scholarly journals Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

2016 ◽  
Vol 17 (4) ◽  
pp. 285-296 ◽  
Author(s):  
Milena Jurisevic ◽  
Gordana Radosavljevic ◽  
Aleksandar Arsenijevic ◽  
Marija Milovanovic ◽  
Nevena Gajovic ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Cisplatin Resistance ◽  
Platinum Complexes ◽  
Ester Group ◽  
Carbon Chain ◽  
Platinum Compound ◽  
Necrotic Cell ◽  
High Level ◽  
Group Carbon ◽  
Ester Chain

Abstract The design of platinum based drugs is not a new field of interest. Platinum complexes are widely used as anticancer agents and currently, approximately 30 platinum(II) and platinum(IV) entered into some of the phases of clinical trials. A special place in today’s research belongs to platinum complexes with diammine ligands. A large number of edda (ethylenediamine- N, N’-diacetate)-type ligands and their corresponding metal complexes has been successfully synthesized. This article summarizes recent progress in research on edda-type-platinum complexes. Some of these agents achieves better effect compared to the gold standard (cisplatin). It has been shown that there is a possible relationship between the length of the ligand ester group carbon chain and its cytotoxic effect. In most cases the longer the ester chain is the greater is the antitumor activity. Of particular interest are the noticeable effects of some new platinum compound with edda-type ligand on cell lines that are known to have a high level of cisplatin-resistance. Exanimate complexes appear to have a different mode of mechanism of action compared with cisplatin which includes apoptotic and necrotic cell death. There are indications that further investigations of these compounds may be very useful in overcoming the problems associated global cancer statistic.

Mustards-Derived Terpyridine–Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination

2021 ◽  
Vol 60 (4) ◽  
pp. 2414-2424
Author(s):  
Muneebah Adams ◽  
Matthew P. Sullivan ◽  
Kelvin K. H. Tong ◽  
David C. Goldstone ◽  
Muhammad Hanif ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Platinum Complexes ◽  
Dna Alkylation

scholarly journals Platinum Complexes in Colorectal Cancer and Other Solid Tumors

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2073
Author(s):  
Beate Köberle ◽  
Sarah Schoch
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Platinum Complexes ◽  
Dna Lesions ◽  
Dna Damage Signaling ◽  
Repair Mechanisms ◽  
P53 Inactivation

Cisplatin is one of the most commonly used drugs for the treatment of various solid neoplasms, including testicular, lung, ovarian, head and neck, and bladder cancers. Unfortunately, the therapeutic efficacy of cisplatin against colorectal cancer is poor. Various mechanisms appear to contribute to cisplatin resistance in cancer cells, including reduced drug accumulation, enhanced drug detoxification, modulation of DNA repair mechanisms, and finally alterations in cisplatin DNA damage signaling preventing apoptosis in cancer cells. Regarding colorectal cancer, defects in mismatch repair and altered p53-mediated DNA damage signaling are the main factors controlling the resistance phenotype. In particular, p53 inactivation appears to be associated with chemoresistance and poor prognosis. To overcome resistance in cancers, several strategies can be envisaged. Improved cisplatin analogues, which retain activity in resistant cancer, might be applied. Targeting p53-mediated DNA damage signaling provides another therapeutic strategy to circumvent cisplatin resistance. This review provides an overview on the DNA repair pathways involved in the processing of cisplatin damage and will describe signal transduction from cisplatin DNA lesions, with special attention given to colorectal cancer cells. Furthermore, examples for improved platinum compounds and biochemical modulators of cisplatin DNA damage signaling will be presented in the context of colon cancer therapy.

Luminescent cyclometallated platinum(ii) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents

2018 ◽  
Vol 5 (2) ◽  
pp. 413-424 ◽  
Author(s):  
Yang Zhang ◽  
Qun Luo ◽  
Wei Zheng ◽  
Zhaoying Wang ◽  
Yu Lin ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Platinum Complexes ◽  
Living Cells ◽  
Dna Probes ◽  
High Potential ◽  
Luminescent Probes ◽  
Dual Targeting

Cyclometallated platinum complexes bearing 4-anilinoquinazolines exhibit high potential as luminescent probes for EGFR/DNA in living cells and dual-targeting anticancer agents.

