scholarly journals THE MORBIDITY OF MAMMARY GLAND CANCER OF FEMALE POPULATION OF THE SIBERIAN FEDERAL DISTRICT

2019 ◽  
Vol 61 (3) ◽  
pp. 123-128
Author(s):  
Irina N. Odintsova ◽  
L. F. Pisareva ◽  
O. A. Ananina ◽  
E. V. Panferova
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Birth Rate ◽  
Malignant Tumors ◽  
Divorce Rate ◽  
Federal District ◽  
Demographic Characteristics ◽  
Siberian Federal District ◽  
Female Population ◽  
Mammary Gland Cancer

The breast cancer is one of main localizations among malignant tumors in women of the Siberian Federal District. In the structure of morbidity it holds first place with such percentage as 20.4% and index of morbidity makes up to 51.2 per 100 000 of female population. The territories with increased and decreased risk are established. The features of prevalence of disease in a certain degree are conditioned by differences in demographic characteristics of populations. The indices of life-span, birth-rate in fertile age and divorce rate effect the level of morbidity of breast cancer in population.

scholarly journals Vacuum-assisted aspiration biopsy in mammology practice. Analysis of 3-year experience

2020 ◽  
Vol 16 (2) ◽  
pp. 19-24
Author(s):  
S. S. Skurikhin ◽  
Yu. V. Suvorova
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Surgical Treatment ◽  
Ultrasound Guidance ◽  
Malignant Tumors ◽  
Aspiration Biopsy ◽  
Practice Analysis ◽  
High Diagnostic Accuracy ◽  
Ultrasound Monitoring ◽  
Residual Tissue

Objective: to analyze the 3-year experience of vacuum-assisted aspiration biopsy under ultrasound guidance in patients with focal mammary neoplasms in categories BIRADS 2–5.Materials and methods. The totals of 121 interventions were performed in 121 patients. In 9 (7.4 %) cases there were more than 1 node in the mammary gland.Results. In 97.7 % cases the removed formations were benign. The breast cancer was detected in 5 (2.3 %) cases; there were cases of malignant tumors in each category according to the BIRADS scale. The complications were registered in 15 (12.3 %) cases and did not require surgical treatment. In 77 (63.3 %) cases the results of ultrasound monitoring were obtained in 6 months after the removal of formations, residual tissue was detected in 6 (4.9 %) patients.Conclusions. The vacuum-assisted aspiration biopsy, thus, has a high diagnostic accuracy; the number of completely removed benign formations allows us to consider the method as an alternative to sectoral resection. It is worth saying that a high percentage of complications is associated with the stage of mastering the method; all complications were resolved conservatively.

METHODICAL APPROACHES TO THE ANALYSIS OF THE ACTIVITIES OF THE CANCER SERVICE ON THE BASIS OF THE FORMS OF STATE REPORTING AND THE DATABASE OF THE POPULATION CANCER REGISTER OF THE NORTHWESTERN FEDERAL DISTRICT. PART II

2019 ◽  
Vol 65 (6) ◽  
pp. 807-815
Author(s):  
Vakhtang Merabishvili ◽  
Aleksey Belyaev
Keyword(s):  
Malignant Tumors ◽  
Objective Assessment ◽  
Survival Rates ◽  
Federal District ◽  
International Standards ◽  
First Year ◽  
Female Population ◽  
Cancer Register ◽  
The Russian Federation ◽  
Dynamic Series

On the second part of the article the main attention is paid to the analysis of survival of patients with malignant tumors calculated on the base of the database of the population cancer register of the northwestern Federal district. The main criterion for assessing the state of oncological service is 1 and 5-years observed and relative survivals of patients with malignant tumors. Unfortunately, the number of cancer registers calculating survival rates of patients with malignant tumors according to international standards is limited in Russia. We present calculations of the dynamic series of the survival median. Defects of its objective assessment are revealed. Positive dynamics of 5-year observed survival of patients with malignant tumors in the Russian Federation is shown. Dynamics of 1 and 5 year survival of cancer patients is considered in pairs taking into account sex, age and stage of disease. There has been some improvement, especially among the female population. As can be seen from the data presented at the first year of observation, about 35 percent of patients die in the region, as in the most European countries.

