scholarly journals Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms

2022 ◽  
Author(s):  
Hirofumi Takeuchi
Keyword(s):  
Design Research ◽  
Dosage Forms ◽  
Patient Centric

scholarly journals Future Perspectives for Patient-Centric Pharmaceutical Drug Product Design with Regard to Solid Oral Dosage Forms

2019 ◽  
Vol 15 (3) ◽  
pp. 318-324 ◽  
Author(s):  
Nélio Drumond
Keyword(s):  
Product Design ◽  
Drug Product ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Healthcare Provision ◽  
Pharmaceutical Drug ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms ◽  
Drug Product Design ◽  
Patient Centric

Abstract Purpose Additional costs for healthcare provision are expected for cases where the level of care provided is not according to the patient’s needs and demands. To address these issues and reduce costs, fundamental changes need to be made on how healthcare provision is administered to patients, which raises the opportunity for the implementation of patient-centric systems. Methods This review addresses the importance of implementing a patient-centric approach in current healthcare provision and emphasizes the need to adjust current development and business models for a successful application of patient-centric care. Results To increase awareness and avoid confusion, the purpose of patient-centric pharmaceutical drug product design is reviewed in detail and future market opportunities for patient-centric drug products are discussed. Conclusions With regard to solid oral dosage forms, the subject of patient-centric pharmaceutical drug product design will focus more on the customization of existing technologies (e.g., dosage form size reduction) to address the needs of specific patient populations such as pediatrics, geriatrics, dysphagia patients, or the cognitively impaired.

scholarly journals KAJIAN INTERAKSI OBAT PADA PENGOBATAN DIABETES MELITUS (DM) DENGAN HIPERTENSI DI INSTALASI RAWAT JALAN RSUD UNDATA PERIODE MARET-JUNI TAHUN 2014

2015 ◽  
Vol 1 (1) ◽  
pp. 35-41
Author(s):  
Ida Nurlaelah ◽  
Alwiyah Mukaddas ◽  
Ingrid Faustine
Keyword(s):  
Diabetes Mellitus ◽  
Drug Interactions ◽  
Design Research ◽  
Secondary Data ◽  
Dosage Forms ◽  
Primary Data ◽  
Medicinal Treatment ◽  
Multiple Drugs ◽  
Diagnosed Diabetes ◽  
Diabetes Melitus

One of the chronic complications of diabetes mellitus is a disorder of macrovascular as hypertension so that in it’s medicinal treatment required therapy with multiple drugs all at once that can lead to drug interactions. Drug interactions can result in increased toxicity and decrease the effectiveness of drugs that interact. This study aims to determine the prescription profile of DM patients with hypertension include the number of drugs prescribed, dosage forms, classes and types of drugs and the incidence of drug interactions theoretically, based on the mechanism drug interactions in outpatient installations of RSUD Undata Palu 2014. This design research is a non-experimental study with descriptive. Retrieval of patient data performed prospectively during the period from March to June 2014. Subjects who fill the inclusion criteria is adult patients that attain age of 18-60 years and diagnosed diabetes mellitus with hypertension are interview to obtain primary data while the secondary data such as medical records and prescriptions. Retrieved 61 sample. Based on dosage forms prescribe profile that most often given to the DM patients with hypertension was tablets (94.5%). Class of diabetes drugs most widely used is a sulfonylurea (21.1%) and hypertension drug classes beta blocker (12.2%). Types of diabetic drugs most widely used was glimepiride (14.2%) and hypertension was bisoprolol (9.2%). The percentage result of drug interactions theoretically was 85.2% (52 patients), drug interactions type that the most occured was pharmacodynamic interactions 72.7%. Diabetes melitus Patients with hypertension in outpatient installations of RSUD Undata Palu 2014 were most potentially subjected to drug interactions

scholarly journals Patient-Centric Medicine Design: Key Characteristics of Oral Solid Dosage Forms that Improve Adherence and Acceptance in Older People

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 905 ◽  
Author(s):  
Zakia Shariff ◽  
Daniel Kirby ◽  
Shahrzad Missaghi ◽  
Ali Rajabi-Siahboomi ◽  
Ian Maidment
Keyword(s):  
Older People ◽  
Negative Impact ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Disease Characteristics ◽  
Age Related ◽  
Health And Social Care ◽  
Age Appropriate ◽  
Patient Centric

Older people represent a very heterogeneous patient population and are the major user group of medication. Age-related changes mean that this population can encounter barriers towards taking medicines orally. The aim of this study was to investigate the characteristics of oral solid dosage forms that contribute to an age appropriate dosage design, with an aim to improve overall medication adherence and acceptance in older people. Fifty-two semistructured interviews were conducted with older people, informal (family) carers, and health and social care professionals. Formulation characteristics impacted three stages of the medication taking process: (1) medication identification and memorability, (2) medication handling and (3) swallowability. Small round tablets (≤7 mm) are least accepted amongst older people and their carers and had a negative impact on all stages. The use of bright, two-coloured preparations and interesting shapes improves identification and further aids memorability of indications and the timing of tablets. Palatability, while useful to enhance swallowability, also has an impact on the visual appeal and memorability of medication. Environmental, patient, medication and disease characteristics also determine preferences for formulation. Developing an age appropriate dosage design for older people, therefore, requires a holistic, patient-centric approach to improve adherence and acceptance.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

Much Ado About Fried Chicken: Abetting Aspiration or Respecting Autonomy?

