Assessment of dental caries and gingival status among a group of type 1 diabetes mellitus and healthy children of South India – a comparative study

2018 ◽  
Vol 31 (12) ◽  
pp. 1305-1310 ◽  
Author(s):  
K.L. Girish Babu ◽  
Priya Subramaniam ◽  
Keerthan Kaje
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Permanent Dentition ◽  
World Health ◽  
Study Group ◽  
Gingival Health ◽  
Diabetic Children

AbstractBackgroundDiabetes mellitus is a metabolic disorder. However, dental caries and periodontal health have not attracted much interest in diabetic patients. This study was carried out to assess the dental caries status and gingival health status in children with type 1 diabetes mellitus (T1DM).MethodsThe study group consisted of 80 children, aged 6–18 years, with T1DM. The dental caries status was recorded using the World Health Organisation (WHO) criteria. Gingival health was assessed using the Loe and Silness gingival index (GI). Data obtained were subjected to statistical analysis.ResultsThe mean dental caries status for primary (decayed, extracted, filled teeth [deft]) and permanent dentition (decayed, missing, filled teeth [DMFT]) scores in diabetic children were 0.44±1.28 and 1.26±2.49, respectively. The GI scores of diabetic children were 0.33±0.48. GI in the study group significantly correlated with DMFT (p<0.001) and deft (p≤0.05).ConclusionsDental caries in primary dentition was lower in diabetic children but was not statistically significant, whereas dental caries in permanent dentition was significantly higher. The gingival condition of diabetic children was healthy.

scholarly journals Prevalência de Lesões de Cárie de Doentes com Diabetes Mellitus Tipo 1 Tratados com Múltiplas Administrações de Insulina e de Indivíduos sem Diabetes

2017 ◽  
Vol 30 (5) ◽  
pp. 402 ◽  
Author(s):  
Diogo Machado ◽  
Ana Coelho ◽  
Anabela Paula ◽  
Francisco Caramelo ◽  
Francisco Carrilho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Plaque Index ◽  
World Health ◽  
Caries Detection ◽  
Nocturnal Hypoglycaemia ◽  
Patients With Diabetes

Introduction: In addition to macro and microvascular complications that are associated with the disease, hyperglycaemia is also a risk factor for several oral complications. The aim of this study is to establish a relationship between dental caries in patients with type 1 diabetes mellitus treated with multiple insulin injections and that of individuals without diabetes. It is also an aim to characterize the oral hygiene habits of this population.Material and Methods: An observational clinical study of analytical and cross-sectional nature was conducted. Thirty patients with type 1 diabetes mellitus and 30 individuals without diabetes were observed and questioned about information regarding their medical history. Oral examination was conducted according to the standards of the World Health Organization and ICDAS was used for caries detection. Statistical analysis was performed and the significance level was set at 5%.Results: Patients with diabetes mellitus showed similar caries levels to that of individuals without diabetes. Patients with diabetes mellitus had a higher dental plaque index. Only 10% of the patients having episodes of nocturnal hypoglycaemia brush their teeth after glucose intake.Discussion: Although there’s some controversy in the literature regarding the prevalence of caries in patients with diabetes mellitus, the results are in agreement with a great number of studies. However, patients with diabetes mellitus have a higher plaque index which can be associated with a higher risk for developing certain oral pathologies.Conclusion: No statistically significant association was found between type 1 diabetes mellitus and dental caries.

scholarly journals Health-related quality of life in people with type 1 Diabetes Mellitus: data from the Brazilian Type 1 Diabetes Study Group

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Ana Carolina Contente Braga de Souza ◽  
◽  
João Soares Felício ◽  
Camila Cavalcante Koury ◽  
João Felício Abrahão Neto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Study Group ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Cardiovascular risk factors in children with type 1 diabetes mellitus

2019 ◽  
Vol 32 (7) ◽  
pp. 699-705 ◽  
Author(s):  
Ying Zhang ◽  
Han Zhang ◽  
Pin Li
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Cardiovascular Risk ◽  
Type 1 Diabetes Mellitus ◽  
Cardiovascular Risk Factors ◽  
Density Lipoprotein ◽  
Diabetic Children

