Exercise-induced albuminuria is related to metabolic syndrome

Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albumin-to-creatinine ratio (ACR) values before and after exercise were 0.40 (0.21–0.89) and 1.06 (0.43–2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise ( P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents ( P < 0.001), higher baseline blood pressure ( P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index ( P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13–3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS.

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C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components

International Journal of Endocrinology ◽

10.1155/2018/7201473 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Feiyu Jiang ◽

Min Yang ◽

Xili Zhao ◽

Rui Liu ◽

Gangyi Yang ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Multiple Stepwise Regression Analysis ◽

Glucose And Lipid Metabolism ◽

Study Population ◽

The Relationship

Objective. C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Methods. We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals. Serum CTRP5 concentrations were determined by ELISA. The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman’s correlation and multiple stepwise regression analysis. Results. Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. Overweight/obese individuals (BMI ≥ 25 kg/m2) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m2) in the study population (124.1 (99.12–147.37) vs. 103.9 (79.15–124.25) μg/L; P<0.01). Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C (P<0.05 or P<0.01). Binary logistic regression revealed that serum CTRP5 levels were associated with MetS. In addition, serum CTRP5 levels gradually decreased with the increase in MetS components. Conclusions. Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance. This trial is registered with ChiCTR-OCS-13003185.

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What Makes a Tweet Fly? Analysis of Twitter Messaging at Four Infection Control Conferences

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2017.170 ◽

2017 ◽

Vol 38 (11) ◽

pp. 1271-1276 ◽

Cited By ~ 12

Author(s):

Brett G. Mitchell ◽

Philip L. Russo ◽

Jonathan A. Otter ◽

Martin A. Kiernan ◽

Landon Aveling

Keyword(s):

Network Analysis ◽

Infection Control ◽

Infection Prevention ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Infection Prevention And Control ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Activity Networks ◽

The Uk

OBJECTIVETo examine tweeting activity, networks, and common topics mentioned on Twitter at 4 international infection control and infectious disease conferences.DESIGNA cross-sectional study.METHODSAn independent company was commissioned to undertake a Twitter ‘trawl’ each month between July 1, 2016, and November 31, 2016. The trawl identified any tweets that contained the official hashtags of the conferences for (1) the UK Infection Prevention Society, (2) IDWeek 2016, (3) the Federation of Infectious Society/Hospital Infection Society, and (4) the Australasian College for Infection Prevention and Control. Topics from each tweet were identified, and an examination of the frequency and timing of tweets was performed. A social network analysis was performed to illustrate connections between users. A multivariate binary logistic regression model was developed to explore the predictors of ‘retweets.’RESULTSIn total, 23,718 tweets were identified as using 1 of the 2 hashtags of interest. The results demonstrated that the most tweets were posted during the conferences. Network analysis demonstrated a diversity of twitter networks. A link to a web address was a significant predictor of whether a tweet would be retweeted (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.9–2.1). Other significant factors predicting a retweet included tweeting on topics such as Clostridium difficile (OR, 2.0; 95% CI, 1.7–2.4) and the media (OR, 1.8; 95% CI, 1.6–2.0). Tweets that contained a picture were significantly less likely to be retweeted (OR, 0.06; 95% CI, 0.05–0.08).CONCLUSIONTwitter is a useful tool for information sharing and networking at infection control conferences.Infect Control Hosp Epidemiol 2017;38:1271–1276

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Association between Free Sugars Intake and Excessive Daytime Sleepiness among Chinese Adolescents

Nutrients ◽

10.3390/nu13113959 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3959

Author(s):

Yue Xi ◽

Qian Lin ◽

Qiping Yang ◽

Fang Li ◽

Hanmei Liu ◽

...

Keyword(s):

