Oral Epithelioid Hemangioendothelioma — Unusual Location of a Rare Entity

AbstractIntroduction:Epithelioid hemangioendothelioma is a rare, locally aggressive vascular tumor, originating from soft tissue, bone, skin, and organs such as the liver or lung, exceptionally located in the oral cavity. Most of the cases of oral epithelioid hemangioendothelioma are asymptomatic, and diagnosis is hampered by the fact that the histological features are somewhat between hemangioma and angiosarcoma, with epithelioid cells, intracytoplasmic vacuoles, low mitotic activity, and (rarely) necrosis. Immunohistochemical analysis is required to rule out carcinoma or other epithelioid vascular neoplasms.Case presentation:We present a rare case of a 59-year-old Caucasian male patient with oral epithelioid hemangioendothelioma for which clinical and cytological diagnosis was difficult, in spite of the patient’s history. The lesion was nonspecific, mimicking ulcerative stomatitis, but histological and immunohistochemical evaluation finally managed to establish the right diagnosis. Subsequently, the patient underwent surgical excision of the lesion followed by oncological treatment — chemotherapy.Conclusions:Although at first examination seemed that another lesion has developed, rigorous histology and immunohistochemistry tests proved the presence of epithelioid hemangioendothelioma, a very rare entity located in the oral cavity, which required a proper surgical and oncological approach.

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Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

Brazilian Dental Science ◽

10.14295/bds.2016.v19i1.1148 ◽

2016 ◽

Vol 19 (1) ◽

pp. 113

Author(s):

Antonione Santos Bezerra Pinto ◽

Vera Cavalcanti De Araújo ◽

Fabrício Passador Santos ◽

José Ferreira de Menezes Filho ◽

Viviane Siqueira ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Hard Palate ◽

Salivary Gland Tumor ◽

Immunohistochemical Analysis ◽

Soft Tissue Tumors ◽

Rare Entity ◽

Gland Tumor ◽

Clinical Imaging ◽

Fibrous Tumor

A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least 2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. KeywordsSolitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.

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Pathohistological and Immunohistochemical Analysis, Differential Diagnosis, Prognosis and Complex Treatment in a Rare Lymphoepithelioma-Like Breast Cancer

Advances in Bioengineering and Biomedical Science Research ◽

10.33140/abbsr.04.01.03 ◽

2021 ◽

Vol 4 (1) ◽

Keyword(s):

Breast Cancer ◽

Differential Diagnosis ◽

Clinical Case ◽

Medical Literature ◽

Immunohistochemical Analysis ◽

Breast Tumors ◽

Oncological Treatment ◽

Malignant Breast ◽

The Right ◽

Epithelial Neoplasm

We present a 78-year-old woman with a rare neoplasm of the right mammary gland – Lymphoepithelioma-like carcinoma (LELC). Lymphoepithelioma-like carcinoma is an undifferentiated neoplasm, consisting of malignant epithelial cells on the background of lymphocytes. Pathomorphological features and immunohistochemical (IHC) analysis determines the rare pathohistological variant of breast cancer. This clinical case of lymphoepithelioma-like breast cancer is the 34th published in medical literature in English. In the discussion, we emphasize the importance of immunohistochemical analysis to assess the differential diagnosis with other benign and malignant breast tumors . Lymphoepithelioma-like breast cancer is an extremely malignant epithelial neoplasm with an unfavorable prognosis, requiring complex oncological treatment.

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Epithelioid Sarcoma-like Hemangioendothelioma a Case Report

Tumori Journal ◽

10.1177/030089160509100512 ◽

2005 ◽

Vol 91 (5) ◽

pp. 436-439 ◽

Cited By ~ 12

Author(s):

Cigdem Tokyol ◽

Nüket Uzüm ◽

Ilhami Kuru ◽

Omer Uluoglu

Keyword(s):

Case Report ◽

Relevant Literature ◽

Epithelioid Sarcoma ◽

Vascular Tumor ◽

Low Grade ◽

Rare Entity ◽

Anterior Aspect ◽

Cubital Fossa ◽

Painful Mass ◽

The Right

Seven cases of an unusual low-grade vascular tumor were reported in a recent study. Despite its similarity to epithelioid sarcoma, this tumor was termed epithelioid sarcoma-like hemangioendothelioma because of the subtle histopathological and immunohistochemical differences. Another case of this rare entity in a 70-year-old woman who suffered from a painful mass on the anterior aspect of the right cubital fossa is presented here, together with a review of the relevant literature.

