Repeated short cycles of nonsteroidal anti-inflammatory drugs and kidney injury in patients with spinal degenerative-dystrophic diseases

Objective: to evaluate kidney function in patients with spinal degenerative-dystrophic diseases (SDDDs) who take nonsteroidal anti-inflammatory drugs (NSAIDs) as repeated short cycles of treatment for severe back pain.Patients and methods. The investigation enrolled 97 patients with SDDDs who took NSAIDs for back pain (a study group). A control group consisted of sexand age-matched healthy individuals who had not used NSAIDs within the past year (n=40). Glomerular filtration rate (GFR) was estimated using the CKD-EPI equation and markers of kidney injury (albuminuria and globulinuria) were measured.Results. In the study group, GFR was decreased to <90 ml/min/1.73 m2 in 61 (62.9%) patients, to <60 ml/min/1.73 m2 in 11 (11.3%); the mean GFR was 77.5 [68.0; 89.0] ml/min/1.73 m2; in the control group, a decline in GFR to 89–60 ml/min/1.73 m2 was recorded in 35 (62.5%) cases; this indicator was >90 ml/min/1.73 m2 in the remaining 15 (37.5%) cases; the mean GFR was 82.5 [70.8; 90.0] ml/min/1.73 m2 (p≥0.05 for all pairwise comparisons). A decrease in GFR to <60 ml/min/1.73 m2 was found in 11 (11.3%) patients in the study group and in nobody in the control group (p=0.026). Elevated albuminuria was noted in 74 (76.3%) patients with SDDDs and in 9 (22.5%) healthy individuals (p<0.05). Albumin/creatinine ratio was 57.1 [33.8; 82.4] mg/g in the study group and 25.0 [17.5; 32.9] mg/g in the control group (p<0.0001). Increased globulinuria was established in all the patients with SDDDs and only in 3 (7.5%) healthy examinees. Globulin/creatinine ratio was 134.7 [77.5; 197.7] mg/g in the study group and 12.9 [0.5; 18.1] mg/g in the control group (p<0.0001).Conclusion. A decline in GFR to <60 ml/min/1.73 m2 was more often seen in the patients taking NSAIDs for spine pain caused by SDDDs than in the healthy individuals. In case of comparable GFR, the level of kidney injury markers was significantly higher in the study group than that in the control group, which suggests that patients with SDDDs who take NSAIDs have subclinical tubulointerstitial and glomerular changes.

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THE CLINICAL COURSE OF MYOCARDIAL INFARCTION PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH ACUTE KIDNEY INJURY

"Medical & pharmaceutical journal "Pulse" ◽

10.26787/nydha-2686-6838-2021-23-2-17-22 ◽

2021 ◽

pp. 17-22

Author(s):

Balabanov A.S. ◽

Tupitcyn V.V. ◽

Tassybayev B.B.

Keyword(s):

Myocardial Infarction ◽

Clinical Signs ◽

Kidney Injury ◽

Functional Class ◽

Control Group ◽

Study Group ◽

Type I ◽

Psychic Disorders ◽

Group A ◽

The Moment

Relevance. Acute kidneys injury (AKI) negatively affects the prognosis of myocardial infarction (MI). Aim. To evaluate MI clinical features (CF) in men under 60 years old (y.o.) with AKI during MI to improve prevention and outcomes. Material and methods. The study included men aged 19-60 years old with type I MI. Patients are divided into two age-comparable groups: I - the study group, with ACI - 25 patients; II - control, without it - 486 patients. A comparative assessment of the MI CF frequency in selected groups were performed. Results. In patients of the study group more often than in the control group, a combination of MI complications (64.0 and 36.9%; respectively; p = 0.009), psychic disorders (20.0 and 6.9%; p = 0.01), chronic heart failure (CHF) of the second functional class and above (NYHA) at the end of the eighth MI week (72.0 and 43.2%; p = 0.005), with a predominance of newly diagnosed CHF forms (36.0 and 28.0%; p = 0.006). In the study group, less often than in the control group, pulmonary hypertension was noted in the first 48 hours of MI (44.0 and 66.0%; p = 0.02) and at the end of the third MI week (38.1 and 60.3%; p = 0.04). Conclusions. There were no specific clinical signs of AKI in men under 60 y.o. with MI. At the same time, the study group has the worst prognosis during the observation period in terms of the frequency of MI complications combinations and CHF, which requires the start of prophylactic therapy from the moment of AKI verification.