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Chinese Adolescents ◽

Binary Logistic Regression Model ◽

School Students ◽

Online Questionnaire ◽

Cross Sectional ◽

Free Sugars

This study aimed to investigate the prevalence of excessive daytime sleepiness (EDS) and explore the association between free sugars intake and EDS. In this cross-sectional study, a total of 1517 middle school students (808 boys and 707 girls) aged 12~14 years were recruited. The study was conducted in Changsha city, China. Adolescents completed an online questionnaire, including the Epworth Sleepiness Scale (ESS), sleep characteristics, a 12-item Food Frequency Questionnaire (FFQ), and other self-reported information. The ESS score ≥ ten was defined as EDS. The anthropometric indices, including height, weight, and waist circumference, were measured and recorded by uniformly trained assistants. Statistical analyses included the Chi-square test and binary logistic regression model. The mean ESS score and free sugars consumption were 6.8 ± 3.9 points and 53.1 ± 44.7 g/d, respectively. The prevalence of EDS among adolescents was 22.5%, and more girls than boys had EDS (26.1% vs. 19.4%, p < 0.05). An exceeded free sugars intake was positively associated with EDS, with the adjusted Odds Ratio (OR) with its 95% Confident Interval (95% CI) of 1.366 (1.060~1.761, p < 0.05). EDS and excessive consumption of free sugars are commonly found among Chinese adolescents. Further studies are needed to confirm whether free sugars restriction can be meaningful to improve daytime drowsiness in those with EDS.

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The Practices of Anaesthesiologists in the Management of Patients with Sickle Cell Disease: Empirical Evidence from Cameroon

Healthcare ◽

10.3390/healthcare9121617 ◽

2021 ◽

Vol 9 (12) ◽

pp. 1617

Author(s):

Dominique Djomo Tamchom ◽

Aristide Kuitchet ◽

Raymond Ndikontar ◽

Serge Nga Nomo ◽

Hermine Fouda ◽

...

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Perioperative Management ◽

Treatment Guideline ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Cell Disease ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Elective Surgical Procedures

Patients with sickle cell disease are more likely to undergo surgery during their lifetime, especially given the numerous complications they may develop. There is a paucity of data concerning the management of patients with sickle cell disease by anaesthesiologists, especially in Africa. This study aimed to describe the practices of anaesthesiologists in Cameroon concerning the perioperative management of patients with sickle cell disease. A cross-sectional study was carried out over four months and involved 35 out 47 anaesthesiologists working in hospitals across the country, who were invited to fill a data collection form after giving their informed consent. The data were analysed using descriptive statistics and a binary logistic regression model. Among the 35 anaesthesiologists included in the study, most (29 (82.9%)) had managed patients with sickle cell disease for both emergency and elective surgical procedures. Most of them had never asked for a haematology consultation before surgery. Most participants (26 (74.3%)) admitted to having carried out simple blood transfusions, while 4 (11.4%) carried out exchange transfusions. The haemoglobin thresholds for transfusion varied from one practitioner to another, between < 6 g/dl and < 9 g/dl. Only 6 (17.1%) anaesthesiologists had a treatment guideline for the management of patients with sickle cell disease in the hospitals where they practiced. Only 9 (25.7%) prescribed a search for irregular agglutinins. The percentage of haemoglobin S before surgery was always available for 5 (14.3%) of the participants. The coefficient (0.06) of the occurrence of a haematology consultation before surgery had a significant influence on the probability of management of post-operative complications (coefficient 0.06, 10% level of probability). This study highlights the fact that practices in the perioperative management of patients with sickle cell disease in Cameroon vary greatly from one anaesthesiologist to another. We disclosed major differences in the current recommendations, which support the fact that even in Sub-Saharan countries, guidelines applicable to the local settings should be published.

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A predictive model for early diagnosis of keratoconus

10.21203/rs.2.21162/v3 ◽

2020 ◽

Author(s):

GRACIA CASTRO-LUNA ◽

ANTONIO PÉREZ-RUEDA

Keyword(s):

Logistic Regression ◽

Predictive Model ◽

Early Stage ◽

Corneal Thickness ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Diagnostic Model ◽

Binary Logistic Regression Model ◽

Cross Sectional

Abstract Background: The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This study aims to describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus and normal corneas. Additionally to propose a diagnostic model of subclinical keratoconus based in binary logistic regression models Methods: The design was a cross-sectional study. It included 205 eyes from 205 patients distributed in 82 normal corneas, 40 early-stage keratoconus and 83 established keratoconus. The rotary Scheimpflug camera (Pentacam® type) analyzed the topographic, pachymetric and aberrometry variables. It performed a descriptive and bivariate analysis of the recorded data. A diagnostic and predictive model of early-stage keratoconus was calculated with the statistically significant variables Results: Statistically significant differences were observed when comparing normal corneas with early-stage keratoconus/ in variables of the vertical asymmetry to 90º and the central corneal thickness. The binary logistic regression model included the minimal corneal thickness, the anterior coma to 90º and posterior coma to 90º. The model properly diagnosed 92% of cases with a sensitivity of 97.59%, specificity 98.78%, accuracy 98.18% and precision 98.78%Conclusions: The differential diagnosis between normal cases and subclinical keratoconus depends on the mínimum corneal thickness, the anterior coma to 90º and the posterior coma to 90º.

