scholarly journals Incidence and risk factors of neonatal thrombocytopenia: a pr

2016 ◽  
Vol 50 (1) ◽  
pp. 31
Author(s):  
Nila Kusumasari ◽  
Rinawati Rohsiswatmo ◽  
Djajadiman Gatot ◽  
Darlan Darwis
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Necrotizing Enterocolitis ◽  
Late Onset ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Neonatal Thrombocytopenia ◽  
Complete Blood Counts

Background Thrombocytopenia is the most common hematological abnormality in the neonatal period. Hemorrhagic manifestations are found in 10% cases of thrombocytopenia. Neonatal thrombocytopenia commonly assumed due to sepsis, despite many risk factors that may caused thrombocytopenia.Objective To obtain incidence and risk factors of neonatal thrombocytopenia.Methods A cross sectional study was conducted in April 2009. Complete blood counts investigation was performed before age of 24 hours, medical conditions and risk factors of mothers and subjects were noted, as well as hemorrhagic manifestations. Subjects with thrombocytopenia were followed for 2 weeks. The risk factors consisted of hypertension in pregnancy, pre-eclampsia, eclampsia, intrauterine growth retardation, gestational diabetes mellitus, perinatal infection, asphyxia, sepsis, and necrotizing enterocolitis.Results Neonatal thrombocytopenia was found 17 (12.1%) of 140 subjects, consisted of 88.2% early onset and 11.8% late onset. Significant risk factor of mother was pre-eclampsia (PR 3.97, 95%CI 1.70 to 9.25), while significant risk factors of neonates were asphyxia (PR 5.66, 95%CI 2.49 to 12.86), sepsis (PR 5.33, 95%CI 2.33-12.19) and necrotizing enterocolitis (p=0.014; PR 9.2 95% CI 5.17 to14.84). We found 29.4% hemorrhagic cases of neonatal thrombocytopenia (i.e.,. skin, gastrointestinal, intracranial hemorrhage).Conclusions The incidence of neonatal thrombocytopenia was 12.2%. Significant risk factor of mother that caused thrombocytopenia was pre-eclampsia, while risk factors of neonates were asphyxia, sepsis and necrotizing enterocolitis.[Paediatr Indones. 2010;50:31-7].

scholarly journals Asthma and Keratoconus: An analysis of the risk factors association with the severity of keratoconus

2020 ◽  
Author(s):  
Srujana Sahebjada ◽  
Elsie Chan ◽  
Jing Xie ◽  
Grant Snibson ◽  
Mark Daniel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Wide Range ◽  
Multivariable Regression

Abstract Background: A cross-sectional study was undertaken in Australia to explore a wide range of risk factors associated with keratoconus. A questionnaire addressing age, gender, educational background, ocular and medical history, smoking and alcohol consumption, and physical examination comprising anthropometric measurements was collected; eye examination was undertaken. The associations between a range of risk factors and keratoconus was determined using univariate and multivariable linear regression analyses.Main Text: A total of 260 keratoconus subjects were included in this study. Mean age of subject was 35.5 (SD= 14.8) years and the majority of the subjects were European 171 (68.2%). Initial univariate regression analysis identified the following risk factors at the p<0.1 level with keratoconus: higher body mass index, smoking cigarettes, diabetes, rheumatoid arthritis and asthma were associated with increased severity of keratoconus, whereas eczema was associated with less severe keratoconus. Following multivariable regression analysis, only asthma remained as a significant risk factor associated with 2.2 diopters (D) steeper average mean keratometry compared to keratoconus subjects having no asthma [p = 0.03; β= 2.18; 95% confidence intervals: 1.22, 4.14].Conclusion: Our study describes the comprehensive assessment of all the known risk factors in a large keratoconus cohort recruited in Australia. Our study has reported asthma as the only risk factor found to be significantly associated with keratoconus. The results of this study allow us to better understand the aetiology of keratoconus and such a knowledge could be useful in instigate systemic management of patients to slow or prevent keratoconus.

