scholarly journals SATB2‐LEMD2 interaction links nuclear shape plasticity to regulation of cognition‐related genes

2020 ◽  
Author(s):  
Patrick Feurle ◽  
Andreas Abentung ◽  
Isabella Cera ◽  
Nico Wahl ◽  
Cornelia Ablinger ◽  
...  
Keyword(s):  
Nuclear Shape ◽  
Regulation Of Cognition

ALPHA DECAY AND FISSION OF ALIGNED NUCLEI

1960 ◽  
Vol 38 (2) ◽  
pp. 290-314 ◽  
Author(s):  
N. R. Steenberg ◽  
R. C. Sharma
Keyword(s):  
Angular Distribution ◽  
High Temperature ◽  
Experimental Work ◽  
Low Temperatures ◽  
Alpha Decay ◽  
Alpha Particles ◽  
Nuclear Shape ◽  
Fission Fragments ◽  
Partial Waves ◽  
High Temperature Approximation

The theory of the angular distribution of alpha particles and of fission fragments from nuclei aligned at low temperatures is presented. Very explicit results are obtained in the high temperature approximation. These are directly dependent upon the branching which takes place to the various allowed partial waves. This branching is influenced by the nuclear shape, but it is shown that for this problem the effect of penetrating a spheroidal barrier is not critical. An application is made to the experimental work so far available and the result is reasonably satisfactory.

Effect of a Triaxial Nuclear Shape on Proton Tunneling: The Decay and Structure ofTm145

2007 ◽  
Vol 99 (8) ◽  
Author(s):  
D. Seweryniak ◽  
B. Blank ◽  
M. P. Carpenter ◽  
C. N. Davids ◽  
T. Davinson ◽  
...  
Keyword(s):  
Nuclear Shape ◽  
Proton Tunneling

scholarly journals An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes

2021 ◽  
Author(s):  
Richa Maheshwari ◽  
Mohammad M Rahman ◽  
Daphna Joseph-Strauss ◽  
Orna Cohen-Fix
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Pore Complex ◽  
Cellular Transformation ◽  
Rnai Screen ◽  
Nuclear Shape ◽  
Nuclear Pore ◽  
Nuclear Morphology ◽  
Anaphase Bridges ◽  
Early Embryos ◽  
Embryonic Viability

Abstract Aberration in nuclear morphology is one of the hallmarks of cellular transformation. However, the processes that, when mis-regulated, result aberrant nuclear morphology are poorly understood. In this study we carried out a systematic, high-throughput RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans embryos. The screen employed over 1700 RNAi constructs against genes required for embryonic viability. Nuclei of early embryos are typically spherical, and their NPCs are evenly distributed. The screen was performed on early embryos expressing a fluorescently tagged component of the nuclear pore complex (NPC), allowing visualization of nuclear shape as well as the distribution of NPCs around the nuclear envelope. Our screen uncovered 182 genes whose down-regulation resulted in one or more abnormal nuclear phenotypes, including multiple nuclei, micronuclei, abnormal nuclear shape, anaphase bridges and abnormal NPC distribution. Many of these genes fall into common functional groups, including some that were not previously known to affect nuclear morphology, such as genes involved in mitochondrial function, the vacuolar ATPase and the CCT chaperonin complex. The results of this screen add to our growing knowledge of processes that affect nuclear morphology and that may be altered in cancer cells that exhibit abnormal nuclear shape.

scholarly journals Metacognitive process and levels of physical activity in university students

2021 ◽  
Vol 16 (2) ◽  
pp. 1-20
Author(s):  
Laura Herrera-Agudelo ◽  
Haney Aguirre-Loaiza ◽  
María De Los Ángeles Ortega Díaz ◽  
Ayda Cristina Rivas Múñoz
Keyword(s):  
Physical Activity ◽  
University Students ◽  
Cognitive Processes ◽  
International Physical Activity Questionnaire ◽  
Short Form ◽  
Metacognitive Awareness ◽  
Regulation Of Cognition ◽  
Main Effects ◽  
Metacognitive Awareness Inventory ◽  
Activity Questionnaire