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Prevalence of Metabolic Syndrome (MetS) and Determinants Among Obese Teachers in Makassar, Indonesia

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v18i2.100 ◽

2020 ◽

Vol 18 (2) ◽

Author(s):

Nurzakiah Hasan MKM ◽

Veni Hadju ◽

Nurhaedar Jafar ◽

Ridwan M. Thaha

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Heart Diseases ◽

Cross Sectional Study ◽

Sitting Time ◽

Moderate Physical Activity ◽

Cross Sectional ◽

Family History Of Diabetes ◽

Increased Risk ◽

Study Population

Metabolic Syndrome (MetS) is related to the increased risk of non-communicable diseases (NCDs). Teacher profession is an adult group with various risks of NCDs. This study aims to assess the determinants of the MetS in teachers with central obesity. Material and Methods: The study was conducted in Makassar, South Sulawesi, Indonesia with cross- sectional study design on 12 secondary schools. The number of samples in this study was 129 teachers. The prevalence of the MetS was determined using criteria from the Joint Interim Statement, while physical activity and sitting time were measured using the International Physical Activity Questionnaire (IPAQ). Results: Respondents in our study were mostly women (78.3%) with an average age of 49.8 years. The prevalence of the MetS in our study population was 39.5%. The prevalence of the Mets was higher in Buginese ethnic (70.6%), respondents with more income (56.9%), bachelor degree (80.4%), married (98%), family history of diabetes mellitus, obesity, hypertension and heart diseases (52.9%), and moderate physical activity (37.3%). There was a significant relationship between sitting time 4 hours; p=0.004), parameters of Mets (p<0.001), LDL (p=0.026), and LDL/HDL ratio (p<0.001) with the Mets. Conclusions: The prevalence of the Mets is high among obese teachers in our study population. Sitting time was an important determinant for MetS among obese teachers.

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A model of visual limitation in patients with keratoconus

Scientific Reports ◽

10.1038/s41598-020-76489-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Antonio Pérez-Rueda ◽

Gracia Castro-Luna

Keyword(s):

Visual Acuity ◽

Logistic Regression ◽

Operating Characteristic ◽

Spherical Aberration ◽

Area Under The Curve ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Corrected Visual Acuity

Abstract This paper aims to calculate a relevance model of visual limitation (V.L.) in keratoconus patients based on refractive and topographic parameters. A cross-sectional study was carried out in Torrecárdenas Hospital, Almería, Spain, between February 2018 and July 2019. It included 250 keratoconus patients. Two groups were created according to a grading system of V.L. based on RETICS (Red Temática de Investigación Cooperativa en Salud) classification: keratoconus patients with no V.L. (best spectacle-corrected visual acuity (BSCVA) ≤ 0.05 logMAR) and keratoconus patients with V.L. (BSCVA > 0.05 logMAR). Correlations and a binary logistic regression were established. V.L. was correlated with maximum curvature (r = 0.649, p < 0.001) and root mean square higher-order aberrations (HOARMS) (r = 0.625, p < 0.001). Binary logistic regression included V.L. as the dependent variable and spherical equivalent, HOARMS, spherical aberration and interaction between the anterior and posterior vertical coma as independent variables. The model was a good fit. Area under the curve (A.U.C.) of receiver operating characteristic (R.O.C.) curve was 0.924, sensitivity 91.90%, specificity 83.60%, accuracy 88.94%; and precision 91.17%. Binary logistic regression model of V.L. is a good fit model to predict the early loss of visual acuity in keratoconus patients.

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A predictive model for early diagnosis of keratoconus

10.21203/rs.2.21162/v2 ◽

2020 ◽

Author(s):

GRACIA CASTRO-LUNA ◽

ANTONIO PÉREZ-RUEDA

Keyword(s):

Logistic Regression ◽

Predictive Model ◽

Corneal Thickness ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Diagnostic Model ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Logistic Regression Models

Abstract Background: The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore to avoid possible refractive surgery that could produce ectasias. This study aims to describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus and normal corneas. Additionally to propose a diagnostic model of subclinical keratoconus based in binary logistic regression models Methods: The design was a cross-sectional study. It included 205 eyes from 205 patients distributed in 82 normal corneas, 40 subclinical keratoconus and 83 established keratoconus The rotary Scheimpflug camera (Pentacam® type) analyzed the topographic, pachymetric and aberrometry variables. It performed a descriptive and bivariate analysis of the recorded data. A diagnostic and predictive model of subclinical keratoconus was calculated with the statistically significant variables Results: Statistically significant differences were observed when comparing normal corneas with subclinical keratoconus/ in variables of the vertical asymmetry to 90º and the central corneal thickness. The binary logistic regression model included the minimal corneal thickness, the anterior coma to 90º and posterior coma to 90º. The model properly diagnosed 92% of cases Conclusions: The differential diagnosis between normal cases and subclinical keratoconus depends on the mínimum corneal thickness, the anterior coma to 90º and the posterior coma to 90º.