Advancements in the Use of Platinum Complexes as Anticancer Agents

2021 ◽  
Vol 21 ◽  
Author(s):  
Rajiv Sharma ◽  
Vikram Jeet Singh ◽  
Pooja A Chawla
Keyword(s):  
Anticancer Agents ◽  
Biomedical Applications ◽  
Clinical Importance ◽  
Platinum Complexes ◽  
Water Soluble ◽  
Platinum Compounds ◽  
Anticancer Compounds ◽  
Cellular Resistance ◽  
Anti Cancer ◽  
Target Effects

Background: The platinum (II) complexes as anticancer agents have been well explored for the development of novel analogs. Yet, none of them achieved clinical importance in oncology. At present, anticancer compounds containing platinum (II) complexes have been employed in the treatment of colorectal, lung, and genitourinary tumors. Among the platinum-based anticancer drugs, Cisplatin (cis-diamine dichloroplatinum (II), cis-[Pt(NH3)2Cl2]) is one of the most potent components of cancer chemotherapy. The nephrotoxicity, neurotoxicity and ototoxicity, and platinum compounds associated resistant cancer are some major disadvantages. Objective: With the rapidly growing interest in platinum (II) complexes in tumor chemotherapy, researchers have synthesized many new platinum analogs as anticancer agents that show better cytotoxicity, and less off-target effects with less cellular resistance. This follows the introduction of oxaliplatin, water-soluble carboplatin, multinuclear platinum and newly synthesized complexes, etc. Method: This review emphasizes recent advancements in drug design and development, the mechanism of platinum (II) complexes, their stereochemistry, current updates, and biomedical applications of platinum-based anticancer agents. Conclusion: In the last few decades, the popularity of platinum complexes as potent anti-cancer agents has risen as scientists have synthesized many new platinum complexes that exhibit better cytotoxicity coupled with less off-target effects.

Evaluation of Biodegradability of Amine Collectors

2010 ◽  
Vol 113-116 ◽  
pp. 267-271 ◽  
Author(s):  
Heng Zhen Yan ◽  
Wen Qi Gong ◽  
Guang Jun Mei ◽  
Xiao Ye Liu ◽  
Shao Hua Chen
Keyword(s):  
Chemical Structure ◽  
Ester Group ◽  
Carbon Chain ◽  
Ammonium Bromide ◽  
Evaluation Standards ◽  
Testing Method

Amine collectors are widely used as oxidized ore collectors.Based on OECD 301B testing method, the biodegradability of amine collectors were analyzed and evaluated, and the values of IB of lauryl amine, octadecylamine, laurtrimonium chloride, lauryl trimethyl ammonium bromide, decane-propyl ether amine and dodecyl propyl ether amine were 173.4, 162.2, 164.6, 171.2, 160.8 and 149.4, respectively. The biodegradation of six test substances all exceeded 10% in 10 days, and all up to over 50% within 28 days. Considering comprehensively the two evaluation standards, the six amine collectors are all biodegradable. Evaluation of the biodegradability of amine collectors provides information that the chemical structure influences the biodegradability of amine collectors. It seems that the existence of ester group decreases the biodegradability of ether amine, and the shorter the carbon chain, the greater the biodegradation occurred.

scholarly journals High-level ab initio quartic force fields and spectroscopic characterization of C2N−

2021 ◽  
Author(s):  
Carlos M. Rocha ◽  
H V J Linnartz
Keyword(s):  
Ab Initio ◽  
Force Fields ◽  
Electron Attachment ◽  
Spectroscopic Characterization ◽  
Carbon Chain ◽  
Molecular Anions ◽  
High Level

