scholarly journals Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers

2019 ◽  
Vol 189 (7) ◽  
pp. 660-670 ◽  
Author(s):  
Tianyi Huang ◽  
Amy L Shafrir ◽  
A Heather Eliassen ◽  
Kathryn M Rexrode ◽  
Shelley S Tworoger
Keyword(s):  
Body Mass Index ◽  
Confidence Interval ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Premenopausal Women ◽  
Inflammatory Biomarkers ◽  
Health Study ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Reproductive Events

Abstract Reproductive events, such as ovulation, trigger an inflammatory cascade. Few studies have examined their long-term influence on inflammatory profiles. We included 3,393 premenopausal and 3,915 postmenopausal women with intact ovaries/uterus from the Nurses’ Health studies (Nurses’ Health Study (1989–1990) and Nurses’ Health Study II (1996–1999)) in an analysis of the association between lifetime ovulatory years (LOY) and levels of inflammatory biomarkers. We estimated LOY as age at menopause (age at blood collection for premenopausal women) minus age at menarche, subtracting years of oral contraceptive (OC) use and 1 year per pregnancy. After adjustment for other inflammation-related factors (e.g., body mass index, exercise, diet), every 5-year increase in LOY was associated with lower C-reactive protein (CRP) levels in both premenopausal (difference = −11.5%, 95% confidence interval: −15.0, −8.0; P < 0.0001) and postmenopausal (difference = −7.2%, 95% confidence interval: −10.0, −4.3; P < 0.0001) women. Older age at menopause (P = 0.007), earlier menarche (P = 0.007), and shorter duration of OC use (P = 0.002) were associated with lower CRP levels in postmenopausal women, whereas duration of OC use was positively associated with CRP levels in premenopausal women (P < 0.0001). LOY was modestly inversely associated with interleukin 6 in postmenopausal women (P = 0.03). Notably, the associations of CRP with LOY were similar in magnitude to associations with exercise and a healthy diet, though weaker than the association with body mass index. Although many reproductive events induce acute inflammation, increased LOY was associated with lower chronic systemic inflammation even after menopause.

scholarly journals Effect of postmenopausal on some liver biochemical markers in Kirkuk women’s

2021 ◽  
Vol 26 (1) ◽  
pp. 17-23
Author(s):  
Noori Mohammed
Keyword(s):  
Body Mass Index ◽  
Alkaline Phosphatase ◽  
Postmenopausal Women ◽  
Phosphatase Activity ◽  
Body Mass ◽  
Alkaline Phosphatase Activity ◽  
Premenopausal Women ◽  
Glutamic Pyruvic Transaminase ◽  
Transaminase Activity ◽  
Glutamic Oxaloacetic Transaminase

   The menopause correlate with changes in physiological, psychological and biochemical characterized, and also body mass index. The study was analyzed the level of glutamic pyruvic transaminase activity (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and estimation of body mass index (BMI) in postmenopausal women (n=20) (50-70)years old and premenopausal women (n=20) (30-40) years old. In postmenopausal women the activity of glutamic pyruvic transaminase (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and body mass index (BMI)  was elevated significantly as compared to premenopausal women (p<0.05) , (P<0.004) , (P<0.002) and (p<0.016) respectably . This study showed with age advances liver become injury and gets abnormal liver functions.

scholarly journals Adiposity Measures and Menstrual Cycle: Do We Envisage a Relation?

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
Rashmi Sinha ◽  
Anup Kumar Kapoor ◽  
Satwanti Kapoor
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Menstrual Cycle ◽  
Body Mass ◽  
Premenopausal Women ◽  
Impedance Method ◽  
Age At Menarche ◽  
Cycle Duration ◽  
Physically Active ◽  
The Relationship

The study aims to see the relationship between menstrual cycle and adiposity measures in Indian populations as menstrual cycle length has an important bearing on fertility and health of women. 415 premenopausal women in the ages 22–50 years residing in Delhi, India constituted the data. The adiposity was assessed by BMI as well as by using Bio-electric impedance method. The information regarding their physical activity pattern and menstrual cycle was recorded, and age at menarche was obtained through recall method. None of the underweight category women had menstrual cycle of less than 25 days. A decrease in body mass index and an increase in the age at menarche were found with the increase in the duration of menstrual cycle. The majority of women with 25–35 days duration of menstrual cycle in the present study were distributed in all the categories of BMI. Age was found to have no effect on longer cycle. The majority of women were in moderately physically active group and experienced menstrual cycle duration of 25–35 days. It is of utmost importance to identify the effects of moderate levels of physical activity, body mass index, and age at menarche on the menstrual cycle to enable the normal reproductive health of women.

