Raised TSH is associated with endothelial dysfunction in Metabolic Syndrome: A case control study

AbstractIntroduction. Endothelial dysfunction has been considered as one of the important factors in pathogenesis of Metabolic Syndrome (Met S). Subclinical hypothyroidism (SCH) has also been reported to be associated with Met S. The aim of our study is to evaluate the association of raised TSH with mediators of endothelial dysfunction in Met S with Subclinical hypothyroidism as compared to healthy controls.Methods. Study population consisted of 100 subjects, out of which 50 were cases of Met S and 50 were healthy controls. Met S group were further divided into two, based on the presence & absence of SCH. Serum insulin, T3, T4, TSH were measured by chemiluminescence based immunoassay (CLIA). Serum nitric oxide (NO) levels were measured by Modified Griess’s method and serum endothelin-1 (ET-1) levels were measured by ELISA.Results. Out of 50 cases of Met S, SCH was diagnosed in 22. The mean serum TSH levels were significantly higher in Met S cases as compared to healthy controls (5.7 ± 1.2 μIU/mL vs. 2.3 ± 1.6 μIU/mL, P <0.0001). Mean serum NO levels were significantly lower in Met S cases as compared to healthy control (15.4 ± 10 μM vs. 21 ± 10 μM, p = 0.009). Mean serum ET-1 levels were significantly higher in Met S cases as compared to healthy controls (2.68 ± 1.7 fmol/mL vs. 2.1 ± 0.84 fmol/mL, p = 0.011). On Pearson’s correlation analysis, TSH showed positive correlation with ET-1 (r = 0.341, p = 0.001) and negative correlation with NO (r = −0.331, p = 0.001). Binary logistic regression analysis showed that TSH, NO and ET-1 has significant odd’s ratio for predicting Met S.Conclusion. Met S cases were screened for thyroid abnormalities and found to have 44% of SCH along with co-existing endothelial dysfunction. Raised TSH in SCH could cause endothelial dysfunction which may lead to Met S and associated co-morbidities. Present study gives new insight in linking endothelial dysfunction and raised TSH in Met S. Therefore, Met S cases should be screened for SCH and treated appropriately to attenuate endothelial dysfunction and associated comorbidities in Met S.

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Relationship between plasma homocysteine and blood pressure in hypertensive Northern-Nigerians

African Health Sciences ◽

10.4314/ahs.v20i1.38 ◽

2020 ◽

Vol 20 (1) ◽

pp. 324-337

Author(s):

Obiageli Uzoamaka Onyemelukwe ◽

Bilkisu Bello Maiha

Keyword(s):

Blood Pressure ◽

Binary Logistic Regression ◽

Plasma Homocysteine ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Cross Sectional ◽

Hypertensive Patients ◽

Blood Pressure Difference ◽

Confounding Variables ◽

Blood Pressures

Aim: The study sought to determine whether there is any relationship between plasma homocysteine and blood pressure levels in Nigerians with essential hypertension. Method: It was a cross-sectional analytical study done on 120 randomly selected hypertensive patients and 120 normal healthy controls seen at the large Conference hall of the Ahmadu Bello University (ABU) Medical Centre, Zaria as well as the ABU Teaching Hospital, Zaria, Northern-Nigeria. Pearson’s Correlation and Binary Logistic Regression analysis determined the rela- tionship between homocysteine and hypertension. Results: Hyperhomocysteinaemia found in the hypertensive patients (22.8 ± 6.6 µmol/L) differed significantly (p<0.001) from controls (10.9 ± 2.8 µmol/L) with significant (p<0.001), blood pressure difference between both groups. Homocysteine signifi- cantly positively correlated with systolic (r = 0.51, p<0.001) and diastolic (r = 0.47, p<0.001) blood pressures in hypertensive subjects. The relation of plasma hcy to hypertension was statistically significant for SBP; OR: 1.08 (95% CI, 1.05-1.11) and DBP; OR: 1.08 (95% CI, 1.03-1.13) in the unadjusted model. When adjusted for confounding variables, hcy was significantly related to SBP; OR: 1.1 (95% CI, 1.04-1.18) but not DBP (p=0.25; OR: 1.06 (95 % CI, 0.96-1.18). The mean plasma folate level was high (115.2 ± 48.0 ng/mL) in the hypertensive subjects. The hyperhomocysteinaemic subjects showed a 2.8 times Odds of developing hypertension. Conclusion: This study showed higher mean plasma homocysteine levels in hypertensives than controls not accounted for by sub-optimal folate levels. Hyperhomocysteinaemia showed a positive relationship to systolic hypertension after adjusting for confounders. Keywords: Plasma homocysteine; hypertension; healthy controls; folic acid; blood pressure; Northern-Nigerians.