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Impact of Whatsapp in improving learning among 9th semester MBBS students

Medpusle International Journal of Surgery ◽

10.26611/1061917 ◽

2021 ◽

Vol 19 (1) ◽

pp. 27-30

Author(s):

Y Satish Reddy ◽

Keyword(s):

Undergraduate Students ◽

Control Group ◽

P Value ◽

Study Group ◽

Opinion Poll ◽

Didactic Teaching ◽

Significant Difference ◽

Group A ◽

The Mean ◽

The Impact

Background: Interactive Teaching learning can be used in clinical subjects like surgery for better participation of students as one-way didactic lectures do not involve active participation of students. WhatsApp is one of the most famous messaging services which everyone use and it is easy, cheaper, and faster. Objective: the purpose of the study was to study the impact of whatsapp in improving learning in general surgery among 9th semester medical students. Methods: This study was conducted among 9th semester MBBS students in Surgery department. Students were divided into group a (study group) and group b(control group) by a simple random sampling. Gastric cancer was discussed among students of both Groups through didactic teaching. after didactic teaching, only Group A students were exposed to social media type of learning, i.e., using WhatsApp, after the session a multiple-choice questionnaire having 10 MCQs was given to both groups and an additional poll was conducted among the Study-group students to assess their perception towards Whatsapp intervention. the mean score obtained by both the groups were compared with unpaired t test. P-value <0.05 is taken as statistically significant. Results: The mean (SD) score of the Study-group was 8.58(1.18) and the mean (SD) score of the Control-group was 5.41(1.32) and statistically significant difference was found between the two groups scores with a p-value less than 0.05 opinion poll found that the intervention of whatsapp among study group was effective. Conclusion: we observed that the usage of WhatsApp in addition to the didactic teaching was found advantageous and enhanced learning in undergraduate students

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Relationship Between Gingivitis and Anterior Teeth Irregularities Among 18 to 26 Years Age Group: A Hospital Based Study in Belgaum, Karnataka

Journal of Oral Health and Community Dentistry ◽

10.5005/johcd-4-3-61 ◽

2010 ◽

Vol 4 (3) ◽

pp. 61-66

Author(s):

Anil Ankola ◽

V. Chandrasekhara Reddy ◽

B R Ashok Kumar

Keyword(s):

Control Group ◽

Dental Arch ◽

Study Group ◽

Age Group ◽

Gingival Index ◽

Anterior Teeth ◽

Group A ◽

The Mean ◽

Anterior Segments ◽

The Relationship

ABSTRACT Aim To study the relationship between gingivitis and irregular teeth in the anterior segments of dental arches. Materials & Methods The sample size of 120 subjects who satisfied the inclusion criteria was randomly selected for the study. These subjects were selected between the age group of 18 to 26 years and divided into two groups. The study group (cases) consists of 60 subjects with irregular teeth in the anterior segments of dental arch. The control group (controls) consists of 60 subjects with well-aligned teeth in the anterior segments of dental arches. Results The mean gingival index of cases & controls were 0.9513 and 0.5959 with standard deviations of 0.7014 and 0.4909 respectively. The t-value was 3.1093 with p<0.001 which was highly significant. Conclusion The mean gingival index of study group was higher than the gingival score of the control group (P<0.001).

