scholarly journals Treatment of diffuse euthyroid goiter in children

2019 ◽  
Vol 45 (1) ◽  
pp. 23-26
Author(s):  
T. E. Taranushenko ◽  
A. Ya. Panfilov ◽  
S. A. Dogadin
Keyword(s):  
Conservative Treatment ◽  
Potassium Iodide ◽  
Thyroid Volume ◽  
Therapeutic Effects ◽  
Weekly Dose ◽  
High Prevalence ◽  
Daily Dose ◽  
Toxic Goiter ◽  
Methods Of Treatment ◽  
Positive Results

High prevalence of diffuse euthyroid goiter and inefficiency of conservative treatment aimed at normalization of thyroid volume necessitate search for optimal methods of treatment. Results of thyroxin and potassium iodide (antistrumin) therapy of 110 children with diffuse toxic goiter, living in a region with medium-grave iodine deficiency, are analyzed. The diagnosis was verified by clinical data, ultrasonic examinations, and hormone measurements. Changes in the volume of the thyroid under the effect of thyroxin and antistrumin therapy could be variously directed: the involved thyroid might enlarge, shrink, or not change at all. Therapeutic effects of thyroxin and antistrumin on the degree of thyroid decrease and incidence of positive results after 6-month therapy were virtually the same. Thyroxin in a daily dose of 2.0-2.5 \xg/kg promoted a decrease and normalization of the thyroid size. Efficacy of thyroxin significantly increased if it was used longer than for 6 months. Potassium iodide (antistrumin) in a weekly dose of 2000 pg (equivalent to daily 200 pg iodine) led to decrease of goiter size and normalization of the thyroid volume. The best results were observed after a no more than 6-month course of treatment. A longer course brought about a tendency to a higher incidence of untoward effects (enlargement of the thyroid).

scholarly journals Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease

2016 ◽  
Vol 4 (1) ◽  
pp. 152-157 ◽  
Author(s):  
Spiro Spasovski ◽  
Zlatanka Belazelkoska ◽  
Mirjana Popovska ◽  
Aneta Atanasovska-Stojanovska ◽  
Vera Radojkova-Nikolovska ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Periodontal Disease ◽  
Total Dose ◽  
Dental Plaque ◽  
Therapeutic Effects ◽  
Gingival Inflammation ◽  
Once Daily ◽  
Full Dose ◽  
Average Value ◽  
Gingival Bleeding

OBJECTIVE: To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease.MATERIAL AND METHODS: A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients a conservative treatment was carried out and ordinated the proper dose doxycycline in total dose during treatment from 3 gr. Index of dental plaque by Löe-Sillness, index of gingival inflammation and gingival bleeding by Cowell were followed.RESULTS: Values of dental plaque in relation first examination, 10th, 20th day, 1 month and 2.5 months, showed that after 2.5 months, average value (x = 0.83) of dental plaque in second group is slightly less than the value (x = 0.93) of dental plaque in the first group. The average value (x = 0.17) of gingival inflammation in second group is significantly less than the value (x = 0.50) of gingival inflammation in the first group. The average value (x = 0.97) of gingival bleeding in patients from the first group was significantly higher than value(x = 0.37) of gingival bleeding in the second group.CONCLUSION: Patients whose therapy was helped by a sub-dose doxycycline demonstrated positive therapeutic effects on gingival inflammation and bleeding.

scholarly journals Increased prevalence of thyroglobulin antibodies in Sri Lankan schoolgirls--is iodine the cause?

2000 ◽  
pp. 185-188 ◽  
Author(s):  
LD Premawardhana ◽  
AB Parkes ◽  
PP Smyth ◽  
CN Wijeyaratne ◽  
A Jayasinghe ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Age Groups ◽  
Thyroid Volume ◽  
Thyroid Peroxidase ◽  
Sri Lankan ◽  
Free T4 ◽  
Thyroglobulin Antibodies ◽  
Age Related ◽  
High Prevalence ◽  
Urine Iodine

OBJECTIVE: Iodine deficiency was the likely cause of a high prevalence of goitre previously in Sri Lankan schoolchildren. Salt iodination was made compulsory in 1993 but there has been no recent study, using modern techniques, of its benefits or harmful effects. METHODS: Three hundred and sixty-seven schoolgirls between the ages of 11 and 16 years had ultrasound thyroid volume, free thyroxine (T4), free tri-iodothyronine (T3), thyrotrophin (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) antibodies, and urine iodine concentrations measured. RESULTS: Median ultrasound thyroid volume ranged from 4.8 ml (11-year-old girls) to 8.6 ml (16-year-old girls) with an age-related increase. Median urine iodine concentrations ranged from 105 to 152 microg/l. Free T4 and free T3 were normal in all, but TSH was elevated in four subjects (5. 53-41.29 mU/l). However, the prevalence of TgAb was markedly raised, ranging between 14.3% (11-year-old girls) and 69.7% (16-year-old girls) (P<0.03). In contrast, the prevalence of TPOAb was 10% or less in all age groups. CONCLUSIONS: Normal median thyroid volumes, iodine concentrations and thyroid function would indicate that iodine deficiency is not a major problem in this group. The high prevalence of TgAb, hitherto unreported, most likely reflects excessive iodination of Tg resulting in increased immunogenicity. There is an urgent need to continuously monitor the adequacy and risks of iodination in this population.