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Exercise-induced albuminuria is related to metabolic syndrome

AJP Renal Physiology ◽

10.1152/ajprenal.00481.2015 ◽

2016 ◽

Vol 310 (11) ◽

pp. F1192-F1196 ◽

Cited By ~ 16

Author(s):

Sharon Greenberg ◽

Shani Shenhar-Tsarfaty ◽

Ori Rogowski ◽

Itzhak Shapira ◽

David Zeltser ◽

...

Keyword(s):

Metabolic Syndrome ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Urinary Albumin ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Metabolic Equivalents ◽

Before And After ◽

Study Population ◽

Exercise Induced

Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albumin-to-creatinine ratio (ACR) values before and after exercise were 0.40 (0.21–0.89) and 1.06 (0.43–2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise ( P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents ( P < 0.001), higher baseline blood pressure ( P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index ( P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13–3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS.

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Menopause and Metabolic Syndrome in Tunisian Women

BioMed Research International ◽

10.1155/2014/457131 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 16

Author(s):

Samir Ben Ali ◽

Hanen Belfki-Benali ◽

Hajer Aounallah-Skhiri ◽

Pierre Traissac ◽

Bernard Maire ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Plasma Lipids ◽

Fasting Glucose ◽

Menopausal Status ◽

Premenopausal Women ◽

Binary Logistic Regression ◽

Binary Logistic Regression Analysis ◽

Mean Values ◽

History Of

Objectives. This study aimed to evaluate the effect of menopausal status on the risk of metabolic syndrome (MetS) in Tunisian women.Methods. We analyzed a total of 2680 women aged between 35 and 70 years. Blood pressure, anthropometric indices, fasting glucose, and lipid profile were measured. The MetS was assessed by the modified NCEP-ATPIII definition.Results. The mean values of waist circumference, blood pressure, plasma lipids, and fasting glucose were significantly higher in postmenopausal than in premenopausal women, a difference that was no longer present when adjusting for age. Except for hypertriglyceridaemia, the frequency of central obesity, hyperglycemia, high blood pressure, and high total cholesterol was significantly higher in postmenopausal than in premenopausal women. After adjusting for age, the significance persisted only for hyperglycemia. The overall prevalence of MetS was 35.9%, higher in postmenopausal (45.7% versus 25.6%) than in premenopausal women. A binary logistic regression analysis showed that menopause was independently associated with MetS (OR = 1.41, 95% CI 1.10–1.82) after adjusting for age, residence area, marital status, family history of cardiovascular disease, education level, and occupation.Conclusions. The present study provides evidence that the MetS is highly prevalent in this group of women. Menopause can be a predictor of MetS independent of age in Tunisian women.

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Physical activity patterns and correlates among adults from a developing country: the Sri Lanka Diabetes and Cardiovascular Study

Public Health Nutrition ◽

10.1017/s1368980012003990 ◽

2012 ◽

Vol 16 (9) ◽

pp. 1684-1692 ◽

Cited By ~ 32

Author(s):

Prasad Katulanda ◽

Ranil Jayawardana ◽

Priyanga Ranasinghe ◽

MH Rezvi Sheriff ◽

David R Matthews

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Regression Analysis ◽

Physical Inactivity ◽

Tertiary Education ◽

Binary Logistic Regression ◽

Female Gender ◽

Binary Logistic Regression Analysis ◽

Sri Lankan ◽

Highly Active

AbstractObjectiveTo evaluate patterns of physical activity (PA), the prevalence of physical inactivity and the relationships between PA and sociodemographic, clinical and biochemical parameters among Sri Lankan adults.DesignDescriptive cross-sectional study.SettingNationally representative population-based survey conducted in Sri Lanka.SubjectsData on PA and associated details were obtained from 5000 adults. PA was assessed using the International Physical Activity Questionnaire (short-form). A binary logistic regression analysis was performed using the dichotomous variable ‘health-enhancing PA’ (0 = ‘active’, 1 = ‘inactive’).ResultsSample size was 4485. Mean age was 46·1 (sd 15·1) years, 39·5 % were males. The mean weekly total MET (metabolic equivalents of task) minutes of PA among the study population was 4703 (sd 4369). Males (5464 (sd 5452)) had a significantly higher weekly total MET minutes than females (4205 (sd 3394); P < 0·001). Rural adults (5175 (sd 4583)) were significantly more active than urban adults (2956 (sd 2847); P < 0·001). Tamils had the highest mean weekly total MET minutes among ethnicities. Those with tertiary education had lowest mean weekly total MET minutes. In all adults 60·0 % were in the ‘highly active’ category, while only 11·0 % were ‘inactive’ (males 14·6 %, females 8·7 %; P < 0·001). Of the ‘highly active’ adults, 85·8 % were residing in rural areas. Results of the binary logistic regression analysis indicated that female gender (OR = 2·1), age >70 years (OR = 3·8), urban living (OR = 2·5), Muslim ethnicity (OR = 2·7), tertiary education (OR = 3·6), obesity (OR = 1·8), diabetes (OR = 1·6), hypertension (OR = 1·2) and metabolic syndrome (OR = 1·3) were all associated with significantly increased odds of being physically ‘inactive’.ConclusionsThe majority of Sri Lankan adults were ‘highly active’ physically. Female gender, older age, urban living, Muslim ethnicity and tertiary education were all significant predictors of physical inactivity. Physical inactivity was associated with obesity, diabetes, hypertension and metabolic syndrome.

