The effectiveness of military physical exercise on irisin concentrations and oxidative stress among male healthy volunteers

AbstractBackgroundIrisin, a newly discovered hormone, is secreted into the circulation from skeletal muscles in response to physical exercise. The biochemical parameters related to irisin secretion have not been sufficiently investigated yet. The aim of this study was to examine the effectiveness of exercise on the level of irisin and its correlation with biochemical and oxidative stress parameters.Materials and methodsIn this pre- and post-test observational study, 39 healthy male volunteers from a military training setting were followed up on between September and November 2015. The individuals who were included in this study were between 22 and 27 years old with an average age of 24. Those with inflammatory disorders or chronic diseases such as diabetes mellitus were excluded from the study. The parameters were measured at the baseline, at 4 weeks, and at 8 weeks of intervention.ResultsThe study found that the systolic and diastolic blood pressures substantially decreased after 8 weeks of intervention. The cholesterol-to-HDL ratio and glucose levels were significantly higher at the baseline compared to 8 weeks. Total protein and albumin were significantly higher following 4 weeks (0.25 and 0.21 g/dL) and 8 weeks (0.32 and 0.16 g/dL), respectively. Meanwhile, total globulin and irisin increased following 8 weeks of the intervention by only 0.16 g/dL and 0.41 μg/mL, respectively. The high sensitivity C-reactive protein (hs-CRP) decreased following 8 weeks (−0.81 μg/mL). The protein carbonyl (PC) decreased following 4 weeks by only 0.34 nmol/L.ConclusionsThis study demonstrated that military training enhanced irisin hormone secretion following 8 weeks of military exercise.

Download Full-text

Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress

The Heart Surgery Forum ◽

10.1532/hsf98.2014326 ◽

2014 ◽

Vol 17 (5) ◽

pp. 271 ◽

Cited By ~ 7

Author(s):

Murat Bicer ◽

Tunay Senturk ◽

Murat Yanar ◽

Ahmet Tutuncu ◽

Arzu Yilmaztepe Oral ◽

...

Keyword(s):

Oxidative Stress ◽

Ischemia Reperfusion ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting ◽

Cabg Surgery ◽

Off Pump ◽

Pump Cabg ◽

Hs Crp ◽

And Oxidative Stress

Background: It has been suggested that off-pump coronary artery bypass grafting (CABG) surgery reduces myocardial ischemia-reperfusion injury, postoperative systemic inflammatory response, and oxidative stress. The aim of this study was to measure serum malondialdehyde (MDA), highsensitivity C-reactive protein (hs-CRP), M30, and M65 levels and to investigate the relationship between M30 levels and oxidative stress and inflammation in patients undergoing onand off-pump CABG surgery. Methods: Fifty patients were randomly assigned to onpump or off-pump CABG surgery (25 patients off-pump and 25 on-pump CABG surgery), and blood samples were collected prior to surgery, and 30 minutes, 60 minutes, 6 hours, and 24 hours after CABG surgery. Results: Compared to the on-pump group, serum MDA levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after the CABG surgery were significantly lower in the off-pump group (P = .001, P = .001, P = .001, and P = .001, respectively). Serum M30 levels were found to be elevated in both groups, returning to baseline at 24 hours. When compared to baseline, the hs-CRP level reached its peak at 24 hours at 13.28 ± 5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dL in the off-pump group. Conclusion: CABG surgery is associated with an increase in inflammatory markers and serum M30 levels, indicating epithelial/endothelial apoptosis in the early period.

Download Full-text

Physical Exercise and Oxidative Stress

Medicina Sportiva ◽

10.2478/v10036-011-0004-2 ◽

2011 ◽

Vol 15 (1) ◽

pp. 30-40 ◽

Cited By ~ 8

Author(s):

Joanna Kruk

Keyword(s):

Oxidative Stress ◽

Physical Exercise ◽

And Oxidative Stress

Download Full-text

Daphnetin Ameliorates Corticosterone-Induced Depressive-Like Behavior and Oxidative Stress in Mice Via Nuclear Factor Erythroid 2-Related Factor/Heme Oxygenase-1 Pathway

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.19:470-476 ◽

2021 ◽

Vol 19 (4) ◽

pp. 470-476

Author(s):

