scholarly journals Serum sclerostin levels in men with idiopathic osteoporosis

2013 ◽  
Vol 168 (4) ◽  
pp. 615-620 ◽  
Author(s):  
B Lapauw ◽  
S Vandewalle ◽  
Y Taes ◽  
S Goemaere ◽  
H Zmierczak ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Whole Body ◽  
Control Group ◽  
Volumetric Bone Mineral Density ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Bone Parameters ◽  
Idiopathic Osteoporosis

ObjectiveSclerostin inhibits osteoblast differentiation and bone formation. If aberrant sclerostin action is involved in less efficient bone acquisition in men with idiopathic low bone mass, this might be reflected in higher serum sclerostin levels.MethodsIn 116 men with idiopathic osteoporosis (≤65 years old), 40 of their sons and healthy controls, areal bone parameters were measured using dual-energy X-ray absorptiometry, and volumetric and geometric bone parameters were measured using peripheral quantitative computed tomography. Serum analytes were measured using immunoassays and estradiol (E2) levels using liquid chromatography–tandem mass spectrometry.ResultsMen with idiopathic low bone mass had lower levels of sclerostin than the controls (0.54±0.17 vs 0.66±0.23 ng/ml;P<0.001). In both groups, sclerostin levels were strongly associated with age; when adjusting for age, no associations with anthropometrics were observed (P>0.14). In multivariate analyses, sclerostin levels displayed a positive association with whole-body bone mineral content (BMC) and areal BMD (aBMD), as well as with trabecular and cortical volumetric bone mineral density (vBMD) at the tibia in the probands. No clear associations were observed in the control group, neither were sclerostin levels associated with BMC at the radius or lumbar spine (allP>0.11). Testosterone, but not E2, was inversely related to sclerostin levels in the probands. No difference in sclerostin levels was found in their sons when compared with their controls.ConclusionLower rather than higher serum sclerostin levels in the probands with idiopathic low bone mass suggest that aberrant sclerostin secretion is not involved in the pathogenesis of low bone mass in these subjects.

High Bone Mineral Density Osteogenesis Imperfecta in a Family with a Novel Pathogenic Variant in COL1A2

2020 ◽  
Vol 93 (4) ◽  
pp. 263-271
Author(s):  
Lara E. Graves ◽  
Christie-Lee Wall ◽  
Julie N. Briody ◽  
Bruce Bennetts ◽  
Karen Wong ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Osteogenesis Imperfecta ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Diagnostic Process ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Pathogenic Variants ◽  
Minimal Trauma

Osteogenesis imperfecta (OI) is a heterogenous group of heritable bone dysplasias characterized by bone fragility, typically low bone mass, joint laxity, easy bruising, and variable short stature. Classical OI is caused by autosomal dominant pathogenic variants in <i>COL1A1</i> or <i>COL1A2</i> that result in either reduced production of normal type 1 collagen or structurally abnormal collagen molecules. Pathogenic variants in these genes generally result in low bone mass. Here, we report a family that had 2 affected individuals who presented with minimal trauma fractures and were found to have elevated bone mineral density (BMD) and a previously unreported variant in <i>COL1A2</i> c.3356C&#x3e;T p.(Ala1119Val). We report the change in BMD using dual-energy X-ray and peripheral quantitative computed tomography over a 2.3-year period in the proband. This case report highlights the importance of BMD studies and genetic testing in the diagnostic process for brittle bone disorders.

scholarly journals Thin healthy women have a similar low bone mass to women with anorexia nervosa

2009 ◽  
Vol 102 (5) ◽  
pp. 709-714 ◽  
Author(s):  
D. Fernández-García ◽  
M. Rodríguez ◽  
J. García Alemán ◽  
J. M. García-Almeida ◽  
M. J. Picón ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Minimum Weight ◽  
Normal Weight ◽  
Control Group ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Anthropometric Parameters ◽  
Healthy Women

An association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involves hormonal and nutritional impairments, though their exact contribution is not clearly established. We compared bone mass in AN patients with women of similar weight with no criteria for AN, and a third group of healthy, normal-weight, age-matched women. The study included forty-eight patients with AN, twenty-two healthy eumenorrhoeic women with low weight (LW group; BMI < 18·5 kg/m2) and twenty healthy women with BMI >18·5 kg/m2 (control group), all of similar age. We measured lean body mass, percentage fat mass, total bone mineral content (BMC) and bone mineral density in lumbar spine (BMD LS) and in total (tBMD). We measured anthropometric parameters, leptin and growth hormone. The control group had greater tBMD and BMD LS than the other groups, with no differences between the AN and LW groups. No differences were found in tBMD, BMD LS and total BMC between the restrictive (n 25) and binge–purge type (n 23) in AN patients. In AN, minimum weight (P = 0·002) and percentage fat mass (P = 0·02) explained BMD LS variation (r2 0·48) and minimum weight (r2 0·42; P = 0·002) for tBMD in stepwise regression analyses. In the LW group, BMI explained BMD LS (r2 0·72; P = 0·01) and tBMD (r2 0·57; P = 0·04). We concluded that patients with AN had similar BMD to healthy thin women. Anthropometric parameters could contribute more significantly than oestrogen deficiency in the achievement of peak bone mass in AN patients.

scholarly journals Plyometrics and lifestyle effects on bone mineral density among premenopausal women: demographic and physiological analysis

