Amelioration of chronic inflammation and oxidative stress indices in diabetic Wistar rats using methanol leaf extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae)

Ethnopharmacological practitioners in Nigeria have used aqueous and ethanol extracts of: The dried leaves were extracted by percolation in 80% methanol:water for 72 h after which the mixture was filtered using Whatman No. 1 (11 μm) filter papers. Acute toxicity studies were done using Wistar rats and given orally up to a dose of 2,000 mg/kg. The animals were monitored for 48 h. The experimental design involved five (5) groups of six (6) albino Wistar diabetic rats each. Groups A, B and C rats received 100, 200 and 400 mg/kg: The administration of the leaf extract up to a dose of 2,000 mg/kg to rats produced absolutely no death or observable signs of toxicity in 48 h. The cotton pellet granuloma weights in 200 mg/kg (44.88±1.2 mg), 400 mg/kg (42.10±1.2 mg): The study showed that