The incidence and pathogenesis of hyperlipidaemia in 16 consecutive acromegalic patients

1982 ◽  
Vol 100 (3) ◽  
pp. 358-362 ◽  
Author(s):  
Ryoyu Takeda ◽  
Ryozo Tatami ◽  
Kosei Ueda ◽  
Hosaku Sagara ◽  
Hajime Nakabayashi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Serum Lipids ◽  
High Growth ◽  
Serum Levels ◽  
Inhibitory Effect ◽  
Type Iii ◽  
The Mean ◽  
Type V ◽  
Serum Gh ◽  
Normal Controls

Abstract. Serum lipids were analyzed in 16 patients with active acromegaly. Of these 62.5% had hyperlipidaemia defined as exceeding the 90% fiducial limits of normal controls. The mean serum cholesterol (5.50 mmol/l) and triglyceride (4.09 mmol/1) levels of the patients were significantly higher than those of age-matched normal controls. Type V hyperlipoproteinaemia was observed in two cases and type III hyperlipoproteinaemia in one. There was no difference in the incidence of diabetes between the normolipidaemic (n = 6) and hyperlipidaemic (n = 10) groups. Serum levels of growth hormone in hypercholestelaemic patients (n = 3) were significantly higher than those of normolipidaemic patients and combined hyperlipidaemic patients (n = 5) tended to have higher levels of growth hormone than normolipidaemic patients. In cases developing type III or type V hyperlipoproteinaemia, the activity of hepatic triglyceride lipase or lipoprotein lipase was decreased, but it increased when serum GH levels fell after therapy for acromegaly. It is suggested that 1) growth hormone may play some role on the pathogenesis of hyperlipidaemia associated with acromegaly, and 2) growth hormone has an inhibitory effect on H-TGL and LPL, and so hyperlipoproteinaemia in some cases of acromegaly might be caused by low H-TGL or LPL activity resulting from high growth hormone levels.

Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study

1984 ◽  
Vol 106 (4) ◽  
pp. 527-531 ◽  
Author(s):  
S. A. Duursma ◽  
J. W. J. Bijlsma ◽  
H. C. Van Paassen ◽  
S. C. van Buul-Offers ◽  
A. Skottner-Lundin
Keyword(s):  
Growth Hormone ◽  
Pilot Study ◽  
Serum Levels ◽  
Preventive Effect ◽  
Positive Role ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal ◽  
Serum Gh

Abstract. Oestrogens have a preventive effect on bone loss in post-menopausal women; however, little is known about their mechanism of action. The aim of this study was to investigate the changes in somatomedins (SM) and growth hormone (GH) concentrations in serum in postmenopausal women after 3 weeks of substitution with 20 μg ethinyloestradiol. A significant decrease was observed in the mean serum levels of SM. measured by bioassay (0.66 ± 0.07 vs 0.38 ± 0.07. P < 0.01), radioimmunoassay (0.62 ± 0.08 vs 0.34 ± 0.03, P < 0.01) and radioreceptorassav (1.14 ± 0.11 vs 0.90 ± 0.09, P < 0.01). The mean serum GH concentration increased (9.4 ± 3.2 vs 16.5 ± 4.6, P < 0.01). A positive role of SM and GH in the changes of bone metabolism after oestrogen substitution in post-menopausal women is discussed.

scholarly journals Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

1998 ◽  
Vol 159 (1) ◽  
pp. 79-83 ◽  
Author(s):  
N LaPaglia ◽  
J Steiner ◽  
L Kirsteins ◽  
M Emanuele ◽  
N Emanuele
Keyword(s):  
Growth Hormone ◽  
Nutritional Status ◽  
Serum Levels ◽  
Male Rat ◽  
Igf I ◽  
Adult Male Rat ◽  
Steady State Levels ◽  
Hormonal System ◽  
Neuroendocrine Responses ◽  
Serum Gh

Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion within the GRF-GH-IGF axis in the adult male rat during almost 3 days of fasting. Serum levels of GH and IGF-I were drastically suppressed by fasting. Daily leptin administration was able to fully prevent the fasting-induced fall in serum GH. Leptin failed to restore IGF-I to control levels, however, suggesting possible GH resistance. Fasting caused an insignificant increase in GH mRNA, while leptin injections significantly increased steady-state levels of this message. The GRF receptor (GRFr) message was not altered with fasting or leptin treatment. Leptin also exhibited effects at the hypothalamic level. Fasting induced a sharp fall in GRF mRNA expression and leptin injections partially prevented this fall. However, there were no observed changes in the hypothalamic GRF content. These results provide evidence that leptin may function as a neuromodulator of the GRF-GH-IGF axis communicating to this hormonal system the nutritional status of the animal.

