The aqueous and methanol extracts of Bambusa vulgaris (Poaceae) improve calcium and phosphorus levels, and bone microstructure in ovariectomized model of osteoporosis

2019 ◽  
Vol 30 (3) ◽  
Author(s):  
Pierre Watcho ◽  
Bernadette Guiadem Kamto Kamto ◽  
Patrick Brice Defo Deeh ◽  
Telesphore Benoit Nguelefack ◽  
Albert Kamanyi ◽  
...  
Keyword(s):  
Therapeutic Drug ◽  
Methanol Extracts ◽  
Metabolic Bone ◽  
Bambusa Vulgaris ◽  
Bone Calcium ◽  
Female Wistar Rats ◽  
Soya Oil ◽  
Trabecular Network ◽  
17Β Estradiol ◽  
Calcium And Phosphorus

Abstract Background Osteoporosis represents the most common metabolic bone disease. Bambusa vulgaris (Poaceae) is a plant with potential antiosteoporotic effects, due to its phytoestrogenic, antioxidative, and anti-inflammatory properties. This study was undertaken to evaluate the effects of aqueous and methanol extracts of B. vulgaris on osteoporosis in rats. Methods Adult female Wistar rats were randomly divided into normal (n = 6) and ovariectomized (n = 42) groups. Twelve weeks after ovariectomy, animals were treated for 4 weeks as follows: distilled water (10 mL/kg, per os (p.o.)), 17β-estradiol (10 μg/kg, intraperitoneal (i.p.)), soya oil (1 mL/kg, i.p.), aqueous or methanol extract of B. vulgaris (55 or 110 mg/kg, p.o.). All rats were weighed daily and sacrificed on day 29. Plasma was collected, and the uterus and femur were dissected out, weighed, and used for biochemical and histological measurements. Results In the untreated ovariectomized females, a non-significant (p > 0.05) increase in body weight and a significant decrease (p < 0.001) in the uterine and bone weights were recorded. Ovariectomy also significantly (p < 0.001) lowered the bone calcium and phosphorus concentrations, and deteriorated the microarchitecture of the femur. Interestingly, B. vulgaris extracts significantly (p < 0.001) improved the bone calcium concentration and femur microarchitecture (increase in trabecular bone density, reorganization of the trabecular network, and increase in bone marrow) with estrogenic-like effects compared to 17β-estradiol. Conclusion These results suggest that B. vulgaris is a potential therapeutic drug for the treatment of osteoporosis. The present findings further justify the ethno-medicinal claims of B. vulgaris.

Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3

1983 ◽  
Vol 244 (2) ◽  
pp. E159-E163
Author(s):  
S. Okamoto ◽  
Y. Tanaka ◽  
H. F. DeLuca ◽  
Y. Kobayashi ◽  
N. Ikekawa
Keyword(s):  
Biological Activity ◽  
Calcium Transport ◽  
Plasma Calcium ◽  
Epiphyseal Plate ◽  
Dihydroxyvitamin D3 ◽  
Responsive Systems ◽  
1,25 Dihydroxyvitamin D3 ◽  
Bone Calcium ◽  
Calcium And Phosphorus

The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known in vivo vitamin D responsive systems. These systems include intestinal calcium transport, bone calcium mobilization, calcification of epiphyseal plate cartilage, and elevation of plasma calcium and phosphorus concentrations. Thus, 24,24-difluoro-1,25-dihydroxyvitamin D3 is the first known analogue with higher potency than 1,25-dihydroxyvitamin D3 in vivo.

scholarly journals LC-MS-based plasma metabolomics reveals metabolic variations in ovariectomy-induced osteoporosis in female Wistar rats

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 24932-24941 ◽  
Author(s):  
Yan Hu ◽  
Xiaojian Zhang ◽  
Yu Shan
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Wistar Rats ◽  
Bone Diseases ◽  
Mineral Density ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone ◽  
Female Wistar Rats

Osteoporosis with a reduction in bone mineral density has become one of the most common metabolic bone diseases.

THE HYPERCALCAEMIC SYNDROME IN RATS BEARING THE WALKER CARCINOSARCOMA 256

1975 ◽  
Vol 78 (3) ◽  
pp. 613-624 ◽  
Author(s):  
H. Minne ◽  
F. Raue ◽  
S. Bellwinkel ◽  
R. Ziegler
Keyword(s):  
Soft Tissue ◽  
Animal Models ◽  
Long Range ◽  
Calcium Metabolism ◽  
Phosphorus Excretion ◽  
Tumour Bearing ◽  
Bone Calcium ◽  
Calcium And Phosphorus

ABSTRACT The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium. These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.

scholarly journals Overview of Important Micronutrients Supplementation in Preterm Infants after Discharge: A Call for Consensus

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 331
Author(s):  
Laura Ilardi ◽  
Alice Proto ◽  
Federica Ceroni ◽  
Daniela Morniroli ◽  
Stefano Martinelli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Preterm Infants ◽  
Complementary Feeding ◽  
Critical Role ◽  
Clinical History ◽  
Metabolic Bone ◽  
Micronutrient Intake ◽  
History Of ◽  
Calcium And Phosphorus ◽  
Nutritional Deficits

