scholarly journals The relationship between infant iron status and risk of neurological impairment

2018 ◽  
Vol 57 (6) ◽  
pp. 291
Author(s):  
Buntat Buntat ◽  
Nurhayati Masloman ◽  
Johnny Rompis
Keyword(s):  
High Risk ◽  
Iron Deficiency ◽  
Iron Status ◽  
Neurological Impairment ◽  
Low Risk ◽  
Perinatal Complications ◽  
Nutritional Disorder ◽  
Persistent Problem ◽  
Developmental Impairment ◽  
The Relationship

Background Iron deficiency (ID) is a commonly found nutritional disorder and a persistent problem, especially in Indonesia. Iron deficiency during the critical period in childhood brain development is estimated to cause irreversible damage that hinders infant development.Objective To determine the relationship between infant iron status and neurological development.Methods We conducted a cross-sectional study at the Growth and Development Outpatient Clinic, Prof. Dr. R. D. Kandou Hospital, Manado, from March to May 2015. By consecutive sampling, we obtained 44 healthy infants aged 7 to 10 months who fulfilled the inclusion criteria. Infants with a history of perinatal complications, such as head trauma, hypoglycemia, respiratory distress syndrome, infection, or malaria were excluded Subjects’ serum hemoglobin and ferritin were examined for iron status. Infants’ risk of neurological impairment was assessed by the Bayley Infant Neurodevelopmental Screener (BINS). Results were analyzed by descriptive analysis for the characteristics and Spearman’s rank correlation coefficient analysis for the relationship between iron status and neurological development.Results From 14 infants with ID, 8 infants had a high risk of developmental impairment. Of the 30 non-ID subjects, 4 infants had a high risk of developmental impairment. Of the 30 non-ID infants, 16 infants had a low risk of impaired development, while 2 infants with ID had low risk of developmental impairment. Spearman’s rho revealed that infant iron deficiency was significantly associated with high risk of neurological impairment. (r=-0.547; P<0.0001).Conclusion Lower serum ferritin levels (iron deficiency) is significantly associated with greater risk of impaired neurological development in infants aged 7-10 months.

scholarly journals The relationship between infant iron status and risk of neurological impairment

2017 ◽  
Vol 57 (6) ◽  
pp. 291
Author(s):  
Buntat Buntat ◽  
Nurhayati Masloman ◽  
Johnny Rompis
Keyword(s):  
High Risk ◽  
Iron Deficiency ◽  
Iron Status ◽  
Neurological Impairment ◽  
Low Risk ◽  
Perinatal Complications ◽  
Nutritional Disorder ◽  
Persistent Problem ◽  
Developmental Impairment ◽  
The Relationship

Background Iron deficiency (ID) is a commonly found nutritional disorder and a persistent problem, especially in Indonesia. Iron deficiency during the critical period in childhood brain development is estimated to cause irreversible damage that hinders infant development.Objective To determine the relationship between infant iron status and neurological development.Methods We conducted a cross-sectional study at the Growth and Development Outpatient Clinic, Prof. Dr. R. D. Kandou Hospital, Manado, from March to May 2015. By consecutive sampling, we obtained 44 healthy infants aged 7 to 10 months who fulfilled the inclusion criteria. Infants with a history of perinatal complications, such as head trauma, hypoglycemia, respiratory distress syndrome, infection, or malaria were excluded Subjects’ serum hemoglobin and ferritin were examined for iron status. Infants’ risk of neurological impairment was assessed by the Bayley Infant Neurodevelopmental Screener (BINS). Results were analyzed by descriptive analysis for the characteristics and Spearman’s rank correlation coefficient analysis for the relationship between iron status and neurological development.Results From 14 infants with ID, 8 infants had a high risk of developmental impairment. Of the 30 non-ID subjects, 4 infants had a high risk of developmental impairment. Of the 30 non-ID infants, 16 infants had a low risk of impaired development, while 2 infants with ID had low risk of developmental impairment. Spearman’s rho revealed that infant iron deficiency was significantly associated with high risk of neurological impairment. (r=-0.547; P<0.0001).Conclusion Lower serum ferritin levels (iron deficiency) is significantly associated with greater risk of impaired neurological development in infants aged 7-10 months.

