Symptoms of central sensitization in patients with inflammatory bowel diseases: a case-control study examining the role of musculoskeletal pain and psychological factors

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Carrie Falling ◽  
Simon Stebbings ◽  
G David Baxter ◽  
Corey A Siegel ◽  
Richard B Gearry ◽  
...  
Keyword(s):  
Perceived Stress ◽  
Inflammatory Bowel Diseases ◽  
Central Sensitization ◽  
Psychological Factors ◽  
Pain Catastrophizing ◽  
Group Differences ◽  
Healthy Controls ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Psychological Features

AbstractObjectivesMusculoskeletal (MSK) pain is a common complaint in patients with inflammatory bowel diseases (IBD). MSK pain in IBD has previously demonstrated association with symptoms of central sensitization; however it is uncertain whether these symptoms are influenced simply by the presence of MSK pain and/or IBD. Primary aim of this study was to investigate whether symptoms of central sensitization differed across three groups: IBD patients with and without MSK pain and healthy controls. Secondary aim was to investigate between-group differences for measures of somatosensory functioning.MethodsCross-sectional study was performed on adults with IBD. Assessments included: central sensitization inventory (CSI), pressure pain threshold, temporal summation, conditioned pain modulation, perceived stress, affect style, anxiety, depression, and pain catastrophizing. One-way analyses of variance and covariance were used to investigate between-group differences for measures of central sensitization and potential confounding by psychological factors.ResultsStudy participants (n=66) were age/gender matched across three study groups. Between-group differences were solely demonstrated for CSI scores [F(2,63)=19.835, p<0.001, r=0.62], with IBD patients with MSK pain demonstrating the highest CSI scores and healthy controls the lowest. After controlling for individual psychological features, post hoc comparisons indicated that CSI scores were significantly different between-groups (p≤0.025) after controlling for most psychological variables, with the exception of perceived stress (p=0.063) and pain catastrophizing (p=0.593).ConclusionsIBD patients as a whole demonstrated significantly greater symptoms of central sensitization compared to healthy controls. However, IBD patients with persistent MSK pain demonstrated the greatest symptoms of central sensitization compared to patients without MSK pain and healthy controls. Between-group differences for CSI in IBD patients with MSK were not confounded by psychological features.ImplicationsStudy results indicate that persistent MSK pain in IBD represents patients with greater central sensitization symptomology. This increased symptomology is suggestive of underlying mechanisms related to central sensitization, highlighting patient potentially at risk for worse pain experiences.

scholarly journals Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Scott A. Handley ◽  
Suzanne Devkota
Keyword(s):  
Colorectal Cancer ◽  
Dark Matter ◽  
Gastrointestinal Tract ◽  
Sample Preparation ◽  
Cross Section ◽  
Inflammatory Bowel Diseases ◽  
Healthy Controls ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Disease Signatures

ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.

scholarly journals P506 Psychological factors and quality of life in inflammatory bowel diseases patients: the Psycho study

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S337-S337
Author(s):  
E. Vegni ◽  
D. Gilardi ◽  
B.E. Corrò ◽  
J. Menichetti ◽  
D. Leone ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Diseases ◽  
Psychological Factors ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Medicina ◽  
2020 ◽  
Vol 56 (8) ◽  
pp. 382
Author(s):  
Angelo Viscido ◽  
Annalisa Capannolo ◽  
Renata Petroni ◽  
Gianpiero Stefanelli ◽  
Giulia Zerboni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Diseases ◽  
Qt Interval ◽  
Qtc Interval ◽  
Healthy Controls ◽  
Review Of The Literature ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.

Circulating Leptin Levels as a Potential Biomarker in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Larissa Gabriela Ferreira de Carvalho ◽  
William Gustavo Lima ◽  
Luiz Gonzaga Vaz Coelho ◽  
Valbert Nascimento Cardoso ◽  
Simone Odília Antunes Fernandes
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Serum Leptin ◽  
Potential Biomarker ◽  
Significant Difference ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Background The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 &gt; 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.

Comparison of Psychological Factors in Patients with Irritable Bowel Syndrome and Inflammatory Bowel Diseases

2015 ◽  
Vol 5 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Mahbobeh Faramarzi ◽  
Javad Shokri-Shirvani ◽  
Farzan Kheirkhah ◽  
Maryam Kianian ◽  
Maryam Ghadiri
Keyword(s):  
Irritable Bowel Syndrome ◽  
Inflammatory Bowel Diseases ◽  
Psychological Factors ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Parental styles and quality of life in the families with adolescents suffering from inflammatory bowel diseases

2017 ◽  
Vol 41 (S1) ◽  
pp. S317-S317
Author(s):  
D. Zmeskalova ◽  
J. Prasko ◽  
M. Ociskova ◽  
E. Karaskova ◽  
V. Mihal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parenting Styles ◽  
Inflammatory Bowel Diseases ◽  
Well Being ◽  
Healthy Controls ◽  
Parental Style ◽  
Parental Styles ◽  
Bowel Diseases ◽  
Inflammatory Bowel

