scholarly journals The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study

2017 ◽  
Vol 6 (4) ◽  
pp. 253-259 ◽  
Author(s):  
Anette Lundqvist ◽  
Herbert Sandström ◽  
Torbjörn Bäckström

Objective Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design A longitudinal, cohort study. Methods Pregnant women (n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results Weight increase correlated significantly to allopregnanolone in late pregnancy increase (rs = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained ≥11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased <11 kg (P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations.

2016 ◽  
Vol 4 (1) ◽  
pp. 1 ◽  
Author(s):  
Eka Nurhayati

<p>Prepregnancy BMI (Body Mass Index) is used as a guide to the nutritional status of the mother before pregnancy and also determine the optimal weight gain in pregnancy. Meanwhile, weight gain during pregnancy is a decisive indicator of the nutritional status of the mother. This retrospective study design aimed to determine the relationship of pre-pregnant BMI and maternal weight gain during pregnancy with birth weight babies. The sample was 71 mothers with children aged 0-6 months were selected by purposive sampling. The results showed 67.6% most respondents in this study had pre-pregnant BMI normal and 62% of respondents experienced weight gain during pregnancy, according to the recommendations. There is a significant relationship between pre-pregnant BMI birth weight (p=0.006), as well as weight gain during pregnancy had no significant relationship with birth weight, with p=0.024.</p>


2012 ◽  
Vol 19 (4) ◽  
pp. 256-263 ◽  
Author(s):  
Mustafa Yasin Selcuk ◽  
Mustafa Gokhan Usman ◽  
Mehtap Oktay ◽  
Ahmet Istanbullu ◽  
Ozhan Ozdemir ◽  
...  

2014 ◽  
Vol 54 (6) ◽  
pp. 727 ◽  
Author(s):  
B. L. Paganoni ◽  
M. B. Ferguson ◽  
G. A. Kearney ◽  
A. N. Thompson

Birthweight is the single largest determinant of survival in lambs and can be predicted from ewe liveweight at conception and liveweight changes during pregnancy. These prediction equations are known for Merino ewes, but it is unknown if they are applicable to non-Merino breeds. We tested the hypothesis that increasing conception weights of ewes will increase the birthweights, survival to weaning and weaning weights of their lambs, irrespective of ewe or sire breed, but that non-Merino lamb birthweights would be less responsive than Merino lamb birthweights, to changes in ewe liveweights during pregnancy. Ewe liveweight, lamb birth and weaning weight records from Merino sires mated to Merino ewes (MM), Border Leicester Merino (Maternal) sires mated to Merino ewes, Poll Dorset or Suffolk (Terminal) sires mated to Merino ewes (TM), and Terminal sires mated to Border Leicester Merino ewes (TMAT) were analysed from the 2007 to 2011 lambings of eight information nucleus flocks. Lamb birthweights increased by 0.032 ± 0.0012 kg from MM ewes and 0.024 ± 0.0026 kg from TMAT ewes with every 1-kg increase in conception weight (P < 0.001). Irrespective of breed, for every 1-kg increase in liveweight change during early and late pregnancy, lamb birthweights increased by 0.021 ± 0.0019 kg and 0.034 ± 0.0019 kg and weaning weights by 0.26 ± 0.013 kg and 0.09 ± 0.011 kg, respectively (P < 0.001). Survival to weaning of single, twin and triplet lambs was highest for lambs from TMAT ewes (89.3% ± 1.25, 84.6% ± 1.49 and 73.4% ± 2.35) and lowest for TM ewes (80.2% ± 1.89, 72.8% ± 2.09 and 57.4% ± 2.98; P < 0.001). Coefficients relating ewe liveweight change during pregnancy to lamb birthweights are similar for Merino and Maternal ewes, however conception weights of Maternal ewes are significantly heavier than Merino ewes when run together, and lamb birthweights from Maternal ewes are less responsive to ewe conception weights. The coefficients reported in this paper will enable development of optimum management guidelines for single-, twin- and triple-bearing Maternal ewes.


2017 ◽  
Vol 20 (11) ◽  
pp. 1928-1940 ◽  
Author(s):  
Kassandra L Harding ◽  
Susana L Matias ◽  
Malay K Mridha ◽  
Stephen A Vosti ◽  
Sohrab Hussain ◽  
...  

AbstractObjectiveTo: (i) determine the prevalence of self-reported eating less and eating down during early and late pregnancy and postpartum, and explore risk factors associated with eating less; (ii) examine the association between eating less and diet quality; and (iii) determine the association between eating less and weight gain during pregnancy.DesignData were collected longitudinally from a cohort of women participating in a community health programme. Diet was assessed at three time points (≤20 weeks’ gestation, 36 weeks’ gestation, 6 months’ postpartum), body weight was measured during study enrolment (≤20 weeks’ gestation) and at 36 weeks’ gestation, and information about the woman and her household was collected at enrolment.SettingThe Rang-Din Nutrition Study in the Rangpur and Dinajpur districts of Bangladesh.SubjectsWomen (n 4011).ResultsThe prevalence of self-reported eating less differed by time point (75·9 % in early pregnancy, 38·8 % in late pregnancy, 7·4 % postpartum; P<0·001). The most common reason for eating less across all time periods was food aversion or loss of appetite. Women who reported eating less in late pregnancy had consumed animal-source foods less frequently in the preceding week than women who reported eating more (mean (sd): 11·7 (7·4) v. 14·8 (9·2) times/week; P<0·001) and had lower weekly weight gain than women who reported eating more (mean (se): 0·27 (0·004) v. 0·33 (0·004) kg/week; P<0·001).ConclusionsEating less has negative implications with respect to diet quality and pregnancy weight gain in this context.


