scholarly journals Two Feet-One Hand Syndrome: A Case Report / Sindrom dva stopala i jedne šake – prikaz slučaja

2015 ◽  
Vol 32 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Milan Bjekić
Keyword(s):  
Tinea Pedis ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Fungal Spores ◽  
Trichophyton Mentagrophytes ◽  
Fungal Culture ◽  
Dorsal Aspect ◽  
Tinea Manus ◽  
Mycological Examination ◽  
The Right

Abstract Two feet-one hand syndrome is a superficial fungal infections of the skin which involves both feet and one hand. Trichophyton rubrum and occasionally Trichophyton mentagrophytes are the usual causative organisms. We present a 32-year-old healthy man with sharply demarcated papular erythematous and squamous lesions on dorsal aspect of the feet and diffuse dry scaling lesions of the right palm. In this syndrome, the development of tinea pedis generally precedes the development of tinea manus, which usually occurs on the hand that excoriated the pruritic feet or picked the toenails with onychomycosis. Our patient often used his dominant right hand to scratch the feet. On mycological examination, fungal spores and mycelia were present and Trichophyton mentagrophytes was isolated. The patient was treated with itraconazole 200 mg daily for two weeks and topical terbinafine cream for four weeks. After the treatment all lesions resolved and fungal culture was negative. Early diagnoses and treatment of tinea pedis and education about prophylaxis, constant care and regular medical assistance would minimize this problem in predisposed individuals.

Sanitization of Contaminated Footwear from Onychomycosis Patients Using Ozone Gas: A Novel Adjunct Therapy for Treating Onychomycosis and Tinea Pedis?

2013 ◽  
Vol 17 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Aditya K. Gupta ◽  
William C. Brintnell
Keyword(s):  
Tinea Pedis ◽  
Trichophyton Rubrum ◽  
Antimicrobial Properties ◽  
Trichophyton Mentagrophytes ◽  
Ozone Exposure ◽  
Adjunct Therapy ◽  
Potential Source

Background: Ozone gas possesses antimicrobial properties against bacteria, viruses, and yeasts. Previously, we demonstrated the efficacy of ozone in killing ATCC strains of the dermatophyte fungi Trichophyton rubrum and Trichophyton mentagrophytes. Objective: To test the efficacy of ozone gas in sanitizing onychomycosis patient footwear contaminated with fungal material as a means of minimizing the risk of reinfection. Methods: Swabs of footwear from onychomycosis patients were cultured prior to and after ozone exposure to test the ability of ozone to sanitize these items. Results: We identified contamination of footwear from most onychomycosis patients, a potential source of reinfection in these individuals. Furthermore, ozone gas was effective in sanitizing contaminated footwear. Conclusion: Ozone gas is effective in sanitizing footwear and represents a novel adjunct therapy to be used in conjunction with antifungal medications and/or devices to better treat onychomycosis and tinea pedis patients in both the short and the long term.

scholarly journals The challenge of Diagnosing Common Dermatomycosis by Reflectance Confocal Microscopy

2021 ◽  
Vol 6 (3) ◽  
pp. 01-07
Author(s):  
Jianyun Lu ◽  
Jinrong Zeng ◽  
Hanyi Zhang ◽  
Yue Zhang ◽  
Lihua Gao ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Fungal Infections ◽  
Pityriasis Versicolor ◽  
Tinea Corporis ◽  
Reflectance Confocal Microscopy ◽  
Fungal Culture ◽  
Image Characteristics ◽  
Tinea Manus ◽  
Microscopy Techniques

Background: Traditional detection of fungal infections of the skin relies on microscopy techniques or fungal culture. Currently, reflectance confocal microscopy (RCM) has been widely applied to assist the diagnosis of commondermatomycosis with advantages of non-invasiveness, celerity, real time, and repeatability. Materials and Methods: A total of 478 clinically suspected dermatomycosis patients were enrolled in this study including 148 cases of tinea manus and pedis, 188 cases of tinea corporis and cruris and 142 cases of pityriasis versicolor. RCM examination was performed to image the lesions. Aim: This study aimed to summarize the image characteristics of in vivo RCM examination on common dermatomycosis and retrospectively evaluate its accuracy as compared with microscopy results. Furthermore, we attempted to tackle the challenges of RCM diagnosis on common dermatomycosis. Results: Based on RCM images, 231 of 478 (48.3%) patients were detected with hyphae. Among all RCM confirmed cases, 58 out of 148 (39.2%) were tinea manus and pedis, 145 out of 188 (77.1%) were tinea corporis and cruris, and 28 out of 142 (19.7%) were pityriasis versicolor. The remaining patients (51.7%) could not be diagnosed by the dermatologist according to RCM. Hyphae structures were primarily identified during diagnoses of dermatomycosis by RCM. Conclusions: RCM is a novel optical imaging technique that confers high-resolution images of fungi. RCM has certain advantages in the diagnosis of tinea manus and pedis. RCM is not suitable for the diagnosis of pityriasis versicolor.