Abstract Objective Cardiovascular disease is a major complication among children with type 1 diabetes mellitus (T1DM). This prospective study aimed at examining the presence of cardiovascular risk factors in children with T1DM. Methods We evaluated several cardiovascular risk factors, including atherosclerosis, artery intima-media thickness (IMT) and metabolic responses, in 175 children with T1DM, with 150 non-diabetic children as normal controls. Results The diabetic children had significantly higher carotid IMT (cIMT) and aortic IMT (aIMT), higher values for diastolic wall stress (DWS), incremental elastic modulus (IEM), and flow-mediated dilatation (FMD) than the controls. The levels of tumor necrosis factor-α (TNF-α), interleukin-4 (IL4), high-sensitivity C-reactive protein (hs-CRP) and leptin were significantly higher in T1DM patients. In T1DM children, the cIMT and aIMT were correlated with several risk factors, including age, weight, body mass index (BMI), duration of diabetes, waist/hip ratio, as well as levels of total cholesterol, triglycerides and apolipoprotein B (apoB). In addition to common risk factors, cIMT was also associated with systolic blood pressure (BP). Other risk factors, such as height, diastolic BP, low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio, apolipoprotein A1 (apoA1) and S-creatinine levels, were not all independent risk factors of cardiovascular disease in T1DM children. Conclusions T1DM is associated with early impairment of the common carotid and aortic artery structure and function, and the diabetic state may be the main risk factor for arterial wall stiffening and thickening.

scholarly journals Oral health knowledge and habits in children with type 1 diabetes mellitus

2009 ◽  
Vol 20 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Crésio Alves ◽  
Márcia Brandão ◽  
Juliana Andion ◽  
Rafaela Menezes
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Oral Health ◽  
Type 1 Diabetes Mellitus ◽  
Health Knowledge ◽  
University Hospital ◽  
Cross Sectional ◽  
Oral Health Knowledge ◽  
Diabetic Children

This study evaluated the oral health knowledge and habits in Brazilian children with type 1 diabetes mellitus (T1DM). A cross-sectional study was performed between November of 2005 and April of 2006 in a public health university hospital, interviewing 55 diabetic children and 55 non-diabetic control children with a semi-structured questionnaire. As much as 55% of the diabetic children and 35.5% of the non-diabetic children were males with mean age of 11.3 ± 3.7 years and 11.2 ± 3.8 years, respectively. The mean duration of the T1DM was of 4.5 ± 0.8 years. Almost half of the diabetic and non-diabetic children brushed their teeth three times a day. Dental floss was used once a day by 30.9% of diabetics and 18.0% of control subjects. A total of 27% of the diabetics vs. 54.5% of non-diabetics had gingival bleeding. The dentist was aware of the T1DM in 74.5% of the cases. As much as 63.8% of the diabetic subjects had been to the dentist within the previous 12 months. In conclusion, although the diabetic children seemed to have better oral health habits than the control children, there is a need for more information regarding oral hygiene and healthy habits.

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

2015 ◽  
Vol 28 (3-4) ◽  
Author(s):  
Mohammed A. Al-Biltagi ◽  
Osama A. Tolba ◽  
Wegdan Mawlana ◽  
Abdallah Abd El Hamed ◽  
May Ghazy
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Type 1 Diabetes Mellitus ◽  
Mitral Annulus ◽  
Resistin Level ◽  
Positive Correlation ◽  
Diabetic Children

