Early life vitamin D depletion and mechanical loading determine methylation changes in the RXRA, Runx2 and osterix promoters in mice

2019 ◽  
Author(s):  
Stephanie Borg ◽  
Nevena Krstic ◽  
Harriet Buckley ◽  
Elizabeth Curtis ◽  
Cyrus Cooper ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mechanical Loading ◽  
Early Life ◽  
Vitamin D Depletion

scholarly journals Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190675 ◽  
Author(s):  
Stephanie A. Borg ◽  
Harriet Buckley ◽  
Robert Owen ◽  
Ana Campos Marin ◽  
Yongtau Lu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Life ◽  
Skeletal Loading ◽  
Vitamin D Depletion ◽  
Mature Bone

Maternal vitamin D depletion disrupts neonatal skeletal development in mice

2015 ◽  
Author(s):  
Harriet Buckley ◽  
Stephanie Borg ◽  
Kirsty Nicholson ◽  
Mark Kinch ◽  
David Hughes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skeletal Development ◽  
Maternal Vitamin ◽  
Vitamin D Depletion

scholarly journals Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1500
Author(s):  
Jabulani R. Ncayiyana ◽  
Leonardo Martinez ◽  
Elizabeth Goddard ◽  
Landon Myer ◽  
Heather J. Zar
Keyword(s):  
Vitamin D ◽  
Child Health ◽  
Vitamin D Deficiency ◽  
Birth Cohort ◽  
Early Life ◽  
Vitamin D Supplementation ◽  
Sub Saharan Africa ◽  
Health Study ◽  
Birth Cohort Study ◽  
Young Infants

Early-life vitamin D deficiency is associated with adverse child health outcomes, but the prevalence of vitamin D deficiency and its correlates in infants remains underexplored, particularly in sub-Saharan Africa. We aimed to investigate the prevalence of vitamin D deficiency and its correlates among young infants in South Africa. This study included 744 infants, aged 6–10 weeks from the Drakenstein Child Health Study, a population-based birth cohort. Infants were categorized into distinct categories based on serum 25(OH)D concentration level including deficient (<50 nmol/L), insufficient (50–74 nmol/L), and sufficient (≥75 nmol/L). Using multivariable Tobit and logistic regression models, we examined the correlates of serum 25(OH)D3 levels. The overall prevalence of vitamin D deficiency was 81% (95% confidence intervals (CI]) 78–83). Multivariable regression analysis showed that serum 25(OH)D3 concentration was independently associated with study site, socioeconomic status, and sex. Birth in winter and breastfeeding were the strongest predictors of lower serum 25(OH)D3 concentration levels. Compared to non-breastfed children, children breastfed were at higher risk of vitamin D deficiency (AOR, 1.96; 95% CI, 1.04–3.67) and breastfeeding for more than one month was associated with greater likelihood of vitamin D deficiency (AOR, 5.40; 95% CI, 2.37–12.32) and lower vitamin D concentrations (−16.22 nmol/L; 95% CI, −21.06, −11.39). Vitamin D deficiency in infants is ubiquitous, under-recognised, and strongly associated with season of birth and breastfeeding in this setting. Nutritional interventions with vitamin D supplementation in national health programs in low- and middle-income countries are urgently needed to improve early-life vitamin D status in infants.

scholarly journals Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze

Thorax ◽  
2018 ◽  
Vol 74 (2) ◽  
pp. 200-202 ◽  
Author(s):  
Hooman Mirzakhani ◽  
Amal A Al-Garawi ◽  
Vincent J Carey ◽  
Weiliang Qiu ◽  
Augusto A Litonjua ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Transforming Growth Factor Beta ◽  
Early Life ◽  
Transforming Growth Factor ◽  
First Year ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Recurrent Wheeze ◽  
First Year Of Life

Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.

Vitamin D in early life: From observation to intervention

2018 ◽  
pp. 53-64
Author(s):  
Nicholas C Harvey ◽  
Rebecca J Moon ◽  
Cyrus Cooper
Keyword(s):  
Vitamin D ◽  
Early Life