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Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

The Scientific World JOURNAL ◽

10.1155/2014/287597 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Marian Majchrzycki ◽

Piotr Kocur ◽

Tomasz Kotwicki

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Pain Reduction ◽

Control Group ◽

Low Back ◽

Deep Tissue ◽

Significant Difference ◽

Inflammatory Drugs ◽

Anti Inflammatory

Objective. To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID).Design. Prospective controlled randomized single blinded trial.Settings. Ambulatory care of rehabilitation.Participants. 59 patients, age 51.8 ± 9.0 years, with chronic low back pain.Interventions. 2 weeks of DTM in the treatment group (TG) versus 2 weeks of DTM combined with NSAID in the control group (CG).Main Outcome Measures. Visual analogue scale, Oswestry disability index (ODI), and Roland-Morris questionnaire (RM).Results. In both the TG and the CG, a significant pain reduction and function improvement were observed. VAS decreased from 58.3 ± 18.2 to 42.2 ± 21.1 (TG) and from 51.8 ± 18.8 to 30.6 ± 21.9 (CG). RM value decreased from 9.8 ± 5.1 to 6.4 ± 4.4 (TG), and from 9.3 ± 5.5 to 6.1 ± 4.6 (CG). ODI value decreased from 29.2 ± 17.3 to 21.4 ± 15.1 (TG) and from 21.4 ± 9.4 to 16.6 ± 9.4 (CG). All pre-post-treatment differences were significant; however, there was no significant difference between the TG and the CG.Conclusion. DTM had a positive effect on reducing pain in patients with chronic low back pain. Concurrent use of DTM and NSAID contributed to low back pain reduction in a similar degree that the DTM did.

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Dynamics of Changes in Isometric Strength and Muscle Imbalance in the Treatment of Women with Low back Pain

BioMed Research International ◽

10.1155/2020/6139535 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Jacek Wilczyński ◽

Alicja Kasprzak

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Lumbar Spine ◽

Muscle Strength ◽

Control Group ◽

Study Group ◽

Low Back ◽

Flexor Muscles ◽

Group A ◽

Group B

The aim of the study was to evaluate the dynamics of isometric changes in strength and muscular lumbar-pelvic imbalances in the treatment of women with low back pain. Forty-one women, nineteen in the study group (A) and twenty-two in the control group (B), participated in the study. Magnetic resonance imaging (MRI) was performed to assess the degree of degenerative changes in the lumbar spine. The diagnosis of isometric muscle strength and their imbalances was performed with the Tergumed 700 device. After six weeks of therapy in the study group (A), there was a significant improvement in the strength of all the examined muscle groups. However, in the control group (B), significant improvement occurred only in the strength of the lumbar flexor muscles and the flexor muscles on the left side. Furthermore, there was a significant intensification of the imbalance of left flexor muscle strength compared to right flexor strength in group B. Significant differences in favour of the study group (A) concerned the strength of the rotator muscles to the left, the strength of the extensor muscles of the lumbar spine, the strength of the flexors of the lumbar spine to the right, and the balance of the strength of the lumbar spine flexors to the left compared to the strength of the flexor muscles to the right. Therapy with the Tergumed 700 system leads to an increase in the muscle strength of the lumbar and pelvic complex, compensating for its imbalance, bringing beneficial effects in the treatment of low back pain.

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Biomarkers of bone remodeling in ankylosing spondylitis patients using nonsteroidal anti-inflammatory drugs: results of an ETHICS research program

Terapevticheskii arkhiv ◽

10.17116/terarkh20178912185-189 ◽

2017 ◽

Vol 89 (12-2) ◽

pp. 185-189

Author(s):

I Z Gaydukova ◽

A V Aparkina ◽

E V Khondkaryan ◽

A P Rebrov

Keyword(s):

