scholarly journals The Relationship of HDL-Apolipoprotein A-I and HDL-Cholesterol to Risk Factors of Coronary Heart Disease: Initial Results of the Prospective Epidemiological Study in Company Employees in Westfalia

1982 ◽  
Vol 20 (5) ◽  
Author(s):  
G. Assmann ◽  
H. Funke ◽  
H. Schriewer
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Epidemiological Study ◽  
Hdl Cholesterol ◽  
Apolipoprotein A ◽  
Prospective Epidemiological Study ◽  
Relationship Of ◽  
The Relationship ◽  
Initial Results

scholarly journals Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

2019 ◽  
Author(s):  
Tom G Richardson ◽  
Eleanor Sanderson ◽  
Tom M. Palmer ◽  
Mika Ala-Korpela ◽  
Brian A Ference ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Apolipoprotein B ◽  
Blood Lipids ◽  
Ldl Cholesterol ◽  
Mendelian Randomization ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Apolipoprotein A ◽  
Relationship Of

AbstractBackgroundCirculating blood lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. We sought to explore the causal relationships of blood lipid traits with risk of CHD using multivariable Mendelian randomization.MethodsWe conducted GWAS of circulating blood lipid traits in UK Biobank (up to n=440,546) for LDL cholesterol, triglycerides and apolipoprotein B to identify lipid-associated SNPs. Using data from CARDIoGRAMplusC4D for CHD (consisting of 60,801 cases and 123,504 controls), we performed univariable and multivariable Mendelian randomization (MR) analyses. Similar analyses were conducted for HDL cholesterol and apolipoprotein A-I.FindingsGWAS identified multiple independent SNPs associated at P<5×10−8 for LDL cholesterol (220), apolipoprotein B (n=255), triglycerides (440), HDL cholesterol (534) and apolipoprotein AI (440). Between 56-93% of SNPs identified for each lipid trait had not been previously reported in large-scale GWAS. Almost half (46%) of these SNPs were associated at P<5×10−8 with more than one lipid related trait. Assessed individually using MR, each of LDL cholesterol (OR 1.66 per 1 standard deviation higher trait; 95%CI: 1.49; 1.86; P=2.4×10−19), triglycerides (OR 1.34; 95%CI: 1.25, 1.44; P=9.1×10−16) and apolipoprotein B (OR 1.73; 95%CI: 1.56, 1.91; P=1.5×10−25) had effect estimates consistent with a higher risk of CHD. In multivariable MR, only apolipoprotein B (OR 1.92; 95%CI: 1.31, 2.81; P=7.5×10−4) retained a robust effect with the estimate for LDL cholesterol (OR 0.85; 95%CI: 0.57; 1.27; P=0.44) reversing and that of triglycerides (OR 1.12; 95%CI: 1.02, 1.23; P=0.01) becoming markedly weaker.Individual MR analyses showed a 1-SD higher HDL-C (OR 0.80; 95%CI: 0.75, 0.86; P=1.7×10−10) and apolipoprotein A-I (OR 0.83; 95%CI: 0.77, 0.89; P=1.0×10−6) to lower the risk of CHD but these effect estimates weakened to include the null on accounting for apolipoprotein B.ConclusionsApolipoprotein B is of fundamental causal relevance in the aetiology of CHD, and underlies the relationship of LDL cholesterol and triglycerides with CHD.

The relationship of serum uric acid to risk factors in coronary heart disease

1968 ◽  
Vol 45 (4) ◽  
pp. 520-528 ◽  
Author(s):  
Allen R. Myers ◽  
Frederick H. Epstein ◽  
H.J. Dodge ◽  
William M. Mikkelsen
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Uric Acid ◽  
Heart Disease ◽  
Serum Uric Acid ◽  
Relationship Of ◽  
The Relationship

Mortality and associated risk factors in diabetics

1985 ◽  
Vol 110 (4_Suppl) ◽  
pp. S21-S26 ◽  
Author(s):  
R. J. Jarrett ◽  
M. J. Shipley
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mortality Risk ◽  
Mortality Rates ◽  
Potential Risk Factors ◽  
Diabetic Population ◽  
Associated Risk Factors ◽  
The Relationship

Summary. In 168 male diabetics aged 40-64 years participating in the Whitehall Study, ten-year age adjusted mortality rates were significantly higher than in non-diabetics for all causes, coronary heart disease, all cardiovascular disease and, in addition, causes other than cardiovascular. Mortality rates were not significantly related to known duration of the diabetes. The predictive effects of several major mortality risk factors were similar in diabetics and non-diabetics. Excess mortality rates in the diabetics could not be attributed to differences in levels of blood pressure or any other of the major risk factors measured. Key words: diabetics; mortality rates; risk factors; coronary heart disease. There are many studies documenting higher mortality rates - particularly from cardiovascular disease -in diabetics compared with age and sex matched diabetics from the same population (see Jarrett et al. (1982) for review). However, there is sparse information relating potential risk factors to subsequent mortality within a diabetic population, information which might help to explain the increased mortality risk and also suggest preventive therapeutic approaches. In the Whitehall Study, a number of established diabetics participated in the screening programme and data on mortality rates up to ten years after screening are available. We present here a comparison of diabetics and non-diabetics in terms of relative mortality rates and the influence of conventional risk factors as well as an analysis of the relationship between duration of diabetes and mortality risk.

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