scholarly journals The iron status and the relationship between iron deficiency and body mass index in middle school girls

2006 ◽  
Vol 49 (11) ◽  
pp. 1174 ◽  
Author(s):  
Hee Youn Han ◽  
Chang Joo Hee ◽  
Hae Sun Shim ◽  
Young Jin Hong ◽  
Byong Kwan Son ◽  
...  
Keyword(s):  
Middle School ◽  
Body Mass Index ◽  
Iron Deficiency ◽  
Body Mass ◽  
Iron Status ◽  
Middle School Girls ◽  
School Girls ◽  
The Relationship

scholarly journals Inflammation in the lungs of patients diagnosed with Cystic Fibrosis: Association with iron deficiency

SURG Journal ◽  
1969 ◽  
Vol 2 (1) ◽  
pp. 3-10
Author(s):  
Dawn Armstrong ◽  
Lindsay Robinson
Keyword(s):  
Cystic Fibrosis ◽  
Iron Deficiency ◽  
Inflammatory Cytokines ◽  
Wide Spectrum ◽  
Iron Status ◽  
Tissue Destruction ◽  
Hypoxic Conditions ◽  
Mediators Of Inflammation ◽  
The Relationship

Cystic Fibrosis (CF) is characterized by a wide spectrum of phenotypic characteristics such as; deep coughing, increased mucous production, and weight loss. However, only recently was the role of inflammation on the etiology of the disease recognized. CF is characterized as a cyclic progression of infective exacerbations and stable periods initiated by the presence of Pseudomonas Aeruginosa (PA). An increase in inflammatory cytokines/mediators and a decrease in anti-inflammatory cytokines contribute to the net inflammation and overall tissue destruction of the lungs. PA is associated with the low iron status that is seen in 60-75% of the CF population, through the presence of iron sequestering siderophores which distract iron from the tissues. Iron deficiency (ID) initiates further symptoms such as; fatigue, tachycardia, weakness, brittle nails etc, in addition to those caused by CF. The colonization of PA may be the cause or a result of increased iron (ferritin) concentrations in the lungs, but independent of the original relationship, results in a decreased iron status. Iron is used by PA under hypoxic conditions such as in the fibrosis lung, as a source of energy. Studies on the relationship between CF and ID contribute a variety of possible causes although currently no direct connection has been discovered. At this stage, further studies in this area are needed. This review will primarily focus on the affects of CF on iron status in humans, and secondarily examine the effect of mediators of inflammation in respects to ID.

scholarly journals MR-proADM and MR-proANP levels in patients with acute pulmonary embolism

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Önsel Öner ◽  
Figen Deveci ◽  
Selda Telo ◽  
Mutlu Kuluöztürk ◽  
Mehmet Balin
Keyword(s):  
Pulmonary Embolism ◽  
High Risk ◽  
Mortality Rate ◽  
Hospital Mortality ◽  
Acute Pulmonary Embolism ◽  
Low Risk ◽  
Control Group ◽  
High Risk Patients ◽  
Risk Patients ◽  
The Relationship

Summary Background The aim of this study was to determine levels of Mid-regional Pro-adrenomedullin (MR-proADM) and Mid-regional Pro-atrial Natriuretic Peptide (MR-proANP) in patients with acute pulmonary embolism (PE), the relationship between these parameters and the risk classification in addition to determining the relationship between 1- and 3-month mortality. Methods 82 PE patients and 50 healthy control subjects were included in the study. Blood samples for MR-proANP and MR-proADM were obtained from the subjects prior to the treatment. Risk stratification was determined according to sPESI (Simplified Pulmonary Embolism Severity Index). Following these initial measurements, cases with PE were assessed in terms of all causative and PE related mortalities. Results The mean serum MR-proANP and MR-proADM levels in acute PE patients were found to be statistically higher compared to the control group (p < 0.001, p < 0.01; respectively) and statistically significantly higher in high-risk patients than low-risk patients (p < 0.01, p < 0.05; respectively). No statistical difference was determined in high-risk patients in case of sPESI compared to low-risk patients while hospital mortality rates were higher. It was determined that the hospital mortality rate in cases with MR-proANP ≥ 123.30 pmol/L and the total 3-month mortality rate in cases with MR-proADM ≥ 152.2 pg/mL showed a statistically significant increase. Conclusions This study showed that MR-proANP and MR-proADM may be an important biochemical marker for determining high-risk cases and predicting the mortality in PE patients and we believe that these results should be supported by further and extensive studies.

