An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ivona Butorac Ahel ◽  
Srecko Severinski ◽  
Kristina Lah Tomulic ◽  
Ana Milardovic ◽  
Kristina Baraba Dekanic ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Early Recognition ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Joubert Syndrome ◽  
High Blood Glucose ◽  
Hyperglycemic Hyperosmolar State ◽  
Life Threatening

Abstract Objectives Hyperglycemic hyperosmolar state (HHS) is one of the most severe acute complications of diabetes mellitus (DM) characterized by severe hyperglycemia and hyperosmolality without significant ketosis and acidosis. What is new? Since HHS in the pediatric population is rare and potentially life-threatening, every reported case is very valuable for raising awareness among healthcare professionals. Case presentation A 7-year-old boy with previously diagnosed Joubert syndrome was admitted due to vomiting, polydipsia and polyuria started several days earlier. He was severely dehydrated, and the initial blood glucose level was 115 mmol/L. Based on clinical manifestations and laboratory results, he was diagnosed with T1DM and HHS. The treatment with intravenous fluid was started and insulin administration began later. He was discharged after 10 days without any complications related to HHS. Conclusions Since HHS has a high mortality rate, early recognition, and proper management are necessary for a better outcome.

scholarly journals Diabetes in COVID-19 patients: challenges and possible management strategies

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Riyan Al Islam Reshad ◽  
Sumaiya Hafiz Riana ◽  
Mohammad Al-baruni Chowdhury ◽  
Abu Tayab Moin ◽  
Faruque Miah ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healthy Lifestyle ◽  
Management Strategies ◽  
Diabetic Patients ◽  
Main Body ◽  
High Blood Glucose ◽  
High Blood Glucose Level ◽  
Global Population

Abstract Background The recent pandemic of coronavirus disease 19 (COVID-19) has been causing intense stress among the global population. In the case of hospitalized and ICU-admitted COVID-19 patients with comorbidities, it has been observed that a major portion of them are diabetic. Therefore, researchers had indicated a link between diabetes mellitus (DM) and COVID-19. Furthermore, DM is a potential risk factor for the severity of COVID-19 cases. Thus, in this study, the correlation existing between diabetic patients and COVID-19 was summarized. Main body of the abstract Diabetic patients have a weaker immune system, less viral clearance rate, malfunctions of metabolic activity due to their high blood glucose level, and other associated problems. This does not increase the susceptibility for the patients to be infected with COVID-19. However, the severity of COVID-19 can worsen due to the comorbidity of DM. Short conclusion Proper management, appropriate use of drugs that do not increase the ACE2 expression, lowering blood glucose level, decreasing the susceptibility of SARS-CoV-2, and maintaining a healthy lifestyle could be effective.

Galectin-3 mediates high-glucose-induced cardiomyocyte injury by the NADPH oxidase/reactive oxygen species pathway

2020 ◽  
Vol 98 (11) ◽  
pp. 826-833
Author(s):  
Jingang Sun ◽  
Lijuan Zhang ◽  
Jianhai Fang ◽  
Shuguo Yang ◽  
Lianghua Chen
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Nadph Oxidase ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
High Glucose ◽  
Cardiac Injury ◽  
High Blood Glucose ◽  
Galectin 3

Galectin-3 is a member of the β-galactoside-binding lectin family taking part in the regulation of inflammation, angiogenesis, and fibrosis. This study was designed to study the improved effect of galectin-3 inhibition on diabetic cardiomyopathy (DCM). Sprague–Dawley rats were randomized into the control, DCM, and DCM + modified citrus pectin (MCP) (a galectin–3 pharmacological inhibitor) groups. After 8 weeks, streptozotocin-induced DCM led to high blood glucose level, oxidative stress, cardiac injury, and dysfunction accompanied by suppressed body mass. On the contrary, MCP (100 mg·kg−1·day−1) administration improved body mass and blood glucose level and attenuated cardiac injury and dysfunction in DCM rats. Additionally, MCP attenuated pathological changes in plasma and myocardial tissue markers of oxidative stress, such as hydrogen peroxide and malonyldialdehyde, although it did not change superoxide dismutase activities, which were decreased in the DCM group. The levels of oxidative stress associated proteins evaluated by Western blot, such as p67phox and NADPH oxidase 4, were obviously increased in the DCM group, while they were reversed by MCP treatment. Therefore, galectin-3-mediated high-glucose-induced cardiomyocyte injury and galectin-3 inhibition attenuated DCM by suppressing NADPH oxidase. These findings suggested that galectin-3 could be a potential target for treatment of patients with DCM.

scholarly journals Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome

Metabolites ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 483
Author(s):  
Laurent Suissa ◽  
Jean-Marie Guigonis ◽  
Fanny Graslin ◽  
Emilie Doche ◽  
Ophélie Osman ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Discriminant Analysis ◽  
Clinical Outcome ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Area Under The Curve ◽  
Stroke Onset ◽  
Stroke Patients ◽  
High Blood Glucose ◽  
High Blood Glucose Level