2020 ◽  
Vol 11 (3) ◽  
pp. 4126-4134
Author(s):  
Golda sahaya Rani R ◽  
Aruna S ◽  
Vijayaraghavan R
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Physiological Parameters ◽  
The Body ◽  
Control Group ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Experimental Group

Bones have a numerous significant functions in the body such as supporting and protecting various organs of the body. Osteoporosis is a disease of bone characterized by low bone mass and micro-architectural deterioration of bone tissue, that leads to enhanced bone fragility and increased likelihood of fractures. Osteoporosis may be caused due to lower than the normal peak bone mass. Low bone mass results in faster rate of bone porosity and predisposes to osteoporotic fractures. Plyometrics is one of the most effective types of exercises for stimulating bone growth .The aim of the study was first to evaluate the effectiveness of plyometrics benefits on physiological parameters of osteoporosis among premenopausal women. Second to find out the association between the physiological parameters of osteoporosis among premenopausal women with selected demographic variables. The research approach was a Quantitative approach. Design adapted for the study was a true Experimental design with one control group and one experimental group. Data collected from 40 self help group women who were the members of kanchi sangamam from a selected area at chennai.sample were collected by using simple random technique.Based on the inclusion criteria and availability of premenopausal women, they were allocated into the control group (n=20) and experimental group (n=20)..plyometrics was given to the experimental group for 12 weeks. The control group did not receive an intervention. it was analyzed by descriptive and inferential statistics The study determined there is significant changes in physiological parameters of osteoporosis among the experimental group(p<0.001).as compared to the control group The study concluded that was an improvement in bone mineral density at the end of intervention.

scholarly journals Associations between Physical Fitness, Bone Mass, and Structure in Older People

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
A. Moradell ◽  
A. Gómez-Cabello ◽  
A. Gómez-Bruton ◽  
B. Muniz-Pardos ◽  
J. Marín Puyalto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Physical Fitness ◽  
Bone Mineral ◽  
Cortical Thickness ◽  
Walking Speed ◽  
Quantitative Computed Tomography ◽  
Mineral Density ◽  
Bone Parameters ◽  
Total Hip

The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, 76.2±5.4 y) from the EXERNET cohort of Zaragoza (Spain) were included in the study. Physical fitness was assessed using the Senior Fitness Test Battery. Peripheral quantitative computed tomography (pQCT) at the tibia and dual-energy X-ray absorptiometry (DXA) at the hip and lumbar spine were used to assess bone and muscle parameters. Partial correlations were used to describe the associations between fitness and bone parameters. A stepwise regression analysis was used to determine the influence of fitness variables on bone parameters. In males, significant correlations were found between lower body strength and agility with bone total mineral density (Tt.BMD) (r=0.41 and -0.50) and cortical thickness (r=0.40 and -0.50, respectively) and walking speed with total and cortical density (r=−0.41 and -0.40, respectively), all measured at tibia (all p<0.05). Regarding DXA, neck areal bone mineral density (aBMD) correlated with flexibility (r=−0.37) and walking speed (r=0.39) and Ward’s triangle with walking speed (r=0.39). Agility predicted Tt.BMD and cortical thickness (r2 change=24.8% and 23.0%), while walking speed predicted cortical bone mineral density (r2 change=19.5%) (all p<0.05). Females showed correlations between balance and total hip aBMD (r=0.27) and trochanter aBMD (r=0.25). Balance predicted trochanter (r2 change=4.2%) and total hip aBMD (r2 change=4.9%) (both p<0.05). In conclusion, bone mass in elderly males seems to be more influenced by physical fitness than in females, being agility and walking speed the variables showing greater associations. Other variables should be taken into account in females for future research.

scholarly journals The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults

2021 ◽  
Vol 18 (6) ◽  
pp. 3321
Author(s):  
Hsin-Hua Chou ◽  
Sao-Lun Lu ◽  
Sen-Te Wang ◽  
Ting-Hsuan Huang ◽  
Sam Li-Sheng Chen
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mass ◽  
Periodontal Disease ◽  
Bone Mineral ◽  
Intervention Program ◽  
Past History ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Periodontal Index

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02–1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P &lt; .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

scholarly journals Effect of 12 weeks of recreational soccer on bone mineral density and sarcopenia in the elderly: a randomized clinical trial

1989 ◽  
Author(s):  
Guilherme Henrique de Lima Matias ◽  
◽  
André dos Santos Costa ◽  
Romulo Maia Carlos Fonseca
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Repeated Measures ◽  
Intervention Group ◽  
The Elderly ◽  
Whole Body ◽  
Control Group ◽  
Mineral Density ◽  
Before And After ◽  
Post Hoc

Objective: To verify the effect of recreational soccer on bone mineral density and sarcopenia in the elderly. Methods: Fourteen elderly people aged 65.9 ± 3.4 years were selected. They were separated into two groups: the intervention group and the control group; the intervention group played recreational soccer for 12 weeks on two days of the week. Assessments were performed for bone mineral density and body muscle mass before and after the intervention. For statistical analysis, the repeated measures ANOVA with Bonferroni’s post hoc test was used. Results: After 12 weeks, there was a significant change in bone mineral density in the region of the total femur (p = 0.020). Analyzing the participants’ sarcopenia, no significant results were found after the intervention period. Conclusion: Playing recreational soccer causes a significant improvement in the total femur and maintains bone regions in the spine, whole body, and femoral neck. Also, it promotes a removal from the threshold for sarcopenia screening in the elderly.

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