BackgroundInflammatory bowel diseases (IBD) in adolescents are chronic medical conditions with a substantial influence on the well-being of the family members.MethodsTotal of 27 adolescents suffered from IBD, and 39 healthy adolescents completed questionnaires ADOR (parenting styles assessed by teenagers), KidScreen-10 (quality of life), SAD (Scale of Anxiety in Children), and CDI (Children's Depression Inventory). Their parents completed the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), and Pediatrics Quality of Life Family Impact Module (PedsQL).ResultsThe parental styles of mothers and fathers of IBD adolescents and the parents of healthy controls were without statistically significant differences except for the fathers’ positive parental style, which was significantly higher in the fathers of controls. There were no statistically significant differences between IBD children and the healthy controls in the quality of life assessed. However, the parents’ quality of life of ill children was statistically significantly lower than of the parents of the controls. The mothers of IBD adolescents were significantly more anxious and the fathers more depressed than the parents of the healthy controls, but there was no difference in the levels of anxiety or depression between IBD adolescents and the controls. Positive parental style of parents of IBD children positively correlated with the quality of life of adolescents. Positive parental style of the fathers correlated negatively with the state and trait children's anxiety and negatively correlated with severity of childhood depression.ConclusionsThe parents of the adolescents with IBD represent important group for psychosocial support.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The potential of metabolic and lipid profiling in inflammatory bowel diseases: a pilot study

2019 ◽  
Author(s):  
Cristian Tefas ◽  
Lidia Ciobanu ◽  
Marcel Tanțău ◽  
Corina Moraru ◽  
Carmen Socaciu
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Statistical Tests ◽  
Plasma Lipid ◽  
Diagnostic Tools ◽  
Metabolic Profiles ◽  
Healthy Controls ◽  
Lipid Profiling ◽  
Lipid Species ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBDs) are conditions that still pose significant problems. A third of the patients are either misdiagnosed or a proper diagnosis of Crohn’s disease (CD) or ulcerative colitis (UC) cannot be made. We need new biomarkers, so that we can offer patients the best treatment and keep the disease in an inactive state for as long as possible. Alterations in metabolic profiles have been incriminated in the pathophysiology of IBD. The aim of the present study was to identify molecules that could serve as biomarkers for a positive diagnosis of IBD as well as to discriminate UC from colonic CD. Twenty-two patients with active colonic IBD (UC = 17, CD = 5) and 24 age- and gender-matched healthy controls were enrolled. Plasma lipid and metabolic profiles were quantified using ultra-high performance liquid chromatography combined with mass spectrometry. Univariate and multivariate statistical tests were employed. Six lipid species and seven metabolites were significantly altered in IBD compared to healthy controls, with the majority belonging to glycerophospholipid, linoleic acid, and sphingolipid metabolisms. Five lipid species and only one metabolite were significantly increased in UC compared to CD. This preliminary study suggests that lipid and metabolic profiling of serum can become diagnostic tools for IBD. In addition, they can be used to differentiate between CD and UC.

scholarly journals High-Resolution Melting Curve Analysis for High-Throughput Genotyping of NOD2/CARD15 Mutations and Distribution of These Mutations in Slovenian Inflammatory Bowel Diseases Patients

2011 ◽  
Vol 30 (5) ◽  
pp. 265-274 ◽  
Author(s):  
Mitja Mitrovič ◽  
Uroš Potočnik
Keyword(s):  
High Resolution ◽  
Inflammatory Bowel Diseases ◽  
High Resolution Melting ◽  
Clinical Samples ◽  
Melting Curve Analysis ◽  
Probe Design ◽  
Healthy Controls ◽  
Unlabeled Probe ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBD) are usually classified into Crohn's disease (CD) and ulcerative colitis (UC). NOD2/CARD15 was the first identified CD-susceptibility gene and was confirmed as the most potent disease gene in CD pathogenesis. ThreeNOD2/CARD15variants, namely two missense polymorphisms R702W (rs2066844) and G908R (rs2066845), and a frame shift polymorphism L1007fs (rs2066847), were associated with CD in Caucasian populations. High resolution melting analysis (HRMA) with saturation LCGreen dyes was previously reported as a simple, inexpensive, accurate and sensitive method for genotyping and/or scanning of rare variants. For this reasons we used qPCR-HRMA for genotypingNOD2/CARD15variants in 588 Slovenian IBD patients and 256 healthy controls. PCR-RFLP was used as a reference method for genotyping of clinical samples. The optimization of an HRM experiment required careful design and adjustment of main parameters, such as primer concentration, MgCl2concentration, probe design and template DNA concentration. Different HRMA approaches were tested and used to develop a reliable and low-cost SNP genotyping assays for polymorphisms inNOD2/CARD15gene. Direct HRMA was the fastest and cheapest HRMA approach for L1007fs and R702W polymorphisms, yet for G908R polymorphism sufficient reliability was achieved after introduction of unlabeled probe. In association analysis, we found statistically significant association of L1007fs (p = 0.001, OR = 3.011, CI95%=1.494–6.071) and G908R (p = 2.62 × 10-4, OR = 14.117, CI95% = 1.884–105.799) polymorphisms with CD patients. At least one ofNOD2/CARD15polymorphisms was found in 78/354 (22.03%) in CD patients, 25/197 (12.69%) in UC patients and in 26/256 (10.15%) in healthy controls. We have successfully implementedNOD2/CARD15HRMA assays, which may contribute to the development of genetic profiles for risk prediction of developing CD and for differential diagnosis of CD vs. UC.

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