scholarly journals Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females

2013 ◽  
Vol 118 (3) ◽  
pp. 649-656 ◽  
Author(s):  
Elizabeth B. Claus ◽  
Lisa Calvocoressi ◽  
Melissa L. Bondy ◽  
Margaret Wrensch ◽  
Joseph L. Wiemels ◽  
...  
Keyword(s):  
Body Mass Index ◽  
San Francisco ◽  
Body Mass ◽  
Hormone Replacement ◽  
Premenopausal Women ◽  
Positive Association ◽  
Age At Menarche ◽  
Intracranial Meningioma ◽  
Significant Positive Association ◽  
Increased Risk

Object The 2-fold higher incidence of meningioma in women compared with men has long suggested a role for hormonally mediated risk factors, but specific mechanisms remain elusive. Methods The study included data obtained in 1127 women 29–79 years of age with intracranial meningioma diagnosed among residents of Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Texas counties between May 1, 2006, and October 6, 2011, and data obtained in 1092 control individuals who were frequency matched for age group and geography with meningioma patients. Results No association was observed for age at menarche, age at menopause, or parity and meningioma risk. Women who reported breastfeeding for at least 6 months were at reduced risk of meningioma (OR 0.78, 95% CI 0.63–0.96). A significant positive association existed between meningioma risk and increased body mass index (p < 0.01) while a significant negative association existed between meningioma risk and current smoking (p < 0.01). Among premenopausal women, current use of oral contraceptives was associated with an increased risk of meningiomas (OR 1.8, 95% CI 1.1–2.9), while current use of hormone replacement therapy among postmenopausal women was not associated with a significant elevation in risk (OR 1.1, 95% CI 0.74–1.67). There was no association between use of fertility medications and meningioma risk. Conclusions The authors' study confirms associations for body mass index, breastfeeding, and cigarette smoking but provides little evidence for associations of reproductive and menstrual factors with meningioma risk. The relationship between current use of exogenous hormones and meningioma remains unclear, limited by the small numbers of patients currently on oral hormone medications and a lack of hormone receptor data for meningioma tumors.

scholarly journals Association of obesity with serum estrogen level in postmenopausal women

2016 ◽  
Vol 45 (2) ◽  
pp. 79-84
Author(s):  
Nahid Yeasmin ◽  
Mir Jakib Hossain ◽  
Iqbal Hossain ◽  
Qazi Shamima Akther
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Diseases ◽  
Waist Circumference ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Abdominal Obesity ◽  
Premenopausal Women ◽  
Control Group ◽  
Cross Sectional ◽  
Estrogen Level

Incidence of obesity among postmenopausal women is increasing throughout the world, leading to life threatening medical problem like cardiovascular diseases, type 2 diabetes mellitus. Estrogen deficiency that develops during menopause is likely the etiological factors for development of abdominal obesity. Increased incidence of cardiovascular diseases in postmenopausal women may be due to abdominal obesity caused by lower level of estrogen hormone. The study was carried out to observe the association of obesity with serum estrogen level in postmenopausal women. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of 90 female subjects were selected from different areas of Dhaka city. Among them, 60 postmenopausal women with age ranging from 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women with age ranging from 20 to 30 years were included as control group for comparison. Waist circumference was measured and body mass index (BMI) was calculated in both groups. Serum estrogen level was estimated in order to assess the hormonal level of postmenopausal women. The value of waist circumference was higher in postmenopausal women than those of premenopausal women and result was statistically non significant. Body mass index value was significantly (p<0.001) higher in postmenopausal women in comparison to those of premenopausal women. In postmenopausal women serum estrogen level was lower than premenopausal women and serum estrogen level showed negative correlation with waist circumference and body mass index values. All these correlations were statistically non significant. Present study revealed that there is association of obesity with serum estrogen level in postmenopausal women.Bangladesh Med J. 2016 May; 45 (2): 79-84

scholarly journals The influence of menopause and body mass index on serum leptin concentrations