scholarly journals The Speed and Acceleration of the Sources of Type III And Type V Solar Radio Bursts Over Large Distances in the Corona

1965 ◽  
Vol 18 (1) ◽  
pp. 67 ◽  
Author(s):  
RT Stewart
Keyword(s):  
Active Region ◽  
Solar Radio ◽  
Radio Bursts ◽  
Solar Radio Bursts ◽  
Mean Velocity ◽  
Lower Corona ◽  
Type Iii ◽  
If Current ◽  
The Mean ◽  
Type V

The outward velocity and acceleration through the solar corona of the disturbances responsible for the emission of 50 type III bursts recorded on the Dapto radio spectrograph are investigated by applying standard electron density models for the corona to the frequency drift of each burst. If current models for an active region are assumed, the velocities often remain unchanged from the lower corona out to heights of at least two solar radii above the photosphere. The mean velocity is about ie. Speeds of sources of type III bursts followed by type V continuum are similar to those for isolated type III bursts.

RELATION BETWEEN THYROID FUNCTION AND SERUM LEVELS OF LONG-ACTING THYROID STIMULATOR

1975 ◽  
Vol 79 (3) ◽  
pp. 451-458 ◽  
Author(s):  
J. C. Davis ◽  
L. J. Hipkin ◽  
V. K. Summers ◽  
T. M. D. Gimlette
Keyword(s):  
Thyroid Function ◽  
Normal Level ◽  
Normal Subjects ◽  
Serum Levels ◽  
The Other ◽  
Causative Role ◽  
Normal Range ◽  
The Mean ◽  
Long Acting ◽  
Normal Controls

ABSTRACT Bioassays of long-acting thyroid stimulator (LATS) were performed in three groups of subjects: in normal controls, in thyrotoxic patients before and serially after 131I treatment, and in patients with hypopituitarism. Of the untreated thyrotoxic patients, 27.7 % had raised serum LATS levels initially. There was no correlation between the relapse rate after 131I therapy and the initial or subsequent LATS titres: in particular, thyrotoxicosis sometimes recurred after an initially high LATS titre had fallen into the normal range. The distribution of the results of LATS assays in the hypopituitary patients was significantly different from that in the normal subjects; 4 out of 27 hypopituitary patients had LATS levels above the normal range, although they had no thyroxicosis. On the other hand, the majority of the patients with hypopituitarism, 19 out of 27, had LATS titres below the mean normal level, possibly due to deficiency of a substance we have termed pseudo LATS. These results raise doubts about a direct causative role for LATS in most cases of thyrotoxicosis.

ABNORMAL RESPONSE OF THYROTROPHIN AND GROWTH HORMONE TO THYROTROPHIN RELEASING HORMONE IN CHRONIC RENAL FAILURE

1975 ◽  
Vol 79 (4) ◽  
pp. 635-643 ◽  
Author(s):  
Koichi Hasegawa ◽  
Yoshiki Matsushita ◽  
Seima Otomo ◽  
Noboru Hamada ◽  
Yoshiki Nishizawa ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Healthy Subjects ◽  
Maximum Level ◽  
Serum Levels ◽  
Thyrotrophin Releasing Hormone ◽  
The Mean ◽  
Maximum Increment ◽  
Serum Gh ◽  
Serum Tsh

ABSTRACT Serum levels of TSH and GH were measured by radioimmunoassay after iv injection of 500 μg of TRH in 9 undialysed patients and 12 dialysed patients with chronic renal failure and in 6 healthy subjects. The basal level of the serum TSH was significantly higher in patients with chronic renal failure than that in healthy subjects. In healthy subjects, serum TSH rose to a maximum level 30 min after TRH injection, while in patients with chronic renal failure, serum TSH rose to a maximum level 60 min after TRH injection. The mean maximum increment of serum TSH in healthy subjects was significantly higher than that in patients with chronic renal failure. Although TSH levels rapidly decreased after initial rise at 30 min after TRH administration in healthy subjects, these did not show significant changes at 60 and 120 min compared with values at 30 min after TRH administration in both dialysed and undialysed patients. The basal level of serum GH was significantly higher in dialysed patients with chronic renal failure than in healthy subjects. Serum GH level was much higher in dialysed patients at 30 min after TRH injection compared with that in healthy subjects. These findings may indicate that the response of the pituitary to TRH is abnormal and that the turnover of TSH and GH is decreased in patients with chronic renal failure.

Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog

1996 ◽  
Vol 134 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Giuseppe Fanciulli ◽  
Osvaldo Oliva ◽  
Paolo A Tomasi ◽  
Alessandra Pala ◽  
Alba Bertoncelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Endogenous Growth ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Inhibitory Effect ◽  
Growth Hormone Administration ◽  
Gh Secretion ◽  
Hormone Administration ◽  
Exogenous Growth ◽  
Serum Gh

Fanciulli G, Oliva O, Tomasi PA. Pala A. Bertoncelli A, Dettori A, Delitala G. Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog. Eur J Endocrinol 1996:134:73–6. ISSN 0804–4643 Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli: in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opioids induce GH secretion in man, we gave the following treatments to six healthy male volunteers: (a) IV saline: (b) a met-enkephalin analog G-DAMME 250 μg IV as a bolus at time ′: (c) hGH 2 IU as an IV bolus at time −180′; (d) G-DAMME as above, preceded by hGH as above. In our study. G-DAMME stimulated GH secretion both basally (peak 17.9 ± 6.0 ng/ml) and, to a lesser extent, after hGH pretreatment (6.0 ± 2.7 ng/ml). Since in our study G-DAMME was able to partially overcome the inhibitory effect of hGH administration, it is suggested that opioids act through an inhibition of somatostatin release and not through a GHRH-dependent pathway. However, an additional direct effect of hGH on pituitary somatotrophes cannot be excluded. Giuseppe Delitala, Chair of Endocrinology, Viale S. Pietro 12, University of Sassari, 07100 Sassari. Italy

Glycine stimulates growth hormone release in man

1980 ◽  
Vol 93 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Kikuo Kasai ◽  
Hitoshi Suzuki ◽  
Tsutomu Nakamura ◽  
Hiroaki Shiina ◽  
Shin-Ichi Shimoda
Keyword(s):  
Growth Hormone ◽  
Blood Sugar ◽  
Normal Subjects ◽  
Serum Levels ◽  
Pituitary Function ◽  
Before And After ◽  
Sugar Levels ◽  
Dose Dependent ◽  
Serum Gh ◽  
Different Doses

Abstract. The influence of glycine, the simplest amino acid, on pituitary function has been investigated in the present study. Different doses (4, 8 or 12 g) of glycine were intravenously infused over 15 or 30 min in normal subjects. Serum levels of GH (growth hormone) and Prl (prolactin) were measured before and after the infusion, and also blood sugar levels were determined. The dose of 4 or 8 g glycine induced a significant increase in serum GH (P < 0.05 or P< 0.001, respectively); however, a more pronounced and significant increase in serum GH levels was observed after infusion at a dose of 12 g glycine (P < 0.001). It was clearly observed that the dose-dependent GH release to intravenous glycine occurred in normal subjects. On the contrary, serum Prl level was not changed significantly, and blood sugar level was transiently, but significantly (P < 0.05), increased after the infusion of 12 g glycine. The present data suggest that glycine might play an important role in the control of hypothalamic-pituitary function.

scholarly journals Influence of Mg2+ on detection of somatogenic and lactogenic components of growth-hormone-binding protein in mammalian sera

1993 ◽  
Vol 293 (2) ◽  
pp. 345-349 ◽  
Author(s):  
T Amit ◽  
Z Hochberg ◽  
R J Barkey
Keyword(s):  
Growth Hormone ◽  
Binding Protein ◽  
Rabbit Serum ◽  
Scatchard Analysis ◽  
Hormone Binding ◽  
Binding Studies ◽  
Type Iii ◽  
Wide Range ◽  
Human Sera ◽  
Serum Gh

