scholarly journals Probiotic Amelioration of Azotemia in 5/6th Nephrectomized Sprague-Dawley Rats

2005 ◽  
Vol 5 ◽  
pp. 652-660 ◽  
Author(s):  
Natarajan Ranganathan ◽  
Beena Patel ◽  
Pari Ranganathan ◽  
Joseph Marczely ◽  
Rahul Dheer ◽  
...  
Keyword(s):  
Renal Failure ◽  
Life Span ◽  
Blood Urea Nitrogen ◽  
Clinical Severity ◽  
Sprague Dawley ◽  
Bacillus Pasteurii ◽  
Urea Nitrogen ◽  
Blood Concentrations ◽  
Nitrogen Levels ◽  
Probiotic Treatment

The present study was to test the hypothesis that selected bacteria instilled into the gastrointestinal tract could help in converting nitrogenous wastes accumulated due to renal insufficiency into nontoxic compounds; thereby, ameliorating the biochemical imbalance. Herein we describe a prospective, blinded, placebo-controlled pilot study, using 5/6thnephrectomized Sprague Dawley rat as a chronic renal failure model. The study group consisted of 36 nephrectomized and 7 non-nephrectomized (control) rats. After two-week nephrectomy stabilization, cohorts of six nephrectomized rats were fed casein-based diet plus one of the following regimens: (A) Control, (B) Placebo (casein-based diet without probiotics), (C)Bacillus pasteurii, (D) Sporolac®, (E) Kibow cocktail, (F) CHR Hansen Cocktail, and (G) ECONORMTM. Subsequently, blood (retro-orbital) and urine (collected for measurements of blood urea-nitrogen and creatinine respectively), body weight and bacterial counts (feces) were obtained at regular intervals. The study end-points were to determine if any of the probiotic dietary supplements facilitated, (1) decreased blood concentrations of uremic toxins, (2) altered renal function, and (3) prolonged survival. After 16 weeks of treatment, regimens C and D significantly prolonged the life span of uremic rats, in addition to showing a reduction in blood urea-nitrogen levels, concluding that supplementation of probiotic formulation to uremic rats slows the progression of azotemia, which may correlate with prolonged life span of uremic rats. Derivative trials of probiotic treatment of larger animals and humans will further assess the potential role of probiotic formulations in delaying the onset and clinical severity of clinical illness at different stages of renal failure.

Origin of Glycosylated Hemoglobin Al in Chronic Renal Failure

1983 ◽  
Vol 6 (2) ◽  
pp. 77-82 ◽  
Author(s):  
S. De Marchi ◽  
E. Cecchin ◽  
C. Camurri ◽  
P. Quaia ◽  
A. Raimondi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Blood Urea Nitrogen ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Urea Nitrogen ◽  
Plasma Bicarbonate ◽  
Arterial Blood ◽  
Blood Ph

In chronic renal failure both HbAI and HbAlc levels have been reported to be elevated. In order to investigate the causes of such increase we measured HbAI (cation-exchange chromatography), blood urea nitrogen, arterial blood pH, plasma bicarbonate, phosphatemia, serum iron and serum ferritin before dialysis in 60 uremic patients receiving long term hemodialysis. The increased levels of HbAI do not correlate with glucose intolerance, phosphatemia, blood urea nitrogen, time averaged concentration of urea, serum iron and serum ferritin. On the contrary the presence of a highly significant correlation between HbAI and arterial blood pH (p < 0.001) and between HbAI and plasma bicarbonate (p < 0.001) seems to emphasize a major role for acidosis in increasing the HbAI levels in uremic patients on long term hemodialysis.

GROWTH-DEPENDENT CHANGES IN BLOOD UREA NITROGEN LEVELS IN LINCOLN AND SOUTHDOWN LAMBS

1969 ◽  
Vol 49 (2) ◽  
pp. 197-204 ◽  
Author(s):  
H. Mukhoty ◽  
W. Combs ◽  
T. D. D. Groves
Keyword(s):  
Body Weight ◽  
Blood Plasma ◽  
Blood Urea Nitrogen ◽  
Growth Period ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Nitrogen Levels ◽  
Rate Of Increase

The concentration of blood plasma urea nitrogen (BUN) was measured at bi-weekly intervals in four groups of growing Lincoln and Southdown lambs which received the same ration throughout their growth period. BUN increased with age and weight in each group. Although all groups showed similar changes in BUN with age, BUN concentration increased at 0.73 × 10−2, 0.88 × 10−2, 0.91 × 10−2, and 1.23 × 10−2 mg per kg of body weight gained in the case of Lincoln males, Lincoln females, Southdown males, and Southdown females, respectively. The average rates of gain for these groups were 0.33, 0.28, 0.26 and 0.20 kg per day, respectively. It appeared from these studies that at any given weight, the more mature animals at that weight tended to have higher BUN concentrations and a higher rate of increase of BUN with weight.

Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

1961 ◽  
Vol 65 (6) ◽  
pp. 805-807 ◽  
Author(s):  
M. A. GALIN ◽  
H. D. NANO ◽  
R. A. DAVIDSON
Keyword(s):  
Blood Urea Nitrogen ◽  
Urea Nitrogen ◽  
Nitrogen Levels

scholarly journals KADAR KOLESTEROL, UREA, KREATININ DARAH DAN KOLESTEROL TELUR AYAM SENTUL DENGAN PENAMBAHAN EKSTRAK BUAH MENGKUDU YANG DISUPLEMENTASI Cu DAN Zn

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Nai Nurazizah ◽  
Nai Nurazizah
Keyword(s):  
Blood Urea Nitrogen ◽  
Animal Husbandry ◽  
Egg Yolk ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Urea Nitrogen ◽  
Nitrogen Levels ◽  
Randomized Design ◽  
Yolk Cholesterol ◽  
Cu And Zn

The research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and ZnThe research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and Zn

scholarly journals THE NEPHROTOXICITY OF CONCURRENT USE OF ENALAPRIL AND GENTAMICIN IN RATS

2018 ◽  
Vol 11 (9) ◽  
pp. 348
Author(s):  
Imad M Al-ani ◽  
Khaleed R Algantri ◽  
Emad M Nafie ◽  
Sinan Mohammed Abdullah Al-mahmood
Keyword(s):  
Experimental Study ◽  
Serum Creatinine ◽  
Blood Urea Nitrogen ◽  
Normal Saline ◽  
Control Group ◽  
Sprague Dawley ◽  
Concurrent Administration ◽  
Urea Nitrogen ◽  
Concurrent Use ◽  
Sprague Dawley Rats

Objective: The present study was aimed to assess the concurrent administration of Enalapril (ENAL) and Gentamicin (GM) in the kidney of rats.Methods: Sixty male Sprague Dawley rats were divided into 4 main groups (n=15) according to the administered dose. Each main group was further subdivided into three subgroups according to the day of sacrificing (n=5). Group (C) was administered daily with normal saline as control, Group (E) was treated with oral ENAL (2 mg/kg/day), Group (G) was treated with GM (75 mg/kg/day), and Group (EG) was treated ENAL (2 mg/kg/day) and GM (75 mg/kg/day). The handling of the experiment persisted daily for 15 days, and the investigational examination carried out on days 5, 10, and 15.Results: The result showed that GM nephrotoxicity augmented with the period of the experimental study, there was rising in the levels of serum creatinine and blood urea nitrogen on the 10th day and persisted in rising significantly during the period on the 15th day of the experiment. Administration of ENAL showed no significant alteration from those of controls. While the concurrent administration of ENAL and GM showed that ENAL gradually increased GM nephrotoxicity, these physiological retrogressions were accompanied with intensive renal histopathological deteriorations.Conclusion: The present study has revealed that the concurrent administration of ENAL enormously aggravated the functional and histological nephrotoxicity of GM in rats.

Suprofen-Induced Acute Renal Failure

1986 ◽  
Vol 20 (11) ◽  
pp. 860-862 ◽  
Author(s):  
Neil E. Henann ◽  
Julian R. Morales
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Case Report ◽  
Young Adult ◽  
Serum Creatinine ◽  
Blood Urea Nitrogen ◽  
Flank Pain ◽  
Urea Nitrogen ◽  
Acute Flank Pain

A case report of acute flank pain with reversible renal failure in a young adult after taking three doses of suprofen is presented. Blood urea nitrogen and serum creatinine values returned to normal from significantly elevated levels on admission.

Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan

2020 ◽  
Vol 17 (2) ◽  
pp. 181
Author(s):  
NOVIANE ANGRELLA ◽  
ROOSTANTIA INDRAWATI ◽  
LESTARI DEWI
Keyword(s):  
Creatinine Level ◽  
Blood Urea Nitrogen ◽  
Coconut Oil ◽  
The Body ◽  
Virgin Coconut Oil ◽  
Urea Nitrogen ◽  
Waste Products ◽  
Nitrogen Levels ◽  
Functional Product ◽  
Male Wistar Rats

<p><strong>ABSTRACT</strong></p><p><strong>Background:</strong><em> </em><em>Virgin Coconut Oil </em>(VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney’s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function.</p><p><strong>Method</strong>: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats’ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats’ total BW/day,  and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats’ total BW/day for 28 day</p><p><strong>Results</strong>: Administrating<strong> </strong>VCO with a dose of 2mL/200gr and 3mL/200gr of the rats’ total BW/day does not affect the blood’s creatinine level while with a dose of 4mL/200gr of the rats’ total BW/day decreases the blood’s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats’ total BW/day does not affect the level of blood urea nitrogen.</p><p><strong>Conclusion: </strong>Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levels<strong></strong></p><p><strong>Keywords</strong><strong>:</strong> <em>Virgin Coconout Oil </em>(VCO), cretinine, blood urea nitrogen.</p>

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