Preterm infants have a lower level of nutrient body stores and immature body systems, resulting in a higher risk of malnutrition. Imbalanced complementary feeding could lead to further risk of nutritional deficits and excesses. However, evidence on their nutritional requirements following hospital discharge is limited. When planning complementary feeding, appropriate micronutrient intake should be considered for their critical role in supporting various body functions. This narrative review summarizes the need for iron, zinc, vitamin D, calcium, phosphate and long-chain polyunsaturated fatty acids (LCPUFAs) supplementation in preterm infants during complementary feeding. Regarding iron and vitamin D, the scientific community is reaching an agreement on supplementation in some categories of prematures. On the contrary, there is still not enough evidence to detail possible recommendations for LCPUFAs, zinc, calcium and phosphorus supplementation. However, these micronutrients are paramount for preterms’ health: LCPUFAs can promote retinal and brain development while calcium and phosphorus supplementation is essential to prevent preterms’ metabolic bone disease (MBD). Waiting for a consensus on these micronutrients, it is clear how the knowledge of the heterogeneity of the prematures population can help adjust the nutritional planning regarding the growth rate, comorbidities and comprehensive clinical history of the preterm infant.

Exchange of Bone Calcium and Phosphorus in vivo

Nature ◽  
1954 ◽  
Vol 173 (4415) ◽  
pp. 1137-1138
Author(s):  
T. G. TAYLOR ◽  
J. H. MOORE ◽  
D. H. TOMLIN
Keyword(s):  
Bone Calcium ◽  
Calcium And Phosphorus

Changes in the regulation of calcium metabolism and bone calcium content during growth in the absence of endogenous prolactin and during hyperprolactinemia: A longitudinal study in male and female Wistar rats

2000 ◽  
Vol 78 (10) ◽  
pp. 757-765 ◽  
Author(s):  
Pritsana Piyabhan ◽  
Nateetip Krishnamra ◽  
Liangchai Limlomwongse
Keyword(s):  
Calcium Metabolism ◽  
Wistar Rats ◽  
Calcium Absorption ◽  
Calcium Content ◽  
Female Rats ◽  
Calcium Retention ◽  
Bone Calcium ◽  
Female Wistar Rats ◽  
Fractional Calcium Absorption

Since endogenous prolactin has been shown to enhance food consumption, calcium absorption, and bone calcium turnover in the pregnant rat, the role of endogenous prolactin in the regulation of calcium metabolism was investigated in 3-day balance studies of female Wistar rats from the age of 3 to 11 weeks. The study was divided into two parts. In part I, calcium metabolism in males and females was compared. In part II, 3-week old female rats were divided into 5 groups: (i) control animals receiving 0.9% NaCl; (ii) animals receiving 6 mg bromocriptine/kg/day (- PRLendo group); (iii) animals receiving 2.5 mg ovine prolactin/kg/day (+PRLexo); (iv) sham-operated animals receiving 0.9% NaCl, and (v) animals with two extra pituitaries implanted under the renal capsule, receiving 0.9% NaCl (AP group). Results showed that rapid growth occurred between 3 and 6 weeks with maximum fractional calcium absorption and calcium retention at 5 weeks of age in both sexes. The data also showed a physiological significance of endogenous prolactin in enhancing calcium absorption and retention in 5 week old rats. In an absence of prolactin, peak calcium absorption was delayed in 7-week old animals, and vertebral calcium content of 11-week old animals was reduced by 18%. Hyperprolactinemia in the AP group was found to enhance fractional calcium absorption and calcium retention at 7, 9, and 11 weeks and increased the femoral calcium content by 16%. It could be concluded that a physiological role of prolactin is the stimulation of calcium absorption and maintainance of bone calcium content during growth and development.Key words: bone calcium content, calcium absorption, calcium balance, hyperprolactinemia, prolactin.

Regulation of calcium metabolism in streptozotocin-induced diabetes

1984 ◽  
Vol 247 (1) ◽  
pp. R120-R123
Author(s):  
R. J. Wood ◽  
L. H. Allen ◽  
F. Bronner
Keyword(s):  
Calcium Absorption ◽  
Diabetic Rats ◽  
Urinary Calcium ◽  
Plasma Calcium ◽  
Calcium Deposition ◽  
Calcium Excretion ◽  
Experimental Animals ◽  
Bone Calcium ◽  
Female Wistar Rats ◽  
Streptozotocin Induced Diabetes

Sixty-nine-day-old female Wistar rats that had been made diabetic 9 days earlier by an intraperitoneal injection of streptozotocin were studied by a combination radioisotope and balance technique that evaluates calcium absorption, excretion, and bone calcium deposition and resorption rates. Streptozotocin-induced diabetes was associated with a marked drop in calcium absorption and a threefold rise in urinary calcium excretion, changes that greatly exceeded the expected effects from the hyperphagia and increased calcium intake of the experimental animals. Bone calcium deposition was halved in the diabetic rats, with bone resorption unchanged and ewqual to the deposition rate. As a result, the bone and body calcium balances were zero in the experimental animals. To maintain plasma calcium near normal under these circumstances, the diabetic animals turned over their skeletal calcium in relationship to the central pool much more rapidly than the controls. Although the skeleton in the normal animals serves as both storehouse and regulator of the plasma calcium, in short-term streptozotocin-induced diabetes there is no calcium storage in bone, with the skeleton only playing the role of regulator of calcium homeostasis.

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