Vitamin D status in infancy and cardiometabolic health in adolescence

2020 ◽  
Vol 113 (1) ◽  
pp. 104-112
Author(s):  
Joshua Garfein ◽  
Kerry S Flannagan ◽  
Sheila Gahagan ◽  
Raquel Burrows ◽  
Betsy Lozoff ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Fat ◽  
Early Life ◽  
Vitamin D Supplementation ◽  
Lower Percentage ◽  
Cardiometabolic Health ◽  
Vitamin D Status ◽  
Percentage Body Fat ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency is associated with obesity-related conditions, but the role of early life vitamin D status on the development of obesity is poorly understood. Objectives We assessed whether serum 25-hydroxyvitamin D [25(OH)D] at age 1 y was related to metabolic health through adolescence. Methods We quantified serum 25(OH)D in samples obtained at age 1 y from 306 participants in a cohort study in Santiago, Chile. Anthropometry was performed at ages 5, 10, and 16/17 y. At 16/17 y, we determined body composition using DXA and quantified metabolic parameters in a blood sample. We examined the associations of infancy 25(OH)D with BMI-for-age z-score (BMIZ) at ages 5, 10, and 16/17 y; with percentage fat and percentage lean body mass at age 16/17 y; and with a metabolic syndrome (MetS) score and its components at age 16/17 y. Results Infancy 25(OH)D was inversely associated with BMIZ in childhood. Every 25-nmol/L difference in 25(OH)D was related to an adjusted 0.11 units lower BMIZ at age 5 y (95% CI: −0.20, −0.03; P = 0.01) and a 0.09 unit lower BMIZ change from ages 1 to 5 y (95% CI: −0.17, −0.01; P = 0.02). Also, every 25-nmol/L 25(OH)D in infancy was associated with an adjusted 1.3 points lower percentage body fat mass (95% CI: −2.2, −0.4; P = 0.005) and an adjusted 0.03 units lower MetS score (95% CI: −0.05, −0.01; P = 0.01) at age 16/17 y, through inverse associations with waist circumference and the HOMA-IR. Conclusions Serum 25(OH)D at age 1 y is inversely associated with childhood BMIZ, percentage body fat at age 16/17 y, and a MetS score at age 16/17 y. Intervention studies are warranted to examine the effects of vitamin D supplementation in early life on long-term cardiometabolic outcomes.

scholarly journals Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Megan M. Knuth ◽  
Debabrata Mahapatra ◽  
Dereje Jima ◽  
Debin Wan ◽  
Bruce D. Hammock ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Early Life ◽  
Life Stage ◽  
Somatic Growth ◽  
Early Life Stage ◽  
Cytokine Signaling ◽  
Central Adiposity ◽  
Stage Development ◽  
Life Stage Development

Abstract Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggests non-calcemic roles for vitamin D including metabolic homeostasis. In this study, we examined the hypothesis that vitamin D deficiency (VDD) during early life stage development precedes metabolic disruption. Three dietary cohorts of zebrafish were placed on engineered diets including a standard laboratory control diet, a vitamin D null diet, and a vitamin D enriched diet. Zebrafish grown on a vitamin D null diet between 2–12 months post fertilization (mpf) exhibited diminished somatic growth and enhanced central adiposity associated with accumulation and enlargement of visceral and subcutaneous adipose depots indicative of both adipocyte hypertrophy and hyperplasia. VDD zebrafish exhibited elevated hepatic triglycerides, attenuated plasma free fatty acids and attenuated lipoprotein lipase activity consistent with hallmarks of dyslipidemia. VDD induced dysregulation of gene networks associated with growth hormone and insulin signaling, including induction of suppressor of cytokine signaling. These findings indicate that early developmental VDD impacts metabolic health by disrupting the balance between somatic growth and adipose accumulation.

Effect of 1,25-dihydroxyvitamin D3 on phospholipid composition of rat renal brush border membrane

1985 ◽  
Vol 249 (1) ◽  
pp. F117-F123 ◽  
Author(s):  
M. Tsutsumi ◽  
U. Alvarez ◽  
L. V. Avioli ◽  
K. A. Hruska
Keyword(s):  
Vitamin D ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Brush Border ◽  
Brush Border Membrane ◽  
Linoleic Acid Content ◽  
Renal Brush Border Membrane ◽  
Vitamin D Depletion ◽  
Renal Brush Border

To analyze the effects of vitamin D on renal tubular cell membrane phospholipid metabolism, the effects of vitamin D depletion and repletion on renal brush border membrane (BBM) phosphatidylethanolamine (PE), phosphatidylcholine (PC), and phosphatidylinositol (PI) were studied. The PC content of BBM from kidneys of rats deprived of vitamin D for 5-6 wk was 33.5 +/- 2.2 nmol Pi/mg protein. This was significantly lower than the PC content of BBM from kidneys of rats supplemented with vitamin D2 for 2 wk, 41.0 +/- 0.4 nmol Pi/mg protein. Vitamin D depletion also decreased the content of BBM PE. The fatty acid composition of BBM PC was altered by vitamin D depletion. Vitamin D depletion increased palmitic acid and decreased stearic, linoleic, and arachidonic acid. Vitamin D repletion with a single physiological dose of 1,25(OH)2D3 (30 pmol), 16 h prior to study tended to increase membrane content of PC and significantly increased the linoleic acid content of the PC fraction. Single-dose vitamin D repletion with a pharmacological dose of 1,25(OH)2D3 (2.4 nmol) produced a significant increase in BBM content of PC and also significantly increased the linoleic acid content of PC. These results demonstrate that vitamin D deficiency affects PC and PE content of rat renal BBM and their fatty acid composition, and that vitamin D repletion with 1,25(OH)2D3 for 16 h partially normalizes the changes in PC.

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