scholarly journals Review. Anticoagulant Therapy in Sepsis. The Importance of Timing

2017 ◽  
Vol 3 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Ecaterina Scarlatescu ◽  
Dana Tomescu ◽  
Sorin Stefan Arama
Keyword(s):  
Anticoagulant Therapy ◽  
Coagulation Activation ◽  
Proper Selection ◽  
Beneficial Effects ◽  
Patient Heterogeneity ◽  
The Difference ◽  
The Right ◽  
Harmful Effects ◽  
Selection Of Patients ◽  
Selection Of

Abstract Sepsis associated coagulopathy is due to the inflammation-induced activation of coagulation pathways concomitant with dysfunction of anticoagulant and fibrinolytic systems, leading to different degrees of haemostasis dysregulation. This response is initially beneficial, contributing to antimicrobial defence, but when control is lost coagulation activation leads to widespread microvascular thrombosis and subsequent organ failure. Large clinical trials of sepsis-related anticoagulant therapies failed to show survival benefits, but posthoc analysis of databases and several smaller studies showed beneficial effects of anticoagulants in subgroups of patients with early sepsis-induced disseminated intravascular coagulation. A reasonable explanation could be the difference in timing of anticoagulant therapy and patient heterogeneity associated with large trials. Proper selection of patients and adequate timing are required for treatment to be successful. The time when coagulation activation changes from advantageous to detrimental represents the right moment for the administration of coagulation-targeted therapy. In this way, the defence function of the haemostatic system is preserved, and the harmful effects of overwhelming coagulation activation are avoided.

Genetic rescue by augmenting gene flow

2017 ◽  
Author(s):  
Richard Frankham ◽  
Jonathan D. Ballou ◽  
Katherine Ralls ◽  
Mark D. B. Eldridge ◽  
Michele R. Dudash ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Gene Flow ◽  
Inbreeding Coefficient ◽  
Outbreeding Depression ◽  
Genetic Rescue ◽  
Evolutionary Potential ◽  
Beneficial Effects ◽  
The Difference ◽  
Inbred Populations ◽  
Harmful Effects

Inbreeding is reduced and genetic diversity enhanced when a small isolated inbred population is crossed to another unrelated population. Crossing can have beneficial or harmful effects on fitness, but beneficial effects predominate, and the risks of harmful ones (outbreeding depression) can be predicted and avoided. For crosses with a low risk of outbreeding depression, there are large and consistent benefits on fitness that persist across generations in outbreeding species. Benefits are greater in species that naturally outbreed than those that inbreed, and increase with the difference in inbreeding coefficient between crossed and inbred populations in mothers and zygotes. However, benefits are similar across invertebrates, vertebrates and plants. There are also important benefits for evolutionary potential of crossing between populations.

Cardioversion of Atrial Fibrillation: How Important is a Long Arrhythmia Duration?

1994 ◽  
Vol 39 (3) ◽  
pp. 78-79
Author(s):  
G.Y.H. Lip ◽  
K.J. Hogg
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Successful Outcome ◽  
Proper Selection ◽  
Long Duration ◽  
Selection Of Patients ◽  
Selection Of

A long duration of atrial fibrillation is usually considered as an adverse feature for successful cardioversion of atrial fibrillation and the maintenance of sinus rhythm. This often leads to the exclusion of such patients from being considered for this procedure. We report three patients in whom atrial fibrillation was present for a long duration (one for 2 years, two for 10 years), and successful cardioversion to sinus rhythm was achieved. Proper selection of patients with atrial fibrillation with an understanding of all features predicting a successful outcome will often allow a good result.

scholarly journals Evaluation of Turnip (Brassica rapa L.) Var PTWG for Yield and Relative Economics under Frontline Demonstrations in District Budgam

2021 ◽  
pp. 58-63
Author(s):  
Ambreen Nabi ◽  
Sabia Akhter ◽  
N. A. Dar ◽  
Vaseem Yousuf ◽  
Khurshid Ahmad Sofi ◽  
...  
Keyword(s):  
Brassica Rapa ◽  
Production Technology ◽  
Seed Treatment ◽  
Front Line ◽  
Proper Selection ◽  
Cultivation Method ◽  
Yield Increase ◽  
Wide Gap ◽  
The Difference ◽  
Selection Of

The study was conducted to evaluate the turnip variety purple top white globe for yield and yield contributing characters  through front line demonstration in District Budgam for three consecutive years 2018,2019 and 2020.A total of 25 FLD’s were distributed in village Roshanabad of block Narbal, District Budgam. The results obtained reveals that the improved variety was having higher yield and hence better returns to the farmers as compared to the local variety. Study also revealed a wide gap in the production technology of turnip. The farmers themselves observed the difference between the improved variety and local. The yield increase of 57.9% over the control and B:C ratio of 3.48 in demonstration plot (2.13 in control) may be attributed to scientific cultivation method viz proper selection of variety, use of quality seed, seed treatment, proper spacing, recommended dose of fertilizers and integrated pest management.