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Robotic and standard surgical intervention as adjunct therapies for retroperitoneal ganglioneuroma resection: a case report

BMC Surgery ◽

10.1186/s12893-021-01146-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wagner M. Tavares ◽

Sabrina Araujo de Franca ◽

Amsterdam S. Vasconcelos ◽

David S. L. Parra ◽

Sergio R. R. Araújo ◽

...

Keyword(s):

Case Report ◽

Immunohistochemical Analysis ◽

Surgical Excision ◽

Post Contrast ◽

Dural Sac ◽

Pathology Classification ◽

Microsurgical Approach ◽

Vertebral Bodies ◽

The Right ◽

Two Stages

Abstract Background Ganglioneuroma (GN) is ranked by the International Neuroblastoma Pathology Classification as a benign tumor. It can occur anywhere along the sympathetic nerve chain and surgical excision is the treatment of choice. Case presentation An 18-year-old female patient sought medical assistance after 6 months of constant dorsal and back pain radiating from the thoracic region to the right abdominal flank. Magnetic resonance imaging revealed a solid nodular lesion with heterogeneous post-contrast enhancement and lobulated contours, centered on the right foramina of D12–L1, with a projection to the intracanal space, which compressed and laterally displaced the dural sac and had a right paravertebral extension between the vertebral bodies of D11 and superior aspect of L2. Ganglioneuroma was diagnosed using immunohistochemical analysis. It was decided to use a surgical approach in two stages: robot assisted for the anterior/retroperitoneal mass and a posterior hemilaminectomy/microsurgical approach to attempt total resection, avoiding the traditional anterior thoracoabdominal surgical incision and optimizing the patient’s postoperative outcomes. No postoperative adverse events were noted, and the patient was discharged on postoperative day 5. Conclusion This retroperitoneal GN presentation was peculiar because it originated at the D12 nerve root, which extended to the retroperitoneal space and inside the spinal canal. We hope that our case report can assist future decisions in similar circumstances.

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Vulval aggressive angiomyxoma – a rare entity

MOJ Clinical & Medical Case Reports ◽

10.15406/mojcr.2021.11.00391 ◽

2021 ◽

Vol 11 (4) ◽

pp. 100-102

Author(s):

Jayakar Thomas

Keyword(s):

Surgical Excision ◽

Reproductive Age ◽

Soft Tissue Tumour ◽

Aggressive Angiomyxoma ◽

Age Group ◽

Rare Entity ◽

Women Of Reproductive Age ◽

Tissue Tumour ◽

The Right ◽

Reproductive Age Group

Aggressive Angiomyxoma is a very rare, distinctive, locally invasive soft tissue tumour, that occurs most commonly in the perineum, pelvis, vulva and vagina. It is seen mostly in women of reproductive age group. It has a tendency for recurrence locally, treatment being surgical excision. We hereby describe a case of 38-year-old patient with a pedunculated growth on the right labium majora.

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Oral masses in African pygmy hedgehogs

Journal of Veterinary Diagnostic Investigation ◽

10.1177/1040638719878870 ◽

2019 ◽

Vol 31 (6) ◽

pp. 864-867

Author(s):

Gabriela Del Aguila ◽

Cristian G. Torres ◽

Francisco R. Carvallo ◽

Carlos M. Gonzalez ◽

Federico F. Cifuentes

Keyword(s):