2000 ◽  
pp. 55-60 ◽  
Author(s):  
P Hadji ◽  
O Hars ◽  
K Bock ◽  
G Sturm ◽  
T Bauer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Leptin

OBJECTIVE: The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN: 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI <25 kg/m(2) (n=137), (b) premenopausal women BMI >25 kg/m(2) (n=81), (c) postmenopausal women BMI <25 kg/m(2) (n=94) and (d) postmenopausal women BMI >25 kg/m(2) (n=122). RESULTS: Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI <25 kg/m(2) (P<0.001). The multiple linear regression analyses showed that BMI was the only statistically significant independent predictor for leptin. In comparison to postmenopausal women, premenopausal women showed a significantly lower mean age, weight, BMI and FSH concentration (P<0. 001), a higher mean height and serum estradiol (P<0.01 and P<0.001 respectively) but significantly lower serum leptin concentration (P<0.01). The multiple linear regression model showed no significant influence of menopausal status or serum estradiol on serum leptin concentration, even after controlling for BMI. CONCLUSIONS: Serum leptin concentrations are significantly higher in pre- and postmenopausal obese women, compared with normal weight controls. Serum leptin concentrations are not influenced by menopausal status or serum estradiol level.

scholarly journals The impact of body mass index on breast cancer incidence among women at increased risk: an observational study from the International Breast Intervention Studies

2021 ◽  
Author(s):  
Samuel G. Smith ◽  
Ivana Sestak ◽  
Michelle. A. Morris ◽  
Michelle Harvie ◽  
Anthony Howell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Treatment Group ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Intervention Studies ◽  
Premenopausal Women ◽  
Increased Risk

Abstract Background We investigated the association between body mass index (BMI) and breast cancer risk in women at increased risk of breast cancer receiving tamoxifen or anastrozole compared with placebo using data from the International Breast Cancer Intervention Studies [IBIS-I (tamoxifen) and IBIS-II (anastrozole)]. Methods Baseline BMI was calculated from nurse assessed height and weight measurements for premenopausal (n = 3138) and postmenopausal (n = 3731) women in IBIS-I and postmenopausal women in IBIS-II (n = 3787). The primary endpoint was any breast cancer event (invasive and ductal carcinoma in situ). We used Cox proportional hazards regression to calculate hazard ratios (HRs) for risk after adjustment for covariates. Results There were 582 (IBIS-I) and 248 (IBIS-II) breast cancer events [median follow-up = 16.2 years (IQR 14.4–17.7) and 10.9 years (IQR 8.8–13.0), respectively]. In adjusted analysis, women with a higher BMI had an increased breast cancer risk in both IBIS-I [HR = 1.06 per 5 kg/m2 (0.99–1.15), p = 0.114] and in IBIS-II [HR per 5 kg/m2 = 1.21 (1.09–1.35), p < 0.001]. In IBIS-I, the association between BMI and breast cancer risk was positive in postmenopausal women [adjusted HR per 5 kg/m2 = 1.14 (1.03–1.26), p = 0.01] but not premenopausal women [adjusted HR per 5 kg/m2 = 0.97 (0.86–1.09), p = 0.628]. There was no interaction between BMI and treatment group for breast cancer risk in either IBIS-I (p = 0.62) or IBIS-II (p = 0.55). Conclusions Higher BMI is associated with greater breast cancer risk in postmenopausal women at increased risk of the disease, but no effect was observed in premenopausal women. The lack of interaction between BMI and treatment group on breast cancer risk suggests women are likely to experience benefit from preventive therapy regardless of their BMI. Trial registration Both trials were registered [IBIS-I: ISRCTN91879928 on 24/02/2006, retrospectively registered (http://www.isrctn.com/ISRCTN91879928); IBIS-II: ISRCTN31488319 on 07/01/2005, retrospectively registered (http://www.isrctn.com/ISRCTN31488319)]

scholarly journals Body Mass Index and Stroke Mortality by Smoking and Age at Menopause Among Korean Postmenopausal Women