2019 ◽  
Vol 28 (3) ◽  
pp. 1356-1362
Author(s):  
Laurence Tan Lean Chin ◽  
Yu Jun Lim ◽  
Wan Ling Choo
Keyword(s):  
Palliative Care ◽  
End Of Life ◽  
Multidisciplinary Team ◽  
Biopsychosocial Model ◽  
Family Members ◽  
Clinical Decisions ◽  
Goals Of Care ◽  
Complex Needs ◽  
Aspiration Risk ◽  
Patient Centric

Purpose Palliative care is a philosophy of care that encompasses holistic, patient-centric care involving patients and their family members and loved ones. Palliative care patients often have complex needs. A common challenge in managing patients near their end of life is the complexity of navigating clinical decisions and finding achievable and realistic goals of care that are in line with the values and wishes of patients. This often results in differing opinions and conflicts within the multidisciplinary team. Conclusion This article describes a tool derived from the biopsychosocial model and the 4-quadrant ethical model. The authors describe the use of this tool in managing a patient who wishes to have fried chicken despite aspiration risk and how this tool was used to encourage discussions and reduce conflict and distress within the multidisciplinary team.

Patient centric optimization of a successful soft mist inhaler

2020 ◽  
Author(s):  
M Meisenheimer ◽  
S Kattenbeck ◽  
M Frank ◽  
A Gardev ◽  
R Krampe ◽  
...  
Keyword(s):  
Patient Centric

Track 2.b Introduction: Design & Democracy

2019 ◽  
Vol 2 (1) ◽  
pp. 213
Author(s):  
Virginia TASSINARI ◽  
Ezio MANZINI ◽  
Maurizio TELI ◽  
Liesbeth HUYBRECHTS
Keyword(s):  
At Risk ◽  
Design Research ◽  
Core Theme ◽  
The Past ◽  
Noam Chomsky ◽  
Local Contexts ◽  
Democratic Discourse ◽  
Different Parts

The issue of design and democracy is an urgent and rather controversial one. Democracy has always been a core theme in design research, but in the past years it has shifted in meaning. The current discourse in design research that has been working in a participatory way on common issues in given local contexts, has developed an enhanced focus on rethinking democracy. This is the topic of some recent design conferences, such PDC2018, Nordes2017 and DRS2018, and of the DESIS Philosophy Talk #6 “Regenerating Democracy?” (www.desis-philosophytalks.org), from which this track originates. To reflect on the role and responsibility of designers in a time where democracy in its various forms is often put at risk seems an urgent matter to us. The concern for the ways in which the democratic discourse is put at risk in many different parts of the word is registered outside the design community (for instance by philosophers such as Noam Chomsky), as well as within (see for instance Manzini’s and Margolin’s call Design Stand Up (http://www.democracy-design.org). Therefore, the need to articulate a discussion on this difficult matter, and to find a common vocabulary we can share to talk about it. One of the difficulties encountered for instance when discussing this issue, is that the word “democracy” is understood in different ways, in relation to the traditions and contexts in which it is framed. Philosophically speaking, there are diverse discourses on democracy that currently inspire design researchers and theorists, such as Arendt, Dewey, Negri and Hardt, Schmitt, Mouffe, Rancière, Agamben, Rawls, Habermas, Latour, Gramsci, whose positions on this topic are very diverse. How can these authors guide us to further articulate this discussion? In which ways can these philosophers support and enrich design’s innovation discourses on design and democracy, and guide our thinking in addressing sensitive and yet timely questions, such as what design can do in what seems to be dark times for democracy, and whether design can possibly contribute to enrich the current democratic ecosystems, making them more strong and resilient?

Social Design for Services Framework

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Melanie SARANTOU ◽  
Satu MIETTINEN
Keyword(s):  
South Africa ◽  
Sustainable Development ◽  
Research Group ◽  
Design Research ◽  
Service Design ◽  
Social Design ◽  
Practical Action ◽  
The Social ◽  
The World

This paper addresses the fields of social and service design in development contexts, practice-based and constructive design research. A framework for social design for services will be explored through the survey of existing literature, specifically by drawing on eight doctoral theses that were produced by the World Design research group. The work of World Design researcher-designers was guided by a strong ethos of social and service design for development in marginalised communities. The paper also draws on a case study in Namibia and South Africa titled ‘My Dream World’. This case study presents a good example of how the social design for services framework functions in practice during experimentation and research in the field. The social design for services framework transfers the World Design group’s research results into practical action, providing a tool for the facilitation of design and research processes for sustainable development in marginal contexts.

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