scholarly journals Relationship between RNASE1, ANG and RNASE6 gene polymorphism and the values of blood indices in suckling piglets

2019 ◽  
Vol 67 (3) ◽  
pp. 385-400
Author(s):  
Hanna Szymańska ◽  
Krystyna Życzko ◽  
Tadeusz Zabolewicz
Keyword(s):  
Iron Deficiency ◽  
Gene Polymorphism ◽  
Iron Status ◽  
Dependent Manner ◽  
Large White ◽  
Blood Indices ◽  
Suckling Piglets ◽  
Hardy Weinberg Equilibrium ◽  
Red Blood Cell Indices ◽  
The Relationship

The relationship between PcR-restriction fragment length polymorphism in RNASE1 (296 A/G), ANG (149 G/T) and RNASE6 (389 C/T) genes and the values of haematological and biochemical blood indices was analysed in crossbred suckling piglets (n = 473), aged 21 ± 3 days (younger, n = 274) and 35 ± 3 days (older, n = 199), descending from Polish Large White × Polish Landrace sows and Duroc × Pietrain boars. The observed distribution of all genotypes was consistent with the Hardy-Weinberg equilibrium. Anaemia was more common in younger piglets with RNASE1 GA genotype but in the blood of older GA piglets a higher count and percentage of granulocytes were noted. This could be related to the destruction of erythrocytes in younger piglets and enhanced host defence in older ones. ANG gene polymorphism was associated with the severity of iron deficiency in younger piglets. This is supposed to be linked with the different ability to protect immune cells against suppression and degradation during iron deficiency. in older piglets, this mutation differentiated the reactivity of the immune system. Varying levels of iron status and red blood cell indices in RNASE6 genotypes presumably resulted from the coupling of genes involved in iron metabolism and expressed in an age-dependent manner.

scholarly journals Behavioral finance: the analysis of investor behavior based on belief and feeling and the investor rationality towards LQ 45 stocks

2018 ◽  
Vol 15 (1) ◽  
pp. 292-298
Author(s):  
Etty Indriani ◽  
Cahyani Tunggal Sari
Keyword(s):  
Regression Analysis ◽  
High Risk ◽  
Behavioral Finance ◽  
Significant Relationship ◽  
Stock Exchange ◽  
Low Risk ◽  
Investor Behavior ◽  
Average Return ◽  
High Return ◽  
The Relationship

This research analyzes behavioral finance, especially the behavior of investors in Yogyakarta, Indonesia Region. The performance of investor behavior is examined based on the LQ 45 stocks return on Indonesia Stock Exchange and questionnaires that are spread out to five securities agents in Yogyakarta.The performance of LQ 45 stocks return is compared to the questionnaire analysis in the “Belief” part at the first and second stages. The first result shows that LQ 45 stocks are profitable. It can be seen from the average return of the stocks that it has positive value and is statistically identical with the LQ 45 index return. This result is in line with the investors’ opinion that LQ 45 stocks are profitable. The second result shows that most of LQ 45 stocks are profitable and give high return. But, this result is also contrary to the opinion of investors towards traditional finance paradigm that investors still believe “high risk – high return, low risk – low return”. Although most of LQ 45 stocks are considered as low risk stocks, many investors prefer to choose LQ 45 stocks. It means that the traditional finance paradigm has weakness. It is proven that investors sometimes act irrationally.The third and fourth stages of the study are aimed to analyze the relationship between feeling and belief towards frequency of transaction each day based on the questionnaire using regression analysis. The result shows that there is significant relationship between feeling and frequency of transaction each day.

