Association of age related severity in oxidative stress and blood urea nitrogen levels in patients with dementia: A coastal Karnataka study

Background: Diabetic nephropathy (DN), a microvascular complication of diabetes has been a significant health issue globally. However, theaflavin enriched black tea extract (BTE-TF) could restrain DN. Objective: The main objective of this exploration was to elucidate the effect of BTE-TF on DN, though the underlying mechanism remains unclear and requires further investigation. Method: The tea leaves were fermented to get black tea extract. Total phenolic content and HPLC were carried out to determine the phenolic content and theaflavin in the extract. Streptozotocin induced diabetic rats were treated with 100, 200, and 400 mg/kg/day BTE-TF extract for 12 weeks. Biochemical parameters like blood glucose, creatinine, blood urea nitrogen (BUN), triglyceride and antioxidant parameters of kidney tissue were measured. Histology, immunohistochemistry and TUNEL assay were performed to observe the effect of the extract with comparison to the standard drug (Metformin 200mg/kg/day). Result: Treated animals exhibited reduced blood glucose levels, blood urea nitrogen (BUN), creatinine, and serum triglycerides. Further, BTE-TF restored the histological alterations in the kidney. Chronic hyperglycaemia resulted in a significant increase in oxidative stress and pro-inflammatory cytokines of NF-kβ pathway. BTE-TF attenuated oxidative stress (p<0.01), inflammation (p<0.05) and apoptosis (p<0.05). Conclusion: This study suggests that BTE-TF exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation, and apoptosis.

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The Ability of Low Blood Urea Nitrogen Levels to Screen for Renal Insufficiency Prior to Intravenous Contrast Administration

Academic Emergency Medicine ◽

10.1197/aemj.9.5.464 ◽

2002 ◽

Vol 9 (5) ◽

pp. 464-464

Author(s):

D. Kuo

Keyword(s):

Renal Insufficiency ◽

Blood Urea Nitrogen ◽

Contrast Administration ◽

Intravenous Contrast ◽

Urea Nitrogen ◽

Nitrogen Levels

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GROWTH-DEPENDENT CHANGES IN BLOOD UREA NITROGEN LEVELS IN LINCOLN AND SOUTHDOWN LAMBS

Canadian Journal of Animal Science ◽

10.4141/cjas69-030 ◽

1969 ◽

Vol 49 (2) ◽

pp. 197-204 ◽

Cited By ~ 2

Author(s):

H. Mukhoty ◽

W. Combs ◽

T. D. D. Groves

Keyword(s):

Body Weight ◽

Blood Plasma ◽

Blood Urea Nitrogen ◽

Growth Period ◽

Urea Nitrogen ◽

Plasma Urea ◽

Nitrogen Levels ◽

Rate Of Increase

The concentration of blood plasma urea nitrogen (BUN) was measured at bi-weekly intervals in four groups of growing Lincoln and Southdown lambs which received the same ration throughout their growth period. BUN increased with age and weight in each group. Although all groups showed similar changes in BUN with age, BUN concentration increased at 0.73 × 10−2, 0.88 × 10−2, 0.91 × 10−2, and 1.23 × 10−2 mg per kg of body weight gained in the case of Lincoln males, Lincoln females, Southdown males, and Southdown females, respectively. The average rates of gain for these groups were 0.33, 0.28, 0.26 and 0.20 kg per day, respectively. It appeared from these studies that at any given weight, the more mature animals at that weight tended to have higher BUN concentrations and a higher rate of increase of BUN with weight.

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Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

Archives of Ophthalmology ◽

10.1001/archopht.1961.01840020807010 ◽

1961 ◽

Vol 65 (6) ◽

pp. 805-807 ◽

Cited By ~ 11

Author(s):

M. A. GALIN ◽

H. D. NANO ◽

R. A. DAVIDSON

Keyword(s):

Blood Urea Nitrogen ◽

Urea Nitrogen ◽

Nitrogen Levels

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KADAR KOLESTEROL, UREA, KREATININ DARAH DAN KOLESTEROL TELUR AYAM SENTUL DENGAN PENAMBAHAN EKSTRAK BUAH MENGKUDU YANG DISUPLEMENTASI Cu DAN Zn

Jurnal Nutrisi Ternak Tropis dan Ilmu Pakan ◽

10.24198/jnttip.v2i1.25833 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Nai Nurazizah ◽

Nai Nurazizah

Keyword(s):

Blood Urea Nitrogen ◽

Animal Husbandry ◽

Egg Yolk ◽

Blood Cholesterol ◽

Fruit Extract ◽

Urea Nitrogen ◽

Nitrogen Levels ◽

Randomized Design ◽

Yolk Cholesterol ◽

Cu And Zn

The research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to = without adding noni fruit extract and Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect decreasing blood cholesterol levet but non significant decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords: noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk cholesterol, sentul chicken, mineral Cu and ZnThe research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to = without adding noni fruit extract and Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect decreasing blood cholesterol levet but non significant decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords: noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk cholesterol, sentul chicken, mineral Cu and Zn

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The association between admission blood urea nitrogen levels with in-hospital and long-term mortality in ST-segment elevation myocardial infarction

Cumhuriyet Medical Journal ◽

10.7197/223.vi.418591 ◽

2018 ◽

Author(s):

Mustafa Adem TATLISU ◽

Adnan KAYA ◽

Muhammed KESKİN

Keyword(s):

