scholarly journals The influence of menopause and body mass index on serum leptin concentrations

2000 ◽  
pp. 55-60 ◽  
Author(s):  
P Hadji ◽  
O Hars ◽  
K Bock ◽  
G Sturm ◽  
T Bauer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Leptin

OBJECTIVE: The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN: 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI <25 kg/m(2) (n=137), (b) premenopausal women BMI >25 kg/m(2) (n=81), (c) postmenopausal women BMI <25 kg/m(2) (n=94) and (d) postmenopausal women BMI >25 kg/m(2) (n=122). RESULTS: Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI <25 kg/m(2) (P<0.001). The multiple linear regression analyses showed that BMI was the only statistically significant independent predictor for leptin. In comparison to postmenopausal women, premenopausal women showed a significantly lower mean age, weight, BMI and FSH concentration (P<0. 001), a higher mean height and serum estradiol (P<0.01 and P<0.001 respectively) but significantly lower serum leptin concentration (P<0.01). The multiple linear regression model showed no significant influence of menopausal status or serum estradiol on serum leptin concentration, even after controlling for BMI. CONCLUSIONS: Serum leptin concentrations are significantly higher in pre- and postmenopausal obese women, compared with normal weight controls. Serum leptin concentrations are not influenced by menopausal status or serum estradiol level.

scholarly journals Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096122
Author(s):  
Jae-Min Park ◽  
Yong-Jae Lee
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Linear Regression Analysis ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Multiple Linear Regression Analysis ◽  
C Reactive Protein ◽  
Reactive Protein

Objective Epidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on the basis of their menopausal status. Methods This cross-sectional study examined the association between serum oestradiol and CRP levels on the basis of menopausal status in 151 premenopausal women aged 42.7 ± 6.7 years and 394 postmenopausal women aged 58.1 ± 6.7 years who participated in a health examination program. Multiple linear regression analysis was conducted using CRP levels as the dependent variable. Results Multiple linear regression analysis showed that serum oestradiol levels were inversely associated with CRP levels in premenopausal women (β coefficient = −0.298) after adjusting for age, body mass index, smoking, mean arterial pressure, and levels of fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, aspartate aminotransferase, and alanine aminotransferase. However, this association was not found in postmenopausal women after adjusting for the same confounding factors. Conclusions Serum oestradiol levels are inversely associated with CRP levels in premenopausal women, but not in postmenopausal women. Lower oestrogenic activity may at least partly contribute to the pathogenesis of chronic inflammation, particularly in premenopausal women.

Serum Leptin and Ghrelin Levels in Premenopausal Women with Stable Body Mass Index during Treatment of Thyroid Dysfunction

Thyroid ◽  
2008 ◽  
Vol 18 (5) ◽  
pp. 545-550 ◽  
Author(s):  
Mariusz Brąclik ◽  
Czesław Marcisz ◽  
Sebastian Giebel ◽  
Arkadiusz Orzeł
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Thyroid Dysfunction ◽  
Premenopausal Women ◽  
Serum Leptin

scholarly journals Effect of postmenopausal on some liver biochemical markers in Kirkuk women’s

2021 ◽  
Vol 26 (1) ◽  
pp. 17-23
Author(s):  
Noori Mohammed
Keyword(s):  
Body Mass Index ◽  
Alkaline Phosphatase ◽  
Postmenopausal Women ◽  
Phosphatase Activity ◽  
Body Mass ◽  
Alkaline Phosphatase Activity ◽  
Premenopausal Women ◽  
Glutamic Pyruvic Transaminase ◽  
Transaminase Activity ◽  
Glutamic Oxaloacetic Transaminase