Breast sarcomas: Is now the time to change our mind?

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e21524-e21524
Author(s):  
I. Galaychuk
Keyword(s):  
Breast Cancer ◽  
Malignant Disease ◽  
Malignant Tumors ◽  
Breast Cancer Incidence ◽  
Morphological Type ◽  
Female Population ◽  
Breast Sarcoma ◽  
Malignant Breast ◽  
Statistical Finding ◽  
Breast Malignancies

e21524 Background: Primary breast sarcoma usually was considered a rare malignant disease [Adem et al., 2004]. The aim of this study is to show the incidence of breast sarcoma in the region with female population of about 600,000. Methods: Retrospective comparative analysis of breast sarcoma and breast cancer incidence in female of Ternopil region for 2000 - 2008. Descriptive statistical method was used. Results: The total of 101 cases of breast sarcoma was diagnosed in female of 39 - 76 years of age. Every year about 11 (6–18) primary breast sarcomas and 256 (233–279) patients with primary breast cancer were detected. The incidence rate of breast sarcoma was 1.14 per 100,000 women in 2000, 2.94 (in 2001), 1.48 (2002), 0.99 (2003), 2.16 (2004), 1.67 (2005), 2.53 (2006), 2.03 (2007) and 1.87/100,000 in 2008. The incidence of breast cancer was ranged from 37.3 to 46.4 per 100,000 of female population. Breast sarcoma consisted of 2.5% of the breast malignancies in 2000, 6.5% (in 2001), 3.3% (2002), 2.6% (2003), 5.4% (2004), 4.1% (2005), 5.9% (2006), 4.4% (2007) and 4.7% in 2008. Pathohistologic examination revealed angiosarcoma in 92.1% of cases. Thus, our findings are significantly different than data of other authors: f.e., the incidence of primary breast sarcoma is at 45 new cases per 10 million women [Confavreux et al., 2003], or 17 new cases per million women [Moore and Kinne, 1996], and breast sarcoma accounting for 0.0006% of breast malignancies which were diagnosed in 1910–2000 [Adem, 2004]. Taking into account all historical and recent data we can suggest beginning of biological changing in correlation between breast malignant tumors–carcinoma and sarcoma. Conclusions: Our statistical finding shows that incidence of breast sarcoma is 1.87 (0.99–2.94) per of 100,000 female population, and now sarcomas consist of 4.4% (2.5–6.5%) of all malignant breast tumors. Angiosarcoma is a most common (92.1%) morphological type of breast sarcomas. No significant financial relationships to disclose.

scholarly journals Effects of Lapatinib on HER2-Positive and HER2-Negative Canine Mammary Carcinoma Cells Cultured In Vitro

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 897
Author(s):  
Antonio Fernando Leis-Filho ◽  
Patrícia de Faria Lainetti ◽  
Priscila Emiko Kobayashi ◽  
Carlos Eduardo Fonseca-Alves ◽  
Renée Laufer-Amorim
Keyword(s):  
Breast Cancer ◽  
Cell Culture ◽  
Mammary Gland ◽  
Cell Cultures ◽  
Kinase Inhibitor ◽  
Predictive Marker ◽  
Her2 Positive ◽  
Her2 Breast Cancer ◽  
Mammary Gland Cancer