scholarly journals Goitre prevalence and epidemiological features in children living in areas with mildly excessive iodine in drinking-water

2013 ◽  
Vol 111 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Shengmin Lv ◽  
Dong Xu ◽  
Yuchun Wang ◽  
Zhenshui Chong ◽  
Yonggui Du ◽  
...  
Keyword(s):  
Drinking Water ◽  
Thyroid Volume ◽  
Hebei Province ◽  
Age Group ◽  
Who Criteria ◽  
Epidemiological Features ◽  
Excessive Iodine ◽  
High Prevalence ◽  
Goitre Prevalence ◽  
Epidemiological Characteristics

The prevalence of goitre in areas with mildly excessive iodine in drinking-water is still under debate. The aim of the present study was to explore the prevalence of goitre and its epidemiological characteristics in these areas using WHO criteria. To this end, three towns with a median water iodine (MWI) of 150–300 μg/l were selected randomly in Hengshui City of Hebei Province of China, and one town with a MWI of 105 μg/l was chosen as a control. A total of 452 children in the three towns and 120 children in the control town were randomly selected to measure thyroid volume (Tvol) by ultrasound. The goitre status of these children was judged using the criteria recommended by the WHO. The overall goitre prevalences in the three towns were 24·6 % (111/452) by age-specific Tvol and 33·0 % (149/452) by body surface area (BSA)-adjusted Tvol, which were significantly higher than that in the control town by both age-specific Tvol (14·0 % (17/120), P= 0·015) and BSA-adjusted Tvol (17·5 % (21/120), P= 0·001). Significant differences were found neither in goitre prevalences across sex by both age-specific Tvol (P= 0·078) and BSA-adjusted Tvol (P= 0·692) nor in that across age group by both BSA-adjusted Tvol (P= 0·461) and age-specific Tvol (P= 0·183). The present study found a high prevalence of goitre in children living in areas with mildly excessive iodine in drinking-water in Hebei Province. No significant differences were found in goitre prevalences across sex and age group. These results suggest that the Tvol reference values recommended by the WHO could be too low for Chinese children.

Old and New Methods of Treatment in General Paralysis: A Comparison of Results

1929 ◽  
Vol 75 (309) ◽  
pp. 250-256
Author(s):  
G. E. Shand
Keyword(s):  
Potassium Iodide ◽  
General Paralysis ◽  
New Methods ◽  
Comparison Of Results ◽  
Methods Of Treatment ◽  
Very High

During the five years prior to the war I carried out a series of investigations on the treatment of general paralysis. The proportion of general paralytics resident at this hospital was then very high—some 40 out of our usual 350 males. The only treatment given by us up to that time had been mercury and potassium iodide.

scholarly journals Exposure-Response Relationships for Efficacy and Safety of Filgotinib and its metabolite GS-829845 in Subjects with Rheumatoid Arthritis Based on Phase 2 and Phase 3 Studies

2021 ◽  
Author(s):  
Amy Meng ◽  
Kacey Anderson ◽  
Cara Nelson ◽  
Liyun Ni ◽  
Shu-Min Chuang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Therapeutic Effects ◽  
Phase 2 ◽  
Phase 3 ◽  
Two Phase ◽  
Once Daily ◽  
Exposure Response ◽  
Daily Dose

Aims:Filgotinib is a potent, oral, JAK1-preferential inhibitor for the treatment of rheumatoid arthritis (RA). This report describes exposure-response (ER) analyses of filgotinib for dose confirmation based on three Phase 3 and two Phase 2 studies in moderate to severe RA patients. Methods:The PK exposures used in ER analyses were derived from population pharmacokinetic analysis. The relationship between filgotinib exposures and various efficacy endpoints (ACR20/50/70 and DAS28) was assessed over octile groups of exposures by using combined exposures of filgotinib and GS-829845 (major, active metabolite). For the ER analyses of safety, exposures were examined between subjects who experienced and who did not experience the evaluated safety events, which was conducted separately for filgotinib and GS-829845. Results:Exposure efficacy relationships consistently revealed high response rates across the exposure range for filgotinib 200 mg once daily dose. A trend of increasing response with increasing exposure was observed over the exposure range for the primary and multiple secondary efficacy endpoints, with exposures associated with the 200 mg dose primarily residing on the curve plateau. For exposure-safety analyses, filgotinib and GS-829845 exposures were similar irrespective of presence/absence of the evaluated safety endpoints, indicating no exposure-safety relationship for common TEAEs, common laboratory abnormalities, serious TEAEs, or serious infections. Conclusions:ER analyses confirmed that filgotinib produced more robust therapeutic effects across the exposure range observed at 200 mg once daily compared to lower doses. The positive exposure-efficacy relationship and a lack of exposure-safety relationship on the evaluated safety endpoints supported the 200 mg once daily dose for commercialization.