scholarly journals A study on prevalence of chronic kidney disease and its risk factors among adults in selected slums of Chennai

2019 ◽  
Vol 6 (2) ◽  
pp. 504
Author(s):  
K. Kokila ◽  
K. Chellavel Ganapathi
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Uncontrolled Hypertension ◽  
Adult Males ◽  
Cross Sectional ◽  
Slum Population

Background: Chronic kidney disease (CKD) is a silent epidemic. The true prevalence of CKD with in a population are very difficult to estimate, since early to moderate CKD were usually asymptomatic. ESRD in the consequence of CKD is one of the most expensive diseases to treat.Only way is to prevent it and Hence this was conducted to estimate the prevalence of CKD and its associated risk factors among adults in selected slums of Chennai.Methods: This is a cross sectional study done from May 2013 to June 2014 in selected slums of Chennai. The study population includes adult males and females. Multi stage sampling method used. Sample size covered was 400. A semi structured questionnaire used as tool. Based on the serum creatinine eGFR calculated using modified MDRD study equation and CKD prevalence was identified. The data was entered in MS excel and analyzed using SPSS version 21.Results: Total of 400 participants involved. Females were predominant in the study. Among them, 67 (16.8%) were diagnosed as CKD patients and Stage 1, 4.0% had stage 2, 3.6% had stage 3, 1.3% had stage 4 and 0.5% had stage 5 at the time of diagnosis.Conclusions: This study revealed prevalence of CKD among slum population was 16.8%. This study showed that old age, uncontrolled hypertension, uneducated, Diabetes with poor control, overuse of analgesics, H/o smoking, obesity, alcoholism, passive smoking, family H/o CKD and proteinuria were significant risk factor for CKD among study subjects. Slum population with risk factors should be regularly screened for CKD.

scholarly journals Risk Factors for Infection with Soil Transmitted Helminths, Cryptosporidium spp., and Giardia duodenalis in Children Enrolled in Preschools in Kafue District, Zambia

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Joyce Siwila ◽  
Annette Olsen
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Significant Risk ◽  
Giardia Duodenalis ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Parasitic Infections ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
Soil Transmitted Helminths

Intestinal parasitic infections are common among children worldwide. This study was aimed at determining risk factors for infection with soil transmitted helminths, Cryptosporidium spp., and Giardia duodenalis, among children in preschools. The study was in two parts: a cross-sectional study in which data were collected from 403 children from 10 preschools and a longitudinal study in which 100 children from four preschools from the previous 10 were selected. Prevalence of Ascaris lumbricoides was 12.0%, while that of hookworm was 8.3%. Overall prevalence of Cryptosporidium and G. duodenalis was 28.0% and 29.0%, respectively. Low education level of parent/guardian was a significant risk factor for A. lumbricoides (OR = 2.35, 95% CI: 1.02–5.41; P=0.04), while roofing types other than corrugated iron sheets were found to be protective for G. duodenalis infection in both bivariate and multivariate analyses (multivariate: OR = 0.67, 95% CI: 0.45–0.99; P=0.04). Low socioeconomic level was found to be protective for Cryptosporidium spp. infection in multivariate analysis (OR = 0.59, 95% CI: 0.35–0.99; P=0.04). In the longitudinal study, none of the factors were associated with either infection. These findings may have implications for other preschools in other districts in Zambia.

scholarly journals Evaluation of individual awareness of diabetes, related risk factors and complications in urban and rural people of Noakhali region, Bangladesh: a population-based study

2016 ◽  
Vol 27 (1) ◽  
pp. 8-15
Author(s):  
Md Khorshed Alam ◽  
Md Ariful Islam ◽  
Abhijit Das ◽  
Palash Karmakar ◽  
Pankaj Chandra Debnath ◽  
...  
Keyword(s):  
Risk Factors ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Population Based ◽  
Cross Sectional Study ◽  
Dominant Group ◽  
Cross Sectional ◽  
Related Risk ◽  
Secondary Study ◽  
The Individual