HER2 is a prognostic and predictive marker widely used in breast cancer. Lapatinib is a tyrosine kinase inhibitor that works by blocking the phosphorylation of the receptor HER2. Its use is related to relatively good results in the treatment of women with HER2+ breast cancer. Thus, this study aimed to verify the effects of lapatinib on four canine primary mammary gland carcinoma cell cultures and two paired metastatic cell cultures. Cultures were treated with lapatinib at concentrations of 100, 500, 1000 and 3000 nM for 24 h and the 50% inhibitory concentration (IC50) for each cell culture was determined. In addition, a transwell assay was performed to assess the ability of lapatinib to inhibit cell migration. Furthermore, we verified HER2 expression by RT-qPCR analysis of cell cultures and formalin-fixed paraffin-embedded tissues from samples corresponding to those used in cell culture. Lapatinib was able to inhibit cell proliferation in all cell cultures, but it was not able to inhibit migration in all cell cultures. The higher the expression of HER2 in a culture, the more sensitive the culture was to treatment. This relationship may be an indication that the expression of HER2 may be a predictive factor and opens a new perspective for the treatment of primary and metastatic mammary gland cancer.

scholarly journals Cervical cancer in women of the Republic of Buryatia (morbidity and mortality compared in subjects of the Siberian Federal District and in Russia as a whole)

2021 ◽  
Vol 67 (2) ◽  
pp. 227-232
Author(s):  
Tat`yana Chimitdorzhieva
Keyword(s):  
Cervical Cancer ◽  
Incidence Rate ◽  
Federal District ◽  
Morbidity And Mortality ◽  
Siberian Federal District ◽  
Female Population ◽  
Irkutsk Region ◽  
High Incidence ◽  
High Incidence Rate ◽  
The Republic

Analysis of the morbidity and mortality dynamics of the female population of cervical cancer (CC) of the Siberian Federal District (SFO) as a whole, as well as by its individual subjects for 18 years, from 2000 to 2017. It showed a steady increase in the incidence of this form of cancer (an increase of 37.3%) and a decrease in mortality (a decrease of 11.7%) in the region as a whole and in all its subjects in comparison with those in the Russian Federation (RF). The steadily high incidence rate of cervical cancer during the period analyzed was recorded in Buryatia - 23.1 ± 1.9, after the Trans-Baikal Territory - 29.6 ± 1.7; and the Republic of Tyva - 27.7 ± 2.3; in the neighboring Irkutsk region - 19.3 ± 0.7 cases per standardized 100 thousand population, the lowest - in Kemerovo - 12.8 ± 0.5 and Novosibirsk region - 12.2 ± 0.3 regions. The consistently high incidence rate of cervical cancer during the analyzed period was recorded in the Trans-Baikal Territory - 29.6 ± 1.7; in the Republics of Tyva - 27.7 ± 2.3 and Buryatia - 23.1 ± 1.9, in the Irkutsk region - 19.3 ± 0.7 cases per standardized 100 thousand people, the lowest - in Kemerovo - 12.8 ± 0.5 and Novosibirsk - 12.2 ± 0.3 regions.The Siberian Federal District leads among other regions of Russia in the incidence of cervical cancer in women (especially in Transbaikalia, Tuva, Buryatia and Irkutsk): from 2000 to 2017, theincidence in the region increased 1.4 times with a forecast of further growth, while mortality rates indicate a positive trend - stabilization of the process. In these territories, the carcinogenic situation is determined by the interaction of a complex of various subsystems comprising it: natural, industrial, and social. Key words: cervical cancer; incidence rate; Siberian Federal District.  

scholarly journals Lack of association between Epstein–Barr virus and mammary tumours in dogs

2018 ◽  
Vol 62 (3) ◽  
pp. 309-315
Author(s):  
Gustavo A. Roa López ◽  
Jhon Jairo Suárez ◽  
Paola Barato ◽  
Noel Verján García
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Mammary Tumours ◽  
Mammary Gland Cancer ◽  
Epstein Barr ◽  
And Control ◽  
First Time