We recently classified the growth-hormone (GH)-binding protein (GH-BP) in a wide range of mammalian [including human (h)] sera and reported the existence of a major lactogenic component in GH-BP of type-III sera (rabbit, horse, dog, pig and cat), based on the capacity of bovine (b) and ovine prolactin (PRL) to displace 125I-labelled human growth hormone (hGH) binding and on direct 125I-bPRL binding studies. In this study, we demonstrate the high degree of Mg2+ dependence of the binding of the classically lactogenic hGH and bPRL, but not that of the somatogenic bGH to various mammalian sera (types I-IV). Serum GH-BP was assayed using a previously described and validated charcoal-separation assay. 125I-hGH binding to rat, ovine, bovine, rabbit, horse, dog and human sera was enhanced 1.5-2.5-fold in the presence of 70 mM Mg2+. The Mg2+ effect was concentration-dependent between 3.7 mM and 70 mM, causing a significant and proportional increase in 125I-hGH binding to serum. Like 125I-hGH, 125I-bPRL binding to type-III sera was also Mg(2+)-dependent. In contrast, 125I-bGH binding to all types of serum GH-BP was not affected by Mg2+ concentrations of up to 35 mM, while 70 mM Mg2+ slightly, but significantly, reduced (by approx. 15%) bGH binding to rabbit serum. In keeping with the Mg(2+)-dependent stimulation of lactogenic hormone binding to GH-BP, 70 mM Mg2+ caused a shift to the left in the displacement curves of hGH and bPRL competing with 125I-hGH binding to rabbit, dog, horse and human sera, while the effects of the somatogens bGH and rabbit GH were shifted to the right. Scatchard analysis of hGH displacement curves with sera from various species yielded linear plots and revealed that Mg2+ significantly increased (2.3-3.0-fold) the affinity constants, but not the binding capacities. These results demonstrate the ability of changes in Mg2+ concentration to determine the degree of differential recognition of somatogens versus lactogens by serum GH-BP. It remains to be determined whether such bivalent cation effects may account, at least in part, for the growth retardation seen in Zn2+ or Mg2+ ion deficiencies.

scholarly journals 36 MEASUREMENT OF 15N-RETENTION AND TYPE I AND TYPE III COLLAGEN SERUM LEVELS PREDICTS RESPONSE OF TREATMENT WITH HUMAN GROWTH HORMONE (hGH)

1988 ◽  
Vol 24 (4) ◽  
pp. 523-523
Author(s):  
D Schnabel ◽  
Th Danne ◽  
H Bröslcke ◽  
D Hartmann ◽  
A Grüters ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Serum Levels ◽  
Type Iii Collagen ◽  
Type I ◽  
Type Iii

Serum Osteopontin Growth hormone , and Other Biochemical Parameters in Children with Acute Lymphoblastic Leukemia

2011 ◽  
Vol 7 (1) ◽  
pp. 1169-1174 ◽  
Author(s):  
Atheer A. Mehde ◽  
Wesen A. Mehdi ◽  
Karima F. Ali
Keyword(s):  
Growth Hormone ◽  
Acute Lymphoblastic Leukemia ◽  
Biochemical Parameters ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Surface Receptors ◽  
The Mean

Acute lymphoblastic leukemia (ALL) is a custom of leukemia, or cancer of the white blood cells categorized by excess lymphoblasts and Chemotherapy is the initial treatment of choice. Most ALL patients will receive a combination of different treatments.Osteopontin (OPN) is a glycoprotein that cooperates with a variety of cell surface receptors, as well as several integrins and CD44. OPN is secreted by numerous human malignancies. We aimed to evaluate serum levels of osteopontin and growth hormone(GH) in patients with Acute lymphoblastic leukemia in childhood. We studied serum levels of OPN ,GH and other biochemical levels of 60 patients that diagnosis as  acute lymphoblastic leukemia.      The mean levels of OPN were significantly higher in patients (10.00± 1.15 ng/ml) than in control (7.62± 0.60 ng/ml). The mean levels of GH levels were significantly lower in patients (2.98± 0.51ng/dl) than in control  (6.02± 1.00 ng/dl. The mean levels of the iron and total protein  in ALL patients  were (95.78± 10.11 µg/dl), (6.08 ± 1.16 g/dl)respectively. The present study  showed a significant  negative correlation between GH with  osteopontin (OPN) ,while there a positive significant  correlate  between GH with  hemoglobin  in patients group compared to control group. The present study Conclude that elevated levels of osteopontin and decreased GH levels at the diagnosis may predict an unfavorable result in  ALL childhood .

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