   The menopause correlate with changes in physiological, psychological and biochemical characterized, and also body mass index. The study was analyzed the level of glutamic pyruvic transaminase activity (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and estimation of body mass index (BMI) in postmenopausal women (n=20) (50-70)years old and premenopausal women (n=20) (30-40) years old. In postmenopausal women the activity of glutamic pyruvic transaminase (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and body mass index (BMI)  was elevated significantly as compared to premenopausal women (p<0.05) , (P<0.004) , (P<0.002) and (p<0.016) respectably . This study showed with age advances liver become injury and gets abnormal liver functions.

scholarly journals Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers

2019 ◽  
Vol 189 (7) ◽  
pp. 660-670 ◽  
Author(s):  
Tianyi Huang ◽  
Amy L Shafrir ◽  
A Heather Eliassen ◽  
Kathryn M Rexrode ◽  
Shelley S Tworoger
Keyword(s):  
Body Mass Index ◽  
Confidence Interval ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Premenopausal Women ◽  
Inflammatory Biomarkers ◽  
Health Study ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Reproductive Events

Abstract Reproductive events, such as ovulation, trigger an inflammatory cascade. Few studies have examined their long-term influence on inflammatory profiles. We included 3,393 premenopausal and 3,915 postmenopausal women with intact ovaries/uterus from the Nurses’ Health studies (Nurses’ Health Study (1989–1990) and Nurses’ Health Study II (1996–1999)) in an analysis of the association between lifetime ovulatory years (LOY) and levels of inflammatory biomarkers. We estimated LOY as age at menopause (age at blood collection for premenopausal women) minus age at menarche, subtracting years of oral contraceptive (OC) use and 1 year per pregnancy. After adjustment for other inflammation-related factors (e.g., body mass index, exercise, diet), every 5-year increase in LOY was associated with lower C-reactive protein (CRP) levels in both premenopausal (difference = −11.5%, 95% confidence interval: −15.0, −8.0; P &lt; 0.0001) and postmenopausal (difference = −7.2%, 95% confidence interval: −10.0, −4.3; P &lt; 0.0001) women. Older age at menopause (P = 0.007), earlier menarche (P = 0.007), and shorter duration of OC use (P = 0.002) were associated with lower CRP levels in postmenopausal women, whereas duration of OC use was positively associated with CRP levels in premenopausal women (P &lt; 0.0001). LOY was modestly inversely associated with interleukin 6 in postmenopausal women (P = 0.03). Notably, the associations of CRP with LOY were similar in magnitude to associations with exercise and a healthy diet, though weaker than the association with body mass index. Although many reproductive events induce acute inflammation, increased LOY was associated with lower chronic systemic inflammation even after menopause.

scholarly journals Association of obesity with serum estrogen level in postmenopausal women

2016 ◽  
Vol 45 (2) ◽  
pp. 79-84
Author(s):  
Nahid Yeasmin ◽  
Mir Jakib Hossain ◽  
Iqbal Hossain ◽  
Qazi Shamima Akther
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Diseases ◽  
Waist Circumference ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Abdominal Obesity ◽  
Premenopausal Women ◽  
Control Group ◽  
Cross Sectional ◽  
Estrogen Level

Incidence of obesity among postmenopausal women is increasing throughout the world, leading to life threatening medical problem like cardiovascular diseases, type 2 diabetes mellitus. Estrogen deficiency that develops during menopause is likely the etiological factors for development of abdominal obesity. Increased incidence of cardiovascular diseases in postmenopausal women may be due to abdominal obesity caused by lower level of estrogen hormone. The study was carried out to observe the association of obesity with serum estrogen level in postmenopausal women. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of 90 female subjects were selected from different areas of Dhaka city. Among them, 60 postmenopausal women with age ranging from 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women with age ranging from 20 to 30 years were included as control group for comparison. Waist circumference was measured and body mass index (BMI) was calculated in both groups. Serum estrogen level was estimated in order to assess the hormonal level of postmenopausal women. The value of waist circumference was higher in postmenopausal women than those of premenopausal women and result was statistically non significant. Body mass index value was significantly (p<0.001) higher in postmenopausal women in comparison to those of premenopausal women. In postmenopausal women serum estrogen level was lower than premenopausal women and serum estrogen level showed negative correlation with waist circumference and body mass index values. All these correlations were statistically non significant. Present study revealed that there is association of obesity with serum estrogen level in postmenopausal women.Bangladesh Med J. 2016 May; 45 (2): 79-84