This cross-sectional study was conducted to evaluate the individual awareness, related risk factors and complications of diabetes with socio-demographic profiles of the study individuals in Noakhali region, Bangladesh during June to December, 2013. A total 250 participants were selected randomly and data were collected using structured questionnaire. Among the respondents 47.20% were found male and 52.80% were female and majorities (52.00%) of the respondents were urban people. Respondents completed secondary study level or below were the dominant group. 9.20%, 27.20%, 12.80% and 34.40% respondents were agriculturist, businessman and housewives respectively. Women showed better knowledge about overall diabetes (20.00%) and blood glucose level (9.60%), in case of causes, symptoms and management men (12.80%, 23.20% and 18.40% respectively) were found dominant than women (10.00%, 16.00% and 12.00% respectively). It was found that 13.20% respondents were suffering from impaired glucose tolerance and 79.20% had diabetes mellitus where female were more vulnerable than male. Family history was found the significant risk factor (p= 0.016; Ç2 = 5.849) for diabetes (total 62%, male 40.65% and female 59.35%), Other risk factors like age (67.20%), obesity (46.40%), hypercholesterolemia (82.00%), excess triglyceride (78.00%) and hypertension (29.60%) remained insignificant respectively and in every cases female were found more vulnerable than men. Study revealed that knowledge regarding diabetes was not up to the mark to the respondents though it is now one of the most pandemic diseases in the world.Bangladesh J Medicine Jan 2016; 27(1) : 8-15

scholarly journals RISK FACTORS OF MORTALITY IN CHILDREN WITH WILMS’ TUMOR AT SOETOMO HOSPITAL SURABAYA

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Maria Christina Shanty ◽  
Sherly Yuniarchan ◽  
Mia Ratwita Andarsini ◽  
I Dewa Gede Ugrasena ◽  
Bambang Permono ◽  
...  
Keyword(s):  
Risk Factors ◽  
Complete Blood Count ◽  
Wilms Tumor ◽  
Significant Risk ◽  
Stage Iv ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Cross Sectional ◽  
Female Ratio

Objective: Wilms’ tumor is the most common childhood renal tumor for about 6% of pediatric malignant disease. The 5-year survival rate in United States increased from approximately from 70% (1970-1973) to 92% (1989-1996). This study was aim to analyze the risk factors of mortality in children with Wilms’ tumor. Material & Methods: A cross-sectional study was conducted in children with Wilms’ tumor at Soetomo Hospital during 2006-2011. The data of demographic, clinical profile, complete blood count, blood urea nitrogen, glomerular filtration rate, histological type, disease stage, metastases and relapse were analyzed as risk factors of mortality using logistic regression. Results: There were 37 Wilms’ tumor children and 5 children were excluded because of incomplete data. The mean age was 3.0 (SD 2.6) years, and male-to-female ratio was 2.5 : 1. There were 5/32 children in stage I, 7/32 children in stage II, 8/32 children in stage III, 11/32 children in stage IV, and 1/32 children in stage V. There were 15/32 children underwent operation. Complete remission occurred in 12/32 children and 1/32 children relapsed. There were 20/32 children died, associated with anemia (P=0.033, OR=6.111, 95% CI=1.056-35.352) and advanced stage (P=0.021, OR=8.000, 95% CI=1.575-40.632). The risk of mortality increased 3.284 folds with every increased stage (P=0.007, 95% CI=1.338-7.775). Conclusion: Disease stage is the significant risk factor of mortality in children with Wilms’ tumor.  

scholarly journals Chlamydia trachomatis IgM and gG antibodies and associated risk factors of among positive and negative HIV women attending consultation at the Mbouo-Banjoun Presbyterian Hospital West Region of Cameroon

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Leonard Fonkeng Sama ◽  
Michel Noubom ◽  
Romeo Joël Nguekam ◽  
Solange Dabou ◽  
Thibau Flaurant Tchouangueu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Venous Blood ◽  
Transmitted Disease ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
Igm Antibodies