While it is now well established that large carbon chain species and radiative electron attachment (REA) are key ingredients triggering interstellar anion chemistry, the role played by smaller molecular anions,...

scholarly journals N-Heterocyclic Carbene-PEI Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact

2018 ◽  
Author(s):  
May Wantz ◽  
Mathilde Bouche ◽  
Georges Dahm ◽  
Neila Chekkat ◽  
Sylvie Fournel ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Water Solubility ◽  
Human Cancer ◽  
Aqueous Media ◽  
Platinum Complexes ◽  
Polymer Chains ◽  
Polymer Carrier ◽  
Human Cancer Cells ◽  
Cancer Cell Death

The high interest in N-heterocyclic platinum carbene complexes in cancer research stems from their high cytotoxicity to human cancer cells, their stability, as well as their ease of functionalization. However, the development of these new molecules as anticancer agents still faces multiple challenges, in particular solubility in aqueous media. Here, we synthesized platinum-NHC bioconjugates that combine water-solubility and cytotoxicity by using polyethyleneimine as polymer carrier. We showed that the activity of these conjugates is modulated by the size of the polymer and the overall density of metal ions onto polymer chains. They displayed an effective activity after only 45 minutes of exposure in vitro correlated with a quick uptake by the cells as shown by the use of various fluorescent-tagged derivatives.

scholarly journals The extraction of SR2+ with dicyclohexano-18-crown-6 in conventional organic solvent and ionic liquid diluents

2020 ◽  
Vol 85 (7) ◽  
pp. 909-922 ◽  
Author(s):  
Zheng Wei ◽  
Yang Gao ◽  
Yu Zhou ◽  
Caishan Jiao ◽  
Meng Zhang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Nitric Acid ◽  
Distribution Ratio ◽  
Nitric Acid Concentration ◽  
Liquid Waste ◽  
Fission Products ◽  
Carbon Chain ◽  
Radioactive Liquid Waste ◽  
Solvent Systems ◽  
High Level

90Sr (t1/2 = 28.8 a), one of the most significant fission products in high-level radioactive liquid waste (HLLW), contributes to a large part of the heat load and radiation. Removal of 90Sr from the HLLW is beneficial for the final treatment of nuclear waste. In this paper, the extraction of Sr2+ was carried out using dicyclohexano-18-crown-6 (DCH18C6) in a variety of diluents including conventional organic solvents and novel ionic liquid solvents. The effect of several factors, such as nitric acid concentration, crown ether concentration and initial strontium concentration on the extraction of Sr2+ have been studied comprehensively. The higher distribution ratio and the stripping efficiency of Sr2+ were obtained with the binary diluents consisted of n-octanol and acetylene tetrachloride, which were compared with that using pure n-octanol as diluent. As for the CnmimNTf2 (n = 2, 4, 6) ionic liquid solvent systems, the distribution ratio of Sr2+ was much higher in the nitric acid medium with low concentration than in the traditional solvent systems. The results showed that DC2mimNTf2 > DC4mimNTf2 > DC6mimNTf2, which indicated that shorter carbon chain benefits the extraction of Sr2+.

scholarly journals Phenylboronic Ester-Modified Anionic Micelles for ROS-Stimuli Response in HeLa Cell

2020 ◽  
Author(s):  
Qiyan Wang ◽  
Yisong Xu ◽  
Nanxia Zhang ◽  
Zhipeng Dong ◽  
Bonan Zhao ◽  
...  
Keyword(s):  
Hela Cell ◽  
Fast Response ◽  
Ester Group ◽  
Tumor Growth Inhibition ◽  
Hela Cell Lines ◽  
Intracellular Ros ◽  
Anionic Micelle ◽  
High Level ◽  
Anionic Micelles ◽  
Drug Nanocarriers

Abstract Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE（Phenylboronic Ester） group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tuomr activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.

Sign in / Sign up

Export Citation Format

Share Document