Glycine stimulates growth hormone release in man

1980 ◽  
Vol 93 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Kikuo Kasai ◽  
Hitoshi Suzuki ◽  
Tsutomu Nakamura ◽  
Hiroaki Shiina ◽  
Shin-Ichi Shimoda
Keyword(s):  
Growth Hormone ◽  
Blood Sugar ◽  
Normal Subjects ◽  
Serum Levels ◽  
Pituitary Function ◽  
Before And After ◽  
Sugar Levels ◽  
Dose Dependent ◽  
Serum Gh ◽  
Different Doses

Abstract. The influence of glycine, the simplest amino acid, on pituitary function has been investigated in the present study. Different doses (4, 8 or 12 g) of glycine were intravenously infused over 15 or 30 min in normal subjects. Serum levels of GH (growth hormone) and Prl (prolactin) were measured before and after the infusion, and also blood sugar levels were determined. The dose of 4 or 8 g glycine induced a significant increase in serum GH (P < 0.05 or P< 0.001, respectively); however, a more pronounced and significant increase in serum GH levels was observed after infusion at a dose of 12 g glycine (P < 0.001). It was clearly observed that the dose-dependent GH release to intravenous glycine occurred in normal subjects. On the contrary, serum Prl level was not changed significantly, and blood sugar level was transiently, but significantly (P < 0.05), increased after the infusion of 12 g glycine. The present data suggest that glycine might play an important role in the control of hypothalamic-pituitary function.

THE EFFECT OF DIAZEPAM ON PITUITARY FUNCTION IN MAN

1972 ◽  
Vol 52 (1) ◽  
pp. 79-85 ◽  
Author(s):  
C. W. H. HAVARD ◽  
V. F. SALDANHA ◽  
R. BIRD ◽  
R. GARDNER
Keyword(s):  
Growth Hormone ◽  
Urinary Excretion ◽  
Blood Sugar ◽  
Adrenal Function ◽  
Pituitary Function ◽  
Hormone Production ◽  
Before And After ◽  
Corticosteroid Response

SUMMARY The integrity of pituitary—adrenal function and growth hormone production was determined in 15 patients before and after treatment with diazepam (30 mg daily). There was no evidence of impairment; nor was the urinary excretion of catecholamines significantly altered. The reproducibility of the plasma corticosteroid response to insulin-induced hypoglycaemia was separately assessed and both the degree of fall in blood sugar and the rise in plasma corticosteroid level were found to be similar.

THE RESPONSE OF PLASMA SUGAR, FREE FATTY ACIDS, 11-HYDROXYCORTICOSTEROIDS AND GROWTH HORMONE TO INSULIN-INDUCED HYPOGLYCAEMIA AND VASOPRESSIN IN PRIMARY MYXOEDEMA

1970 ◽  
Vol 48 (3) ◽  
pp. 389-400 ◽  
Author(s):  
F. P. VINCE ◽  
BARBARA J. BOUCHER ◽  
R. D. COHEN ◽  
JEAN GODFREY
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Free Fatty Acids ◽  
Normal Subjects ◽  
Pituitary Function ◽  
Hypothalamic Dysfunction ◽  
Lysine Vasopressin ◽  
Before And After ◽  
Plasma Ffa ◽  
Plasma Gh

SUMMARY The plasma sugar, free fatty acids (FFA), 11-hydroxycorticosteroids (11-OHCS) and growth hormone (GH) response to insulin-induced hypoglycaemia, have been studied in 19 patients with primary myxoedema and 13 normal subjects. Nine of the myxoedematous patients were restudied after treatment. The plasma 11-OHCS response to lysine vasopressin (LVP) was studied in the myxoedematous subjects and again in eight of them after treatment. In myxoedema the plasma sugar falls to a lesser extent and more slowly in response to insulin than normal and takes longer to recover. The fall in plasma FFA is not different from normal, but recovery of plasma FFA is delayed. The responses to insulin-induced hypoglycaemia of plasma GH and 11-OHCS may be smaller than normal in myxoedema and tend to improve on treatment. Altered GH and 11-OHCS responses to insulin-induced hypoglycaemia in myxoedema are not necessarily due to pituitary or hypothalamic dysfunction. No difference was found in the response of plasma 11-OHCS to LVP before and after treatment. Pituitary function cannot be fully assessed in the presence of hypothyroidism.