scholarly journals Antifungal Activity of Maytenin and Pristimerin

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Fernanda P. Gullo ◽  
Janaina C. O. Sardi ◽  
Vânia A. F. F. M. Santos ◽  
Fernanda Sangalli-Leite ◽  
Nayla S. Pitangui ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Human Keratinocytes ◽  
Trichophyton Mentagrophytes ◽  
Pharmacological Activities ◽  
Etiologic Agents ◽  
High Incidence ◽  
Maytenus Ilicifolia

Fungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agentsTrichophyton rubrumandTrichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plantMaytenus ilicifolia(Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents.

scholarly journals A clinicomycological study on chronic dermatophytosis in a tertiary care hospital in North India: An observational study

2021 ◽  
Vol 12 (4) ◽  
pp. 374-380
Author(s):  
Rabiya Bashir ◽  
Naina Kala Dogra ◽  
Bella Mahajan
Keyword(s):  
Trichophyton Rubrum ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Sun Exposure ◽  
Trichophyton Mentagrophytes ◽  
The Body ◽  
Tinea Corporis ◽  
Fungal Culture ◽  
Care Hospital ◽  
Chronic Dermatophytosis

Background: Chronic dermatophytosis is a considerable challenge in routine clinical practice. There is, however, scarce information available in the literature on its extent and characteristics. Aim: The aim of this study was to evaluate the host-related factors of chronic dermatophytosis and to identify the common fungal isolates. Methods: The study enrolled a total of 145 cases of chronic dermatophytosis attending the out-patient department of a tertiary care hospital in Jammu from November 2017 through October 2018. A detailed history was taken, followed by a clinical examination and investigations such as routine baseline investigations, an absolute eosinophil count, a wet mount for direct microscopy, and a fungal culture. Results: The most common presentation was tinea corporis with tinea cruris (33.1%), followed by tinea corporis alone. The majority of the patients (54.5%) had more than 20% of the body surface area involved. Most of the patients were manual workers (n = 44; 30.3%). The number of hours of sun exposure varied between 1 to 8.5 hours (mean ± SD: 3.53 ± 1.75 h). The fungal culture was positive in 65 (44.8%) patients. The most frequent isolates were Trichophyton mentagrophytes (53.8%), followed by Trichophyton rubrum (38.5%). Conclusion: We found Trichophyton mentagrophytes the predominant pathogen in chronic dermatophytosis, followed by Trichophyton rubrum, which demonstrates a changing trend as far as the causative organism is considered. Besides, various risk factors for chronicity such as prolonged sun exposure, lack of proper hygiene, wearing tight-fitting synthetic clothes, the use of topical steroids, and non-compliance to treatment were identified.

scholarly journals Efektivitas Air Rebusan dan Air Perasan Lengkuas Merah (Alpinia purpurata K.schum) dalam Menghambat Pertumbuhan Trichophyton rubrum Jamur Penyebab Kutu Air (Tinea pedis)

2018 ◽  
Vol 9 (3) ◽  
pp. 382
Author(s):  
Eka Sulistianingsih ◽  
Mimi Sugiarti
Keyword(s):  
Tinea Pedis ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Antifungal Drugs ◽  
Minimum Concentration ◽  
Randomized Design ◽  
Soles Of The Feet ◽  
Alpinia Purpurata ◽  
Growth Of Fungi ◽  
Boiled Water

<p><em>Tinea pedis</em> is dermatophytosis in the feet, especially between the fingers and soles of the feet. Chronic fungal infections in the form of peeling and skin rupture are the main manifestations, accompanied by pain and itching. Antifungal drugs have limitations, such as a narrow spectrum of antifungals, adverse effects on certain tissues and resistance to certain antifungals. One of the plants that are used for treatment is red-angled Galangal (<em>Alpinia purpurata K.Schum</em>). The research objective was to compare the effectiveness of boiled water and red galangal juice <em>(Alpinia purpurata K.schum)</em> in inhibiting the growth of fungus Trichophyton rubrum which causes water flea (<em>Tinea pedis</em>). The research was experimental with a completely randomized design (CRD) design. The independent variable is red galangal juice (<em>Alpinia purpurata K.schum</em>) and red galangal boiled water (<em>Alpinia purpurata K.schum</em>) with a concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80 %, 90%, 100% and the dependent variable is the growth of fungus Trichophyton rubrum. Data analysis used the ANOVA test, followed by the BNT test (Smallest Real Difference) and T-test.The results showed that red galangal boiled water (<em>Alpinia purpurata K.schum</em>) did not have the ability to inhibit the growth of Trichophyton rubrum fungi. Red galangal juice (<em>Alpinia purpurata K.schum</em>) has the ability to inhibit the growth of fungi Trichophyton rubrum and the minimum concentration that can inhibit the growth of fungi Trichophyton rubrum is 10% with a mean inhibitory zone of 24.37 mm.</p>

scholarly journals Dermatophytoses in children: study of 137 cases

2001 ◽  
Vol 43 (2) ◽  
pp. 83-85 ◽  
Author(s):  
Nurimar C. FERNANDES ◽  
Tiyomi AKITI ◽  
Maria da Glória C. BARREIROS
Keyword(s):  
Tinea Pedis ◽  
Tinea Capitis ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Etiologic Agent ◽  
Microsporum Canis ◽  
Clinical Form ◽  
Tinea Unguium ◽  
The Third ◽  
Few Data