Oral Cavity ◽

Clinical Signs ◽

Surgical Excision ◽

Gingival Hyperplasia ◽

Mesenchymal Tumors ◽

Caudal Portion ◽

Neural Origin ◽

Oral Neoplasms ◽

The Right ◽

Privately Owned

African pygmy hedgehogs ( Atelerix albiventris) frequently develop oral neoplasms, and most of these neoplasms are malignant. We characterized oral masses detected in hedgehogs at clinical examination. During a 1-y period, we diagnosed oral cavity masses in 27 privately owned hedgehogs; 16 were female and 11 were male, with ages of 2–7 y (mean: 4.3 y). Eight masses were non-neoplastic and were diagnosed as gingival hyperplasia (GH). Nineteen masses were neoplastic, of which 17 were squamous cell carcinomas (SCCs) and 2 were mesenchymal tumors (1 spindle cell tumor of probable neural origin, and 1 hemangiosarcoma). The GHs were noninvasive, exophytic, and did not recur after surgical excision. The SCCs were highly invasive tumors that induced facial deformation and were located in the caudal portion of the oral cavity, with 12 of them arising from the right-caudal maxilla. Thus, clinical signs, growth pattern, and anatomic location can be used to suspect a diagnosis of SCC among the other possible diagnoses, such as GH, in this location. However, histopathology is necessary for confirmation. Also, hemangiosarcoma should be considered among the differential diagnoses.

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Clinicopathological, histochemical and immunohistochemical aspects of angioleiomyoma of the cheek: a case report

Revista Odonto Ciência ◽

10.15448/1980-6523.2016.2.15353 ◽

2016 ◽

Vol 31 (2) ◽

pp. 101

Author(s):

Paula Daniele Matheus ◽

Manoela Domingues Martins ◽

Luise Meurer ◽

Lucas N. Sant´Ana ◽

Manoel Santa’Ana Filho

Keyword(s):

Smooth Muscle ◽

Case Report ◽

Gastrointestinal Tract ◽

Oral Cavity ◽

Buccal Mucosa ◽

Immunohistochemical Analysis ◽

Surgical Excision ◽

Left Cheek ◽

Local Surgical Excision ◽

Epithelioid Leiomyoma

Introduction: Leiomyomas are benign smooth muscle neoplasms that preferably affect the genitals, skin, and gastrointestinal tract, being rarely seen in the oral cavity. They re commonly classified into three microscopic patterns: solid leiomyoma, angioleiomyoma (ALM), and epithelioid leiomyoma. The most frequently reported sites of occurrence of oral ALM are the lip (48.6%), palate (21.1%), buccal mucosa and tongue (9.2%), and intraosseous lesions (8.3%).Case report: A 62 years old male presented a painless swelling in the left cheek. In this report histopathological and immunohistochemical analysis were made to confirm the diagnosis, since several lesions were possible. The treatment was local surgical excision of the tumor.

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Multicentric epithelioid hemangioendothelioma of humerus and scapula

Indian Journal of Musculoskeletal Radiology ◽

10.25259/ijmsr_38_2021 ◽

2021 ◽

Vol 0 ◽

pp. 1-5

Author(s):

S B Dhanya ◽

Ramakrishna Narayanan ◽

Anu Kapoor ◽

Shantveer G. Uppin

Keyword(s):

