scholarly journals Shp2 signaling suppresses senescence in Py MT ‐induced mammary gland cancer in mice

2015 ◽  
Vol 34 (11) ◽  
pp. 1493-1508 ◽  
Author(s):  
Linxiang Lan ◽  
Jane D Holland ◽  
Jingjing Qi ◽  
Stefanie Grosskopf ◽  
Regina Vogel ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Cancer

scholarly journals THE MORBIDITY OF MAMMARY GLAND CANCER OF FEMALE POPULATION OF THE SIBERIAN FEDERAL DISTRICT

2019 ◽  
Vol 61 (3) ◽  
pp. 123-128
Author(s):  
Irina N. Odintsova ◽  
L. F. Pisareva ◽  
O. A. Ananina ◽  
E. V. Panferova
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Birth Rate ◽  
Malignant Tumors ◽  
Divorce Rate ◽  
Federal District ◽  
Demographic Characteristics ◽  
Siberian Federal District ◽  
Female Population ◽  
Mammary Gland Cancer

The breast cancer is one of main localizations among malignant tumors in women of the Siberian Federal District. In the structure of morbidity it holds first place with such percentage as 20.4% and index of morbidity makes up to 51.2 per 100 000 of female population. The territories with increased and decreased risk are established. The features of prevalence of disease in a certain degree are conditioned by differences in demographic characteristics of populations. The indices of life-span, birth-rate in fertile age and divorce rate effect the level of morbidity of breast cancer in population.

scholarly journals Combination Therapy with DETA/NO and Clopidogrel Inhibits Metastasis in Murine Mammary Gland Cancer Models via Improved Vasoprotection

2018 ◽  
Vol 15 (11) ◽  
pp. 5277-5290 ◽  
Author(s):  
Kseniia Porshneva ◽  
Diana Papiernik ◽  
Mateusz Psurski ◽  
Marcin Nowak ◽  
Rafał Matkowski ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Combination Therapy ◽  
Cancer Models ◽  
Mammary Gland Cancer

scholarly journals Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer

2018 ◽  
Vol 19 (7) ◽  
pp. 2116 ◽  
Author(s):  
Agata Pawlik ◽  
Artur Anisiewicz ◽  
Beata Filip-Psurska ◽  
Marcin Nowak ◽  
Eliza Turlej ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Lymph Nodes ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Cancer Metastasis ◽  
Transforming Growth Factor ◽  
Mouse Mammary Gland ◽  
Th2 Response ◽  
Mammary Gland Cancer

In our previous study, calcitriol and its analogs PRI-2191 and PRI-2205 stimulated 4T1 mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory response in 4T1-bearing mice treated with these compounds. Gene expression analysis of the splenocytes and regional lymph nodes demonstrated prevalence of the T helper lymphocytes (Th2) response with an increased activity of regulatory T (Treg) lymphocytes in mice treated with these compounds. We also observed an increased number of mature granulocytes and B lymphocytes and a decreased number of TCD4+, TCD4+CD25+, and TCD8+, as well as natural killer (NK) CD335+, cells in the blood of mice treated with calcitriol and its analogs. Among the splenocytes, we observed a significant decrease in NK CD335+ cells and an increase in TCD8+ cells. Calcitriol and its analogs decreased the levels of interleukin (IL)-1β and IL-10 and increased the level of interferon gamma (IFN-γ) in the plasma. In the tumor tissue, they caused an increase in the level of IL-10. Gene expression analysis of lung tissue demonstrated an increased level of osteopontin (Spp1) and transforming growth factor β (TGF-β) mRNA. The expression of Spp1 was also elevated in lymph nodes. Calcitriol and its analogs caused prevalence of tumor-conducive changes in the immune system of 4T1 tumor-bearing mice, despite the induction of some tumor-disadvantageous effects.

scholarly journals Antiproliferative effect of berberine on canine mammary gland cancer cell culture

2016 ◽  
Vol 6 (1) ◽  
pp. 95-98 ◽  
Author(s):  
Reyhaneh Sefidabi ◽  
Pejman Mortazavi ◽  
Saeed Hosseini
Keyword(s):  
Cell Culture ◽  
Mammary Gland ◽  
Cancer Cell ◽  
Antiproliferative Effect ◽  
Mammary Gland Cancer ◽  
Canine Mammary Gland

Atm Heterozygosity Cooperates with Loss of Brca1 to Increase the Severity of Mammary Gland Cancer and Reduce Ductal Branching

2005 ◽  
Vol 65 (19) ◽  
pp. 8736-8746 ◽  
Author(s):  
T.J. Bowen ◽  
Hiroyuki Yakushiji ◽  
Cristina Montagna ◽  
Sonia Jain ◽  
Thomas Ried ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Cancer ◽  
Ductal Branching

scholarly journals Gene expression profiling of chemically induced rat mammary gland cancer

2005 ◽  
Vol 26 (2) ◽  
pp. 503-509 ◽  
Author(s):  
Liang Shan ◽  
Minshu Yu ◽  
Elizabeth G. Snyderwine
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Chemically Induced ◽  
Mammary Gland Cancer ◽  
Rat Mammary Gland
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