2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Anneloes E. Ruifrok ◽  
Ellen Althuizen ◽  
Nicolette Oostdam ◽  
Willem van Mechelen ◽  
Ben Willem Mol ◽  
...  

Objective. To evaluate the relationship of physical activity (PA) and sedentary behaviour with gestational weight gain (GWG) and birth weight.Design. Combined data from two prospective studies: (1) nulliparous pregnant women without BMI restrictions and (2) overweight and obese pregnant women at risk for gestational diabetes.Methods. Daily PA and sedentary behaviour were measured with an accelerometer around 15 and at 32–35 weeks of gestation. The association between time spent in moderate-to-vigorous PA (MVPA) and in sedentary activities with GWG and birth weight was determined. Main outcome measures were GWG between 15 and 32 weeks of gestation, average GWG per week, and birth weight.Results. We studied 111 women. Early in pregnancy, 32% of women spent ≥30 minutes/day in at least moderate PA versus 12% in late pregnancy. No significant associations were found between time spent in MVPA or sedentary behaviour with GWG or birth weight.Conclusions.We found no relation between MVPA and sedentary behaviour with GWG or birth weight. The small percentage of women meeting the recommended levels of PA indicates the need to inform and support pregnant women to maintain regular PA, as there seems to be no adverse effect on birth weight and maintaining PA increases overall health.


EMBRIO ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 46-55
Author(s):  
Dina Henukh ◽  
Siti Nur Asyah Jamillah Ahmad ◽  
Aning Pattypeilohy

During pregnancy, mothers are prone to experiencing nutritional problems. This problem can be fatal and exceptionally perilous for both the fetus and the mother. Malnutrition in pregnant women encompasses a huge enough affect on the growth process of the fetus and the child to be born, one of which is stunting. Toddlers' stunting in NTT is ranked 34th in Indonesia with a short presentation of 22.30% and very short 18.00%, while the incidence of stunting in TTS district reaches 57.3%. The point of the study was to analyze the relationship between maternal weight gain and newborn weight with the frequency of stunting. This type of research used case control with retrospective approach. The population of all children under five with incidence of stunting and non-stunting, the subjects of the study were 200 samples in 8 Public Helath Center in TTS district. Data collection using a questionnaire and with univariate and bivariate analysis and tested using the Chi-square test. The results showed that maternal weight gain during pregnancy in stunting infants had a weight gain that was not according to the recommendation, which was 55%, experiencing weight gain as recommended during pregnancy was 45%, while the weight of newborns who were stunted had an abnormal weight gain 60 % and the normal weight gain is 40%. After doing the Chi-Square test, the Asymp was obtained. Sig. is 0.000 <α (0.05). Therefore, it can be concluded that there’s a critical relationship between maternal weight gain during pregnancy and birth weight on the incidence of stunting.


2019 ◽  
Vol 2 (1) ◽  
pp. 95-102
Author(s):  
Susanti Pratamaningtyas ◽  
Shinta Kristianti ◽  
Siti Nurhidayatul Ilma Nafiah

Preeclampsia is a special condition during pregnancy where hypertension and proteinuria occur after 20 weeks of gestation in mothers who have had normal blood pressure. Symptoms that arise in preeclampsia are edema, hypertension, and proteinuria. One of the factors that make incidence of preeclampsia is obesity. Women with abnormal weight have a greater risk of preeclampsia. The purpose of this study was to determine the relationship of weight gain during pregnancy to the incidence of preeclampsia in Gambiran Hospital, Kediri. Simple random sampling was used with a population of 117 mothers. 91 mothers were taken to be respondents, this study was conducted on 6-9 May 2019. The research instrument used recapitulation sheet. The results of statistical tests showed that there was a relationship between weight gain during pregnancy and the incidence of preeclampsia in Gambiran Hospital, Kediri City. The Chi Square test results show that the value of ρ value is 0.022, then 0.022 <0.05, so it can be concluded that there is a Relationship between Increasing Weight During Pregnancy with the incidence of Preeclampsia in Gambiran Hospital, Kediri City.


2014 ◽  
Vol 42 (4) ◽  
Author(s):  
Mamoru Morikawa ◽  
Takahiro Yamada ◽  
Rina Akaishi ◽  
Takashi Yamada ◽  
Ryutaro Nishida ◽  
...  

AbstractIt is unknown whether weekly maternal weight gain differs between Japanese women with singleton, twin, and triplet pregnancies.Gestational weight gain defined as net weight gain during pregnancy was analyzed in 135,036 pregnant Japanese women, including 128,838 with singletons, 5573 with twins, and 132 with triplets, who gave birth at ≥22 weeks of gestation between 2007 and 2009. Weekly weight gain was defined as follows: gestational weight gain÷[gestational week (GW) at Delivery–2].Length of gestation (weeks, mean±SD) decreased significantly (38.2±2.6, 35.3±3.0, and 32.7±2.8) with increasing number of fetuses, while overall gestational weight gain (kg) was significantly smaller in women with singletons than in those with either twins or triplets (9.6±4.4 vs. 10.9±4.8 or 10.9±5.2, respectively). Thus, weekly maternal weight gain (kg/week) increased significantly with increasing number of fetuses (0.26±0.12, 0.33±0.13, and 0.35±0.16). Among women with delivery at or after GW 34, difference in gestational weight gain (kg) was prominent between the three groups (9.8±4.4, 11.4±4.7, and 13.0±5.1 for singleton, twin, and triplet pregnancies, respectively, P<0.001 between any two groups).Weekly maternal weight gain increases with increasing number of fetuses. Our figures may be useful for advising Japanese women with multifetal pregnancies regarding gestational weight gain.


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