Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, p = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.

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Zinc deficiency in Japanese children with idiopathic short stature

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0129 ◽

2019 ◽

Vol 32 (10) ◽

pp. 1083-1087 ◽

Cited By ~ 2

Author(s):

Kei Yoshida ◽

Tatsuhiko Urakami ◽

Remi Kuwabara ◽

Ichiro Morioka

Keyword(s):

Short Stature ◽

Zinc Deficiency ◽

Serum Insulin ◽

Serum Zinc ◽

Zinc Level ◽

Idiopathic Short Stature ◽

Japanese Children ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background and methods We investigated the frequency of zinc deficiency in Japanese children with idiopathic short stature, and evaluated whether serum zinc levels correlated with background factors, including age and standard deviation scores (SDSs) for height and serum insulin-like growth factor (IGF)-1 levels. The study subjects consisted of 89 Japanese children. Results The mean serum zinc level was 79 ± 12 (49–108) μg/dL. Of all the children, 48.3% had a low zinc level, in the 60–80 μg/dL range, and 6.7% had zinc deficiency with a zinc level below 60 μg/dL. The majority with a low zinc level and zinc deficiency were asymptomatic other than for short stature. We found no significant correlations of serum zinc with age, or the SDSs for height and serum IGF-1 levels, in either the entire subject population or those with a zinc level below 80 μg/dL. Conclusions We found a low zinc level to be common in Japanese children with idiopathic short stature, whereas actual zinc deficiency was rare. However, other as yet unknown mechanisms not associated with the growth hormone (GH)-IGF-1 axis could be involved in growth retardation in idiopathic short stature.

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Association Between Serum Zinc Levels and the Risk of Parkinson’s Disease: a Meta-Analysis

Biological Trace Element Research ◽

10.1007/s12011-017-0941-2 ◽

2017 ◽

Vol 179 (1) ◽

pp. 45-51 ◽

Cited By ~ 7

Author(s):

Hualei Sun ◽

Xinxin Liu ◽

Huina Ge ◽

Teng Wang ◽

Yan Wang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Meta Analysis ◽

Serum Zinc ◽

Zinc Levels ◽

Serum Zinc Levels

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Serum Zinc Status in Post Menopausal Women Attending in a Tertiary Care Hospital of Bangladesh

BIRDEM Medical Journal ◽

10.3329/birdem.v9i2.41281 ◽

2019 ◽

Vol 9 (2) ◽

pp. 147-150

Author(s):

Nadia Ferdous ◽

Farzana Akonjee Mishu ◽

Shamsunnahar ◽

Fahmida Islam ◽

Shabnam Sarwar Sejooti

Keyword(s):

Clinical Symptoms ◽

Tertiary Care ◽

Serum Zinc ◽

Premenopausal Women ◽

Care Hospital ◽

College Hospital ◽

Medical College ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross-sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology , Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal womenaged between 45-70 years were considered as case and another 50 regular menstruating premenopausal women aged between 30-40 years were selected as control. Results: The mean age of case and control groups was 50.5± 2.3 years and 36.5± 4.4 years respectively. In this study serum zinc levels in cases and controls were 71.54 ± 5.69 ìg /dl and 74.68 ± 5.453 ìg/dl respectively, and there was significant difference(p<0.01). Conclusion: Serum zinc level was significantly decreased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum zinc levels might be incorporated in every postmenopausal for possible prevention of complications. Birdem Med J 2019; 9(2): 147-150

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Dysgeusia Due to Zinc Deficiency After Pancreaticoduodenectomy Requiring Continuous Intravenous Zinc Supplementation: a Case Report and Literature Review

10.21203/rs.3.rs-957498/v1 ◽

2021 ◽

Author(s):

Hironobu Hata ◽

Yojiro Ota ◽

Katsuhiko Uesaka ◽

Yutaka Yamazaki ◽

Tsubasa Murata ◽

...

