MANAGEMENT OF PATIENTS WITH RHEUMATIC HEART DISEASES AND CHRONIC HEART FAILURE

Heart failure - severe, common clinical syndrome that is the result of many heart diseases is progressive, significantly reduces the life expectancy of patients and impairs its quality. Leading nosological forms the structure of coronary heart disease for many years, is a myocardial infarction. Growing proportion of elderly in most populations, increased survival after acute myocardial infarction (AMI) resulted in a significant increase in the number of patients with chronic heart failure (CHF). Increased tone of the sympathetic division precedes the development of chronic cerebral ischemia and, therefore, may complicate the course of disease in the presence of chronic heart failure.

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Effects of Enalapril on TLR2/NF-κB Signaling Pathway and Inflammatory Factors in Rabbits with Chronic Heart Failure

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/9594607 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Yanping Tang ◽

Zelin Xu ◽

Xinyu Chen ◽

Nan Wang ◽

Xu Deng ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Signaling Pathway ◽

Heart Diseases ◽

Signal Transduction Pathway ◽

Angiotensin Converting Enzyme Inhibitors ◽

Clinical Syndrome ◽

Inflammatory Factors ◽

Tlr2 Expression ◽

Converting Enzyme Inhibitors

Chronic heart failure (CHF) refers to the state of persistent heart failure, which is a complex clinical syndrome of various advanced heart diseases. The toll-like receptor 2 (TLR2)/nuclear transcription factor-κB (NF-κB) signal transduction pathway is one of the pathological mechanisms of CHF. Adriamycin can significantly induce the upregulation of TLR2 expression. Angiotensin-converting enzyme inhibitors (ACEI) are commonly used drugs for the treatment of CHF. In our study, the CHF model was established by injection of doxorubicin into the rabbit ear vein. The effect of enalapril on the TLR2/NF-κB signaling pathway in CHF rabbits has been analyzed and determined. Our research results showed that enalapril reduced the inflammatory response by inhibiting the activation of the TLR2/NF-κB signaling pathway, thereby improving cardiac structure, myocardial remodeling, and cardiac function.

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Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2016-0512 ◽

2017 ◽

Vol 95 (3) ◽

pp. 268-274 ◽

Cited By ~ 15

Author(s):

Ismayil Ahmet ◽

Hyun-Jin Tae ◽

Edward G. Lakatta ◽

Mark Talan

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Systolic Function ◽

Heart Diseases ◽

Myocardial Infarct ◽

Aortic Pulse Wave Velocity ◽

Loop Analysis ◽

Short Term Exposure ◽

Functional Deterioration

A short-term exposure to resveratrol at high dosages exerts a remarkable cardioprotective effect. Whether a long-term exposure to resveratrol at low dosages that can be obtained through consumption of a resveratrol-rich diet is beneficial to heart diseases is unknown. We tested the effects of a resveratrol-enriched diet on cardiovascular remodeling of chronic heart failure (CHF) in rats resulting from permanent ligation of left coronary artery. Two weeks after surgery, rats were started on either a resveratrol-enriched (R; 5 mg/kg per day; n = 23) or normal (Control; n = 23) diet for next 10 months. Serial echocardiography in Control showed a significant decline in LV ejection fraction, increases in LV end-systolic and end-diastolic volumes, and expansion in myocardial infarct from pre-treatment values. In R, compared with Control, there were substantial improvements in those parameters. End-point LV pressure-volume loop analysis showed a significantly improved LV systolic function and AV-coupling, an index of energy transfer efficacy between the heart and aortic tree, in R compared with Control (p < 0.05). Aortic pulse wave velocity, a measure of arterial stiffness, was significantly lower in R (389 ± 15 cm/s; p < 0.05) compared with Control (489 ± 38 cm/s). These results demonstrated that long-term dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in CHF.

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Outcomes of diuretics in rheumatic heart disease with compensated chronic heart failure: a retrospective study

ESC Heart Failure ◽

10.1002/ehf2.12987 ◽

2020 ◽

Vol 7 (6) ◽

pp. 3929-3941

Author(s):

Cheng Liu ◽

Yanxian Lai ◽

Tianwang Guan ◽

Yan Shen ◽

Yichao Pan ◽

...