Background:Chlamydia trachomatis (CT) infection in the genitourinary tract is the most prevalent bacterial sexually transmitted disease (STD) worldwide. Genital chlamydial infection has a huge impact on sexual and reproductive health, and it is very common in developed and developing countries. This study aimed to determine the seroprevalance and risk factors for C. trachomatisinfection in women seeking medical care in the locality of Mbouo-BanjounWest Region of Cameroon. Methods: We conducted a cross-sectional hospital based study from November 2016 to June 2017 in which we recruited 204 consenting women aged 18 to 55 years. A questionnaire was administered to study participants and potential risk factors for Chlamydia exposure sought. Venous blood was collected and serum from each participant analysed for C. trachomatis infection as evidenced by positive anti-C. trachomatisIgG and IgM antibodies detected using the Sandwich Enzyme-Linked ImmunoSorbent Assay (ELISA) technique. The proportion of anti-C. trachomatis antibody was calculated and predictors of C. trachomatis infection analysed by univariate and multivariate regression. Epi-Info 7 was used for statistical analyses. A p < 0.05 was considered significant in all analyses. Results: The seroprevalence of anti-C. trachomatisantibodies (IgM or IgG) was found to be62.25% [127/204]. Among seropositive women, 37.15% [77/204] were seropositive for IgG antibodies while 47.54% [97/204] were seropositive for IgM antibodies and 23.04% [47/204] where seropositive for both IgM and IgG antibodies. Among the risk factors evaluated, marital status (P= 0.03) and knowledge of Chlamydia (P= 0.001) were observed to be an independent risk factor of C. trachomatisinfection. Conclusions: Our findings suggest recent C. trachomatisexposure is high in our study population, and may constitute a significant risk factor for, ocular and pulmonary infection in new born child, infertility to women. Education and screening of HIV-positive individuals and pregnant women for C. trachomatisinfection may be important primary prevention strategies in this population.

scholarly journals Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

2018 ◽  
Vol 8 (3) ◽  
pp. 223-231 ◽  
Author(s):  
Tomohiro Yubi ◽  
Jun Hata ◽  
Tomoyuki Ohara ◽  
Naoko Mukai ◽  
Yoichiro Hirakawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Mri ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Cerebral Microbleeds ◽  
Health Examination ◽  
Cross Sectional ◽  
Comprehensive Health ◽  
Japanese Elderly

BackgroundWe investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly.MethodsIn 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2*-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis.ResultsThe crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ε4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers.ConclusionsOur study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.

scholarly journals Necrotizing enterocolitis in term neonates: Possible risk factors

2020 ◽  
Vol 9 ◽  
pp. 22
Author(s):  
Ayman Elhosny ◽  
Corné De Vos ◽  
Behrouz Banieghbal
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Necrotizing Enterocolitis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Term Neonates ◽  
Maternal Risk ◽  
Premature Neonates ◽  
Study Results ◽  
Neonatal Risk Factors

Background: Necrotizing enterocolitis (NEC) is a common surgical disease in premature neonates, however, it may occasionally occur in term neonates. The etiology of NEC in prematurity is multifactorial but is still not well understood in term neonates. In this study, the maternal and neonatal risk factors, along with underlying pathology that may precipitate NEC in term neonates are investigated.  Methods: A retrospective study investigating the maternal and neonatal risk factors for NEC in term neonates (G.A ≥37 weeks) was performed over an 8-years period (January 2009 to March 2017). We used the second group of healthy term neonates over the same period as a control group. The data were collected from medical records. Term babies with the primary diagnosis of NEC were included in the review. Premature neonates (G.A <37 weeks) and NEC secondary to intestinal obstruction (e.g. Hirschsprung’s disease) were excluded from the study. Results: Of 194 babies with NEC, 14 were term neonates. Maternal risk factors: maternal age, Rhesus status, nicotine use, medication use, chronic and gestational illness were not found to be significant, however, maternal methamphetamine (MA) abuse was found to be a significant risk factor. Neonatal risk factors: genetic disorder, mode of delivery, type of milk, and invasive procedure were not found to be significant, but the presence of congenital heart disease (CHD) was a significant risk factor. Three neonates with CHD (3/4) in the group of term neonates with NEC also had maternal MA use. Conclusion: NEC in term neonates is rarely encountered. CHD is well known to precipitate the disease in premature or full-term neonates, as also noted in this cohort. MA usage was also noted as a possible underlying cause.