Ankylosing Spondylitis ◽

Bone Resorption ◽

Comparison Group ◽

Control Group ◽

Type I ◽

Healthy Individuals ◽

On Demand ◽

Ethics Research ◽

Inflammatory Drugs ◽

Anti Inflammatory

Aim. To evaluate changes in the concentration of biomarkers for osteoproliferation and bone resorption in ankylosing spondylitis (AS) patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in different regimens. Subjects and methods. Forty patients with AS (according to the modified New York criteria), who had BASDAI ≥ 4.0 at baseline and at 52 weeks of on-demand NSAID treatment were examined and randomized into 2 groups: 1) 30 patients who used continuously oral tenoxicam 20 mg daily (a study group); 2) 10 patients who continued previous therapy (a comparison group). BASDAI and ASDAS were calculated; the serum levels of C-reactive protein, C-terminal type I procollagen propeptide (PICP), and C-terminal telopeptide of type I collagen (CTX-I) were measured at baseline and at 52 and 56 weeks of treatment. A control group consisted of 19 healthy volunteers. Results. The continuous use of NSAIDs (tenoxicam) decreased higher baseline BASDAI and ASDAS scores. There were no changes in the indicators of AS activity in the patients who took on-demand NSAIDs. Baseline CTX-I levels did not differ between the patients with AS and the healthy individuals; those declined during continuous intake of tenoxicam and remained unchanged during on-demand administration. In the patients with AS, baseline PICP levels exceeded those in the healthy individuals. In the tenoxicam-treated patients, the concentrations of PICP at baseline and at 52 and 56 weeks were 17.1±9.0, 16.8±9.9, and 13.29±6.7 ng/ml, respectively (p=0.0001 for differences between the baseline and week 56 levels); in the comparison group, PICP levels did not change statistically significantly (p≥0.05 for all intergroup comparisons). Conclusion. Changing the inefficient long-term on-demand use of NSAIDs to their continuous intake is associated with a rapid decrease in clinical AS activity (within 4 weeks) with a reduction in the higher baseline concentration of the marker for osteoproliferation and in the normal level of the marker for bone resorption.

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Aspirin, Nonsteroidal Anti-Inflammatory Drugs, and Epistaxis

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949810700808 ◽

1998 ◽

Vol 107 (8) ◽

pp. 671-674 ◽

Cited By ~ 26

Author(s):

Huey L. Tay ◽

Alexander D. McMahon ◽

Josie M. M. Evans ◽

Thomas M. MacDonald

Keyword(s):

Record Linkage ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Study Group ◽

Inflammatory Drugs ◽

Community Controls ◽

Anti Inflammatory ◽

The Relationship ◽

Control Study

To assess the relationship between nonsteroidal anti-inflammatory drugs (NSAIDs) and spontaneous epistaxis in adults over 50 years old, a case control study was carried out by using a record linkage database for the population of Tayside, Scotland, which included 319,465 people. The study group consisted of 326 patients who were hospitalized with epistaxis between May 1989 and December 1992, but who had not previously been hospitalized with this diagnosis. Six community controls and 4 hospital controls, matched for age and sex to each case, were used. Previous exposure to prescribed aspirin and other NSAIDs was investigated. There was a significant association between aspirin exposure and epistaxis when either community or hospital controls were used (p <.001). Patients who had aspirin prescriptions had a relative risk of hospital admission for epistaxis of between 2.17 and 2.75, depending on the control group used. No association between non-aspirin NSAIDs and epistaxis was evident with either control group.

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Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

The Heart Surgery Forum ◽

10.1532/hsf.1367 ◽

2015 ◽

Vol 18 (4) ◽

pp. 171 ◽

Cited By ~ 1

Author(s):

Tolga Demir ◽

Mehmet Umit Ergenoglu ◽

Hale Bolgi Demir ◽

Nursen Tanrikulu ◽

Mazlum Sahin ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass ◽

Myocardial Protection ◽

Troponin T ◽

Artery Bypass ◽

Control Group ◽

Study Group ◽

Cabg Surgery ◽

Anti Inflammatory ◽

Pump Coronary Artery Bypass

Background: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). Methods: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. Results: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P < .001; T3: P < .001; T4: P < .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group (P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001). Conclusions: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.

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