AbstractResistin is an adipocyte-derived signaling polypeptide described in adipose tissue, which acts as a metabolic link between inflammation and atherosclerosis. This study aimed to assess the relation between right ventricular (RV) function assessed by echocardiography and resistin levels in recently diagnosed type-1 diabetic children.The study was conducted as a prospective cohort study and it included 30 children with type-1 diabetes mellitus as a patient group and 30 healthy children matched for age and sex as controls. It evaluated RV functions by tissue Doppler imaging, speckle tracking imaging, and real-time three-dimensional echocardiography (RT3DE), as well as assessing resistin serum level using enzyme-linked immunosorbent assay.The left ventricle (LV) showed no significant difference between the two groups in E/A ratio across the mitral valve, ejection fraction, and S wave mitral annulus. However, it showed significant decrease in the E′/A′ wave of mitral annulus, impairment of LV myocardial performance index (MPI), and decrease in LV EF measured by RT3DE in diabetic patients compared to the control group. Significant differences in the mean value of tricuspid annular systolic excursion (TASE), pulmonary artery pressure, longitudinal systolic strain (RV LSS), MPI, and RV ejection fraction were observed between the studied groups. Yet, no significant differences in E/A ratio and S value were observed between the two groups. Significant positive correlation of resistin level with age of studied group and significant negative correlation of resistin with both TASE and RV LSS values were also observed.We confirmed the presence of subclinical RV systolic and diastolic dysfunction in type-1 diabetic children with positive correlation between resistin level and RV dysfunction among them.

scholarly journals The Influence of Type 1 Diabetes Mellitus on Dental Caries and Salivary Composition

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Lulëjeta Ferizi ◽  
Fatmir Dragidella ◽  
Lidvana Spahiu ◽  
Agim Begzati ◽  
Vjosa Kotori
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Oral Health ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Flow Rate ◽  
Buffer Capacity ◽  
Salivary Flow ◽  
Control Group

Diabetes mellitus is the most common chronic disease that affects the oral health. The aim of the study is to evaluate the dental caries, salivary flow rate, buffer capacity, and Lactobacilli in saliva in children with type 1 diabetes mellitus compared to the control group.Methods.The sample consisted of 160 children of 10 to 15 years divided into two groups: 80 children with type 1 diabetes mellitus and 80 children as a control group. Dental caries was assessed using the DMFT index for permanent dentition. Stimulated saliva was collected among all children. Salivary flow rate and buffer capacity were measured, and the colonies ofLactobacillusin saliva were determined. The observed children have answered a number of questions related to their dental visits and parents’ education. The data obtained from each group were compared statistically using the chi-square test and Mann–WhitneyU-test. The significant level was set atp<0.05.Results. DMFT in children with type 1 diabetes was significantly higher than that in the control group (p<0.001). Diabetic children have a low level of stimulated salivary flow rate compared to control children (0.86 ± 0.16 and 1.10 ± 0.14). The buffer capacity showed statistically significant differences between children with type 1 diabetes and control group (p<0.001). Also, children with type 1 diabetes had a higher count and a higher risk ofLactobacilluscompared to the control group (p<0.05andp<0.001).Conclusion. The findings we obtained showed that type 1 diabetes mellitus has an important part in children’s oral health. It appears that children with type 1 diabetes are exposed to a higher risk for caries and oral health than nondiabetic children.

scholarly journals Neonatal Near Miss among Newborns of Women with Type 1 Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Luiza R. Morais ◽  
Beatriz C. Patz ◽  
Felipe F. Campanharo ◽  
Patricia M. Dualib ◽  
Sue Y. Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Maternal Morbidity ◽  
Near Miss ◽  
University Hospital ◽  
World Health ◽  
Health Organization ◽  
Neonatal Near Miss

Objective. To investigate the frequency of neonatal near miss (NNM) and associate it with maternal morbidity in newborns of women with type 1 diabetes mellitus (T1DM). Methods. This was a cross-sectional retrospective study from a secondary analysis of data retrieved from medical records of pregnant women with T1DM cared at a Brazilian university hospital between 2005 and 2015. Maternal near miss (MNM) and potentially life-threatening conditions (PTLC) were classified according to the World Health Organization criteria. NNM was classified according to the Pan American Health Organization Neonatal Near Miss Working Group criteria. Association of maternal morbidity with NNM was assessed using chi-square test. Results. There were 122 newborns (NB) among 137 T1DM pregnancies. Thirty-seven NB presented NNM—incidence of 303 NNM per 1000 live births (37/122). NNM was associated with MNM (P<0.001, OR (95% CI): 17.15 (1.85–159.12)). PLTC did not increase the odds of NNM (P=0.07; OR (95% CI): 2.1281 (0.92–4.91)). Seven newborns died, six of them from pregnancies without severe maternal morbidity. 71% of the neonatal death (5/7) occurred in malformed neonates. Conclusion. MNM was associated with NNM among women with T1DM, and PLTC, paradoxically, did not increase NNM.