Chao Liu ◽

Chao Liang ◽

Jie Huang

Keyword(s):

Oxidative Stress ◽

Consumption Rate ◽

Tail Suspension Test ◽

Protein Carbonyl ◽

Heme Oxygenase 1 ◽

Related Factor ◽

Sucrose Consumption ◽

Markers Of Oxidative Stress ◽

Swimming Test ◽

And Oxidative Stress

We have investigated the effect of daphnetin on depressive-like behavior and oxidative stress caused by corticosterone in mice. To this end, we have analyzed the effect of corticosterone alone and combination of corticosterone and daphnetin on three behavioral indices of depressive-like behavior - sucrose consumption rate, forced swimming test, and tail suspension test as well as biochemical markers of oxidative stress - malondialdehyde, nitrite, protein carbonyl, nonprotein sulfhydryl and glutathione contents as well as hippocampal cell apoptosis. The results support the conclusion that daphnetin diminished corticosterone induced depressive like behavior and oxidative stress by activating Nrf2/HO-1 pathway.

Download Full-text

Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

The Indonesian Biomedical Journal ◽

10.18585/inabj.v2i3.127 ◽

2010 ◽

Vol 2 (3) ◽

pp. 131

Author(s):

Waode Nurfina ◽

Irawan Yusuf ◽

Mansyur Arif

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Iron Status ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Metabolic Conditions ◽

Inflammatory State ◽

And Oxidative Stress

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

Download Full-text

hs-CRP and oxidative stress in young CAD patients: A pilot study

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-008-0073-8 ◽

2008 ◽

Vol 23 (4) ◽

pp. 334-336 ◽

Cited By ~ 11

Author(s):

Suman B. Sharma ◽

Seema Garg ◽

Abhinav Veerwal ◽

Sridhar Dwivedi

Keyword(s):

Oxidative Stress ◽

Pilot Study ◽

Hs Crp ◽

And Oxidative Stress

Download Full-text

Abstract 441: Gamma-glutamyltransferase and Markers of Subclinical Atherosclerosis in Patients with Psoriasis

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.36.suppl_1.441 ◽

2016 ◽

Vol 36 (suppl_1) ◽

Author(s):

Kenan Demircioglu ◽

Feyza Aksu ◽

Mustafa Caliskan ◽

Yusuf Yilmaz

Keyword(s):

Subclinical Atherosclerosis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Control Group ◽

Gamma Glutamyltransferase ◽

Glucose Levels ◽

Hs Crp

Introduction: Gamma-glutamyltransferase(GGT) plays a catalytic role in degradation of glutathione. Serum GGT is accepted as a marker of oxidative stress.The aim of this study is to investigate the relationship between serum GGT levels and epicardial adipose tissue (EFT) thickness, carotid intima media thickness (CIMT) measurements in patients with psoriasis. Methods: The study population included 89 patients with psoriasis and 79 healthy volunteers. After overnight fasting, blood samples were taken for to determine blood glucose levels and establishing cholesterol profiles including TG, TC, LDL cholesterol and high-density lipoprotein (HDL) cholesterol; GGT; and high- sensitivity C-reaktive protein (hs-CRP) levels. A high-resolution B-mode ultrasound machine (Toshiba, aplio XU) with a 7.5 MHz linear transducer used for examing CIMT.The right common carotid artery (CCA), approximately 1 cm proximal to the bifurcation, was longitudinally selected and CIMT was defined as the distance between the intima and the media. Results: 89 patients with psoriasis (age:41.7±10.9 years;41 women, 48 men), and 71 healthy control subjects (age:40.4±8.2 years;39 women, 32 men) were included. There were no significant variation for age and sex between two groups(p>0.05).The hs-CRP and GGT values were significantly higher in psoriasis, compared with the controls (hs-CRP:1.35(0.9-3.6)mg/l for psoriasis group, 0.45(0.29-0.79)mg/l for control group, p<0.001; GGT:20.6±9.6 U/l for psoriasis group, 16.7±8.0 U/l for control group, p=0.02. In psoriatic patients, CIMT and EFT were significantly inreased (0.60(0.50-0.68)mm vs. 0.50 (0.40-0.60)mm;p=0.007, 0.67±0.20cm; 0.27±0.12cm; p<0.001, respectively) compared with the control group. CIMT significantly positively correlated with EFT, age, BMI, diastolic BP and GGT.EFT significantly positively correlated with GGT, CIMT, age, hs-CRP, systolic BP and TG and negatively correlated with HDL cholesterol. Discussion: The pathophysiology of atherosclerosis in psoriasis is not fully explained.GGT may be used as an indicator of subclinical atherosclerosis like CRP.