Despite the fact that glucose is the main fuel of the brain, hyperglycemia at hospital admission is generally associated with a poor functional outcome in stroke patients. This paradox may be explained by the lack of information about the blood glucose level at stroke onset. Here, we analyzed the metabolome of blood cells entrapped in cerebral thrombi to gain insight into their metabolism at stroke onset. Fourty-one consecutive stroke patients completely recanalized by mechanical thrombectomy within 6 h were included. The metabolome of retrieved thrombi was analyzed by liquid chromatography tandem with mass spectrometry. Discriminant Analysis (sparse Partial Least Squares Discriminant Analysis (sPLS-DA)) was performed to identify classification models and significant associated features of favorable clinical outcome at 3 months (modified Rankin Scale (mRS) < 2). sPLS-DA of the metabolomes of cerebral thrombi discriminated between stroke patients with a favorable or poor clinical outcome (Area Under the Curve (AUC) = 0.992 (0.931–1)). In addition, our results revealed that high sorbitol and glucose levels in the thrombi positively correlated with favorable clinical outcomes. Sorbitol, a short-term glycemic index reflecting a high blood glucose level at stroke onset, was found to be an independent predictor of good outcome (AUC = 0.908 (0.807–0.995)). This study demonstrates that a high blood glucose level at stroke onset is beneficial to the clinical outcome of the patient.

scholarly journals Healing of Extraction Socket in Diabetic Patients- A Hospital based Retrospective Study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1427-1430
Author(s):  
Chidambaram Shathviha P ◽  
Herald J Sherlin ◽  
Mebin Mathew
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healing Process ◽  
Diabetic Patients ◽  
Age Group ◽  
High Blood Glucose ◽  
High Blood Glucose Level ◽  
Surgical Extraction ◽  
Extraction Treatment

Diabetes is a common metabolic disorder which is an inability to regulate blood glucose due to insulin deficiency or resistance. During extraction, diabetic patients suffer various complications. One among them is most commonly seen delayed wound healing. The aim of this study is to evaluate the prevalence of delay in the healing process of extraction sockets in diabetic patients. This retrospective cross-sectional study was carried out in a hospital setting where all case sheets for six months were filtered from the patient management software. Samples of all patients with diabetes and the extraction treatment were filtered. Three hundred sixteen patients were used for this study. The data is collected and imported to SPSS for statistical analysis and results are obtained. Among 316 patients, 77 were diabetic and had undergone extraction treatment. Satisfactory healing was observed in diabetic patients undergoing normal extraction within the age group 60-70 years and with blood glucose level within normal range (54%). Unhealed sockets were observed in diabetic patients who underwent surgical extraction within the age group of 60-70 years and with high blood glucose level (10.2%). Majority of patients with normal blood glucose level have satisfactory healing and patients with high blood glucose level have unhealed sockets. Dentists should be aware that diabetic patients of poor glucose control undergoing traumatic extraction are prone to delayed healing processes which lead the patient to discomfort and infections. Patients should be advised to have a proper diet and controlled level of glucose to prevent oral complications.

Design and Validation of a Low-Cost Non-Invasive Device to Detect Overnight Hypoglycemia

2018 ◽  
Author(s):  
Jonathan Lesko ◽  
Stephen Seibert ◽  
Yong Zhu
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Electrodermal Activity ◽  
Low Cost ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Life Threatening ◽  
Invasive Device ◽  
The Individual

Research in the field of blood glucose monitoring systems has led to incredible advancements over the past several decades. The blood glucose level of a diabetic patient is vital to monitor since large swings in blood sugar can cause life threatening damage to the individual. The importance of blood glucose monitoring increases when a patient experiences hypoglycemia, which can be very dangerous. The objective of this project is to create a low cost portable device that utilizes the modular bio-signal sensor kit BITalino and Arduino Uno microcontroller to measure and process the electrodermal activity (EDA) and electrocardiography (ECG) signals that can be associated with a drop in the subject’s blood glucose level to detect hypoglycemia in diabetics.

scholarly journals Construction of diabetic mice model carrying external wound for the evaluation of topical applications on the impaired wound healing

2018 ◽  
Vol 1 (6) ◽  
pp. 127-138
Author(s):  
Thanh Kha Thanh Vu ◽  
Phung Thi Minh Duong ◽  
Huy Thanh Nguyen ◽  
Hung Van Nguyen ◽  
Nhan Tri Nguyen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Glucose ◽  
Health Status ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Mice ◽  
Mice Model ◽  
High Blood Glucose ◽  
Impaired Wound Healing ◽  
Human Pathology

Chronic leg ulcer is one of the diabetic complications causing continuous pain and higher mortality risk. The therapeutic treatment of chronic diabetic wounds can be studied through animal models which simulate the human pathology. Experimental diabetes in mice induced by streptozotocin (STZ) is an easy method with low cost. There have been several studies using STZ for diabetic mice model of cutaneous excisional wound. However, those procedures are different in many factors such as dose of STZ, mouse weight, blood glucose level and the method for assessing health status in mice. We have constructed the criteria to evaluate the health status of the experimental mice including skin color, fur condition, ability to move and body condition. These criteria of health status wereused together with the blood glucose level to evaluate the male mice’s sensitivity to a single high dose (100-150 mg/kg) of STZ. Approximately 40 % of 20–28 g weighted mice, which were injected by 125 mg/kg STZ, developed diabetes in a good health status in the first two weeks after injection. Mice with blood glucose level higher than 200 mg/dL had damaged islet and stably high blood glucose as well as stable health status after two weeks carrying wounds. The wound healing process of the diabetic wounded mice occured relatively slower than that of the control group (non diabetic). The model of diabetic wounded mice has been used to evaluate of the wound healing effect of the rhPDGF-BB protein which has been used in the treatment of chronic wounds caused by human diabetes.

Sign in / Sign up

Export Citation Format

Share Document