Relationship of IGF1 and bone parameters in 7--16 year old apparently healthy Indian children

Introduction.Significant correlations between BMI and some body circumferences have been previously reported. In this study we investigated if the average of the sum of eight body circumferences can be a substitute for BMI.Patients and Methods.BMI and eight body circumferences (neck, waist, hip, arm, forearm, wrist, thigh, and ankle) were measured in 193 apparently healthy women aged 20–83, and within a wide range of BMI. Women with BMI ≤ 24.9 were designated as normal, with BMI 25–29.9 as overweight and with BMI ≥ 30 as obese. The relationship of the average body circumference (ABC) of the sum of the eight circumferences, and of each individual circumference with BMI, was evaluated.Results.ABC had the strongest correlation with BMI (r=0.95,P<0.001) among all the circumferences tested. Hip circumference had the strongest correlation with BMI (r=0.89,P<0.001) among the circumferences of individual body sites. Receiver-Operator Characteristic analysis showed that women with ABC > 44.0 cm could be recognized as having BMI ≥ 25 with sensitivity 90.2% and specificity 88.5%, while women with ABC > 47.1 cm could be diagnosed as having BMI ≥ 30 with sensitivity 92.2% and specificity 91.5%.Conclusion.An average body circumference strongly correlated with BMI in women and can serve as a surrogate of BMI.

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G8P[6] rotaviruses isolated from Amerindian children in Mato Grosso do Sul, Brazil, during 2009: close relationship of the G and P genes with those of bovine and bat strains

Journal of General Virology ◽

10.1099/vir.0.058099-0 ◽

2014 ◽

Vol 95 (3) ◽

pp. 627-641 ◽

Cited By ~ 14

Author(s):

Adriana Luchs ◽

Maria do Carmo Sampaio Tavares Timenetsky

Keyword(s):

Genetic Relationship ◽

Close Contact ◽

Indian Children ◽

Mato Grosso ◽

Fruit Bat ◽

Bovine Strain ◽

Close Relationship ◽

Group A ◽

Relationship Of ◽

Mato Grosso Do Sul

During the 2009 national group A rotavirus (RVA) surveillance, five unusual strains of the human G8P[6] genotype were detected in Brazilian indian children with acute gastroenteritis. The aim of this study was to carry out sequence analysis of the two outer capsid proteins (VP4 and VP7) and the inner capsid protein (VP6) of the G8P[6] strains detected in order to provide further information on the genetic relationship between human and animal RVA. A total of 68 stool samples, collected in Mato Grosso do Sul during 2009, were tested for RVA using ELISA, following by reverse transcriptase-PCR and sequencing. RVA infection was detected in 7.3 % of samples (5/68). The IAL-RN376 G8 sequence shares a clade with bovine and human strains, displaying highest nucleotide identity to African human strains DRC86 and DRC88, followed by African bovine strain NGRBg8. IAL-RN376 and IAL-RN377 P[6] sequences showed highest identity to human strain R330 from Ireland, and a close genetic relationship to African fruit bat RVA strain KE4852/07. Strains IAL-RN376 and IAL-RN377 display genogroup I VP6 specificity and the I2 genotype, and share high nucleotide identities with human strains B1711, 272-BF and 06-242, and moderate identities with bovine (RUBV81, 86 and KJ9-1) and porcine (HP140) strains. This study suggested that a reassortment between bovine and bat RVA strains could have occurred in animal host(s) preceding the transmission to humans. In the indigenous population, zoonotic transmission is probably fairly frequent as the inhabitants live in close contact with animals under conditions of poor hygiene.

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