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Post-destructive eye surgery, associated depression at Sekuru Kaguvi Hospital Eye Unit, Zimbabwe: Pilot Study

African Vision and Eye Health ◽

10.4102/aveh.v72i2.48 ◽

2013 ◽

Vol 72 (2) ◽

Author(s):

M. M. Kawome ◽

R. Masanganise

Keyword(s):

Cross Sectional Study ◽

Current Management ◽

Cross Sectional ◽

Systematic Random Sampling ◽

Eye Surgery ◽

Management Protocol ◽

Before And After ◽

Patient Health ◽

Study Population ◽

Structured Questionnaire

Destructive eye surgery is associated with more complications than just loss of visual functions of the eye and aesthetics. Currently there is very little published literature on post-destructive eye surgery associated depression. Zimbabwe has been experiencing a surge in the rate of destructive eye surgery done at the National Tertiary Eye Unit. This situation could be churning out lots of unrecognized depressed clients into the community who require assistance in one form or another.Objectives: To determine the prevalence of post-destructive eye surgery associated depression among patients attending Sekuru Kaguvi Hospital Eye Unit and assess if the current management protocol of patients undergoing destructive eye surgery at the Eye Unit addresses the problem adequately.Methods: A cross-sectional study of 28 randomly selected patients who had destructive eye surgeries at Sekuru Kaguvi Hospital was conducted over five months from 1st March 2012 to end of July 2012. A structured questionnaire containing 15 questions on the following items: gender, age, diagnosis, surgical procedure done, expectations before and after surgery, adequacy of counseling given and involvement of family was used to collect data. Nine questions to assess depression were adapted from the Patient Health Questionnaire (PHQ-9).Setting: The study was conducted at SekuruKaguvi Hospital Eye Unit, Parirenyatwa Group of Hospitals in Harare.Results: Twenty-eight patients who underwent destructive eye surgery during the study period were selected using systematic random sampling. The gender ratio was 1:1 and the mean age was 38.7 years with a range from 24 to 65 years. Fifty percent of the patients in the study had orbital exenteration while the rest had enucleation (14%) and evisceration (36%). Twenty-eight percent of the study population had depression.Conclusion: Destructive eye surgery is frequently associated with depression and our current management protocol of patients undergoing destructive eye surgery does not address this problem.

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A Predictive Study of Resilience and Its Relationship with Academic and Work Dimensions during the COVID-19 Pandemic

Journal of Clinical Medicine ◽

10.3390/jcm9103258 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3258 ◽

Cited By ~ 1

Author(s):

Silvia San Román-Mata ◽

Félix Zurita-Ortega ◽

Pilar Puertas-Molero ◽

Georgian Badicu ◽

Gabriel González-Valero

Keyword(s):

Ad Hoc ◽

Emergency Services ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Academic Variables ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Academic Level ◽

Resilience Scale ◽

Professional Occupation

Background: The aim of the present study was to describe the resilience levels in a Spanish population during the Coronavirus (COVID-19) pandemic and to analyze the existing associations between high resilience and socio-demographic, work, and academic parameters. Method: 1176 individuals aged 18–67 years participated in a descriptive cross-sectional study. The participants were administered the 10-item resilience scale developed by Connor-Davidson (CD-RISC-10) and an ad-hoc questionnaire that collected information on socio-demographic, work, and academic variables. Basic descriptive data were used to statistically analyze the data, and a binary logistic regression model was developed incorporating the professional occupation, academic level, whether the respondent worked in emergency services, and whether the respondent had dependents. Results: Slightly more than a quarter of the participants showed low resilience, almost half reported moderate resilience, and slightly more than a quarter had high resilience. Those who were employed were 2.16-times more likely to have high resilience, whilst those with higher education were 1.57-times more likely. Those working in emergency services were 1.66-times more likely, and those with dependents were 1.58-times more likely to have high resilience. Conclusion: In addition to the relationships found, a need to improve the resilience levels in the population was found.

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