Keyword(s):

Zinc Deficiency ◽

Oral Surgery ◽

Oral Care ◽

Serum Zinc ◽

Zinc Level ◽

Normal Serum ◽

Acrodermatitis Enteropathica ◽

Proximal Jejunum ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies regarding the development of zinc deficiency after PD and presented the case of a patient with zinc deficiency after PD, who required home intravenous zinc replacement.Case presentation: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously under readmission. Her serum zinc levels recovered, and the lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home.Conclusion: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of dysgeusia associated with zinc deficiency after cancer surgery, as well as that induced by chemotherapy or head and neck radiation therapy.

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Zinc Intake, Zinc Serum Levels, and Intelligence in School Children in Rural Areas

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5869 ◽

2021 ◽

Vol 9 (E) ◽

pp. 394-397

Author(s):

Rostika Flora ◽

Nur Alam Fajar ◽

Fatmalina Febri ◽

Indah Yuliana ◽

Yuliarti Yuliarti ◽

...

Keyword(s):

Zinc Deficiency ◽

School Children ◽

Significant Relationship ◽

Rural Areas ◽

Serum Zinc ◽

Zinc Intake ◽

Serum Zn ◽

Zinc Levels ◽

Serum Zinc Levels ◽

Low Serum

BACKGROUND: Children in rural areas are susceptible to zinc deficiency. Zinc deficiency in children can affect cognitive function in children. Zinc plays a role in cellular function and critical brain growth processes, including cell replication, DNA and RNA synthesis, and the release of neurotransmitters. AIM: This study aimed to analyze the condition of zinc deficiency and its relationship with the level of intelligence in children in rural areas. METHODS: The study design was cross-sectional, with a sample of 44 elementary school children aged 9–12 years taken randomly. Blood was drawn to measure serum Zn-levels, and serum Zn-levels were measured using Colorimetric Assay Kit (E-BC-K137). Zinc intake data were obtained from the food recall form, which was carried out 3 × 24 h. The level of intelligence is measured by the Culture Fair Intelligence Test method. The sample characteristics data obtained through a questionnaire. Furthermore, the data were analyzed using the Chi-square test. RESULTS: About 84.2% of children with insufficient zinc intake had low serum Zn-levels. There was a significant relationship between zinc intake and serum zinc levels (p = 0.026; PR = 4.293). Children with low serum zinc levels of 96.5% have intelligence levels below average. There was a significant relationship between serum zinc levels and intelligence level as well (p = 0.001; PR = 24,500). CONCLUSION: Zinc deficiency in children is characterized by low serum Zn-levels. Low serum Zn-level is caused by low zinc intake, thus children with low serum Zn-levels are at risk of having intelligence level below average. Therefore, health education about the importance of zinc intake in children should be given to parents, so that the incidence of zinc deficiency in children can be reduced.

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A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190718 ◽

2019 ◽

Vol 6 (2) ◽

pp. 722

Author(s):

Syed Mohamed ◽

Santosh Kumar ◽

J. Kumutha

Keyword(s):

Cord Blood ◽

Growth Parameters ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Cross Sectional ◽

Medical College ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

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Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1633 ◽

2019 ◽

Vol 12 (1) ◽

pp. 239-243

Author(s):

Khairun Nisa Berawi ◽

Maya Nurul Hidayati ◽

Susianti Susianti ◽

Roro Rukmi W. Perdami ◽

Tiwuk Susantiningsih ◽

...