Download Full-text

Retinol-binding protein 4 (RBP4) and high sensitivity C-reactive protein (hs-CRP) levels in patients with diminished ovarian reserve (DOR): a cross-sectional study

Reproductive Biology and Endocrinology ◽

10.1186/s12958-020-00670-4 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Wen Zou ◽

Zehao Wang ◽

Jing Xia ◽

Jing Yang

Keyword(s):

Oxidative Stress ◽

Vitamin A ◽

Ovarian Reserve ◽

High Sensitivity ◽

Diminished Ovarian Reserve ◽

Retinol Binding Protein ◽

C Reactive Protein ◽

Retinol Binding Protein 4 ◽

Reactive Protein ◽

Hs Crp

Abstract Background Antioxidant/oxidant imbalance has been reported to be related to diminished ovarian reserve (DOR). Vitamin A (retinol), a kind of antioxidant, plays a role in restoring ovarian oxidative damage, while C-reactive protein (CRP) is the classical marker of oxidative stress and has recently been identified as an independent variable that is associated with low anti-Mullerian hormone (AMH) levels in young women with DOR. Additionally, retinol binding protein 4 (RBP4) can be considered a substitute for retinol in healthy, nonobese women. The study aim was to determine the relationship between serum RBP4, high sensitivity C-reactive protein (hs-CRP) concentrations and ovarian reserve in nonobese DOR patients. Methods This study included 24 DOR women and 48 normal ovarian reserve (NOR) women from the reproductive medical center of Renmin Hospital of Wuhan University. The serum RBP4 and high-sensitivity CRP (hs-CRP) levels were measured with ELISA kits. Results RBP4 levels (20,648.36 ± 5475.16 ng/ml vs 23,986.48 ± 5995.64 ng/ml, p = 0.025) were decreased, and hs-CRP levels (695.08 ± 1090.19 ng/ml vs 364.32 ± 786.29 ng/ml, p = 0.012) were increased in the DOR group. Serum RBP4 was positively related to AMH (Pearson r = 0.518, p = 0.000), while hs-CRP was negatively correlated with AMH (Spearman r = − 0.345, p = 0.005). after adjustments were made for the covariables, multiple line regression analysis showed that positive association between RBP4 and AMH still existed (β = 0.450, p < 0.001). Conclusion Decreased serum RBP4 levels and increased serum hs-CRP were observed in DOR patients in our study, and the strong correlation between RBP4 and AMH supports the notion that oxidative stress plays a role in DOR, and that appropriate levels of antioxidant vitamin A may be protective against ovarian reserve dysfunction.

Download Full-text

Exhaustive Physical Exercise Effects on Nitric Oxide, Uric Acid, Antioxidant Activity and Oxidative Stress in Saliva of Elite Triathlete

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000274395.82535.aa ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S356

Author(s):

José Guerrero ◽

David GonzalAez ◽

Ramón Marquina ◽

Jean C. Zambrano ◽

Antonio Rodríguez-Malaver ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Antioxidant Activity ◽

Uric Acid ◽

Physical Exercise ◽

And Oxidative Stress

Download Full-text

Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302011000200004 ◽

2011 ◽

Vol 55 (2) ◽

pp. 121-126 ◽

Cited By ~ 7

Author(s):

Aline Margioti Zanella ◽

Marcelo Arruda Nakazone ◽

Marcela Augusta Souza Pinhel ◽

Dorotéia Rossi Silva Souza

Keyword(s):

Oxidative Stress ◽

Physical Activity ◽

Physical Exercise ◽

Lipid Profile ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Beneficial Effects ◽

Apolipoprotein A ◽

And Oxidative Stress ◽

Cholesterol Fraction

OBJECTIVE: To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). SUBJECTS AND METHODS: Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. RESULTS: FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). CONCLUSIONS: These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

Download Full-text