Gene Amplification as Means for Determining Therapeutic Strategies in Human Cancers

2000 ◽  
Vol 38 (9) ◽  
Author(s):  
Gregory J. Tsongalis ◽  
Richard W. Cartun ◽  
Andrew Ricci
Keyword(s):  
Gene Amplification ◽  
Therapeutic Strategies ◽  
Human Cancers

scholarly journals Genetic Engineering of Zebrafish in Cancer Research

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2168
Author(s):  
Ludivine Raby ◽  
Pamela Völkel ◽  
Xuefen Le Bourhis ◽  
Pierre-Olivier Angrand
Keyword(s):  
Genetic Alterations ◽  
Therapeutic Strategies ◽  
Molecular Signatures ◽  
Reverse Genetic ◽  
Human Cancers ◽  
Oncogenic Mutations ◽  
Cancer Models ◽  
Conditional Expression ◽  
Cancer Initiation

Zebrafish (Danio rerio) is an excellent model to study a wide diversity of human cancers. In this review, we provide an overview of the genetic and reverse genetic toolbox allowing the generation of zebrafish lines that develop tumors. The large spectrum of genetic tools enables the engineering of zebrafish lines harboring precise genetic alterations found in human patients, the generation of zebrafish carrying somatic or germline inheritable mutations or zebrafish showing conditional expression of the oncogenic mutations. Comparative transcriptomics demonstrate that many of the zebrafish tumors share molecular signatures similar to those found in human cancers. Thus, zebrafish cancer models provide a unique in vivo platform to investigate cancer initiation and progression at the molecular and cellular levels, to identify novel genes involved in tumorigenesis as well as to contemplate new therapeutic strategies.

Alternative mechanisms of gene amplification in human cancers

2004 ◽  
Vol 41 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Yoshitaka Kuwahara ◽  
Chikako Tanabe ◽  
Tatsuro Ikeuchi ◽  
Kazuhiko Aoyagi ◽  
Michiko Nishigaki ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Human Cancers

scholarly journals Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability

2015 ◽  
Vol 44 (2) ◽  
pp. 558-572 ◽  
Author(s):  
Jiyeon Yun ◽  
Sang-Hyun Song ◽  
Jee-Youn Kang ◽  
Jinah Park ◽  
Hwang-Phill Kim ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Chromosomal Instability ◽  
Replication Complex ◽  
Human Cancers ◽  
High Level

scholarly journals Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Sarah K. Madden ◽  
Aline Dantas de Araujo ◽  
Mara Gerhardt ◽  
David P. Fairlie ◽  
Jody M. Mason
Keyword(s):  
Transcription Factor ◽  
Side Effects ◽  
Therapeutic Strategy ◽  
Tumor Regression ◽  
Therapeutic Strategies ◽  
Lessons Learned ◽  
Direct Inhibition ◽  
Human Cancers ◽  
E Box

Abstractc-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this to be a viable therapeutic strategy. Here we reassess the challenges of directly targeting c-Myc, evaluate lessons learned from current inhibitors, and explore how future strategies such as miniaturisation of Omomyc and targeting E-box binding could facilitate translation of c-Myc inhibitors into the clinic.

scholarly journals Esophageal Cancer: Insights from Mouse Models

2015 ◽  
Vol 8s1 ◽  
pp. CGM.S21218 ◽  
Author(s):  
Marie-Pier Tétreault
Keyword(s):  
Esophageal Cancer ◽  
Mouse Models ◽  
Molecular Mechanisms ◽  
Human Subjects ◽  
Surgical Techniques ◽  
Therapeutic Strategies ◽  
Human Cancers ◽  
Genetic Modifications ◽  
Wide Range ◽  
Gestation Time

Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause of cancer-related death worldwide. Despite recent advances in the development of surgical techniques in combination with the use of radiotherapy and chemotherapy, the prognosis for esophageal cancer remains poor. The cellular and molecular mechanisms that drive the pathogenesis of esophageal cancer are still poorly understood. Hence, understanding these mechanisms is crucial to improving outcomes for patients with esophageal cancer. Mouse models constitute valuable tools for modeling human cancers and for the preclinical testing of therapeutic strategies in a manner not possible in human subjects. Mice are excellent models for studying human cancers because they are similar to humans at the physiological and molecular levels and because they have a shorter gestation time and life cycle. Moreover, a wide range of well-developed technologies for introducing genetic modifications into mice are currently available. In this review, we describe how different mouse models are used to study esophageal cancer.

scholarly journals Gene amplification and associated loss of 5′ regulatory sequences of CoAA in human cancers

Oncogene ◽  
2006 ◽  
Vol 26 (6) ◽  
pp. 822-835 ◽  
Author(s):  
Y Sui ◽  
Z Yang ◽  
S Xiong ◽  
L Zhang ◽  
K L Blanchard ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Regulatory Sequences ◽  
Human Cancers

scholarly journals Human MUS81: A Fence-Sitter in Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Sisi Chen ◽  
Xinwei Geng ◽  
Madiha Zahra Syeda ◽  
Zhengming Huang ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Dna Repair ◽  
Embryonic Development ◽  
Cell Viability ◽  
Gene Mutations ◽  
Therapeutic Strategies ◽  
Endonuclease Activity ◽  
Dna Structures ◽  
Human Cancers

MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene mutations completely alter the role of MUS81 in human cancers. Here, we review the recent understanding of how MUS81 functions in tumors with distinct genetic backgrounds and discuss the potential therapeutic strategies targeting MUS81 in cancer.

scholarly journals Mapping Scientific and Technological Production Related to the MYC Gene

2021 ◽  
Vol 11 (4) ◽  
pp. 5897-5908
Author(s):  
Fabio Pacheco Estumano Da Silva
Keyword(s):  
Drug Target ◽  
Target Genes ◽  
Progressive Increase ◽  
Therapeutic Strategies ◽  
Human Cancers ◽  
Technological Production ◽  
The Usa ◽  
Myc Gene ◽  
Patent Documents ◽  
Multiple Drugs

In appropriate activation of c-MYC proto-oncogene contributes to the development of human cancers. Searches for therapies that target genes and proteins related to neoplastic phenotypes have become frequent. Therefore, inhibiting c-MYC expression has been the target for developing and testing multiple drugs and strategies for the treatment of various human cancers. This study aimed to map scientific and technological productions on the MYC gene at the Scielo, PubMed and Orbit Intelligence platforms between 2000 and 2019. The scientific prospecting revealed 1,259 articles. The most detected categories were: molecular biology, MYC mutations and those addressing the MYC as a drug target or therapeutic strategies. A progressive increase in the number of articles in this last category was found. Technological mapping detected 10,059 patent documents, with 20.2% granted. China and the USA were the largest filers, accounting for more than 40%. Biotechnology was the field with the highest number of patents. Biotechnology and the pharmaceutical sector predominated in the second half of the period investigated, both in scientific and technological prospecting. Our study points to a scientific and technological effort in the development of therapeutic strategies against cancer, in which MYC is among the main targets.

Functional characterization of EMSY gene amplification in human cancers

2011 ◽  
Vol 225 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Paul M Wilkerson ◽  
Konstantin J Dedes ◽  
Daniel Wetterskog ◽  
Alan Mackay ◽  
Maryou B Lambros ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Functional Characterization ◽  
Human Cancers
Sign in / Sign up

Export Citation Format

Share Document