AbstractIntroductionEpstein–Barr virus (EBV) is a γ-herpesvirus associated with various neoplasms in humans and is a probable aetiological agent in breast cancer; however, a causal relationship has not yet been established. Because of the epidemiological and clinicopathological similarities between breast cancer and canine mammary tumours, dogs have been proposed as a valid model for breast cancer.Material and MethodsA total of 47 canine mammary gland tumour tissues were processed by routine histopathological technique with haematoxylin-eosin staining and classified according to the type of neoplasm. DNA was extracted from paraffin-embedded tissues and the EBNA-1 gene and the BamHI-W region specific for EBV were evaluated by nested PCR.ResultsThe histopathological evaluation revealed 2 benign neoplasms, and many carcinomas: 2 in situ, 9 simple, 3 solid, 10 complex, and 21 mixed. One sample was positive for the EBNA-1 gene, while all were negative for the BamHI-W region.ConclusionNo association was found between EBV and mammary tumours in dogs. However, here we report for the first time the presence of an EBV gene sequence in a canine mammary tumour. It is likely that detection of EBV might be affected by the quality and quantity of DNA extracted from paraffin-embedded tissues. Additional studies are necessary to establish any association of EBV with mammary gland cancer in humans and in dogs, which could eventually lead to better public health prevention and control.

scholarly journals NATURAL REPRODUCTION OF THE POPULATION SIBERIAN FEDERAL DISTRICT AT THE BEGINNING OF THE SECOND WAVE OF DEPOPULATION (PECULIARITIES AND PREDICTION)

2019 ◽  
Vol 63 (3) ◽  
pp. 116-121
Author(s):  
S. N. Filimonov ◽  
Olga I. Baran ◽  
V. A. Ryabov
Keyword(s):  
Mortality Rate ◽  
Birth Rate ◽  
Federal District ◽  
Natural Increase ◽  
Siberian Federal District ◽  
Short Term ◽  
Term Prediction ◽  
Natural Reproduction ◽  
Short Term Prediction ◽  
Second Wave

Since 2017, a new stage of depopulation has begun in Russia related to a reduction in the birth rate. The consequences of the “demographic gap” of the 1990s have reached the present time and there has been a sharp decrease in the number of women of active reproductive age, especially from 25 to 29 years old. Objective. The aim is the analysis of the dynamics and prediction of natural reproduction of the population in the Siberian Federal District and its individual administrative territories at the beginning of the second wave of depopulation. Material and methods. Data on the birth rate, mortality and natural increase (decrease) per 1000 population of the Russian Federation, the Siberian Federal District and of individual territories of the Siberian Federal District are obtained on the website of the Federal Service of State Statistics. To analyze the dynamics of natural reproduction of the population of the Siberian Federal District for 2000-2018 and for a short-term prediction of indices, the capabilities of the Microsoft Office application (MS Excel) were used and several variants of approximation of birth rate, mortality rate and natural increase (decrease) in the population were considered using the following trends: linear, logarithmic, and degree (third degree polynomial). Results. A short-term prediction based on the trends indicates a continuation of the emerging trend: the birth rate in the Siberian Federal District will decrease, and the natural decline in the population will increase. With this approximation, the mortality rate of the population will increase. Conclusion. In the coming years, the containment of depopulation in the Siberian Federal District is possible due to the favorable ratio of birth rate and mortality rate in the Republics of Tyva, Altai, Buryatia, and Khakassia. Of particular concern is the significant natural decline in the population in the Kemerovo Region and the Altai Territory. The problem of reducing mortality and, accordingly, increasing life expectancy can be solved only with an increase in the level of culture, education, medical care and with a wide spread of healthy lifestyles.

scholarly journals Prognostic analysis of epidemiological indicators of the breast cancer among women in the Udmurt Republic

2019 ◽  
Vol 100 (6) ◽  
Author(s):  
S V Batov ◽  
V M Napol'skikh ◽  
N A Svirin ◽  
I V Tchurakov ◽  
I I Batova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Breast Cancer Incidence ◽  
Female Population ◽  
Prognostic Analysis ◽  
Udmurt Republic ◽  
The Russian Federation ◽  
The Republic ◽  
The Moment