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Novel and traditional anthropometric indices for identifying metabolic syndrome in non-overweight/obese adults

10.21203/rs.3.rs-52907/v2 ◽

2020 ◽

Author(s):

Lihong Wu ◽

WenHua Zhu ◽

Qiaohua Qiao ◽

Lijuan Huang ◽

Yiqi Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Screening Method ◽

Density Lipoprotein ◽

Binary Logistic Regression ◽

Shape Index ◽

Volume Index ◽

Binary Logistic Regression Analysis ◽

Obese People ◽

Anthropometric Indices ◽

Cross Sectional

Abstract Background: Metabolic syndrome (MetS) in non-overweight/obese people is insidiously associated with cardiovascular disease (CVD). Novel anthropometric indices can reflect central obesity better than the traditional anthropometric indices. Therefore, we hypothesize that these newly developed anthropometric indices can better identify MetS in non-overweight/obese people than conventional indices. Methods: Cross-sectional data of sociodemographic, biochemical and anthropometric indices were collected from 2916 non-overweight/obese Chinese people. A body shape index (ABSI), body roundness index (BRI), waist-to-height ratio (WHtR), weight-adjusted-waist index (WWI) and abdominal volume index (AVI) were calculated. Partial correlation analysis was used to clarify the correlation between anthropometric indices and MetS variables. Binary logistic regression analysis was applied to assess the association between anthropometric indices and MetS and its components. Receiver-operating characteristic (ROC) curve was used to identify the diagnostic ability of anthropometric indices for MetS and its components. The area under curve (AUC) difference between WHtR and each new anthropometric index was compared in pairs.Results: After adjusting for covariates, AVI had the optimal ability of identifying MetS (AUC: 0.743 for male, 0.819 for female) and the strongest correlation with high-density lipoprotein cholesterol (HDL-C) (coe: -0.227 for male, -0.207 for female) and the highest odds rations (OR) with low HDL-C group (male: OR=1.37, female: OR=1.55). The WHtR was comparable to BRI in assessing MetS (AUC: 0.739 for male, 0.817 for female). WHtR or BRI could also well identify hypertension (AUC: 0.602 for male, 0.688 for female) and dysglycemia (AUC: 0.669 for male, 0.713 for female) and female's high triglyceride level (AUC 0.712). The recognition ability of the two was equivalent. The ability of ABSI and WWI to identify MetS was weak.Conclusions: AVI is the optimal anthropometric indices to identify MetS in non-overweight/obese Chinese adults. BRI and WHtR can also be considered as discriminators, while ABSI and WWI are weak discriminators. WHtR is easy to measure. So, it is recommended as an early preliminary screening method for the MetS in non-overweight/obese people.

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ALS phenotype is influenced by age, sex, and genetics

Neurology ◽

10.1212/wnl.0000000000008869 ◽

2020 ◽

Vol 94 (8) ◽

pp. e802-e810 ◽

Cited By ~ 14

Author(s):

Adriano Chiò ◽

Cristina Moglia ◽

Antonio Canosa ◽

Umberto Manera ◽

Fabrizio D'Ovidio ◽

...