Keyword(s):

Univariate Analysis ◽

Serum Zinc ◽

Zinc Content ◽

Zinc Level ◽

Bivariate Analysis ◽

Cross Sectional ◽

The Mean ◽

The Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

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Comparison of maternal serum and neonatal cord blood levels of zinc in relation to birth weight and period of gestation

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20212880 ◽

2021 ◽

Vol 8 (8) ◽

pp. 1349

Author(s):

Shabbeer Ahmed ◽

Avula Kanthi Sagar

Keyword(s):

Birth Weight ◽

Cord Blood ◽

Zinc Deficiency ◽

Serum Zinc ◽

Maternal Serum ◽

Blood Levels ◽

P Value ◽

Zinc Levels ◽

Blood Zinc ◽

Serum Zinc Levels

Background: Women are at increased risk of zinc deficiency during pregnancy because of high fetal requirements for zinc. Severe maternal zinc deficiency has been associated with poor fetal growth, spontaneous abortion and congenital malformations (i.e., anencephaly), whereas milder forms of zinc deficiency have been associated with low birth weight (LBW), intrauterine growth retardation, and preterm delivery. However, the research relating maternal zinc status and birth weight has not produced consistent results. This study has been undertaken to confirm the association between maternal serum zinc concentration and birth weight and period of gestation in setting like India.Methods: A total of 100 new-borns were included and divided into two groups, the ‘study group’ had babies with birth weight <2.5 kg and control group’ with babies >2.5 kg birth weight. Cord blood from the new-borns and serum samples of mothers were collected and the zinc levels were measured.Results: The correlation of cord blood and the maternal serum zinc levels were assessed in relation to birth weight and the gestational age. The results were compared between the two groups. The difference in values between the two groups was statistically significant, maternal serum zinc levels and birth weight (84.78±21.62 vs 66.04±18.66) (‘P’ value 0.04), cord blood zinc levels and birth weight (98.44±22.59 vs 79.78±19.54) (‘P’ value <0.001). The maternal serum and cord blood zinc was compared between the preterm and term; the results were statistically significant.Conclusions: The maternal and cord blood levels of zinc are correlated well with the birth weight and the gestational age at delivery. Supplementation of zinc during gestation might help reduce the incidence of IUGR and the risk of prematurity.

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Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis

Nutrients ◽

10.3390/nu12030764 ◽

2020 ◽

Vol 12 (3) ◽

pp. 764 ◽

Cited By ~ 1

Author(s):

Satoshi Shimizu ◽

Ritsukou Tei ◽

Masahiro Okamura ◽

Nobuteru Takao ◽

Yoshihiro Nakamura ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Zinc Deficiency ◽

Serum Albumin Level ◽

Serum Zinc ◽

Japanese Patients ◽

Zinc Level ◽

Albumin Level ◽

Zinc Levels ◽

Inadequate Dietary Intake ◽

Serum Zinc Levels

Background: It is known that patients on hemodialysis (HD) are prone to developing zinc deficiency due to removal of zinc by HD, inadequate dietary intake, and reduced gastrointestinal zinc absorption. However, the prevalence of zinc deficiency in patients on peritoneal dialysis (PD) has not been well established. Methods: Serum zinc levels were compared between 47 patients on PD and 47 patients on HD matched for age, sex, and duration of dialysis. A serum zinc level < 60 μg/dL was defined as clinical zinc deficiency and a level of 60–80 μg/dL as subclinical zinc deficiency. The prevalence of zinc deficiency and associated clinical factors were determined in both groups. Results: Clinical zinc deficiency was found in 59.6% of the PD group and 70.2% of the HD group (p = 0.391). Subclinical zinc deficiency was found in 40.4% of the PD group and 29.8% of the HD group. Age, body mass index, and serum albumin level were identified as independent predictors of zinc deficiency in the PD group by multivariate analysis. Conclusions: A higher prevalence of clinical and subclinical zinc deficiency was found in patients on PD. The rates were comparable between patients on PD and those on HD after adjustment for confounding factors.

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Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

BioMed Research International ◽

10.1155/2014/474108 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Majid Rostami Mogaddam ◽

Nastaran Safavi Ardabili ◽

Nasrollah Maleki ◽

Maedeh Soflaee

Keyword(s):

Acne Vulgaris ◽

Serum Zinc ◽

Atomic Absorption Spectrophotometry ◽

Zinc Level ◽

Healthy Controls ◽

Serum Zinc Level ◽

Absorption Spectrophotometry ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

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