Myocardial Infarction ◽

Blood Urea Nitrogen ◽

Urea Nitrogen ◽

St Segment Elevation ◽

Nitrogen Levels ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Long Term Mortality

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Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan

Hang Tuah Medical journal ◽

10.30649/htmj.v17i2.230 ◽

2020 ◽

Vol 17 (2) ◽

pp. 181

Author(s):

NOVIANE ANGRELLA ◽

ROOSTANTIA INDRAWATI ◽

LESTARI DEWI

Keyword(s):

Creatinine Level ◽

Blood Urea Nitrogen ◽

Coconut Oil ◽

The Body ◽

Virgin Coconut Oil ◽

Urea Nitrogen ◽

Waste Products ◽

Nitrogen Levels ◽

Functional Product ◽

Male Wistar Rats

ABSTRACTBackground: Virgin Coconut Oil (VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney’s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function.Method: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats’ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats’ total BW/day, and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats’ total BW/day for 28 dayResults: Administrating VCO with a dose of 2mL/200gr and 3mL/200gr of the rats’ total BW/day does not affect the blood’s creatinine level while with a dose of 4mL/200gr of the rats’ total BW/day decreases the blood’s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats’ total BW/day does not affect the level of blood urea nitrogen.Conclusion: Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levelsKeywords: Virgin Coconout Oil (VCO), cretinine, blood urea nitrogen.

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Probiotic Amelioration of Azotemia in 5/6th Nephrectomized Sprague-Dawley Rats

The Scientific World JOURNAL ◽

10.1100/tsw.2005.86 ◽

2005 ◽

Vol 5 ◽

pp. 652-660 ◽

Cited By ~ 45

Author(s):

Natarajan Ranganathan ◽

Beena Patel ◽

Pari Ranganathan ◽

Joseph Marczely ◽

Rahul Dheer ◽

...

Keyword(s):

Renal Failure ◽

Life Span ◽

Blood Urea Nitrogen ◽

Clinical Severity ◽

Sprague Dawley ◽

Bacillus Pasteurii ◽

Urea Nitrogen ◽

Blood Concentrations ◽

Nitrogen Levels ◽

Probiotic Treatment

The present study was to test the hypothesis that selected bacteria instilled into the gastrointestinal tract could help in converting nitrogenous wastes accumulated due to renal insufficiency into nontoxic compounds; thereby, ameliorating the biochemical imbalance. Herein we describe a prospective, blinded, placebo-controlled pilot study, using 5/6thnephrectomized Sprague Dawley rat as a chronic renal failure model. The study group consisted of 36 nephrectomized and 7 non-nephrectomized (control) rats. After two-week nephrectomy stabilization, cohorts of six nephrectomized rats were fed casein-based diet plus one of the following regimens: (A) Control, (B) Placebo (casein-based diet without probiotics), (C)Bacillus pasteurii, (D) Sporolac®, (E) Kibow cocktail, (F) CHR Hansen Cocktail, and (G) ECONORMTM. Subsequently, blood (retro-orbital) and urine (collected for measurements of blood urea-nitrogen and creatinine respectively), body weight and bacterial counts (feces) were obtained at regular intervals. The study end-points were to determine if any of the probiotic dietary supplements facilitated, (1) decreased blood concentrations of uremic toxins, (2) altered renal function, and (3) prolonged survival. After 16 weeks of treatment, regimens C and D significantly prolonged the life span of uremic rats, in addition to showing a reduction in blood urea-nitrogen levels, concluding that supplementation of probiotic formulation to uremic rats slows the progression of azotemia, which may correlate with prolonged life span of uremic rats. Derivative trials of probiotic treatment of larger animals and humans will further assess the potential role of probiotic formulations in delaying the onset and clinical severity of clinical illness at different stages of renal failure.

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Plasma corticosterone, hemoglobin, creatinine and blood urea nitrogen levels, and urinary corticosteroid amounts in mice made hypothermic by exposure to −10 °C

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y71-088 ◽

1971 ◽

Vol 49 (7) ◽

pp. 657-665

Author(s):

Bernard Grad ◽

Firouz Rafizadeh

Keyword(s):

Renal Function ◽

Renal Impairment ◽

Adrenal Cortex ◽

Blood Urea Nitrogen ◽

Plasma Corticosterone ◽

Hemoglobin Level ◽

Plasma Creatinine ◽

Urea Nitrogen ◽

Nitrogen Levels ◽

Lower Urinary

The plasma corticosterone (PC) levels of mice adapted to 27–28 °C rose significantly when they were exposed to the cold at −10 °C until they became comatose, the increase being significantly less during a second similar exposure a week later. The PC elevations which occurred at −10 °C before the mice became comatose could be due in some degree to renal impairment, as indicated by increases in blood urea nitrogen and plasma creatinine levels during the first and second exposures, respectively. However, hemoconcentration as indicated by changes in the hemoglobin level could not account for the increase in the PC level. Mice that became comatose at −10 °C also had significantly elevated PC levels which were probably not primarily due to hemoconcentration or renal impairment. Mice recovering from coma in the warmth also had elevated PC levels for 6 h after the first exposure and for 1 day after the second one. At 1 and 7 days following exposure to the cold, the adrenal cortex no longer appeared to be hyperfunctional. Renal function appeared to have been impaired for 4 h following the first exposure and for at least 7 days after the second one. This impairment could account for the elevated PC levels and lower urinary corticosteroid amounts observed on the first day following the second exposure.

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