scholarly journals The relationship between the female athlete triad and injury rates in collegiate female athletes

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11092
Author(s):  
Mutsuaki Edama ◽  
Hiromi Inaba ◽  
Fumi Hoshino ◽  
Saya Natsui ◽  
Sae Maruyama ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Body Weight ◽  
High Risk ◽  
Low Risk ◽  
Risk Category ◽  
Moderate Risk ◽  
Long Distance ◽  
Injury Group ◽  
The Relationship ◽  
Risk Categories

Background This study aimed to clarify the relationship between the triad risk assessment score and the sports injury rate in 116 female college athletes (average age, 19.8 ± 1.3 years) in seven sports at the national level of competition; 67 were teenagers, and 49 were in their 20s. Methods Those with menstrual deficiency for >3 months or <6 menses in 12 months were classified as amenorrheic athletes. Low energy availability was defined as adolescent athletes having a body weight <85% of ideal body weight, and for adult athletes in their 20s, a body mass index ≤17.5 kg/m2. Bone mineral density (BMD) was measured on the heel of the right leg using an ultrasonic bone densitometer. Low BMD was defined as a BMD Z-score <−1.0. The total score for each athlete was calculated. The cumulative risk assessment was defined as follows: low risk (a total score of 0–1), moderate risk (2–5), and high risk (6). The injury survey recorded injuries referring to the injury survey items used by the International Olympic Committee. Results In swimming, significantly more athletes were in the low-risk category than in the moderate and high-risk categories (p = 0.004). In long-distance athletics, significantly more athletes were in the moderate-risk category than in the low and high-risk categories (p = 0.004). In the moderate and high-risk categories, significantly more athletes were in the injury group, whereas significantly more athletes in the low-risk category were in the non-injury group (p = 0.01). Significantly more athletes at moderate and high-risk categories had bone stress fractures and bursitis than athletes at low risk (p = 0.023). Discussion These results suggest that athletes with relative energy deficiency may have an increased injury risk.

scholarly journals Pulse Probiotic Superfood as Iron Status Improvement Agent in Active Women—A Review

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2121
Author(s):  
Yolanda Victoria Rajagukguk ◽  
Marcellus Arnold ◽  
Anna Gramza-Michałowska
Keyword(s):  
High Risk ◽  
Iron Deficiency ◽  
Beneficial Effect ◽  
21St Century ◽  
Functional Food ◽  
Dietary Intervention ◽  
Iron Absorption ◽  
Iron Status ◽  
Reproductive Age ◽  
Women Of Reproductive Age

Active women or women of reproductive age (15–49 years old) have a high risk of suffering from anaemia. Anaemia is not solely caused by iron deficiency, however, the approaches to improve iron status in both cases are greatly related. Improving the iron status of active women can be done by dietary intervention with functional food. This review aims to provide insights about the functional food role to increase iron absorption in active women and the potency of pulse probiotic superfood development in dry matrices. Results showed that the beneficial effect of iron status is significantly improved by the synergic work between probiotic and prebiotic. Furthermore, chickpeas and lentils are good sources of prebiotic and the consumption of pulses are related with 21st century people’s intention to eat healthy food. There are wide possibilities to develop functional food products incorporated with probiotics to improve iron status in active woman.