Aim. To study a number of epidemiological indicators of a breast cancer in the Udmurt Republic for their assessment and prediction of dynamics. Methods. A retrospective analysis of data on a breast cancer of the population cancer register of the Udmurt Republic was performed in comparison with the corresponding statistics in the Russian Federation in 2017. For assessment of the received results the software BIOSTAT 4.3 was used. The forecast of epidemiological intensive indicators was calculated by methods of linear and polynomial trends. Results. The ratio of breast cancer (17.8% in 2017) among the female population of the Republic was the highest among all malignant tumors. In 2017 the crude indicator of breast cancer morbidity equaled 69.80 per 100 000, and standardized one 40.50 per 100 000. The standardized indicator of breast cancer incidence in Udmurtia was one of the lowest in Russia (77th rank place among 85 territorial entities). Crude mortality rate was 19.10 per 100 000, and standardized one 10.00 per 100 000 (82nd rank place in the Russian Federation). The ratio of the patients actively revealed (among registered numbre) was 45.8% (the average Russian value, 38.7%). Early diagnostics of tumor was carried out in 71.6% of patients, stage 1 of the disease was revealed in 34.3% of cases (in the Russian Federation average data, 69.9% and 26.0%, respectively). Forecasting till 2022 shows a trend of further growth of detectability of malignant tumors of breast at early stages among female population in the Udmurt Republic. Lethality of patients during the first year from the moment of diagnosis was 5.4% (the average Russian indicator, 6.0%). Conclusion. Morbidity and mortality rates of breast cancer in the Udmurt Republic in 2017 were lower than the average Russian indicators, and the statistical analysis does not show a negative trend till 2022.

scholarly journals Cervical cancer incidence in the Siberian Federal District

2021 ◽  
Vol 16 (4) ◽  
pp. 76-83
Author(s):  
L. D. Zhuikova ◽  
I. N. Odintsova ◽  
О. A. Ananina ◽  
L. V. Pikalova ◽  
N. Р. Lyakhova
Keyword(s):  
Cervical Cancer ◽  
Incidence Rate ◽  
Cancer Care ◽  
Federal District ◽  
Incidence Rates ◽  
Reproductive Age ◽  
Malignant Neoplasms ◽  
Siberian Federal District ◽  
Female Population

Background. When planning preventive measures and providing specialized care, it is important to take into account the epidemiology of malignant neoplasms.Objective: to analyze the incidence of cervical cancer in 10 territories of the Siberian Federal District.Materials and methods. Based on the data of the Federal State Statistics Service, the incidence of cervical cancer and the quality of cancer care were analyzed in 10 cancer centers for the years 2005–2019. Results. During the study period, an increase in the incidence of cervical cancer was observed in the Siberian Federal District. The maximum increase in the incidence rate was observed in most territories of the Tyva Republic (102.3 %). The decrease in the incidence rate was recorded in the Altai Republic (–15.4 %) and Tomsk Oblast (–14.3 %). The age-specific incidence rates were stable in patients aged 65 years and older, and a 1.4-fold increase was observed in women of the reproductive age (20–44 years). The highest incidence rates were observed in the age groups 35–39 years (37.8 %) and 40–44 years (42.0 %). The improvement in the rates of quality of cancer care indicated the high proportion of morphologically verified cancers, early cancer detection and high proportion of patients who were followed up for 5 years or more. The rates of late-stage cervical cancer and one-year mortality remain high.Conclusions. From 2004 to 2019, an increase in the incidence of cervical cancer was observed in the female population of the Siberian Federal District. The highest risk of cervical cancer was observed in women of the reproductive age (20–44 years). It is necessary to develop and organize anti-cancer measures to improve cancer care

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