scholarly journals Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy inKRASWild-Type Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Tze-Kiong Er ◽  
Chih-Chieh Chen ◽  
Luis Bujanda ◽  
Marta Herreros-Villanueva
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor Receptor ◽  
Predictive Biomarkers ◽  
Genetic Determinants ◽  
Secondary Resistance ◽  
Epidermal Growth ◽  
The Right ◽  
Colorectal Cancer Patients ◽  
Selection Of Patients ◽  
Selection Of

Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies. Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, and ultimately providing clinical benefit.KRASmutations in codons 12 and 13 are recognized prognostic and predictive biomarkers that should be analyzed at the clinic prior to the administration of anti-EGFR therapy. However, still an important fraction ofKRASwild-type patients do not respond to the treatment. The identification of additional genetic determinants of primary or secondary resistance to EGFR targeted therapy for further improving the selection of patients is urgent. Herein, we review the latest published literature highlighting the most important genes that may predict resistance to anti-EGFR monoclonal antibodies in colorectal cancer patients. According to the available findings, the evaluation ofBRAF,NRAS,PIK3CA, andPTENstatus could be the right strategy to select patients who are likely to respond to anti-EGFR therapies. In the future, the combination of those biomarkers will help establish consensus that can be introduced into clinical practice.

scholarly journals Arrhythmogenic Cardiomyopathy—Current Treatment and Future Options

2021 ◽  
Vol 10 (13) ◽  
pp. 2750
Author(s):  
Federico Migliore ◽  
Giulia Mattesi ◽  
Alessandro Zorzi ◽  
Barbara Bauce ◽  
Ilaria Rigato ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Ventricular Dysfunction ◽  
Original Description ◽  
Current Treatment ◽  
Muscle Disease ◽  
Arrhythmogenic Cardiomyopathy ◽  
The Right ◽  
Selection Of Patients ◽  
Selection Of ◽  
Myocardial Lesions

Arrhythmogenic cardiomyopathy (ACM) is an inheritable heart muscle disease characterised pathologically by fibrofatty myocardial replacement and clinically by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Although, in its original description, the disease was believed to predominantly involve the right ventricle, biventricular and left-dominant variants, in which the myocardial lesions affect in parallel or even mostly the left ventricle, are nowadays commonly observed. The clinical management of these patients has two main purposes: the prevention of SCD and the control of arrhythmic and heart failure (HF) events. An implantable cardioverter defibrillator (ICD) is the only proven lifesaving treatment, despite significant morbidity because of device-related complications and inappropriate shocks. Selection of patients who can benefit the most from ICD therapy is one of the most challenging issues in clinical practice. Risk stratification in ACM patients is mostly based on arrhythmic burden and ventricular dysfunction severity, although other clinical features resulting from electrocardiogram and imaging modalities such as cardiac magnetic resonance may have a role. Medical therapy is crucial for treatment of VAs and the prevention of negative ventricular remodelling. In this regard, the efficacy of novel anti-HF molecules and drugs acting on the inflammatory pathway in patients with ACM is, to date, unknown. Catheter ablation represents an effective strategy to treat ventricular tachycardia relapses and recurrent ICD shocks. The present review will address the current strategies for prevention of SCD and treatment of VAs and HF in patients with ACM.

scholarly journals Penerapan Metode Analytical Hierarchy Process (AHP) untuk Menentukan Supplier Ikan Teri (Studi Kasus di PT. Urchindize Indonesia)

2019 ◽  
Vol 10 (2) ◽  
pp. 86-94
Author(s):  
Noor Nailie Azzat ◽  
◽  
Mufidah Ulwiyatun Nafisah ◽  
Keyword(s):  
Analytical Hierarchy Process ◽  
Supplier Selection ◽  
Quality Criteria ◽  
Assessment Method ◽  
Ahp Method ◽  
Proper Selection ◽  
The Right ◽  
Hierarchy Process ◽  
Selection And Assessment ◽  
Selection Of

PT Urchindize has more than 35 anchovy suppliers, although the company has many suppliers, it still often encounters obstacles. The obstacle felt by the company is that the supplier has not been able to meet a number of standard criteria owned by the company. The company has not yet implemented the proper selection and assessment method for suppliers. Based on this, the company must select suppliers to get suppliers who are truly able to meet company needs consistently and with quality. Based on the results of data processing using the Analytical Hierarchy Process (AHP) method, obtained the most influential criteria in supplier selection in the following order of priority: price criteria, delivery criteria, quality criteria, supplier relationship criteria, service criteria and responsibility. While the right supplier in the selection of suppliers for PT. Urchindize namely Mr. Ali Yudin became the main priority with a weight of 0.181, second was Mr. Akhsan with a weight of 0.159, third was Mr. Sugiyanto with a weight of 0.141, fourth was Mr. Junaidi with a weight of 0.118, the fifth was Mr. Masdawi with a weight of 0.102, the sixth was is Mrs. Mustarikah with a weight of 0.081, seventh is Mr. Sofyan and Mr. Idris with a weight of 0.073, eighth is Mr. Yusman with a weight of 0.044, the last priority is Mr. Abdul Rokhman with a weight of 0.037.