Keyword(s):

Motor Neurons ◽

Differential Susceptibility ◽

Binary Logistic Regression ◽

Population Based ◽

Older Age ◽

Binary Logistic Regression Analysis ◽

Behavioral Impairment ◽

Younger Age ◽

Study Population ◽

Male Sex

ObjectiveTo assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort.MethodsThe study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995–2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly upper motor neuron [PUMN], respiratory) and cognitive phenotypes (normal, ALS with cognitive impairment [ALSci], ALS with behavioral impairment [ALSbi], ALSci and ALSbi combined [ALScbi], ALS–frontotemporal dementia [FTD]). Binary logistic regression analysis was adjusted for sex, age, and genetics.ResultsBulbar phenotype correlated with older age (p < 0.0001), women were more affected than men at increasing age (p < 0.0001), classic with younger age (p = 0.029), men were more affected than women at increasing age (p < 0.0001), PUMN with younger age (p < 0.0001), flail arm with male sex (p < 0.0001) and younger age (p = 0.04), flail leg with male sex with increasing age (p = 0.008), and respiratory with male sex (p < 0.0001). C9orf72 expansions correlated with bulbar phenotype (p < 0.0001), and were less frequent in PUMN (p = 0.041); SOD1 mutations correlated with flail leg phenotype (p < 0.0001), and were less frequent in bulbar (p < 0.0001). ALS-FTD correlated with C9orf72 (p < 0.0001) and bulbar phenotype (p = 0.008), ALScbi with PUMN (p = 0.014), and ALSci with older age (p = 0.008).ConclusionsOur data suggest that the spatial–temporal combination of motor and cognitive events leading to the onset and progression of ALS is characterized by a differential susceptibility to the pathologic process of motor and prefrontal cortices and lower motor neurons, and is influenced by age, sex, and gene variants. The identification of those factors that regulate ALS phenotype will allow us to reclassify patients into pathologically homogenous subgroups, responsive to targeted personalized therapies.

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Modern Contraception: Uptake and Correlates among Women of Reproductive Age-Group in a Rural Community of Osun State, Nigeria

Ethiopian Journal of Health Sciences ◽

10.4314/ejhs.v30i4.8 ◽

2020 ◽

Vol 30 (4) ◽

Author(s):

Ajibola Idowu ◽

Grace Chinyere Ukandu ◽

Jeremiah Mattu ◽

Damilola Olawuyi ◽

Adeola Abiodun ◽

...

Keyword(s):

Contraceptive Use ◽

Binary Logistic Regression ◽

Educational Status ◽

Reproductive Age ◽

Binary Logistic Regression Analysis ◽

Pregnancy Risk ◽

Chi Square ◽

Multi Stage ◽

Study Population ◽

Main Determinants

BACKGROUND: Universal contraceptive access is one of the key strategies for achieving sustainable developments in any country. Yet, uptake has remained low in most developing nations like Nigeria. The reasons for low use must be contextually understood to aid effective contraceptive programming. This study assessed contraceptive use and its determinants among reproductive aged women in Ejigbo, Osun State, Nigeria.METHOD: A quantitative study involving 405 participants which were recruited using multi-stage sampling method was carried out. Data were collected using pretested semi-structured, intervieweradministered questionnaire. Chi-Square test and binary logistic regression analysis were used for inferential statistics.RESULTS: The mean age of the respondents was 28±6. The majority (92.8%) of the respondents were aware of family planning, 68.9% of them possessed good knowledge but only 53% of them demonstrated favorable contraceptive attitude. Less than half (33.0%) of those who had heard about contraception were current users of modern methods. Injectables (45.0%) and male condoms (30.0%) were the most prevalent contraceptive methods among the respondents. The main determinants of contraceptive uptake were respondents’ educational status (AOR=0.525, 95%CI=0.284-0.972), contraceptive knowledge (OR=0.512, 95%CI=1.242-1.968) and attitude (OR=0.512, 95%CI=1.242- 1.968). Fear of perceived side effects (45.2%), low pregnancy risk perception (35.7%) and spousal refusal (12.5%) were the main reasons for non-contraceptive use among non-users.CONCLUSION: Contraceptive demand in the study population was low in spite of high awareness level. There is a need to increase contraceptive literacy in the study population and make the services more acceptable to rural dwellers so as to meet the SDG-3 target in Nigeria.

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Novel and traditional anthropometric indices for identifying metabolic syndrome in non-overweight/obese adults

10.21203/rs.3.rs-52907/v3 ◽

2020 ◽

Author(s):

Lihong Wu ◽

WenHua Zhu ◽

Qiaohua Qiao ◽

Lijuan Huang ◽

Yiqi Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Screening Method ◽

Density Lipoprotein ◽

Binary Logistic Regression ◽

Shape Index ◽

Volume Index ◽

Binary Logistic Regression Analysis ◽

Obese People ◽

Anthropometric Indices ◽

Cross Sectional

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The severity of essential hypertension in terms of blood pressure values does not depend on NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms in the West-Ukrainian population

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.10.032 ◽

2021 ◽

Vol 11 (10) ◽

pp. 332-341

Author(s):