Guanylyl cyclase C (GCC) expression in lymph nodes (LNs) as a determinant of recurrence in stage II colon cancer (CC) patients (pts).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 3639-3639
Author(s):  
Daniel J. Sargent ◽  
Qian Shi ◽  
Sharlene Gill ◽  
Christophe Louvet ◽  
Richard Bernard Everson ◽  
...  
Keyword(s):  
High Risk ◽  
Cox Regression ◽  
Risk Group ◽  
Tumor Grade ◽  
High Risk Group ◽  
Low Risk ◽  
Stage Ii ◽  
Risk Class ◽  
Tissue Procurement ◽  
The Relationship

3639 Background: The first phase of the multi-center prospectively specified retrospective study Validating Indicators To Associate Recurrence (VITAR), assessing the relationship between GCC gene expression in formalin fixed (FFPE) LNs and time to recurrence (TTR) in stage II CC pts not treated with adjuvant chemotherapy (Sargent, Annals Surg Onc 2011), showed promising initial results. Here we report a validation set of 463 new stage II CC pts. Methods: GCC mRNA was quantified by RT-qPCR using FFPE LNs from untreated T3N0 CC pts diagnosed from 1999-2008 with at least 12 LNs examined , blinded to clinical outcomes. Patients were classified by GCC LN ratio (LNR) (high risk: LNR > 0.1; low risk: LNR ≤ 0.1), with LNR defined as ratio of GCC positive to GCC informative LNs. Cox regression models tested the relationship between GCC and the primary endpoint of TTR, adjusted for age, tumor grade, number of LN examined pathologically, and lymphovascular invasion. Mismatch repair (MMR) status was also assessed. All primary analyses and cut-points were pre-specified. Results: 46pts (10%) recurred (rec), median follow-up was 65 months, median LNs examined was 20, and 42% (195/463) were classified high risk. Overall, TTR was not significantly associated with binary GCC LNR risk class (HR=1.47, p=.208) or DFS (HR= 1.39, p=.097). One site’s (n=97) tissue grossing method precluded appropriate LN assessment with existing GCC qualification methods. Excluding this site resulted in a TTR HR=1.91, p=0.051 (multivariate). In a post-hocanalysis excluding this site and using a 3-level GCC risk group of high (LNR > 0.20), intermediate (0.10 < LNR < 0.20) and low (LNR < 0.10), high risk group pts had a 5-yr rec risk of 22% versus 8% in low risk (HR 2.72, p=0.006). MMR status was not significantly associated with TTR (multivariate p=0.30). Conclusions: GCC status is a promising prognostic factor in appropriately staged stage II CC pts not treated with adjuvant therapy independent of traditional histopathology risk factors, but GCC determination must be performed with methodology adapted to the tissue procurement and fixation technique. Outcome associations were strengthened when considering a 3-level GCC categorization.

scholarly journals The Relationship between Locomotive Syndrome Risk, Gait Pattern, and Standing Posture in Young Japanese Women: A Cross-Sectional Study

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 565
Author(s):  
Yuichi Uesugi ◽  
Saki Kanaya ◽  
Hiroko Nakanishi ◽  
Yoshihiko Naito
Keyword(s):  
High Risk ◽  
Stride Length ◽  
Risk Group ◽  
High Risk Group ◽  
Low Risk ◽  
Locomotive Syndrome ◽  
Standing Posture ◽  
Cross Sectional ◽  
Young Japanese Women ◽  
The Relationship

Young people are also at risk of developing locomotive syndrome for unclear reasons. Therefore, we sought to evaluate the locomotive syndrome risk in young Japanese women and the relationship between standing posture and gait patterns. We used survey materials for physical measurements, locomotive syndrome risk tests, normal and maximum walking test, a standing posture test, and physical activity measures. A questionnaire-based cross-sectional survey was conducted with 100 Japanese female university students. The participants were divided into two groups (high-risk and low-risk groups) based on locomotive syndrome risk tests. The high-risk group accounted for 65.0% of the total participants. The high-risk group had a significantly slower walking speed and lower walking stride length than the low-risk group during maximum walking. Additionally, this high-risk group had a more prone posture than the low-risk group. Furthermore, the low-risk group included more individuals who belonged to middle and high school athletic clubs than the high-risk group. The locomotive syndrome risk was related to the walking pattern, standing posture, and past exercise habits. Therefore, long stride length, correct standing posture, and exercise habits acquired from a young age are important measures for preventing locomotive syndrome in young adults.

Sign in / Sign up

Export Citation Format

Share Document