Dermatophytoses are common fungal infections caused by dermatophytes but there are few data about this condition in the childhood. 137 children below the age of 12 and clinically diagnosed as tineas were investigated prospectively at Instituto de Puericultura e Pediatria, Rio de Janeiro, from 1994 to 1999. Hair, skin/nails scraping and pus swabs were collected from lesions and processed for fungus. Male children from 2 to 12 years were mostly affected; tinea capitis (78 cases) mainly caused by Microsporum canis (46 cases) was the most common clinical form. Tinea corporis (43 cases) mainly caused by Trichophyton rubrum (17 cases) accounted for the second most frequent clinical form. Tinea cruris (10 cases) with Trichophyton rubrum (5 cases) as the most common etiologic agent accounted for the third most frequent clinical form. Tinea pedis and tinea unguium were much less frequent (3 cases each). Trichophyton rubrum was the most common etiologic agent isolated in these cases (3 cases).

scholarly journals Griseococcin(1) from Bovistella radicata (Mont.) Pat and Antimicrobial Activity

2020 ◽  
Author(s):  
zeng qingmei ◽  
yong ye ◽  
Qinghua Zeng
Keyword(s):  
Tinea Pedis ◽  
Inhibitory Concentration ◽  
Trichophyton Rubrum ◽  
Pathogenic Fungus ◽  
Deae Cellulose ◽  
Trichophyton Mentagrophytes ◽  
2D Nmr ◽  
Chemical Formula ◽  
Zone Of Inhibition ◽  
Ft Ir

Abstract Bovistella radicata (Mont.) Pat was a natural plant with multiple medicinal values. The purified compound purified from Bovistella radicata (Mont.) Pat by DEAE-cellulose and sephadex LC-20 column which could inhibit main pathogens leading to tinea pedis. Based on the spectral (HPLC, FT-IR, 1D and 2D NMR etc.) studies, purified compounds were identified as the Griseococcin(1) which were naphthoquinone derivatives, the Chemical formula and MW of Griseococcin(1) was determined as C37O10H43N and 661 Da. Minimum inhibitory concentration(MIC) and zone of inhibition(ZOI) of Griseococcin(1) were 31.2, 31.2 µg/ml and 18.06 ± 0.85 mm, 15.01 ± 1.02 mm respectively against main pathogenic fungus Trichophyton rubrum and Trichophyton mentagrophytes.

scholarly journals Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis

2011 ◽  
Vol 55 (9) ◽  
pp. 4420-4421 ◽  
Author(s):  
Alfonso J. Carrillo-Muñoz ◽  
Cristina Tur-Tur ◽  
Delia C. Cárdenes ◽  
Dolors Estivill ◽  
Gustavo Giusiano
Keyword(s):  
Tinea Pedis ◽  
Fungicidal Activity ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Clinical Isolates ◽  
Geometric Means ◽  
Epidermophyton Floccosum ◽  
Content Type ◽  
Causative Agents

ABSTRACTThe fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis,Trichophyton rubrum,Trichophyton mentagrophytes, andEpidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher forT. mentagrophytesthan for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

scholarly journals In vitro antifungal activity of Candida culture extracts against Trichophyton rubrum and Trichophyton mentagrophytes.

2021 ◽  
Vol 1 (4) ◽  
pp. 135-152
Author(s):  
Thiago Henrique Lemes ◽  
Guilherme Silva Torrezan ◽  
Carlos Roberto Polaquini ◽  
Luis Octavio Regasini ◽  
Bianca Gottardo de Almeida ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Galleria Mellonella ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Trichophyton Mentagrophytes ◽  
Recurrence Rates ◽  
Isolation And Identification ◽  
Microdilution Method ◽  
Broth Microdilution Method

Onychomycoses are nail infections caused primarily by dermatophytes fungi, yeasts, and other filamentous fungi, characterized by persistent infections, prolonged therapy, and high recurrence rates. In clinical practice, some of these occurrences present two or more microorganisms, and the interactions among them can change the chemical environment mediated by small diffusible molecules, producing a competitive niche. The aim of this study was to evaluate the antifungal activity of individual extracts of pure cultures of Candida albicans and C. parapsilosis against dermatophytes. To obtain the fungal extracts, cultures were filtered through a 0.2 μm membrane and submitted to liquid-liquid extraction using ethyl acetate. The Minimal Inhibitory Concentration (MIC) of each extract was evaluated by broth microdilution method and checkerboard assay with fluconazole against clinical isolates of Trichophyton rubrum and T. mentagrophytes. The invertebrate model of Galleria mellonella was used to evaluate the toxicity of the extracts. As results, the extracts of C. albicans and C. parapsilosis showed antifungal activity with MICs between 31,2 – 2000 μg/mL. In association with fluconazole, synergistic effect was detected for all combinations. The extracts presented low toxicity in G. mellonella. In the future, isolation and identification of the extract compounds may allow new therapeutic approaches in the control of fungal infections.

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