Background: Cognitive processes are associated with Systematic Physical Activity (SPA). However, few studies have evaluated the relation between SPA and Metacognition (MC). Objectives: (1) to study the effect of the SPA levels on MC, and (2) to explore the covariance of gender. Method: Through a Non-Experimental design and with intentional sampling, 270 university students participated (Mage= 25.3, SD= 1.5, min= 18, max= 51), 209 men (77.4%), and 61 women (22.6%). The International Physical Activity Questionnaire-Short Form (IPAQ-SF) and The Metacognitive Awareness Inventory were completed. The MANOVA showed that SPA levels significantly affected MC. The MANCOVA did not show a gender effect. Results: The main effects indicated that moderate and vigorous SPA levels favor MC. Differences were observed between the low vs vigorous SPA levels (p= .035, 95% CI [-1.49, -0.03]) in the knowledge of cognition factor. Similarly, there are differences in the regulation of cognition between low vs moderate SPA levels (p= .013, 95% CI [-1.86, -0.16]), and low vs vigorous (p= .044, 95% CI [-1.72 , -0.15]). Conclusions: moderate and vigorous SPA levels favor CM, mainly the regulation of cognition. In contrast, the vigorous SPA level favors the knowledge of cognition.

scholarly journals Models of Metacognition

2019 ◽  
Vol 7 (2) ◽  
pp. 1-4
Author(s):  
C Thenmozhi
Keyword(s):  
Active Role ◽  
Adaptive Behaviour ◽  
Metacognitive Skills ◽  
Social And Emotional ◽  
Domain Specific ◽  
Versus Domain ◽  
Emotional Aspects ◽  
Regulation Of Cognition ◽  
Knowledge Memory ◽  
And Control

Thinking is a common process. Cognitive ability includes knowledge, memory and metacognition.  Knowledge requires memory. These two are inextricably linked. Parents and teachers need to encourage children to take an active role in their learning and show them how to use what they know to the best advantage. Cognition is primarily a mental process. A successful theory of cognition would answer both the epistemological and biological questions. The purpose is to put forward a theory of cognition, that should provide an epistemological insight into the phenomenon of cognition. The concept of metacognition involves knowledge and control of self and control of the process. A metacognitive process consists of planning, strategies, knowledge, monitoring, evaluating and terminating. The Automation of Cognitive and Metacognitive Processes, Social and Emotional aspects of Metacognition, Domain General Versus domain specific Metacognitive Skills. Mata cognition, Intelligence and adaptive behaviour, Ann Brown distinguished between knowledge about cognition and regulation of cognition, Private Speech and Development of Metacognition is the models of metacognition.

scholarly journals Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL) For Accurate Diagnosis and Prognosis of Ovarian Cancer

2021 ◽  
Author(s):  
Duhita Sengupta ◽  
Sk Nishan Ali ◽  
Aditya Bhattacharya ◽  
Joy Mustafi ◽  
Asima Mukhopadhyay ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Morphological Changes ◽  
Hybrid Learning ◽  
Nuclear Shape ◽  
Machine Learning Techniques ◽  
Serous Carcinoma ◽  
Altered Expression ◽  
Diagnosis And Prognosis ◽  
Wide Range

Abstract Nuclear morphological features are potent determining factors for clinical diagnostic approaches adopted by pathologists to analyse the malignant potential of cancer cells. Considering the structural alteration of nucleus in cancer cells, various groups have developed machine learning techniques based on variation in nuclear morphometric information like nuclear shape, size, nucleus-cytoplasm ratio and various non-parametric methods like deep learning have also been tested for analysing immunohistochemistry images of tissue samples for diagnosing various cancers. Our aim is to study the morphometric distribution of nuclear lamin proteins as a specific parameter in ovarian cancer tissues. Besides being the principal mechanical component of the nucleus, lamins also present a platform for binding of proteins and chromatin thereby serving a wide range of nuclear functions like maintenance of genome stability, chromatin regulation. Altered expression of lamins in different subtypes of cancer is now evident from data across the world. It has already been elucidated that in ovarian cancer, extent of alteration in nuclear shape and morphology can determine degree of genetic changes and thus can be utilized to predict the outcome of low to high form of serous carcinoma. In this work, we have performed exhaustive imaging of ovarian cancer versus normal tissue and introduced a novel Deep Hybrid Learning approach on the basis of the distribution of lamin proteins. Although developed with ovarian cancer datasets in view, this architecture would be of immense importance in accurate and fast diagnosis and prognosis of all types of cancer associated with lamin induced morphological changes and would perform across small/medium to large datasets with equal efficiency.

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