3-triazoles. Over the past decade, there has been a surge of activity in this field, with novel denitrogenative reactions of pyridotriazoles induced by metal compounds, light, and Brønsted and Lewis acids having been devised. As a result, heterocyclic compounds and functionalized α-picolines as well as bio­active molecules have been synthesized. In the review, emphasis is also placed on the mechanisms of the new reactions.1 Introduction2 Ring-Chain Isomerization of Pyridotriazoles3 Metal-Catalyzed Reactions3.1 Rh(II) Catalysis3.2 Rh(III) Catalysis3.3 Cu Catalysis3.4 Pd Catalysis3.5 Catalysis by Other Metals4 Metal-Free Reactions5 Conclusion

Recent advances in organic reactions catalyzed by graphene oxide and sulfonated graphene as heterogeneous nanocatalysts: a review

2017 ◽  
Vol 41 (20) ◽  
pp. 11471-11497 ◽  
Author(s):  
Ozra Mohammadi ◽  
Mohsen Golestanzadeh ◽  
Majid Abdouss
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Organic Reactions ◽  
Successive Reaction ◽  
Catalytic Systems ◽  
The Past ◽  
Recent Advances ◽  
Sulfonated Graphene ◽  
Thermal Stability Of

Over the past decade, the application of carbocatalyst systems has been preferred over that of homogeneous catalytic systems because of their advantages such as physical and thermal stability of the catalysts in successive reaction runs and reusability.

scholarly journals Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances

2021 ◽  
Vol 8 ◽  
Author(s):  
Muhammad Faisal ◽  
Aamer Saeed
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Properties ◽  
Future Research ◽  
The Past ◽  
Anti Cancer ◽  
Potential Applications ◽  
Synthetic Approaches ◽  
Anti Fungal ◽  
Anti Hiv ◽  
Different Parts

In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies. Owing to its numerous potential applications, in the past two decades, there is an increase in the importance of designing novel quinazolines, exploring promising routes to synthesize quinazolines, investigating different properties of quinazolines, and seeking for potential applications of quinazolines. The present review article describes synthesis of quinazolines via eco-friendly, mild, atom-efficient, multi-component synthetic strategies reported in the literature. The discussion is divided into different parts as per the key methods involved in the formation of quinazoline skeletons, aiming to provide readers an effective methodology to a better understanding. Consideration has been taken to cover the most recent references. Expectedly, the review will be advantageous in future research for synthesizing quinazolines and developing more promising synthetic approaches.

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

Ionic Liquids for the Synthesis of Five-Membered N,N-, N,N,N- and N,N,N,NHeterocycles

2019 ◽  
Vol 23 (11) ◽  
pp. 1214-1238 ◽  
Author(s):  
Navjeet Kaur ◽  
Pranshu Bhardwaj ◽  
Meenu Devi ◽  
Yamini Verma ◽  
Neha Ahlawat ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Reaction Medium ◽  
Environmental Issues ◽  
Organic Reaction ◽  
Environment Friendly ◽  
The Past ◽  
Area Of Interest ◽  
Major Subject

Due to special properties of ILs (Ionic Liquids) like their wide liquid range, good solvating ability, negligible vapour pressure, non-inflammability, environment friendly medium, high thermal stability, easy recycling and rate promoters etc. they are used in organic synthesis. The investigation for the replacement of organic solvents in organic synthesis is a growing area of interest due to increasing environmental issues. Therefore, ionic liquids have attracted the attention of chemists and act as a catalyst and reaction medium in organic reaction with high activity. There is no doubt that ionic liquids have become a major subject of study for modern chemistry. In comparison to traditional processes the use of ionic liquids resulted in improved, complimentary or alternative selectivities in organic synthesis. The present manuscript reported the synthesis of multiple nitrogen containing five-membered heterocyclic compounds using ionic liquids. This review covered interesting discoveries in the past few years.

Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present

2020 ◽  
Vol 20 (10) ◽  
pp. 908-920 ◽  
Author(s):  
Su-Min Wu ◽  
Xiao-Yang Qiu ◽  
Shu-Juan Liu ◽  
Juan Sun
Keyword(s):  
Monoamine Oxidase ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
The Past ◽  
Structure Activity ◽  
Receptor Interactions ◽  
Heterocyclic Derivatives ◽  
Inhibitory Activities ◽  
Leading Compounds ◽  
Heterocyclic Moiety

Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neurodegenerative diseases such as depression, Parkinson’s disease and Alzheimer’s disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single heterocyclic derivatives with MAO inhibitory activities during the past decade. This review covers recent pharmacological advancements of single heterocyclic moiety along with structure- activity relationship to provide better correlation among different structures and their receptor interactions.

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