EFFECT OF l-DOPA ADMINISTRATION ON GROWTH HORMONE SECRETION IN NORMAL SUBJECTS AND PARKINSONIAN PATIENTS

1972 ◽  
Vol 54 (3) ◽  
pp. 425-433 ◽  
Author(s):  
F. CAVAGNINI ◽  
M. PERACCHI ◽  
G. SCOTTI ◽  
U. RAGGI ◽  
A. E. PONTIROLI ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Significant Rise ◽  
Arginine Infusion ◽  
Physiological Regulation ◽  
Gh Secretion ◽  
Before And After ◽  
Serum Gh

SUMMARY The effect of both oral and intravenous administration of l-DOPA on growth hormone (GH) secretion was studied in a group of normal volunteers: a significant rise of serum GH levels was observed in both cases. Growth hormone release in response to insulin hypoglycaemia and to arginine infusion was evaluated in a group of Parkinsonian patients before and after 25 days' treatment with l-DOPA plus a DOPA-decarboxylase inhibitor. In addition, GH response to the above stimuli was studied in a group of patients who had been under treatment for more than 6 months with l-DOPA alone. In untreated Parkinsonian patients, GH response to insulin hypoglycaemia was at the lower limit of normal range while arginine-induced GH release was significantly reduced. Treatment with l-DOPA did not increase GH responses. Some possible interpretations of the results are discussed. The findings support the possibility that dopamine plays a role in the physiological regulation of GH secretion, as in the case of luteinizing hormone, follicle-stimulating hormone and prolactin release.

scholarly journals The acute effect of resistance exercise on serum growth hormone and blood glucose in healthy non-obese adolescent subject

2021 ◽  
Author(s):  
Hemant Madavi ◽  
Chitra Srivastava ◽  
Preeti Kanawjia ◽  
Jalaj Saxena
Keyword(s):  
Growth Hormone ◽  
Resistance Exercise ◽  
Blood Sugar ◽  
Serum Growth Hormone ◽  
Obese Adolescent ◽  
Post Exercise ◽  
Random Blood Sugar ◽  
Male And Female ◽  
Sugar Levels ◽  
Serum Gh

Background: The growth hormone (GH) response to resistance training is altered by many factors including sex steroid concentrations, fitness, intensity of exercise, age, gender, duration of exercise and glycemic state but the exact understanding of the interplay of different exercises to GH levels and its induced physiological adaptations is still obscure. This study aimed to see how resistance exercise affects GH levels and its correlation to plasma glucose levels in healthy non-obese adolescent subjects.Methods: 48 healthy non-obese adolescent subjects, 24 males and 24 females were included in the study. High volume exercise training regimen was used which involved major muscle group of arms, legs and trunk. Pre and post exercise levels of serum GH and random blood sugar were estimated in male and female groups.Results: The mean body mass index (BMI) of male and female groups was 23.22±3.12 kg/m2 and 20.40±4.49 kg/m2, respectively. The post-exercise serum GH levels in male and females increased significantly by 0.54±1.041 ng/ml (p<0.05) and 0.85±1.023 ng/ml (p<0.001) respectively. The random blood sugar levels in males after exercise significantly increased (p<0.05) by 7.16±12.61 mg/dl and in females by 6.20±12.09 mg/dl (p<0.05). There was significant correlation (p<0.05) between increase in serum GH levels and increase in random blood sugar levels in both male and female group.Conclusions: Exercise induced increase in GH and its interplay with serum glucose can be better gained access into via metanalytical/elaborate studies of the major hormones and fuels involved. 

BESTIMMUNG DER INSULINAKTIVITÄT IM MENSCHLICHEM SERUM NACH GLUKOSEBELASTUNG ALS PRÜFUNG DER FUNKTIONSFÄHIGKEIT DES PANKREAS

1963 ◽  
Vol 42 (3) ◽  
pp. 437-452 ◽  
Author(s):  
H. Daweke
Keyword(s):  
Blood Sugar ◽  
Pancreatic Insufficiency ◽  
Normal Subjects ◽  
Insulin Binding ◽  
Epididymal Adipose Tissue ◽  
Moderate Increase ◽  
Glucose Loading ◽  
Before And After ◽  
Oral Hypoglycaemic Drugs ◽  
Severity Of The Disease

Using the method of glucose-1-14C oxydation to 14CO2 on the rat epididymal adipose tissue, the insulin-like activities (ILA) in the serum have been compared before and after oral loading with glucose in normal subjects, in maturity-onset diabetics and in insulin-requiring diabetics. In maturity-onset diabetics mean fasting values were found to be 30% below normal while in insulin-requiring diabetics they were 85% above normal. In normal subjects there was observed, 30 minutes after glucose loading, a moderate increase in blood sugar together with an increase of ILA of 222% above the starting value; in maturity-onset diabetics the increase in ILA was only 106% while the blood sugar was markedly increased. After glucose loading in maturity-onset diabetics, the total amount of insulin detected during the period of the experiment was, on the average, only 45% of that found in normal subjects. In insulin requiring diabetics there was no increase but, on the contrary, a steady decrease of the ILA values, while the blood sugar excessively increased. In general ILA values were higher than those in maturity-onset diabetics. No difference in response was found between maturity-onset diabetics treated with diet alone and those treated with diet and oral hypoglycaemic drugs. In contrast to the absolute ILA values, the index of insulin reserve, is of value in assessing the functional capacity of the pancreas. This index decreases progressively with the severity of the disease and reaches a maximum of 54% of the normal in maturity-onset diabetics, which can satisfactorily be explained by pancreas insufficiency. Only in some cases of insulin-requiring diabetics was an insulin reserve still detectable. The biological inactivity of the insulin circulating in the blood can be deduced from the increased ILA-values, as compared with those found in maturity-onset diabetics. Obviously some of this insulin can be released by the addition of glucose. It is likely that, in addition to pancreatic insufficiency, insulin-binding or insulin-inactivating antibodies play a part in the pathogenesis of insulin-requiring diabetes.