scholarly journals PREVALENSI DAN FAKTOR RISIKO INFEKSI Toxocara cati PADA KUCING PELIHARAAN DI KOTA BOGOR (Prevalence and Risk Factors of Toxocara cati Infection in Bogor Pet Cats)

2016 ◽  
Vol 10 (2) ◽  
pp. 139-142
Author(s):  
Murniati Murniati ◽  
Etih Sudarnika ◽  
Yusuf Ridwan
Keyword(s):  
Risk Factors ◽  
Care Management ◽  
Significant Risk ◽  
Public Health Problem ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Toxocara Cati ◽  
Chi Square ◽  
Cross Sectional ◽  
Pet Owner

The aims of this research were to estimate the prevalence and to determine the risk factors related to Toxocara cati (T. cati) infection in pet cats in Bogor. This study was cross sectional study using two types of data; laboratory examination results of feces samples and interview results of the cat owner using a structured questionnaires including characteristics of pet owner and pet care management. The data obtained from this study was analyzed using chi-square test. The results showed that 85 of 243 cats were positively infected by T. cati with 35% prevalence. The significant risk factor associated with the T. cati infection were: sex, sand provided, deworming and type of feed. Pet care management in Kota Bogor were well managed, however the prevalence of T. cati infection was still high. Therefore it can be a potential public health problem especially on cat owners.

scholarly journals Concordance of chronic conditions among the household members in Shanghai: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e031240 ◽  
Author(s):  
Yingyi Qin ◽  
Yibin Guo ◽  
Yuanjun Tang ◽  
Cheng Wu ◽  
Xinji Zhang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Conditions ◽  
Chronic Condition ◽  
Significant Risk ◽  
Disease Status ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Health Insurance Status ◽  
Household Members

ObjectivesMembers living in the same household tend to share some similar behaviours and environment. We want to quantitatively assess the associations of chronic conditions to investigate the concordance of disease status among the household members.SettingShanghai, China.ParticipantsOur data were from the fifth Health Service Survey in Shanghai in 2013. 12 002 households with 31 531 residents were selected in this survey by using a three-stage, stratified, random sampling method.Outcome measuresFive highly prevalent chronic conditions, namely hypertension, diabetes, ischaemic heart disease (IHD), cerebrovascular disease (CVD) and obesity were chosen. The generalised estimating equations (GEE) model was used to estimate the associations adjusted for age, gender, education status, health insurance status, smoking and drinking. Using a subsample of adult children with parents’ chronic conditions as the key risk factor and a subsample of wives with the chronic conditions of the husband as key risk factor, we reran our GEE models to explore chronic condition concordance within these relationships.ResultsA total of 10 198 households with 27 010 adult participants were included. Using all adult household members, we found positive statistically significant associations between one’s chronic conditions and the same disease status of their household members (hypertension (OR=3.26, 95% CI 3.02 to 3.52); diabetes (OR=1.68, 95% CI 1.40 to 2.01); IHD (OR=5.31, 95% CI 3.56 to 7.92); CVD (OR=3.40, 95% CI 1.99 to 5.80); obesity (OR=3.41, 95% CI 2.34 to 4.96)). The results of analysing ad-child subsample and spouse subsample also showed similar associations. Moreover, the potential concordance of different chronic conditions was found between hypertension and diabetes.ConclusionsWe found chronic condition concordance within households. This study provides evidence that the chronic conditions of other members of a household may be a significant risk factor for a household member’s own health.

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