scholarly journals Periodontal Diseases and Dental Caries in Children with Type 1 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Marta Novotna ◽  
Stepan Podzimek ◽  
Zdenek Broukal ◽  
Erika Lencova ◽  
Jana Duskova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Periodontal Diseases ◽  
Control Of Diabetes ◽  
Diabetic Population ◽  
The Impact ◽  
The Relationship

Type 1 diabetes mellitus is a chronic metabolic disease of an autoimmune origin with early manifestation predominantly in the childhood. Its incidence has been rising in most European countries. Diabetes has been intensively studied by all branches of medicine. There were a number of studies investigating oral consequences of diabetes; however, unambiguous conclusions were drawn only for the relationship between diabetes and periodontal impairment. Many studies confirmed higher plaque levels and higher incidence of chronic gingivitis both in adults and in children with diabetes. Juvenile periodontitis is rare both in healthy subjects and in those with type 1 diabetes. Yet certain findings from well-conducted studies, for example, differences in oral microflora or the impact of metabolic control of diabetes on periodontal health, indicate a higher risk of periodontitis in children with type 1 diabetes. As for the association of diabetes and dental caries, the results of the studies are inconsistent. However, it was found that some risk factors for dental caries are either more or less prevalent in the diabetic population. Despite an extensive research in this area we have to acknowledge that many questions have remained unanswered. There is a need for continued, thorough research in this area.

scholarly journals Frequency of Janus Kinas 2V617F (JAK2V617F) Mutation among Children with Type 1 Diabetes Mellitus

2020 ◽  
pp. 13-17
Author(s):  
Nadia Farouk Zekry ◽  
Omyma Galal ◽  
Mohammed H. Hassan ◽  
Hala M. Sakhr ◽  
Rana Toghan
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Gene Mutation ◽  
Janus Kinase ◽  
Jak2v617f Mutation ◽  
Diabetic Children ◽  
Stat Pathway

Background and Objectives: Type 1 Diabetes mellitus (T1DM) is a disorder of glucose homeostasis results from the destruction of β- cells of the pancreas with subsequent insulin deficiency and hyperglycemia. Acquired mutation (V617F) affecting the JAK2 gene disrupts the auto-inhibition of JAK2 and results in constitutive activation of the Janus Kinase 2(JAK2)/signal transducer and activator of transcription (STAT) pathway. Once activated, the JAK/STAT pathway stimulates cell proliferation, differentiation, migration and apoptosis critically involved in growth control. Studies investigating the possible role of Janus kinas 2V617F (JAK2V617F) mutation and risk of T1DMor development of diabetic complications among such children are very few. So we aimed in this pilot study to estimate the relative frequency of Janus kinas 2V617F (JAK2V617F) mutation among a sample of children with T1DM. Patients and Methods: This cross-sectional study included 25 Egyptian children with T1DM. Full clinical evaluation, routine laboratory investigations including kidney function, RBG, HbA1C and A/C ratio were done. Determination of JAK 2v617f gene mutation was performed using real time-PCR. Results: The included diabetic children were 15 males and 10 females. Their mean random blood glucose was 272mg/dl±33 SD. Two cases exhibited mutation in the form of heterozygous type (Aa) representing 8% of the total included diabetic children and the remaining 23 (92%) diabetic children showed normal wild alleles (AA). There was a non-significant correlation between the glycemic control and the presence of JAK 2v617f gene mutation, p˃0.05. Conclusions: JAK 2v617f gene mutation present in a small percentage of non-complicated T1DM with lack of its correlation with the glycemic control.

Sign in / Sign up

Export Citation Format

Share Document