scholarly journals PENGARUH KONSUMSI KULIT MANGGIS TERHADAP PENURUNAN KADAR GULA DARAH PADA PENDERITA DIABETES MELLITUS DI DESA METESEH BOJA KENDAL TAHUN 2013

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Budi Herminto ◽  
Diyono ◽  
Shinta Dewi Kusuma
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
T Test ◽  
P Value ◽  
Average Value ◽  
Mangosteen Peel ◽  
Wide Range ◽  
Before And After ◽  
Sugar Levels ◽  
The Village

Abstract Background. Prevalensidiabetes mellitus in Indonesia potentially increased dramatically from 8.4 million people in 2000 to 21.3 million people in 2030. Diabetes mellitus may develop so bad with various complicated, diabetus mellitus of year to year growing a wide range of treatment options including non- medicinal chemistry ( Hebal ) . One type of therapy is continuously studied using mangosteen peel efectivitness. Research Objectives. Knowing the effect of the consumption of mangosteen rind to decrease blood sugar in the Village District of Boja Meteseh Kendal This is a research Methods. Quasi experiment with pre- post design eksperimental.Responden study are all patients with diabetes mellitus in the village of Boja Meteseh many as 17 people , as many as 16 samples taken. Sampling technic used was simple random sampling . Data obtained by the method of observation of assessing the results of measurements of blood sugar levels before and after taking of mangosteen skin . The data were processed with pairet t - test ( p = 0.05 ) using SPSS 18 . Results : ( 1 ) blood sugar levels before taking mangosteen peel at the most in the range of 301-400 mg / dL with a percentage of 43.75 % , the lowest blood sugar levels in the category of 501-600 mg / dL , with a percentage of 12.5 % , with an average value of 392.63 . ( 2 ) Blood sugar levels after consumption of mangosteen peel at the most in the range of 200-300 mg / dL , the percentage of blood sugar levels are the lowest in the category of 501-600 mg / dL , with a percentage of 12.5 % , with an average value of 371.31 mg / dL ( 3 ) There are significant differences in blood sugar levels before and after consuming mangosteen peel with a value of 0.001 t - Test Conclusion : Consumption of mangosteen peel significant effect on lowering blood sugar levels by t - test results of 5 % ( 0.05), obtained P value of 0.001. Keywords: Blood Sugar Levels, Skin Mangosteen, Diabetes Mellitus

scholarly journals Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

1998 ◽  
Vol 159 (1) ◽  
pp. 79-83 ◽  
Author(s):  
N LaPaglia ◽  
J Steiner ◽  
L Kirsteins ◽  
M Emanuele ◽  
N Emanuele
Keyword(s):  
Growth Hormone ◽  
Nutritional Status ◽  
Serum Levels ◽  
Male Rat ◽  
Igf I ◽  
Adult Male Rat ◽  
Steady State Levels ◽  
Hormonal System ◽  
Neuroendocrine Responses ◽  
Serum Gh

Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion within the GRF-GH-IGF axis in the adult male rat during almost 3 days of fasting. Serum levels of GH and IGF-I were drastically suppressed by fasting. Daily leptin administration was able to fully prevent the fasting-induced fall in serum GH. Leptin failed to restore IGF-I to control levels, however, suggesting possible GH resistance. Fasting caused an insignificant increase in GH mRNA, while leptin injections significantly increased steady-state levels of this message. The GRF receptor (GRFr) message was not altered with fasting or leptin treatment. Leptin also exhibited effects at the hypothalamic level. Fasting induced a sharp fall in GRF mRNA expression and leptin injections partially prevented this fall. However, there were no observed changes in the hypothalamic GRF content. These results provide evidence that leptin may function as a neuromodulator of the GRF-GH-IGF axis communicating to this hormonal system the nutritional status of the animal.

scholarly journals “Japanese Ants (Tenebrio Molitor) Stabilize Blood Sugar Levels For Diabetics”: The Current Issue OF Herbal Medicine In Indonesia"