scholarly journals Analisis Performa Rasio Kompresi Pada Metode Differensiasi ASCII Dan Lempel Ziv Welch (LZW)

2018 ◽  
Vol 1 (2) ◽  
pp. 20-26
Author(s):  
Tommy Tommy ◽  
Rosyidah Siregar ◽  
Amir Mahmud Husein ◽  
Mawaddah Harahap ◽  
Ferdy Riza
Keyword(s):  
Data Compression ◽  
Compression Ratio ◽  
Difference Method ◽  
Compression Method ◽  
Differentiation Method ◽  
Large Size ◽  
The Difference ◽  
The Right ◽  
Selection Of ◽  
Input Character

ASCII differentiation is a compression method that utilizes the difference value or the difference between the bytes contained in the input character. Technically, the ASCII differentiation method can be done using a coding dictionary or using windowing block instead of the coding dictionary. Previous research that has been carried out shows that the ASCII differentiation compression ratio is good enough but still needs to be analyzed on performance from the perspective of the compression ratio of the method compared to other methods that have been widely used today. In this study an analysis of the comparison of the ASCII Difference method with other compression methods such as LZW will be carried out. The selection of LZW itself is done by reason of the number of data compression applications that use the method so that it can be the right benchmark. Comparison of the compression ratio performed shows the results of ASCII differentiation have advantages compared to LZW, especially in small input characters. Whereas in large input characters, LZW can optimize the probability of pairs of characters that appear compared to ASCII differentiation which is glued to the difference values ​​in each block of input characters so that in large size characters LZW has a greater compression ratio compared to ASCII differentiation.

Performance topics in harpsichord music in the second half of the 18th century – Part 1

2019 ◽  
Vol 1 (11) ◽  
pp. 29-42
Author(s):  
Marek Pilch
Keyword(s):  
18Th Century ◽  
Piano Music ◽  
Necessary Condition ◽  
Proper Selection ◽  
Basso Continuo ◽  
Starting Point ◽  
Keyboard Music ◽  
The Right ◽  
Selection Of

The present article is connected in terms of its topic with the text entitled Harpsichord or piano? Different concepts in the 18th century keyboard music published by the author in “Notes Muzyczny” no. 1 (9) 2018, and it is the continuation of the discussion on the capacities and ways of performance of music from the Classical period, which is now understood as piano music, on the harpsichord. Subsequent parts will touch on peculiar performance topics connected with the role of the harpsichord in that period: the understanding and rendering of the dynamics, the performance of arpeggios, and the ornamentation. The starting point of the author’s deliberations is the textbook by Daniel Gottlob Türk entitled Klavierschule oder Anweisung zum Klavierspielen für Lehrer und Lernende mit kritischen Anmerkungen. (Leipzig, Halle 1789) and textbooks by other theoreticians of that period (J. J. Quantz, C. Ph. E. Bach), as well as modern publications (F. Neumann, C. Brown, S. Rampe, J. Trinkewitz). The possibility of the rendering of the dynamics understood as the capacity to influence the strength of single sounds is not the necessary condition for performing keyboard compositions from the second half of the 18th century. Neither is it the feature placing keyboard instruments in any particular hierarchy of values. In the 18th century sources it is hard to find any opinions stating that harpsichords were perceived as worse than other keyboard instruments due to the impossibility of shaping the dynamics of individual sounds. The most significant remarks referring to the performance are the topics connected with expression. The dynamics is not the only mean thanks to which a performance becomes expressive. It is possible to play in an expressive way on the harpsichord, yet it is achieved thanks to articulatory measures, agogic nuances, the right way of hitting keys and the proper selection of texture while playing basso continuo.

Cochlear Nerve Section for Intractable Tinnitus

1995 ◽  
Vol 74 (7) ◽  
pp. 468-476 ◽  
Author(s):  
Jack L. Pulec
Keyword(s):  
Spiral Ganglion ◽  
Accurate Diagnosis ◽  
Cochlear Nerve ◽  
Careful Examination ◽  
Complete Relief ◽  
Proper Selection ◽  
Nerve Section ◽  
Subjective Tinnitus ◽  
Selection Of Patients ◽  
Selection Of

Tinnitus is a common and often very disturbing symptom. The majority of patients can now be successfully treated either by conservative medical treatment or by specific surgery. Intractable subjective tinnitus originating within the cochlea or cochlear nerve can frequently be successfully treated by cochlear nerve section. The cochlear nerve must be severed medial to the spiral ganglion to obtain optimum results. One hundred fifty-one cases are reported. Complete relief of tinnitus was achieved in 101 patients, worthwhile improvement was obtained in 43 patients and 7 patients obtained no improvement. The indications for this surgery will be given. Careful examination, accurate diagnosis, and proper selection of patients with intractable tinnitus for cochlear nerve section offer a good chance for success.

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