Adult Population ◽

Bone Lesion ◽

Vascular Tumor ◽

Epithelioid Hemangioendothelioma ◽

Adolescent Male ◽

Lytic Lesion ◽

Imaging Features ◽

Post Contrast ◽

Imaging Characteristics ◽

The Right

Epithelioid hemangioendothelioma (EH) is a rare malignant vascular tumor occurring mainly in the liver and lungs, with bones being a rare site and primarily seen in the adult population. We present a rare case of multicentric EH in the right humerus in an adolescent male, who presented with complaints of pain and swelling in the right shoulder. Radiographs and Computed tomography showed a large expansile lytic lesion in the proximal end of the right humerus with areas of cortical destruction and matrix calcification. On Magnetic resonance imaging, the lesion was predominantly isointense on T1-weighted image, hyperintense on T2-weighted, and Short Tau Inversion Recovery images with prominent flow voids within. On post-contrast sequences, the lesion showed intense heterogenous enhancement with a non-enhancing central necrotic area. Multiple smaller lytic lesions with similar imaging characteristics were also found in the mid and distal shaft of the right humerus and the right coracoid process. Differentials of Telangiectatic osteosarcoma, Giant cell tumor, brown tumors of hyperparathyroidism, and metastasis were considered. Core biopsy revealed that the lesion was an EH. Though the imaging features of EH are non-specific, it may be considered in the differential diagnosis of an expansile lytic bone lesion with no periosteal reaction, showing cortical break and soft tissue component, especially if it is multifocal and multicentric.

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Unusual facial lipoma

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-8637201400040000111798 ◽

2014 ◽

Vol 62 (4) ◽

pp. 425-430

Author(s):

Raphael Oliveira de MENESES ◽

Sócrates Steffano Silva TAVARES ◽

Tony Santos PEIXOTO ◽

Maria do Socorro ARAGÃO ◽

Gustavo Pina GODOY

Keyword(s):

Oral Cavity ◽

Surgical Excision ◽

Complete Removal ◽

Benign Tumors ◽

Mature Adipocyte ◽

Mesenchymal Neoplasm ◽

The Face ◽

Large Maximum ◽

The Right ◽

Slow Growing

Lipoma is a benign mesenchymal neoplasm of soft tissue composed of mature adipocyte cells, being among the most common benign tumors. However, it has been reported that they are uncommon in the oral cavity, representing between 15% and 20% of cases involving the head and neck, and between 1% and 5% of all benign neoplasms of the oral cavity. As for their clinical features, lipomas present as slow-growing and asymptomatic, with an associated yellowish submucosal growth, and may not be well circumscribed. Lipomas are known to grow to around 0.5 to 2 cm, but can have very large maximum diameters. Surgical excision is the treatment of choice, recurrence being rare. The reported case is of a 74 year old, female patient, exhibiting a large lipoma in the right genial-masseteric region, which is unusual with the clinic presentation of lipomas occurring on the face. The patient was subjected to the complete removal of the lesion, was monitored for 6 months and presented no signs of recurrence.

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Intraosseous Myofibroma of the Mandible in a 7-Year-Old Patient: A Case Report

Malaysian Journal of Paediatrics and Child Health ◽

10.51407/mjpch.v27i1.117 ◽

2021 ◽

Vol 27 (1) ◽

pp. 1-7

Author(s):

Meshala Bala Sundram ◽

Navasheilla Retna Retnasingam ◽

Bahruddin Saripudin ◽

Zuraiza Mohamad Zaini

Keyword(s):

Differential Diagnosis ◽

Oral Cavity ◽

Histopathological Examination ◽

Smooth Muscle Actin ◽

Neck Region ◽

Immunohistochemical Analysis ◽

Surgical Excision ◽

Permanent Molar ◽

Complete Surgical Excision ◽

Left Posterior

Myofibroma is a benign fibrous tumour that occurs predominantly in the head and neck region followed by the trunk and extremities. However, cases occurring in the oral cavity are rare, presenting with a variable clinical appearances and wide differential diagnosis. We reported a case of a 7-year-old girl who was referred to the Department of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging painless swelling on the left posterior region of the mandible over the past 3 months. The swelling was associated with ulceration and displaced lower left first permanent molar. Radiographic investigations reported well-defined radiolucency at molar area, alveolar expansion and bone resorption of the left posterior alveolar ridge of the mandible. Complete surgical excision of the lesion was performed under general anaesthesia. Histopathological examination revealed proliferation of spindle shaped cells with biphasic growth pattern. Immunohistochemical staining showed strong positivity with vimentin and smooth muscle actin whilst negative for desmin, S100 and CD34 establishing the diagnosis of myofibroma. Although rare, myofibroma should be considered as a differential diagnosis for solitary firm swelling in the oral cavity. Histopathological examination together with immunohistochemical analysis is essential for an accurate diagnosis.

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