Keyword(s):

Heart Failure ◽

Heart Disease ◽

Retrospective Study ◽

Chronic Heart Failure ◽

Rheumatic Heart Disease ◽

Rheumatic Heart

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Etiological profile in patients with heart failure

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20203092 ◽

2020 ◽

Vol 8 (8) ◽

pp. 2845

Author(s):

Madhavi Sarkari ◽

Mithilesh Yadav ◽

Ashutosh Kr. Rai

Keyword(s):

Heart Failure ◽

Heart Disease ◽

Rheumatic Heart Disease ◽

Heart Diseases ◽

Failure Criteria ◽

Epidemiological Studies ◽

Elderly Male ◽

Cross Sectional ◽

Valvular Heart Diseases ◽

Rheumatic Heart

Background: The incidence and prevalence rates of heart failure (HF) are increasing worldwide. The prevalence of HF rises exponentially with increasing age and affects 4% to 8% of people older than 65. The leading causes of HF in India include coronary artery disease (CAD), diabetes, hypertension, rheumatic valvular heart diseases and primary cardiac muscle diseases. Rheumatic heart disease (RHD) is still a common cause of HF in India. Epidemiological studies have estimated that 1.5% to 2% population experience HF and it is the main reason for hospital admission of elderly patients. The objective of this study was to establish the etiological factors of heart failureMethods: A cross sectional study of 150 patients above the age of 18 years presented with heart failure diagnosed clinically on the basis of Framingham heart failure criteria and echocardiography, done over a period of one year in department of medicine in BRD medical college Gorakhpur Uttar Pradesh.Results: A total of 150 patients were include in this analysis the majority of patients were male (57.3%). Age of patients ranged from 18 - 70 years and 84% patients were above the age of 40 years.Conclusions: Heart failure was more prevalent in elderly male above 40 years of age. Myocardial infarction, DCMP, rheumatic heart disease and hypertensive heart failure are the common etiology leading to heart failure.

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Cardiogenic Shock in other Heart Diseases: Acute Decompensation of Chronic Heart Failure, Myocarditis, Transient Apical Ballooning Syndrome, Peripartum Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathies, and Thyrotoxicosis

Cardiogenic Shock ◽

10.1002/9781444316926.ch8 ◽

2009 ◽

pp. 172-199

Author(s):

Fredric Ginsberg ◽

Joseph E. Parrillo

Keyword(s):

Heart Failure ◽

Hypertrophic Cardiomyopathy ◽

Chronic Heart Failure ◽

Cardiogenic Shock ◽

Heart Diseases ◽

Apical Ballooning ◽

Peripartum Cardiomyopathy ◽

Apical Ballooning Syndrome ◽

Acute Decompensation

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Platelet Proteome Changes in Dogs with Chronic Heart Failure

10.21203/rs.3.rs-46168/v1 ◽

2020 ◽

Author(s):

Pinar LEVENT ◽

Meriç KOCATÜRK ◽

Emel AKGÜN ◽

Ahmet SARIL ◽

Ozge ÇEVİK ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Inflammatory Responses ◽

Heart Diseases ◽

Protein Composition ◽

Label Free ◽

Canis Lupus Familiaris ◽

Protein Database ◽

Guanine Nucleotide Binding Protein

Abstract Background: Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in chronic heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n=10) and dogs with CHF due to myxomatous mitral valve degeneration (n=10) were used. Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results: Totally 107 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in the CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in the CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses.Conclusion: This study describes by first time the changes in the protein composition in platelets of dogs with CHF. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF and could be a tool for further investigations about the prevention and treatment of this disease.

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Vitamin D Dietary Supplementation: Relationship with Chronic Heart Failure

Journal of AOAC International ◽

10.5740/jaoacint.17-0447 ◽

2018 ◽

Vol 101 (4) ◽

pp. 939-941 ◽

Cited By ~ 3

Author(s):

Giuseppe Dattilo ◽

Matteo Casale ◽

Emanuela Avventuroso ◽

Pasqualina Laganà

Keyword(s):

Heart Failure ◽

Vitamin D ◽

Chronic Heart Failure ◽

Heart Diseases ◽

Low Cost ◽

Public Health Problem ◽

Hypovitaminosis D ◽

Vitamin D Supplementation ◽

World Health ◽

Regulatory Function

Abstract It is estimated that over 1 billion people worldwide have a deficiency of vitamin D, also known as hypovitaminosis D, which the World Health Organization has defined as a public health problem. Beyond its historical homeostasis regulatory function of calcium and phosphorus, in relation to the preservation of the skeletal system, several studies show today a close connection between hypovitaminosis D and the genesis of rheumatic, autoimmune, neoplastic, and cardiovascular diseases. With exclusive reference to cardiovascular aspects, multiple heart diseases such as hypertension, myocardial ischemia, and heart failures might have deficiency in vitamin D as an important causative factor. Because of the influence of concomitant pathologies caused by antibiotic-resistant agents, the function of this vitamin should be critically evaluated. However, the role of vitamin D remains to be established; only a few studies have tested the effects of its supplementation in patients with chronic heart failure diseases, and reported results are unclear. It is important to implement studies in this field in order to assess the real benefits induced by vitamin D supplementation in cardiovascular patients and, in particular, in patients with heart failure. Should the research confirm actual clinical improvement after treatment with vitamin D, such a supplementation might represent a new low-cost therapeutic approach to improving quality of life.

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