Stroke ◽  
2009 ◽  
Vol 40 (11) ◽  
pp. 3428-3435 ◽  
Author(s):  
Sang-Wook Yi ◽  
Nemekhee Odongua ◽  
Chung Mo Nam ◽  
Jae Woong Sull ◽  
Heechoul Ohrr
Keyword(s):  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Stroke Mortality ◽  
Age At Menopause

scholarly journals Association between body mass index and 1-year outcome after acute myocardial infarction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D.W Kim
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Body Mass Index ◽  
Confidence Interval ◽  
Body Mass ◽  
Cardiac Death ◽  
Funding Source ◽  
Group Iii ◽  
End Point ◽  
Group I

Abstract Background Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as “Body Mass Index (BMI) paradox”. However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year major cardiocerebrovascular events (MACCE) after AMI. Methods and findings Among 13,104 AMI patients registered in an Institute of Health in Korea between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group I; &lt;22 kg/m2, 22 ≤ Group II &lt;26 kg/m2, Group III; ≥26 kg/m2). The primary end point was a composite of cardiac death (CD), myocardial infarction (MI), target vessel revascularization (TVR), and cerebrovascular events at 1 year. Over the median follow-up of 12 months, the composite of primary end point occurred more frequently in the Group I patients than in the Group III patients (primary endpoint: adjusted hazard ratio [aHR], 1.290; 95% confidence interval [CI] 1.024 to 1.625, p=0.031). Especially, cardiac death in MACCE components played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p=0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year MACCE after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Research of Korea Centers for Disease Control and Prevention and the Korea Health Technology R&D Project, Ministry of Health & Welfare (HI13C1527), Republic of Korea.

Pre-pregnancy body mass index is associated with offspring body composition in adulthood before adiposity-related disorders: a retrospective cohort

2020 ◽  
pp. 1-17
Author(s):  
Ilana Eshriqui ◽  
Angélica Marques Martins Valente ◽  
Luciana Dias Folchetti ◽  
Bianca de Almeida-Pititto ◽  
Sandra Roberta G. Ferreira
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Retrospective Cohort ◽  
Statistical Significance ◽  
Directed Acyclic Graphs ◽  
Health Study ◽  
Appendicular Skeletal Muscle ◽  
Three Body

Abstract Objective: To investigate the association between maternal pre-pregnancy body mass index (BMI) and offspring body composition in adulthood. Design: Retrospective cohort. Undergraduates of nutrition or nutritionists were recruited at the baseline of the Nutritionists’ Health Study between 2014 and 2017. Maternal pre-pregnancy BMI and current life aspects were self-reported through online questionnaires. Three body compartments were DXA-determined. The following variables were obtained: body-fat (%), fat mass index (FMI) (kg/m2), android-to-gynoid fat ratio, visceral adipose tissue (VAT) (cm3), appendicular skeletal muscle mass index (ASMI) (kg/m2), total bone and femur mineral content (g) and density (g/cm2). Linear regression adjusted according to directed acyclic graphs recommendation was performed. Setting: São Paulo, Brazil. Participants: Healthy non-pregnant women (aged 20-45 years) (n=150). Results: Median age and BMI were 22 years (IQR=20; 29) and 22.3 kg/m2 (IQR=20.4; 25.3). Pre-pregnancy BMI≥25 kg/m2 was reported by 14.7% of mothers. In fully adjusted models, maternal pre-pregnancy BMI was associated with their daughters’ body-fat % (β=0.31; 95%CI=0.0004; 0.63), FMI (β=0.17; 95%CI=0.03; 0.30, android-to-gynoid ratio (β=0.01; 95%CI=0.004; 0.02) and VAT (β=0.09; 95%CI=0.02; 0.16), but not with total bone density (β=0.001; 95%CI=-0.003; 0.006) and content (β=7.13; 95%CI=-4.19; 18.46). Direct association with ASMI was also detected, but lost statistical significance when participants whose mothers were underweight were excluded. Conclusions: Maternal pre-pregnancy body mass index was directly associated with offspring general and visceral adiposity but seem not to be associated with bone mass. Results reinforce importance of avoiding excess of maternal adiposity, as an attempt to break the vicious cycle of obesity transmission.

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