scholarly journals Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women

2010 ◽  
Vol 163 (6) ◽  
pp. 873-878 ◽  
Author(s):  
Kawaljit Kaur Khokhar ◽  
Sharda Sidhu ◽  
Gurcharan Kaur
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Menopausal Status ◽  
Sandwich Elisa ◽  
Competitive Elisa ◽  
Obese Subjects ◽  
Normotensive Subjects ◽  
Normal Women

ObjectiveThe present study was aimed at evaluating the correlation between leptin and hypertension in normal and obese hypertensive pre- (Pre-M) and postmenopausal (Post-M) women of Jalandhar city (Punjab, India).DesignFor the present study, 78 Pre-M and Post-M women were recruited in four categories as follows: i) normal normotensive, ii) obese normotensive, iii) normal hypertensive, and iv) obese hypertensive. Body mass index was considered as the index of obesity. Guidelines given by JNC-VII were followed for the assessment of hypertension. Leptin was assayed by sandwich ELISA, and estradiol (E2) was assayed by competitive ELISA.ResultsLeptin level was found to be significantly higher in normal Pre-M women (P<0.02) than that of normal Post-M women. Obese subjects had significantly higher leptin level (P<0.001) than the normal women. In the case of hypertensive subjects, leptin level was significantly higher than that of normotensive counterparts. E2 level was found significantly lower in Post-M women (P<0.001) than that of Pre-M women as well as in hypertensive women than that of normotensive subjects. A positive correlation was observed between blood pressure (BP) and leptin, but significant association was observed in hypertensive normal and obese Pre-M and Post-M women only.ConclusionIt is concluded from the present findings that leptin contributes to the regulation of BP in hypertensive normal as well as in the obese Pre-M and Post-M women. So, leptin may be a regulator of BP in hypertensive women independent of the degree of obesity and the menopausal status.

scholarly journals Body mass index interaction with SCN10A effects on cardiovascular autonomic neuropathy risk in a Chinese Han population

2018 ◽  
Vol 01 (01) ◽  
pp. 53-58
Author(s):  
Guo-Zhuo Wang ◽  
Zhi-Jun Liu ◽  
Kai Xia ◽  
Ke-Qin Zhang ◽  
Zi-Hui Tang
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Autonomic Neuropathy ◽  
Body Mass ◽  
Large Scale ◽  
Linear Regression Analysis ◽  
Cardiovascular Autonomic Neuropathy ◽  
Chinese Han ◽  
Positive Interaction

Background: The aim of this study was to estimate the extent to which the interaction between SCN10A (rs7375096) and body mass index (BMI) affects susceptibility to cardiovascular autonomic neuropathy (AN) in a Chinese Han sample. Method: We conducted a large-scale, population-based study including 791 overweight patients and 1186 controls to analyze the interaction between SCN10A and BMI with regard to CAN. All participants were genotyped for the presence of SCN10A (rs7375036) polymorphisms. Univariate and multiple linear regression analyses were employed to detect these relationships. The interaction between rs7375036 and BMI with regard to CAN susceptibility on an additive scale was estimated by using the relative excess risk due to interaction, the proportion attributable to interaction, and the synergy index. Results: Univariate analyses found no significant association between rs7375036 single nucleotide polymorphism and CAN. After controlling for potential confounding factors, the multiple linear regression analysis showed a significant association between BMI and CAN ([Formula: see text], OR = 1.121). In addition, a significant positive interaction effect of BMI and rs7375036 on CAN was detected ([Formula: see text]). Conclusion: Our findings suggest that BMI and SCN10A (rs7375036) have interaction effects that influence the CAN.

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