2018 ◽  
Vol 2 (02) ◽  
pp. 164-168
Author(s):  
Asirotul Marifah Marifah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Sampling Technique ◽  
Lower Blood ◽  
Patients With Diabetes ◽  
Independent Variable ◽  
Sugar Levels ◽  
The Relationship ◽  
Different Doses

There are still many of our people who have never heard or even seen the shape of the Japanese ants, so sometimes people consume Japanese ants with different doses between people with each other and even some who consume Japanese ants are not appropriate doses because they want to get well soon. The purpose of research to know the relationship between consumption patterns of Japanese ants and blood sugar levels of people with diabetes mellitus. The design of this study is correlational analytic with crossectional approach. Variables of this research there are two that is the pattern of consumption of Japanese ants as an independent variable and blood sugar levels as the dependent variable. The population of this study was all patients with diabetes Mellitus who had suffered > 5 years who consumed Japanese ants in Grinting Village Karangjeruk Village Jatirejo Subdistrict Mojokerto regency as many as 10 respondents. in the sampling of researchers using total sampling technique. Data collection with an observation sheet of Japanese ant consumption and blood sugar level. The result of the research showed that most of the respondents consume Japanese ants regularly as much as 6 respondents (60%) and most respondents have blood sugar level in the normal category that is between 100-125 mg/dl as many as 6 respondents (60%). Consumption Japanese ants can routinely lower blood sugar levels of people with diabetes mellitus because ants contain enzymes that can keep blood sugar levels diabetics.

scholarly journals “Japanese Ants (Tenebrio Molitor) Stabilize Blood Sugar Levels For Diabetics”: The Current Issue OF Herbal Medicine In Indonesia"

2018 ◽  
Vol 2 (02) ◽  
pp. 164-168
Author(s):  
Asirotul Marifah Marifah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Sampling Technique ◽  
Lower Blood ◽  
Patients With Diabetes ◽  
Independent Variable ◽  
Sugar Levels ◽  
The Relationship ◽  
Different Doses

There are still many of our people who have never heard or even seen the shape of the Japanese ants, so sometimes people consume Japanese ants with different doses between people with each other and even some who consume Japanese ants are not appropriate doses because they want to get well soon. The purpose of research to know the relationship between consumption patterns of Japanese ants and blood sugar levels of people with diabetes mellitus. The design of this study is correlational analytic with crossectional approach. Variables of this research there are two that is the pattern of consumption of Japanese ants as an independent variable and blood sugar levels as the dependent variable. The population of this study was all patients with diabetes Mellitus who had suffered > 5 years who consumed Japanese ants in Grinting Village Karangjeruk Village Jatirejo Subdistrict Mojokerto regency as many as 10 respondents. in the sampling of researchers using total sampling technique. Data collection with an observation sheet of Japanese ant consumption and blood sugar level. The result of the research showed that most of the respondents consume Japanese ants regularly as much as 6 respondents (60%) and most respondents have blood sugar level in the normal category that is between 100-125 mg/dl as many as 6 respondents (60%). Consumption Japanese ants can routinely lower blood sugar levels of people with diabetes mellitus because ants contain enzymes that can keep blood sugar levels diabetics.

scholarly journals The Difference in Effect of Arabica Coffee Gayo Beans and Leaf (Coffea Arabica Gayo) Extract on Decreasing Blood Sugar Levels in Healthy Mice

2019 ◽  
Vol 7 (20) ◽  
pp. 3363-3365
Author(s):  
Sake Juli Martina ◽  
Pradeepa A. P. Govindan ◽  
Arlinda Sari Wahyuni
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Leaf Extract ◽  
Alternative Therapy ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Arabica Coffee ◽  
Before And After ◽  
The Difference ◽  
Sugar Levels

BACKGROUND: High incidence rate of diabetes mellitus (DM) and increased incidence of complications from DM as well as the use of less effective antidiabetic drugs and high financing to treat demands alternative therapy. AIM: This study was conducted to determine the difference in the effect of Arabica coffee gayo bean and leaf extract on blood sugar levels in healthy mice before and after the intervention of extract and fasting and postprandial blood glucose level after consumption of glucose. METHODS: This research is an experimental research study. The study used experimental animals which were divided into 8 groups which are the control group (Aquadest), group given Acarbose, the group given the Arabica coffee gayo bean extract with dosage of 50 mg, 100 mg and 200 mg in healthy mice, the group given the Arabica coffee gayo leaf extract with dosage of 30 mg, 60 mg and 120 mg in healthy mice. RESULTS: The results of the study obtained are before and after the intervention of extract showed the difference of p= 0.523 and after consumption of glucose the fasting and postprandial result showed the difference of p = 0.005. CONCLUSION: The use of Arabica coffee gayo bean and leaf extract showed a high decrease in blood glucose levels (BGL) compared to the control group.

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