scholarly journals Peculiarities of endodontic treatment of chronic symptomatic periodontitis on oncological disease and chemotherapy

2019 ◽  
Vol 06-07 (1-2) ◽  
pp. 8-11
Author(s):  
O.V. Vozniy ◽  
A.M. Filon
Keyword(s):  
Oral Cavity ◽  
Dental Care ◽  
Endodontic Treatment ◽  
Malignant Neoplasms ◽  
Dental Disease ◽  
Chemotherapy Treatment ◽  
Periapical Lesions ◽  
High Prevalence ◽  
Inflammatory Processes ◽  
Methods Of Treatment

Providing dental care to cancer patients has been and remains very relevant. Studies of the oral cavity in this category of patients have found a high prevalence of dental disease and, as a consequence, a significant need for dental care. Chemotherapy can cause complications such as stomatitis, mucositis, exacerbation of chronic pulpitis, and periodontitis. Patients with an unsanctioned oral cavity run the risk of developing these complications, unlike patients who regularly visit the dentist. The aim of our work was to study the features of endodontic treatment of patients with malignant neoplasms receiving chemotherapy treatment and to confirm the use of atraumatic and conservative methods of treatment of periapical inflammatory processes. The results obtained confirm that the elimination of infection in the root canal of the teeth leads to the regeneration of periapical lesions of bone tissue. The size of the lesion does not affect the tactics of treatment.

scholarly journals Prevalence of Helicobacter pylori vacA, cagA, cagE1, cagE2, dupA and oipA Genotypes in Patients With Gastrointestinal Diseases

2020 ◽  
Author(s):  
Hossein Masoumi Asl ◽  
Ali Badamchi ◽  
Shima Javadinia ◽  
Siamak Khaleghi ◽  
Leila Tehraninia ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastrointestinal Diseases ◽  
Cancer Group ◽  
Urease Test ◽  
High Prevalence ◽  
Vaca Gene ◽  
H Pylori ◽  
Positive Results ◽  
Gastroenterology Unit

Helicobacter pylori (H. pylori) is a bacterium that resides in the human stomach, which is associated with gastroduodenal diseases. We investigate the prevalence of cagA, vacA, oipA, cagE1, cagE2 and dupA genotypes in H. pylori isolated from patients with Gastric ulcer, duodenal ulcer, and Gastric Cancer. Collected 74 samples from the Gastroenterology Unit of the Rasool Akram Hospital were included in this study. Gastric disorders were identified by endoscopy .gastric cancer was further confirmed by histopathology. H. pylori were detected by the urease test. Subsequently, DNA was extracted from gastric tissue of the subjects with the CLO-test yielded positive results. In general, 74 patients with a mean age of 53.45 years (Range 22 to 86-year-old), including 45 men and 29 women, were studied. Among 74 H. pylori-positive patients, 70 (94.5%) patients were positive for the cagA gene. About 95.8% (23/24) of the patients with gastric carcinoma were dupA positive and VacA gene (91.8%). The oipA genotype was detected in 71 (96%) of H.pylori positive samples. This gene was more common in patients with gastritis rather than cancer group. Also, 97.2% of 74 H. pylori isolates were cagE2-positive. In 25 patients with PUD, the occurrence percent of cagA+/VacA+, cagA+/Vac- , cagA- /VacA+ and cagA- /VaxA- genotypes were found 80%, 12%, 4.2% and 4.2 respectively. The results of the present study suggest that a high prevalence of virulent factors could contribute to the risk of developing gastroduodenal diseases.

scholarly journals Dystocia due to congenital defects in Iraqi ewes at Fallujah

2018 ◽  
Vol 11 (2) ◽  
pp. 33-36
Author(s):  
A Majeed ◽  
A Alwon ◽  
Q Aboud ◽  
A Mohammed ◽  
A Abood
Keyword(s):  
Veterinary Medicine ◽  
Congenital Anomalies ◽  
Private Clinic ◽  
Congenital Defects ◽  
High Prevalence ◽  
Different Types ◽  
Methods Of Treatment ◽  
Clinical Cases

The study was conducted on 14 clinical cases of congenital anomalies in Iraqi ewes out of 474 Iraqi ewes suffering from dystocia cases presented to the clinic of department of obstetrics\ College of Veterinary Medicine/ University of Fallujah and Private Clinic) during the period from 1995 to 2017. The Prevalence of anomalies was 2.95% in Iraqi ewes recorded at Fallujah. High prevalence of anomalies were observed in male in this study 9/14 (64.28%) than in female 5/14 (35.72%). Different types of congenital anomalies that leads to dystocia were arthrogryposis (4/14-28.57%), brachygnathia (4/14-28.57%), hydrocephalus (3/14-21.42%) and ascites (3/14-21-42%). Prenatal losses was noticed in all cases. The methods of treatment used to relief these cases were C.S and fetotomy.

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