Andrii Sydorchuk ◽

Larysa Sydorchuk

Keyword(s):

Blood Pressure ◽

Binary Logistic Regression ◽

Binary Logistic Regression Analysis ◽

The West ◽

Epidemiological Analysis ◽

Nos3 Gene ◽

Healthy Control ◽

Essential Arterial Hypertension ◽

Polymorphic Variants ◽

Control Study

Objective: to evaluate the association of essential arterial hypertension (EAH) and its severity with genes polymorphism of NOS3 (rs2070744) and GNB3 (rs5443) in West-Ukrainian population. Materials and methods. One-hundred EAH patients (48 – healthy control) participated in the cohort case-control study. Blood pressure (BP), Creatinine, glucose, lipids panel were studied. GNB3 (rs5443) and NOS3 (rs2070744) genotyping performed by TaqMan probes (CFX96™Real-Time PCR). Risk assessed by Relative Risk, Odds Ratio and 95% Confidential intervals. Results. A mutation of the NOS3 gene (786T>C, rs2070744) and the GNB3 gene (825C>T, rs5443) in the homozygous state in the West-Ukrainian population suffers from EAH occurs with a frequency of 16.67% and 8.33%, with no differences with the control subjects (p>0.05). In both groups dominate the T-allele of the NOS3 gene and the C-allele of the GNB3 gene: in patients by 12.5% (c2=4.50; p=0.034) and 41.66% (c2=50.0; p<0.001), in the control – by 25.0% (c2=12.0; p<0.001) and 40.0% (c2=33.33; p<0.001), respectively. The results of the binary logistic regression analysis did not confirm the prediction of the EAH appearance by polymorphic variants of the NOS3 (rs2070744) and GNB3 (rs5443) genes. However, the TT genotype of the GNB3 gene (rs5443) increases unreliably the EAH risk almost twice as likely [OR=2.0; OR 95%CI:0.40-10.82; p>0.05]. Epidemiological analysis did not confirm the association of the NOS3 gene with the EAH severity. But T-allele of the GNB3 gene increases the probability of high normal BP almost 5 times [OR=4.86; OR 95%CI:0.99-24.75; p=0.042]. Conclusions: NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms are not associated with blood pressure values and EAH severity as well.

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Optimism is a Nonnegligible Factor Associated With Compliance to Urate Lowering Therapy in Patients With Gout: A Prospective Study

10.21203/rs.3.rs-144137/v1 ◽

2021 ◽

Author(s):

Wenkai Zhao ◽

Zhixiang Huang ◽

Yukai Huang ◽

Qidang Huang ◽

Shuyang Chen ◽

...

Keyword(s):

Disease Duration ◽

Depression Scale ◽

Medication Possession Ratio ◽

Binary Logistic Regression ◽

Poor Compliance ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Life Orientation Test ◽

Self Rating ◽

Lowering Therapy

Abstract Background: Optimism has different effects on patients with chronic rheumatic disease. Gout is an increasingly prevalent disorder around the world, while the compliance to urate lowering therapy (ULT) of gout patients is poor. The objective of this study was to assess the optimism of gout patients. Contributors to optimism and poor compliance were also explored.Methods: A total of 530 gout patients, 174 ankylosing spondylitis (AS) patients, 60 rheumatoid arthritis (RA) patients and 324 healthy volunteers were included. Optimism, anxiety, and depression were measured by the life orientation test-revised (LOT-R), self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Demographic and disease characteristic were recorded, including education, residence, disease duration, etc. Severity of pain in the involved joints was assessed by the visual analog scale (VAS). Concentration of serum uric acid (SUA) was collected at baseline and the last examination within the follow-up. Compliance to ULT was investigated by the medication possession ratio (MPR) in 3 months. The contributors to optimism and poor compliance were detected by the multivariate and binary logistic regression analysis.Results: The LOT-R score of gout patients was higher than AS and RA patients, but there was no statistical difference between gout patients and healthy controls. The SAS and SDS score of gout patients were lower than AS and RA patients, while the SDS score of gout patients was higher than healthy controls. The mean disease duration and VAS score were 5.0 (2.0-7.3) years and 2.0 (0.0-4.0). Percentage of gout patients with an MPR<0.8 was 55.1%. Insufficient education contributed to optimism in gout patients. Insufficient education, living in countryside, higher concentration of SUA and higher LOT-R score led to poor compliance to ULT.Conclusion. The optimism of gout patients is greater compared with AS and RA patients. The compliance to ULT is poor, which ascribes to optimism. Furthermore, the optimism of gout patients may attribute to insufficient education.

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